8C2P
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![BU of 8c2p by Molmil](/molmil-images/mine/8c2p) | FMDV 3D polymerase in complex with 3B3 | Descriptor: | Protein 3B-3, RNA-directed RNA polymerase 3D-POL | Authors: | Ferrer-Orta, C, Veraguer, N. | Deposit date: | 2022-12-22 | Release date: | 2023-04-26 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Dual role of the foot-and-mouth disease virus 3B1 protein in the replication complex: As protein primer and as an essential component to recruit 3Dpol to membranes. Plos Pathog., 19, 2023
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8C1N
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5LOB
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![BU of 5lob by Molmil](/molmil-images/mine/5lob) | |
5LO8
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![BU of 5lo8 by Molmil](/molmil-images/mine/5lo8) | |
4WYL
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![BU of 4wyl by Molmil](/molmil-images/mine/4wyl) | Mutant K18E of 3D polymerase from Foot-and-Moth Disease Virus | Descriptor: | ACETATE ION, GLYCEROL, MANGANESE (II) ION, ... | Authors: | Ferrer-Orta, C, Verdaguer, N, de la Higuera, I, Domingo, E. | Deposit date: | 2014-11-17 | Release date: | 2015-05-06 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Multifunctionality of a picornavirus polymerase domain: nuclear localization signal and nucleotide recognition. J.Virol., 89, 2015
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3GPE
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![BU of 3gpe by Molmil](/molmil-images/mine/3gpe) | Crystal Structure Analysis of PKC (alpha)-C2 domain complexed with Ca2+ and PtdIns(4,5)P2 | Descriptor: | CALCIUM ION, PHOSPHATE ION, Protein kinase C alpha type, ... | Authors: | Ferrer-Orta, C, Querol-Audi, J, Fita, I, Verdaguer, N. | Deposit date: | 2009-03-23 | Release date: | 2009-05-05 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural and mechanistic insights into the association of PKCalpha-C2 domain to PtdIns(4,5)P2. Proc.Natl.Acad.Sci.USA, 106, 2009
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4IQX
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![BU of 4iqx by Molmil](/molmil-images/mine/4iqx) | Mutant P44S P169S M296I of Foot-and-mouth disease Virus RNA-dependent RNA polymerase | Descriptor: | 3D polymerase, RNA (5'-R(*AP*UP*GP*GP*GP*CP*C)-3'), RNA (5'-R(*GP*GP*CP*CP*C)-3') | Authors: | Ferrer-Orta, C, Verdaguer, N, Agudo, R, Perez-Luque, R. | Deposit date: | 2013-01-14 | Release date: | 2013-02-06 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | A multi-step process of viral adaptation to a mutagenic nucleoside analogue by modulation of transition types leads to extinction-escape. Plos Pathog., 6, 2010
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5N8X
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5N95
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1WNE
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![BU of 1wne by Molmil](/molmil-images/mine/1wne) | Foot and Mouth Disease Virus RNA-dependent RNA polymerase in complex with a template-primer RNA | Descriptor: | 5'-R(*CP*AP*UP*GP*GP*GP*CP*C)-3', 5'-R(*GP*GP*CP*CP*C)-3', MAGNESIUM ION, ... | Authors: | Ferrer-Orta, C, Arias, A, Perez-Luque, R, Escarmis, C, Domingo, E, Verdaguer, N. | Deposit date: | 2004-07-31 | Release date: | 2004-08-31 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure of Foot-and-Mouth Disease Virus RNA-dependent RNA Polymerase and Its Complex with a Template-Primer RNA J.Biol.Chem., 279, 2004
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1U09
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![BU of 1u09 by Molmil](/molmil-images/mine/1u09) | Footand Mouth Disease Virus RNA-dependent RNA polymerase | Descriptor: | polyprotein | Authors: | Ferrer-Orta, C, Arias, A, Perez-Luque, R, Escarmis, C, Domingo, E, Verdaguer, N. | Deposit date: | 2004-07-13 | Release date: | 2004-08-31 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Structure of Foot-and-Mouth Disease Virus RNA-dependent RNA Polymerase and Its Complex with a Template-Primer RNA J.Biol.Chem., 279, 2004
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2E9R
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![BU of 2e9r by Molmil](/molmil-images/mine/2e9r) | Foot-and-mouth disease virus RNA-dependent RNA polymerase in complex with a template-primer RNA and with ribavirin | Descriptor: | 5'-R(*CP*AP*UP*GP*GP*GP*CP*CP*C)-3', 5'-R(*CP*CP*C*GP*GP*GP*CP*CP*C)-3', MAGNESIUM ION, ... | Authors: | Ferrer-Orta, C, Arias, A, Perez-Luque, R, Escarmis, C, Domingo, E, Verdaguer, N. | Deposit date: | 2007-01-26 | Release date: | 2007-06-26 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | Sequential structures provide insights into the fidelity of RNA replication Proc.Natl.Acad.Sci.Usa, 104, 2007
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2EC0
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![BU of 2ec0 by Molmil](/molmil-images/mine/2ec0) | RNA-dependent RNA polymerase of foot-and-mouth disease virus in complex with a template-primer RNA and ATP | Descriptor: | 5'-R(*GP*GP*GP*CP*CP*CP*A)-3', 5'-R(P*AP*UP*GP*GP*GP*CP*CP*C)-3', MAGNESIUM ION, ... | Authors: | Ferrer-Orta, C, Arias, A, Perez-Luque, R, Escarmis, C, Domingo, E, Verdaguer, N. | Deposit date: | 2007-02-09 | Release date: | 2007-06-26 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Sequential structures provide insights into the fidelity of RNA replication Proc.Natl.Acad.Sci.Usa, 104, 2007
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2E9T
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![BU of 2e9t by Molmil](/molmil-images/mine/2e9t) | Foot-and-mouth disease virus RNA-polymerase RNA dependent in complex with a template-primer RNA and 5F-UTP | Descriptor: | 5'-R(*GP*GP*GP*CP*CP*CP*(5FU))-3', 5'-R(P*UP*AP*GP*GP*GP*CP*CP*C)-3', MAGNESIUM ION, ... | Authors: | Ferrer-Orta, C, Arias, A, Perez-Luque, R, Escarmis, C, Domingo, E, Verdaguer, N. | Deposit date: | 2007-01-26 | Release date: | 2007-06-26 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Sequential structures provide insights into the fidelity of RNA replication Proc.Natl.Acad.Sci.Usa, 104, 2007
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2JB9
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![BU of 2jb9 by Molmil](/molmil-images/mine/2jb9) | PhoB response regulator receiver domain constitutively-active double mutant D10A and D53E. | Descriptor: | PHOSPHATE REGULON TRANSCRIPTIONAL REGULATORY PROTEIN PHOB | Authors: | Ferrer-Orta, C, Arribas-Bosacoma, R, Kim, S.-K, Blanco, A.G, Pereira, P.J.B, Gomis-Ruth, F.X, Wanner, B.L, Coll, M, Sola, M. | Deposit date: | 2006-12-05 | Release date: | 2007-01-04 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The X-Ray Crystal Structures of Two Constitutively Active Mutants of the E. Coli Phob Receiver Domain Give Insights Into Activation J.Mol.Biol., 366, 2007
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3KNA
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![BU of 3kna by Molmil](/molmil-images/mine/3kna) | M296I mutant of foot-and-mouth disease virus RNA-polymerase in complex with a template- primer RNA | Descriptor: | 3D polymerase, MAGNESIUM ION, RNA (5'-R(*AP*UP*GP*GP*GP*CP*C)-3'), ... | Authors: | Ferrer-Orta, C, Verdaguer, N, Perez-Luque, R. | Deposit date: | 2009-11-12 | Release date: | 2010-07-07 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of foot-and-mouth disease virus mutant polymerases with reduced sensitivity to ribavirin J.Virol., 84, 2010
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3KOA
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![BU of 3koa by Molmil](/molmil-images/mine/3koa) | M296I mutant of foot-and-mouth disease virus RNA-polymerase in complex with a template- primer RNA and GTP | Descriptor: | 3D polymerase, DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Ferrer-Orta, C, Verdaguer, N, Perez-Luque, R. | Deposit date: | 2009-11-13 | Release date: | 2010-07-07 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure of foot-and-mouth disease virus mutant polymerases with reduced sensitivity to ribavirin J.Virol., 84, 2010
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3KLV
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![BU of 3klv by Molmil](/molmil-images/mine/3klv) | M296I G62S mutant of foot-and-mouth disease virus RNA-polymerase in complex with a template- primer RNA | Descriptor: | 3D polymerase, MAGNESIUM ION, RNA (5'-R(*AP*UP*GP*GP*GP*CP*C)-3'), ... | Authors: | Ferrer-Orta, C, Sierra, M, Agudo, R, Perez-Luque, R, Arias, A, Verdaguer, N. | Deposit date: | 2009-11-09 | Release date: | 2010-07-07 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure of foot-and-mouth disease virus mutant polymerases with reduced sensitivity to ribavirin J.Virol., 84, 2010
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3KMS
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![BU of 3kms by Molmil](/molmil-images/mine/3kms) | G62S mutant of foot-and-mouth disease virus RNA-polymerase in complex with a template- primer RNA trigonal structure | Descriptor: | 3D polymerase, MAGNESIUM ION, RNA (5'-R(*AP*UP*GP*GP*GP*CP*C)-3'), ... | Authors: | Ferrer-Orta, C, Verdaguer, N, Perez-Luque, R. | Deposit date: | 2009-11-11 | Release date: | 2010-07-07 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of foot-and-mouth disease virus mutant polymerases with reduced sensitivity to ribavirin J.Virol., 84, 2010
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3KMQ
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![BU of 3kmq by Molmil](/molmil-images/mine/3kmq) | G62S mutant of foot-and-mouth disease virus RNA-polymerase in complex with a template- primer RNA, tetragonal structure | Descriptor: | 3D polymerase, RNA (5'-R(*GP*GP*CP*CP*C)-3'), RNA (5'-R(P*GP*GP*GP*CP*C)-3') | Authors: | Ferrer-Orta, C, Verdaguer, N, Perez-Luque, R. | Deposit date: | 2009-11-11 | Release date: | 2010-07-07 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Structure of foot-and-mouth disease virus mutant polymerases with reduced sensitivity to ribavirin J.Virol., 84, 2010
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2F8E
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![BU of 2f8e by Molmil](/molmil-images/mine/2f8e) | Foot and Mouth Disease Virus RNA-dependent RNA polymerase in complex with uridylylated VPg protein | Descriptor: | MAGNESIUM ION, MANGANESE (II) ION, RNA-dependent RNA polymerase, ... | Authors: | Ferrer-Orta, C, Arias, A, Perez-Luque, R, Escarmis, C, Domingo, E, Verdaguer, N. | Deposit date: | 2005-12-02 | Release date: | 2006-03-28 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The structure of a protein primer-polymerase complex in the initiation of genome replication Embo J., 25, 2006
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2D7S
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![BU of 2d7s by Molmil](/molmil-images/mine/2d7s) | Foot and Mouth Disease Virus RNA-dependent RNA polymerase in complex with VPg protein | Descriptor: | RNA-dependent RNA polymerase, VPg1 protein | Authors: | Ferrer-Orta, C, Arias, A, Perez-Luque, R, Escarmis, C, Domingo, E, Verdaguer, N. | Deposit date: | 2005-11-29 | Release date: | 2006-03-28 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The structure of a protein primer-polymerase complex in the initiation of genome replication Embo J., 25, 2006
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4WYW
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![BU of 4wyw by Molmil](/molmil-images/mine/4wyw) | Mutant K20E of 3D polymerase from Foot-and-Mouth Disease Virus | Descriptor: | ACETATE ION, GLYCEROL, RNA-directed RNA polymerase 3D-POL, ... | Authors: | Ferrer-Orta, C, Verdaguer, N, de la Higuera, I, Domingo, E. | Deposit date: | 2014-11-18 | Release date: | 2015-05-06 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Multifunctionality of a picornavirus polymerase domain: nuclear localization signal and nucleotide recognition. J.Virol., 89, 2015
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2E9Z
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![BU of 2e9z by Molmil](/molmil-images/mine/2e9z) | Foot-and-mouth disease virus RNA-polymerase in complex with a template- primer RNA, ATP and UTP | Descriptor: | 5'-R(*CP*AP*UP*GP*GP*GP*CP*CP*C)-3', 5'-R(*GP*GP*GP*CP*CP*CP*A)-3', MAGNESIUM ION, ... | Authors: | Ferrer-Orta, C, Arias, A, Perez-Luque, R, Escarmis, C, Domingo, E, Verdaguer, N. | Deposit date: | 2007-01-29 | Release date: | 2007-06-26 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Sequential structures provide insights into the fidelity of RNA replication Proc.Natl.Acad.Sci.Usa, 104, 2007
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1KWM
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![BU of 1kwm by Molmil](/molmil-images/mine/1kwm) | Human procarboxypeptidase B: Three-dimensional structure and implications for thrombin-activatable fibrinolysis inhibitor (TAFI) | Descriptor: | CITRIC ACID, Procarboxypeptidase B, ZINC ION | Authors: | Pereira, P.J.B, Segura-Martin, S, Ferrer-Orta, C, Vendrell, J, Aviles, F.-X, Coll, M, Gomis-Rueth, F.-X. | Deposit date: | 2002-01-30 | Release date: | 2002-06-05 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Human procarboxypeptidase B: three-dimensional structure and implications for thrombin-activatable fibrinolysis inhibitor (TAFI). J.Mol.Biol., 321, 2002
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