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PDB: 102 件
2BIQ
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human p53 core domain mutant T123A-M133L-H168R-V203A-N239Y-R249S- N268D
分子名称: CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者Joerger, A.C, Fersht, A.R.
登録日2005-01-25
公開日2005-01-26
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structures of P53 Cancer Mutants and Mechanism of Rescue by Second-Site Suppressor Mutations
J.Biol.Chem., 280, 2005
1UOL
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BU of 1uol by Molmil
Crystal structure of the human p53 core domain mutant M133L/V203A/N239Y/N268D at 1.9 A resolution.
分子名称: CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者Joerger, A.C, Allen, M.D, Fersht, A.R.
登録日2003-09-19
公開日2003-10-16
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal Structure of a Superstable Mutant of Human P53 Core Domain. Insights Into the Mechanism of Rescuing Oncogenic Mutations
J.Biol.Chem., 279, 2004
2C6A
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BU of 2c6a by Molmil
Solution structure of the C4 zinc-finger domain of HDM2
分子名称: UBIQUITIN-PROTEIN LIGASE E3 MDM2, ZINC ION
著者Yu, G.W, Allen, M.D, Andreeva, A, Fersht, A.R, Bycroft, M.
登録日2005-11-08
公開日2006-01-04
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Solution Structure of the C4 Zinc Finger Domain of Hdm2.
Protein Sci., 15, 2006
2C6B
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Solution structure of the C4 zinc-finger domain of HDM2
分子名称: UBIQUITIN-PROTEIN LIGASE E3 MDM2, ZINC ION
著者Yu, G.W, Allen, M.D, Andreeva, A, Fersht, A.R, Bycroft, M.
登録日2005-11-08
公開日2006-01-04
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Solution Structure of the C4 Zinc Finger Domain of Hdm2.
Protein Sci., 15, 2006
1SS1
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BU of 1ss1 by Molmil
STAPHYLOCOCCAL PROTEIN A, B-DOMAIN, Y15W MUTANT, NMR, 25 STRUCTURES
分子名称: Immunoglobulin G binding protein A
著者Sato, S, Religa, T.L, Daggett, V, Fersht, A.R.
登録日2004-03-23
公開日2004-04-06
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献From The Cover: Testing protein-folding simulations by experiment: B domain of protein A.
Proc.Natl.Acad.Sci.USA, 101, 2004
2FEJ
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BU of 2fej by Molmil
Solution structure of human p53 DNA binding domain.
分子名称: Cellular tumor antigen p53, ZINC ION
著者Perez-Canadillas, J.M, Tidow, H, Freund, S.M, Rutherford, T.J, Ang, H.C, Fersht, A.R.
登録日2005-12-16
公開日2006-01-31
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of p53 core domain: Structural basis for its instability
Proc.Natl.Acad.Sci.Usa, 103, 2006
1W4H
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Peripheral-subunit from mesophilic, thermophilic and hyperthermophilic bacteria fold by ultrafast, apparently two-state transitions
分子名称: DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE
著者Ferguson, N, Sharpe, T.D, Schartau, P.J, Allen, M.D, Johnson, C.M, Fersht, A.R.
登録日2004-07-23
公開日2005-07-20
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Ultra-Fast Barrier-Limited Folding in the Peripheral Subunit-Binding Domain Family.
J.Mol.Biol., 353, 2005
1W4F
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Peripheral-subunit from mesophilic, thermophilic and hyperthermophilic bacteria fold by ultrafast, apparently two-state transitions
分子名称: DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE
著者Ferguson, N, Sharpe, T.D, Schartau, P.J, Allen, M.D, Johnson, C.M, Fersht, A.R.
登録日2004-07-23
公開日2005-07-20
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Ultra-Fast Barrier-Limited Folding in the Peripheral Subunit-Binding Domain Family.
J.Mol.Biol., 353, 2005
1W4G
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Peripheral-subunit binding domains from mesophilic, thermophilic, and hyperthermophilic bacteria fold by ultrafast, apparently two-state folding transitions
分子名称: DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE
著者Ferguson, N, Sharpe, T.D, Schartau, P.J, Allen, M.D, Johnson, C.M, Sato, S, Fersht, A.R.
登録日2004-07-23
公開日2005-07-20
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Ultra-Fast Barrier-Limited Folding in the Peripheral Subunit-Binding Domain Family.
J.Mol.Biol., 353, 2005
1JON
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GROEL (HSP60 CLASS) FRAGMENT COMPRISING RESIDUES 191-345
分子名称: GROEL, HSP60 CLASS
著者Buckle, A.M, Fersht, A.R.
登録日1996-05-30
公開日1997-03-12
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Chaperone activity and structure of monomeric polypeptide binding domains of GroEL.
Proc.Natl.Acad.Sci.USA, 93, 1996
1KID
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GROEL (HSP60 CLASS) FRAGMENT (APICAL DOMAIN) COMPRISING RESIDUES 191-376, MUTANT WITH ALA 262 REPLACED WITH LEU AND ILE 267 REPLACED WITH MET
分子名称: GROEL (HSP60 CLASS)
著者Buckle, A.M, Fersht, A.R.
登録日1996-12-13
公開日1997-09-17
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献A structural model for GroEL-polypeptide recognition.
Proc.Natl.Acad.Sci.USA, 94, 1997
1HL2
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Crystal structure of N-acetylneuraminate lyase from E. coli mutant L142R in complex with b-hydroxypyruvate
分子名称: 3-HYDROXYPYRUVIC ACID, N-ACETYLNEURAMINATE LYASE SUBUNIT
著者Joerger, A.C, Fersht, A.R.
登録日2003-03-12
公開日2003-05-09
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Mimicking Natural Evolution in Vitro: An N-Acetylneuraminate Lyase Mutant with an Increased Dihydrodipicolinate Synthase Activity
Proc.Natl.Acad.Sci.USA, 100, 2003
1KCQ
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BU of 1kcq by Molmil
Human Gelsolin Domain 2 with a Cd2+ bound
分子名称: CADMIUM ION, GELSOLIN
著者Kazmirski, S.L, Isaacson, R.L, An, C, Buckle, A, Johnson, C.M, Daggett, V, Fersht, A.R.
登録日2001-11-09
公開日2002-01-04
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Loss of a metal-binding site in gelsolin leads to familial amyloidosis-Finnish type.
Nat.Struct.Biol., 9, 2002
2NNT
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BU of 2nnt by Molmil
General structural motifs of amyloid protofilaments
分子名称: Transcription elongation regulator 1
著者Ferguson, N, Becker, J, Tidow, H, Tremmel, S, Sharpe, T.D, Krause, G, Flinders, J, Petrovich, M, Berriman, J, Oschkinat, H, Fersht, A.R.
登録日2006-10-24
公開日2006-11-14
最終更新日2023-12-27
実験手法SOLID-STATE NMR
主引用文献General structural motifs of amyloid protofilaments.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2J21
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Human p53 core domain mutant M133L-V203A-N239Y-N268D-R282W
分子名称: CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者Joerger, A.C, Fersht, A.R.
登録日2006-08-15
公開日2006-09-20
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs.
Proc.Natl.Acad.Sci.USA, 103, 2006
2J1Y
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Human p53 core domain mutant M133L-V203A-N239Y-G245S-N268D
分子名称: CALCIUM ION, CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者Joerger, A.C, Fersht, A.R.
登録日2006-08-15
公開日2006-09-20
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs.
Proc.Natl.Acad.Sci.USA, 103, 2006
2J20
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Human p53 core domain mutant M133L-V203A-N239Y-N268D-R273C
分子名称: CELLULAR TUMOR ANTIGEN P53, SULFATE ION, ZINC ION
著者Joerger, A.C, Ang, H.C, Fersht, A.R.
登録日2006-08-15
公開日2006-09-20
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs.
Proc.Natl.Acad.Sci.USA, 103, 2006
2J1Z
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BU of 2j1z by Molmil
Human p53 core domain mutant M133L-V203A-N239Y-N268D-F270L
分子名称: CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者Joerger, A.C, Fersht, A.R.
登録日2006-08-15
公開日2006-09-20
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs.
Proc.Natl.Acad.Sci.USA, 103, 2006
2J1X
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Human p53 core domain mutant M133L-V203A-Y220C-N239Y-N268D
分子名称: CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者Joerger, A.C, Fersht, A.R.
登録日2006-08-15
公開日2006-09-20
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs.
Proc.Natl.Acad.Sci.USA, 103, 2006
2J1W
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Human p53 core domain mutant M133L-V143A-V203A-N239Y-N268D
分子名称: CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者Joerger, A.C, Fersht, A.R.
登録日2006-08-15
公開日2006-09-20
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs.
Proc.Natl.Acad.Sci.USA, 103, 2006
1K5R
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YAP65 WW domain S24-Amino-Ethylsulfanyl-Acetic Acid mutant
分子名称: 65 KDA YES-ASSOCIATED PROTEIN, Fragment of WBP-1
著者Ferguson, N, Pires, J.R, Toepert, F, Johnson, C.M, Pan, Y.P, Volkmer-Engert, R, Schneider-Mergener, J, Daggett, V, Oschkinat, H, Fersht, A.R.
登録日2001-10-12
公開日2001-11-02
最終更新日2023-11-15
実験手法SOLUTION NMR
主引用文献Using flexible loop mimetics to extend phi-value analysis to secondary structure interactions.
Proc.Natl.Acad.Sci.USA, 98, 2001
4AGP
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Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5176
分子名称: 2-{[4-(diethylamino)piperidin-1-yl]methyl}-6-iodo-4-(3-phenoxyprop-1-yn-1-yl)phenol, CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者Joerger, A.C, Wilcken, R, Fersht, A.R, Boeckler, F.M.
登録日2012-01-30
公開日2012-03-21
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant P53.
J.Am.Chem.Soc., 134, 2012
4AGL
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Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan784
分子名称: 2,4-BIS(IODANYL)-6-[[METHYL-(1-METHYLPIPERIDIN-4-YL)AMINO]METHYL]PHENOL, CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者Joerger, A.C, Wilcken, R, Boeckler, F.M, Fersht, A.R.
登録日2012-01-30
公開日2012-03-21
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant P53.
J.Am.Chem.Soc., 134, 2012
4AGQ
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Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5196
分子名称: 2-{[4-(diethylamino)piperidin-1-yl]methyl}-6-iodo-4-[3-(phenylamino)prop-1-yn-1-yl]phenol, CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者Joerger, A.C, Wilcken, R, Boeckler, F.M, Fersht, A.R.
登録日2012-01-30
公開日2012-03-21
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.42 Å)
主引用文献Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant P53.
J.Am.Chem.Soc., 134, 2012
4AGN
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Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5116
分子名称: 2-{[4-(DIETHYLAMINO)PIPERIDIN-1-YL]METHYL}-4-(3-HYDROXYPROP-1-YN-1-YL)-6-IODOPHENOL, CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者Joerger, A.C, Wilcken, R, Boeckler, F.M, Fersht, A.R.
登録日2012-01-30
公開日2012-03-21
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant P53.
J.Am.Chem.Soc., 134, 2012

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