3N25
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![BU of 3n25 by Molmil](/molmil-images/mine/3n25) | The structure of muscle pyruvate kinase in complex with proline, pyruvate, and Mn2+ | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, MANGANESE (II) ION, ... | 著者 | Fenton, A.W, Johnson, T.A, Holyoak, T. | 登録日 | 2010-05-17 | 公開日 | 2010-07-28 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | 主引用文献 | The pyruvate kinase model system, a cautionary tale for the use of osmolyte perturbations to support conformational equilibria in allostery. Protein Sci., 19, 2010
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8F5T
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![BU of 8f5t by Molmil](/molmil-images/mine/8f5t) | Rabbit muscle pyruvate kinase in complex with sodium and magnesium | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, MAGNESIUM ION, ... | 著者 | Holyoak, T, Fenton, A.W. | 登録日 | 2022-11-15 | 公開日 | 2023-05-24 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | 主引用文献 | PYK-SubstitutionOME: an integrated database containing allosteric coupling, ligand affinity and mutational, structural, pathological, bioinformatic and computational information about pyruvate kinase isozymes. Database (Oxford), 2023, 2023
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8F5U
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![BU of 8f5u by Molmil](/molmil-images/mine/8f5u) | Rabbit muscle pyruvate kinase in complex with magnesium, potassium and pyruvate | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, ... | 著者 | Holyoak, T, Fenton, A.W. | 登録日 | 2022-11-15 | 公開日 | 2023-05-24 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | PYK-SubstitutionOME: an integrated database containing allosteric coupling, ligand affinity and mutational, structural, pathological, bioinformatic and computational information about pyruvate kinase isozymes. Database (Oxford), 2023, 2023
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8F6M
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![BU of 8f6m by Molmil](/molmil-images/mine/8f6m) | Complex of Rabbit muscle pyruvate kinase with ADP and the phosphonate analogue of PEP mimicking the Michaelis complex. | 分子名称: | (E)-2-METHYL-3-PHOSPHONOACRYLATE, ADENOSINE-5'-DIPHOSPHATE, ALANINE, ... | 著者 | Holyoak, T, Fenton, A.W. | 登録日 | 2022-11-16 | 公開日 | 2023-05-24 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | PYK-SubstitutionOME: an integrated database containing allosteric coupling, ligand affinity and mutational, structural, pathological, bioinformatic and computational information about pyruvate kinase isozymes. Database (Oxford), 2023, 2023
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6NN5
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![BU of 6nn5 by Molmil](/molmil-images/mine/6nn5) | The structure of human liver pyruvate kinase, hLPYK-W527H | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, Pyruvate kinase PKLR | 著者 | McFarlane, J.S, Ronnebaum, T.A, Meneely, K.M, Fenton, A.W, Lamb, A.L. | 登録日 | 2019-01-14 | 公開日 | 2019-06-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.256 Å) | 主引用文献 | Changes in the allosteric site of human liver pyruvate kinase upon activator binding include the breakage of an intersubunit cation-pi bond. Acta Crystallogr.,Sect.F, 75, 2019
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6NN7
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![BU of 6nn7 by Molmil](/molmil-images/mine/6nn7) | The structure of human liver pyruvate kinase, hLPYK-GGG | 分子名称: | 1,2-ETHANEDIOL, CITRATE ANION, GLYCEROL, ... | 著者 | McFarlane, J.S, Ronnebaum, T.A, Meneely, K.M, Fenton, A.W, Lamb, A.L. | 登録日 | 2019-01-14 | 公開日 | 2019-06-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | 主引用文献 | Changes in the allosteric site of human liver pyruvate kinase upon activator binding include the breakage of an intersubunit cation-pi bond. Acta Crystallogr.,Sect.F, 75, 2019
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6NN8
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![BU of 6nn8 by Molmil](/molmil-images/mine/6nn8) | The structure of human liver pyruvate kinase, hLPYK-S531E | 分子名称: | 1,2-ETHANEDIOL, Pyruvate kinase PKLR | 著者 | McFarlane, J.S, Ronnebaum, T.A, Meneely, K.M, Fenton, A.W, Lamb, A.L. | 登録日 | 2019-01-14 | 公開日 | 2019-06-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.416 Å) | 主引用文献 | Changes in the allosteric site of human liver pyruvate kinase upon activator binding include the breakage of an intersubunit cation-pi bond. Acta Crystallogr.,Sect.F, 75, 2019
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2G50
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![BU of 2g50 by Molmil](/molmil-images/mine/2g50) | The location of the allosteric amino acid binding site of muscle pyruvate kinase. | 分子名称: | 1,2-ETHANEDIOL, 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, ALANINE, ... | 著者 | Holyoak, T, Williams, R, Fenton, A.W. | 登録日 | 2006-02-22 | 公開日 | 2006-05-09 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Differentiating a Ligand's Chemical Requirements for Allosteric Interactions from Those for Protein Binding. Phenylalanine Inhibition of Pyruvate Kinase. Biochemistry, 45, 2006
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6NN4
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![BU of 6nn4 by Molmil](/molmil-images/mine/6nn4) | The structure of human liver pyruvate kinase, hLPYK-D499N, in complex with Fru-1,6-BP | 分子名称: | 1,2-ETHANEDIOL, 1,6-di-O-phosphono-beta-D-fructofuranose, PHOSPHOENOLPYRUVATE, ... | 著者 | McFarlane, J.S, Ronnebaum, T.A, Meneely, K.M, Fenton, A.W, Lamb, A.L. | 登録日 | 2019-01-14 | 公開日 | 2019-06-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Changes in the allosteric site of human liver pyruvate kinase upon activator binding include the breakage of an intersubunit cation-pi bond. Acta Crystallogr.,Sect.F, 75, 2019
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2KUO
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![BU of 2kuo by Molmil](/molmil-images/mine/2kuo) | Structure and identification of ADP-ribose recognition motifs of APLF and role in the DNA damage response | 分子名称: | Aprataxin and PNK-like factor, ZINC ION | 著者 | Li, G.Y, McCulloch, R.D, Fenton, A, Cheung, M, Meng, L, Ikura, M, Koch, C.A. | 登録日 | 2010-02-23 | 公開日 | 2010-05-05 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure and identification of ADP-ribose recognition motifs of aprataxin PNK-like factor (APLF) required for the interaction with sites of DNA damage response To be Published
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4IMA
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![BU of 4ima by Molmil](/molmil-images/mine/4ima) | The structure of C436M-hLPYK in complex with Citrate/Mn/ATP/Fru-1,6-BP | 分子名称: | 1,2-ETHANEDIOL, 1,6-di-O-phosphono-beta-D-fructofuranose, ADENOSINE, ... | 著者 | Zhang, B, Holyoak, T, Fenton, A.W, Tang, Q.L, Prasannan, C.B, Deng, J.P. | 登録日 | 2013-01-02 | 公開日 | 2013-01-23 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.954 Å) | 主引用文献 | Energetic Coupling between an Oxidizable Cysteine and the Phosphorylatable N-Terminus of Human Liver Pyruvate Kinase. Biochemistry, 52, 2013
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4IP7
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![BU of 4ip7 by Molmil](/molmil-images/mine/4ip7) | Structure of the S12D variant of human liver pyruvate kinase in complex with citrate and FBP. | 分子名称: | 1,2-ETHANEDIOL, 1,6-di-O-phosphono-beta-D-fructofuranose, ADENOSINE, ... | 著者 | Holyoak, T, Fenton, A.W. | 登録日 | 2013-01-09 | 公開日 | 2013-01-30 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Energetic Coupling between an Oxidizable Cysteine and the Phosphorylatable N-Terminus of Human Liver Pyruvate Kinase. Biochemistry, 52, 2013
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