4IP7
Structure of the S12D variant of human liver pyruvate kinase in complex with citrate and FBP.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Pyruvate kinase isozymes L | polymer | 543 | 58592.2 | 4 | UniProt (P30613) Pfam (PF00224) Pfam (PF02887) | Homo sapiens (human) | Pyruvate kinase 1, L-type pyruvate kinase, liver pyruvate kinase |
| 2 | AA, E, L, T (D, A, B, C) | MANGANESE (II) ION | non-polymer | 54.9 | 4 | Chemie (MN) | |||
| 3 | BA, F, M, U (D, A, B, C) | CITRATE ANION | non-polymer | 189.1 | 4 | Chemie (FLC) | |||
| 4 | CA, G, N, V (D, A, B, C) | 1,6-di-O-phosphono-beta-D-fructofuranose | non-polymer | 340.1 | 4 | Chemie (FBP) | |||
| 5 | EA, FA, GA, H, I... (D, A, B, C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 9 | Chemie (EDO) | |||
| 6 | J, P (A, B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) | |||
| 7 | HA, K, R, Z (D, A, B, C) | SODIUM ION | non-polymer | 23.0 | 4 | Chemie (NA) | |||
| 8 | W, X (C) | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 2 | Chemie (1PE) | |||
| 9 | DA (D) | ADENOSINE | non-polymer | 267.2 | 1 | Chemie (ADN) | |||
| 10 | IA, JA, KA, LA (A, B, C, D) | water | water | 18.0 | 1324 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 543 (UniProt: P30613)
| PDB | External Database | Details |
|---|---|---|
| Asp 12 | Ser 12 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 234368.7 | |
| Non-Polymers* | Number of molecules | 30 |
| Total formula weight | 3943.2 | |
| All* | Total formula weight | 238311.9 |
