4IP7

Structure of the S12D variant of human liver pyruvate kinase in complex with citrate and FBP.

Summary for 4IP7

Entry DOI	10.2210/pdb4ip7/pdb
Descriptor	Pyruvate kinase isozymes L, MANGANESE (II) ION, CITRATE ANION, ... (10 entities in total)
Functional Keywords	kinase, glycolysis, allosteric, phosphorylation mimic, liver, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	238311.93
Authors	Holyoak, T.,Fenton, A.W. (deposition date: 2013-01-09, release date: 2013-01-30, Last modification date: 2023-09-20)
Primary citation	Holyoak, T.,Zhang, B.,Deng, J.,Tang, Q.,Prasannan, C.B.,Fenton, A.W. Energetic Coupling between an Oxidizable Cysteine and the Phosphorylatable N-Terminus of Human Liver Pyruvate Kinase. Biochemistry, 52:466-476, 2013 Cited by PubMed: 23270483 DOI: 10.1021/bi301341r PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation