6CFF
 
 | | Stimulator of Interferon Genes Human | | 分子名称: | (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, Stimulator of interferon genes protein | | 著者 | Fernandez, D, Li, L, Ergun, S.L. | | 登録日 | 2018-02-14 | | 公開日 | 2019-03-13 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.396 Å) | | 主引用文献 | STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition.
Cell, 178, 2019
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6W8E
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8GKO
 | | Crystal Structure Analysis of Aspergillus fumigatus alkaline protease | | 分子名称: | 1,2-ETHANEDIOL, Alkaline protease 1, FORMYL GROUP, ... | | 著者 | Fernandez, D, Diec, D.D.L, Guo, W, Russi, S. | | 登録日 | 2023-03-20 | | 公開日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.06 Å) | | 主引用文献 | Targeting Aspergillus allergen oryzin with a chemical probe at atomic precision.
Sci Rep, 13, 2023
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8GKQ
 | | Crystal Structure Analysis of Aspergillus fumigatus alkaline protease | | 分子名称: | 1,2-ETHANEDIOL, Alkaline protease 1, CALCIUM ION, ... | | 著者 | Fernandez, D, Diec, D.D.L, Guo, W, Russi, S. | | 登録日 | 2023-03-20 | | 公開日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Targeting Aspergillus allergen oryzin with a chemical probe at atomic precision.
Sci Rep, 13, 2023
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8GKP
 | | Crystal Structure Analysis of Aspergillus fumigatus alkaline protease | | 分子名称: | Alkaline protease 1, DI(HYDROXYETHYL)ETHER, FORMIC ACID, ... | | 著者 | Fernandez, D, Diec, D.D.L, Guo, W, Russi, S. | | 登録日 | 2023-03-20 | | 公開日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Targeting Aspergillus allergen oryzin with a chemical probe at atomic precision.
Sci Rep, 13, 2023
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6XKD
 | | Structure of ligand-bound mouse cGAMP hydrolase ENPP1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ... | | 著者 | Fernandez, D, Li, L. | | 登録日 | 2020-06-26 | | 公開日 | 2021-06-02 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structure-Aided Development of Small-Molecule Inhibitors of ENPP1, the Extracellular Phosphodiesterase of the Immunotransmitter cGAMP.
Cell Chem Biol, 27, 2020
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3GLJ
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3HUV
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3I1U
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3HLP
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6DNK
 | | Human Stimulator of Interferon Genes | | 分子名称: | Stimulator of interferon genes protein, cGAMP | | 著者 | Fernandez, D, Li, L, Ergun, S.L. | | 登録日 | 2018-06-06 | | 公開日 | 2019-03-13 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition.
Cell, 178, 2019
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6NQT
 | | GalNac-T2 soaked with UDP-sugar | | 分子名称: | MANGANESE (II) ION, Polypeptide N-acetylgalactosaminyltransferase 2, [[(2~{R},3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R},6~{R})-3-(hex-5-ynoylamino)-6-(hydroxymethyl)-4,5-bis(oxidanyl)oxan-2-yl] hydrogen phosphate | | 著者 | Fernandez, D, Bertozzi, C.R, Schumann, B, Agbay, A. | | 登録日 | 2019-01-21 | | 公開日 | 2020-01-29 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | | 主引用文献 | Bump-and-Hole Engineering Identifies Specific Substrates of Glycosyltransferases in Living Cells.
Mol.Cell, 78, 2020
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6CY7
 | | Human Stimulator of Interferon Genes | | 分子名称: | (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, GLYCEROL, IMIDAZOLE, ... | | 著者 | Fernandez, D, Li, L, Ergun, S.L. | | 登録日 | 2018-04-04 | | 公開日 | 2019-03-13 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition.
Cell, 178, 2019
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5A52
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7MW8
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7MJC
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7MJD
 | | Crystal Structure Analysis of ALDH1B1 | | 分子名称: | 8-(2-methoxyphenyl)-10-(4-phenylphenyl)-1$l^{4},8-diazabicyclo[5.3.0]deca-1(7),9-diene, Aldehyde dehydrogenase X, mitochondrial, ... | | 著者 | Fernandez, D, Chen, J.K. | | 登録日 | 2021-04-20 | | 公開日 | 2022-06-08 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | | 主引用文献 | Inhibitors targeted to aldehyde dehydrogenase
Nat.Chem.Biol., 2022
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7N1S
 | | Crystal Structure Analysis of Xac Nucleotide Pyrophosphatase/Phosphodiesterase | | 分子名称: | Phosphodiesterase-nucleotide pyrophosphatase, TETRAETHYLENE GLYCOL, ZINC ION | | 著者 | Fernandez, D, Li, L, Brown, J.A, Carozza, J.A. | | 登録日 | 2021-05-28 | | 公開日 | 2022-06-01 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | ENPP1's regulation of extracellular cGAMP is a ubiquitous mechanism of attenuating STING signaling.
Proc.Natl.Acad.Sci.USA, 119, 2022
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4K90
 | | Extracellular metalloproteinase from Aspergillus | | 分子名称: | BORIC ACID, CALCIUM ION, Extracellular metalloproteinase mep, ... | | 著者 | Fernandez, D, Russi, S, Vendrell, J, Monod, M, Pallares, I. | | 登録日 | 2013-04-19 | | 公開日 | 2013-10-23 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | A functional and structural study of the major metalloprotease secreted by the pathogenic fungus Aspergillus fumigatus.
Acta Crystallogr.,Sect.D, 69, 2013
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8U45
 | | Crystal Structure Analysis of Aspergillus fumigatus alkaline protease | | 分子名称: | Alkaline protease 1, CALCIUM ION, CHLORIDE ION, ... | | 著者 | Fernandez, D, Diec, D.D.L, Guo, W, Russi, S. | | 登録日 | 2023-09-08 | | 公開日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Targeting Aspergillus allergen oryzin with a chemical probe at atomic precision.
Sci Rep, 13, 2023
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6W7P
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3KGQ
 | | Carboxypeptidase A liganded to an organic small-molecule: conformational changes | | 分子名称: | ACETONE, CITRIC ACID, Carboxypeptidase A1, ... | | 著者 | Fernandez, D, Boix, E, Pallares, I, Aviles, F.X, Vendrell, J. | | 登録日 | 2009-10-29 | | 公開日 | 2010-10-27 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structural and Functional Analysis of the Complex between Citrate and the Zinc Peptidase Carboxypeptidase A
Enzyme Res, 2011, 2011
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7RAD
 | | Crystal Structure Analysis of ALDH1B1 | | 分子名称: | 1,2-ETHANEDIOL, 3-(2-methoxyphenyl)-1-(4-phenylphenyl)-6,7,8,9-tetrahydro-5~{H}-imidazo[1,2-a][1,3]diazepine, Aldehyde dehydrogenase X, ... | | 著者 | Fernandez, D, Chen, J.K. | | 登録日 | 2021-07-01 | | 公開日 | 2022-06-08 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Inhibitors targeted to aldehyde dehydrogenase
Nat.Chem.Biol., 2022
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7SCI
 | | AM0627 metallopeptidase from Akkermansia muciniphila | | 分子名称: | CHLORIDE ION, FORMIC ACID, Peptidase M60 domain-containing protein, ... | | 著者 | Fernandez, D, Bertozzi, C.R, Shon, D.J. | | 登録日 | 2021-09-28 | | 公開日 | 2022-04-27 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structure-guided mutagenesis of a mucin-selective metalloprotease from Akkermansia muciniphila alters substrate preferences.
J.Biol.Chem., 298, 2022
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2V77
 | | Crystal Structure of Human Carboxypeptidase A1 | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CARBOXYPEPTIDASE A1, OCTANE-1,3,5,7-TETRACARBOXYLIC ACID, ... | | 著者 | Pallares, I, Fernandez, D, Comellas-Bigler, M, Fernandez-Recio, J, Ventura, S, Aviles, F.X, Vendrell, J. | | 登録日 | 2007-07-27 | | 公開日 | 2008-07-01 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.603 Å) | | 主引用文献 | Direct interaction between a human digestive protease and the mucoadhesive poly(acrylic acid).
Acta Crystallogr. D Biol. Crystallogr., D64, 2008
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