6T3W
 
 | | Coxsackie B3 2C protein in complex with S-Fluoxetine | | 分子名称: | (3S)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine, 2C protein, SODIUM ION, ... | | 著者 | El Kazzi, P, Papageorgiou, N, Ferron, F.P, Bauer, L, van Kuppeveld, F, Coutard, B. | | 登録日 | 2019-10-11 | | 公開日 | 2020-11-18 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | | 主引用文献 | Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex.
Sci Adv, 8, 2022
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8CB3
 | | SARS-CoV Macro domain complexed with 3-(N-morpholino)propanesulfonic acid | | 分子名称: | 3[N-MORPHOLINO]PROPANE SULFONIC ACID, GLYCEROL, Papain-like protease nsp3 | | 著者 | Morin, B, Ferron, F, Coutard, B, Canard, B, Marseilles Structural Genomics Program @ AFMB (MSGP) | | 登録日 | 2023-01-25 | | 公開日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.572 Å) | | 主引用文献 | SARS-CoV Macro domain complexed with 3-(N-morpholino)propanesulfonic acid
To Be Published
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8PWK
 | | human HINT1 in complex with compound AT8003 | | 分子名称: | Histidine triad nucleotide-binding protein 1, SODIUM ION, [(2~{R},3~{R},4~{R},5~{R})-5-[2-azanyl-6-(methylamino)purin-9-yl]-4-fluoranyl-4-methyl-3-oxidanyl-oxolan-2-yl]methyl dihydrogen phosphate | | 著者 | Zimberger, C, Canard, B, Ferron, F. | | 登録日 | 2023-07-20 | | 公開日 | 2024-07-31 | | 最終更新日 | 2024-09-04 | | 実験手法 | X-RAY DIFFRACTION (2.095 Å) | | 主引用文献 | The activation cascade of the broad-spectrum antiviral bemnifosbuvir characterized at atomic resolution.
Plos Biol., 22, 2024
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8PTS
 | | human GUK1 in complex with compound AT8001 | | 分子名称: | GLYCEROL, Guanylate kinase, [(2~{R},3~{R},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-4-fluoranyl-4-methyl-3-oxidanyl-oxolan-2-yl]methyl dihydrogen phosphate | | 著者 | Zimberger, C, Canard, B, Ferron, F. | | 登録日 | 2023-07-14 | | 公開日 | 2024-07-24 | | 最終更新日 | 2024-09-04 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | The activation cascade of the broad-spectrum antiviral bemnifosbuvir characterized at atomic resolution.
Plos Biol., 22, 2024
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8PIE
 | | Crystal structure of the human nucleoside diphosphate kinase B domain in complex with the product AT-8500 formed by catalysis of compound AT-9010 | | 分子名称: | GLYCEROL, Nucleoside diphosphate kinase B, [(2~{R},3~{R},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-4-fluoranyl-4-methyl-3-oxidanyl-oxolan-2-yl]methyl phosphono hydrogen phosphate | | 著者 | Feracci, M, Chazot, A, Ferron, F, Alvarez, K, Canard, B. | | 登録日 | 2023-06-21 | | 公開日 | 2024-07-31 | | 最終更新日 | 2024-09-04 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The activation cascade of the broad-spectrum antiviral bemnifosbuvir characterized at atomic resolution.
Plos Biol., 22, 2024
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8QCH
 | | Human Adenosine deaminase-like protein in complex with compound AT8001 | | 分子名称: | Adenosine deaminase-like protein, DI(HYDROXYETHYL)ETHER, SODIUM ION, ... | | 著者 | Zimberger, C, canard, B, Ferron, F. | | 登録日 | 2023-08-26 | | 公開日 | 2024-07-31 | | 最終更新日 | 2024-09-04 | | 実験手法 | X-RAY DIFFRACTION (2.442 Å) | | 主引用文献 | The activation cascade of the broad-spectrum antiviral bemnifosbuvir characterized at atomic resolution.
Plos Biol., 22, 2024
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6T2A
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6T6L
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6S3A
 | | Coxsackie B3 2C protein in complex with S-Fluoxetine | | 分子名称: | (3S)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine, 2C protein, CHLORIDE ION, ... | | 著者 | El Kazzi, P, Papageorgiou, N, Ferron, F.P, Bauer, L, van Kuppeveld, F, Coutard, B. | | 登録日 | 2019-06-24 | | 公開日 | 2021-01-13 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | | 主引用文献 | Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex.
Sci Adv, 8, 2022
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2XYV
 | | Crystal structure of the nsp16 nsp10 SARS coronavirus complex | | 分子名称: | CHLORIDE ION, MAGNESIUM ION, NON-STRUCTURAL PROTEIN 10, ... | | 著者 | Decroly, E, Debarnot, C, Ferron, F, Bouvet, M, Coutard, B, Imbert, I, Gluais, L, Papageorgiou, N, Ortiz-Lombardia, M, Lescar, J, Canard, B. | | 登録日 | 2010-11-19 | | 公開日 | 2011-10-26 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | | 主引用文献 | Crystal Structure and Functional Analysis of the Sars-Coronavirus RNA CAP 2'-O-Methyltransferase Nsp10/Nsp16 Complex.
Plos Pathog., 7, 2011
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2XYR
 | | Crystal structure of the nsp16 nsp10 SARS coronavirus complex | | 分子名称: | CHLORIDE ION, MAGNESIUM ION, NON-STRUCTURAL PROTEIN 10, ... | | 著者 | Decroly, E, Debarnot, C, Ferron, F, Bouvet, M, Coutard, B, Imbert, I, Gluais, L, Papageorgiou, N, Ortiz-Lombardia, M, Lescar, J, Canard, B. | | 登録日 | 2010-11-18 | | 公開日 | 2011-10-26 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal Structure and Functional Analysis of the Sars-Coronavirus RNA CAP 2'-O-Methyltransferase Nsp10/Nsp16 Complex.
Plos Pathog., 7, 2011
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2XYQ
 | | Crystal structure of the nsp16 nsp10 SARS coronavirus complex | | 分子名称: | CHLORIDE ION, MAGNESIUM ION, NON-STRUCTURAL PROTEIN 10, ... | | 著者 | Decroly, E, Debarnot, C, Ferron, F, Bouvet, M, Coutard, B, Imbert, I, Gluais, L, Papageorgiou, N, Ortiz-Lombardia, M, Lescar, J, Canard, B. | | 登録日 | 2010-11-18 | | 公開日 | 2011-10-19 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal Structure and Functional Analysis of the Sars-Coronavirus RNA CAP 2'-O-Methyltransferase Nsp10/Nsp16 Complex.
Plos Pathog., 7, 2011
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6SX8
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6SY8
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4CP5
 | | ndpK in complex with (Rp)-SPMPApp | | 分子名称: | NUCLEOSIDE DIPHOSPHATE KINASE, CYTOSOLIC, [[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-sulfanyl-phosphoryl] phosphono hydrogen phosphate | | 著者 | Priet, S, Ferron, F, Alvarez, K, Verron, M, Canard, B. | | 登録日 | 2014-01-31 | | 公開日 | 2015-02-11 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | | 主引用文献 | Enzymatic Synthesis of Acyclic Nucleoside Thiophosphonate Diphosphates: Effect of the Alpha-Phosphorus Configuration on HIV-1 RT Activity.
Antiviral Res., 117, 2015
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4C5Q
 | | measles virus phosphoprotein tetramerization domain | | 分子名称: | PHOSPHOPROTEIN | | 著者 | Blocquel, D, Habchi, J, Durand, E, Sevajol, M, Ferron, F, Papageorgiou, N, Longhi, S. | | 登録日 | 2013-09-14 | | 公開日 | 2014-04-09 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Coiled-Coil Deformations in Crystal Structures: The Measles Virus Phosphoprotein Multimerization Domain as an Illustrative Example.
Acta Crystallogr.,Sect.D, 70, 2014
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4C6A
 | | High Resolution Structure of the Nucleoside diphosphate kinase | | 分子名称: | DI(HYDROXYETHYL)ETHER, NUCLEOSIDE DIPHOSPHATE KINASE, CYTOSOLIC | | 著者 | Priet, S, Ferron, F, Alvarez, K, Verron, M, Canard, B. | | 登録日 | 2013-09-18 | | 公開日 | 2013-11-20 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | Enzymatic Synthesis of Acyclic Nucleoside Thiophosphonate Diphosphates: Effect of the Alpha-Phosphorus Configuration on HIV-1 RT Activity.
Antiviral Res., 117, 2015
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2D1L
 | | Structure of F-actin binding domain IMD of MIM (Missing In Metastasis) | | 分子名称: | Metastasis suppressor protein 1 | | 著者 | Lee, S.H, Kerff, F, Chereau, D, Ferron, F, Dominguez, R. | | 登録日 | 2005-08-27 | | 公開日 | 2006-09-12 | | 最終更新日 | 2017-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Structural basis for the actin-binding function of missing-in-metastasis
Structure, 15, 2007
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2EYI
 | | Crystal structure of the actin-binding domain of human alpha-actinin 1 at 1.7 Angstrom resolution | | 分子名称: | Alpha-actinin 1 | | 著者 | Borrego-Diaz, E, Kerff, F, Lee, S.H, Ferron, F, Li, Y, Dominguez, R. | | 登録日 | 2005-11-09 | | 公開日 | 2006-08-29 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Crystal structure of the actin-binding domain of alpha-actinin 1: Evaluating two competing actin-binding models.
J.Struct.Biol., 155, 2006
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2EYN
 | | Crystal structure of the actin-binding domain of human alpha-actinin 1 at 1.8 Angstrom resolution | | 分子名称: | Alpha-actinin 1 | | 著者 | Borrego-Diaz, E, Kerff, F, Lee, S.H, Ferron, F, Li, Y, Dominguez, R. | | 登録日 | 2005-11-09 | | 公開日 | 2006-08-29 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal structure of the actin-binding domain of alpha-actinin 1: Evaluating two competing actin-binding models.
J.Struct.Biol., 155, 2006
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3GQO
 | | Crystal structure of macro domain of Venezuelan Equine Encephalitis virus in complex with ADP-ribose | | 分子名称: | ADENOSINE-5-DIPHOSPHORIBOSE, Non-structural protein 3 | | 著者 | Malet, H, Jamal, S, Coutard, B, Ferron, F, Canard, B. | | 登録日 | 2009-03-24 | | 公開日 | 2009-07-21 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | The crystal structures of Chikungunya and Venezuelan equine encephalitis virus nsP3 macro domains define a conserved adenosine binding pocket
J.Virol., 83, 2009
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3H1U
 | | Structure of ubiquitin in complex with Cd ions | | 分子名称: | CADMIUM ION, Ubiquitin | | 著者 | Qureshi, I.A, Ferron, F, Cheung, P, Lescar, J. | | 登録日 | 2009-04-14 | | 公開日 | 2009-05-05 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Crystallographic structure of ubiquitin in complex with cadmium ions
BMC RES NOTES, 2, 2009
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5LTF
 | | Crystal structure of Lymphocytic choriomeningitis mammarenavirus endonuclease complexed with catalytic ions | | 分子名称: | MAGNESIUM ION, RNA-directed RNA polymerase L | | 著者 | Saez-Ayala, M, Yekwa, E.L, Canard, B, Ferron, F. | | 登録日 | 2016-09-06 | | 公開日 | 2017-09-13 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | | 主引用文献 | Crystal structures ofLymphocytic choriomeningitis virusendonuclease domain complexed with diketo-acid ligands.
IUCrJ, 5, 2018
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5LS4
 | | Mopeia virus exonuclease domain complexed with Calcium | | 分子名称: | CALCIUM ION, DI(HYDROXYETHYL)ETHER, Nucleoprotein, ... | | 著者 | Yekwa, E.L, Canard, B, Ferron, F. | | 登録日 | 2016-08-22 | | 公開日 | 2017-07-05 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.469 Å) | | 主引用文献 | Activity inhibition and crystal polymorphism induced by active-site metal swapping.
Acta Crystallogr D Struct Biol, 73, 2017
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5LTN
 | | Crystal structure of Lymphocytic choriomeningitis mammarenavirus endonuclease complexed with DPBA | | 分子名称: | 2-4-DIOXO-4-PHENYLBUTANOIC ACID, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Saez-Ayala, M, Yekwa, E.L, Canard, B, Alvarez, K, Ferron, F. | | 登録日 | 2016-09-07 | | 公開日 | 2017-09-13 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | | 主引用文献 | Crystal structures of Lymphocytic choriomeningitis virusendonuclease domain complexed with diketo-acid ligands.
Iucrj, 5, 2018
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