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PDB: 34 件

5WB8
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Crystal structure of the epidermal growth factor receptor extracellular region in complex with epigen
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, Epigen, ...
著者Bessman, N.J, Freed, D.M, Moore, J.O, Ferguson, K.M, Lemmon, M.A.
登録日2017-06-28
公開日2017-10-18
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics.
Cell, 171, 2017
8UKV
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Crystal structure of nanobody/VHH domain of 34E5 in complex with the extracellular region of the epidermal growth factor variant III (EGFRvIII)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, ...
著者Stayrook, S.E, Ferguson, K.M, Bagchi, A.
登録日2023-10-15
公開日2024-06-19
実験手法X-RAY DIFFRACTION (2.94 Å)
主引用文献Structural insights into the role and targeting of EGFRvIII
Structure, 2024
2AHX
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Crystal structure of ErbB4/HER4 extracellular domain
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Receptor tyrosine-protein kinase erbB-4, SULFATE ION, ...
著者Bouyain, S, Longo, P.A, Li, S, Ferguson, K.M, Leahy, D.J.
登録日2005-07-28
公開日2005-09-27
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.396 Å)
主引用文献The extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand
Proc.Natl.Acad.Sci.USA, 102, 2005
1YY8
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Crystal structure of the Fab fragment from the monoclonal antibody cetuximab/Erbitux/IMC-C225
分子名称: Cetuximab Fab Heavy chain, Cetuximab Fab Light chain
著者Li, S, Schmitz, K.R, Jeffrey, P.D, Wiltzius, J.J.W, Kussie, P, Ferguson, K.M.
登録日2005-02-24
公開日2005-04-26
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis for inhibition of the epidermal growth factor receptor by cetuximab
Cancer Cell, 7, 2005
1YY9
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Structure of the extracellular domain of the epidermal growth factor receptor in complex with the Fab fragment of cetuximab/Erbitux/IMC-C225
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cetuximab Fab Heavy chain, ...
著者Li, S, Schmitz, K.R, Jeffrey, P.D, Wiltzius, J.J.W, Kussie, P, Ferguson, K.M.
登録日2005-02-24
公開日2005-04-26
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.605 Å)
主引用文献Structural basis for inhibition of the epidermal growth factor receptor by cetuximab
Cancer Cell, 7, 2005
3KN1
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Crystal Structure of Golgi Phosphoprotein 3 N-term Truncation Variant
分子名称: Golgi phosphoprotein 3, SULFATE ION
著者Schmitz, K.R, Bessman, N.J, Setty, T.G, Ferguson, K.M.
登録日2009-11-11
公開日2009-12-15
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献PtdIns4P recognition by Vps74/GOLPH3 links PtdIns 4-kinase signaling to retrograde Golgi trafficking.
J.Cell Biol., 187, 2009
7LEN
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Crystal structure of the epidermal growth factor receptor extracellular region with R84K mutation in complex with epiregulin crystallized with trehalose
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Hu, C, Leche II, C.A, Stayrook, S.E, Ferguson, K.M, Lemmon, M.A.
登録日2021-01-14
公開日2021-11-17
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias.
Nature, 602, 2022
7LFS
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Crystal structure of the epidermal growth factor receptor extracellular region with A265V mutation in complex with epiregulin
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 4 of Epidermal growth factor receptor, ...
著者Hu, C, Leche II, C.A, Stayrook, S.E, Ferguson, K.M, Lemmon, M.A.
登録日2021-01-18
公開日2021-11-17
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias.
Nature, 602, 2022
7LFR
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Crystal structure of the epidermal growth factor receptor extracellular region with R84K mutation in complex with epiregulin crystallized with spermine
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, Proepiregulin, ...
著者Hu, C, Leche II, C.A, Stayrook, S.E, Ferguson, K.M, Lemmon, M.A.
登録日2021-01-18
公開日2021-11-17
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias.
Nature, 602, 2022
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件を2024-06-19に公開中

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