5O3O
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![BU of 5o3o by Molmil](/molmil-images/mine/5o3o) | Pronase-treated paired helical filament in Alzheimer's disease brain | Descriptor: | Microtubule-associated protein tau | Authors: | Fitzpatrick, A.W.P, Falcon, B, He, S, Murzin, A.G, Murshudov, G, Garringer, H.G, Crowther, R.A, Ghetti, B, Goedert, M, Scheres, S.H.W. | Deposit date: | 2017-05-24 | Release date: | 2017-07-26 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Cryo-EM structures of tau filaments from Alzheimer's disease. Nature, 547, 2017
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5O3T
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![BU of 5o3t by Molmil](/molmil-images/mine/5o3t) | Straight filament in Alzheimer's disease brain | Descriptor: | Microtubule-associated protein tau | Authors: | Fitzpatrick, A.W.P, Falcon, B, He, S, Murzin, A.G, Murshudov, G, Garringer, H.G, Crowther, R.A, Ghetti, B, Goedert, M, Scheres, S.H.W. | Deposit date: | 2017-05-24 | Release date: | 2017-07-26 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-EM structures of tau filaments from Alzheimer's disease. Nature, 547, 2017
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8BGS
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![BU of 8bgs by Molmil](/molmil-images/mine/8bgs) | |
7NRV
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![BU of 7nrv by Molmil](/molmil-images/mine/7nrv) | Paired helical filament from Alzheimer's disease with PET ligand APN-1607 | Descriptor: | Microtubule-associated protein tau | Authors: | Shi, Y, Murzin, A.G, Falcon, B, Epstein, A, Machin, J, Tempest, P, Newell, K.L, Vidal, R, Garringer, H.J, Sahara, N, Higuchi, M, Ghetti, B, Jang, M, Scheres, S.H.W, Goedert, M. | Deposit date: | 2021-03-04 | Release date: | 2021-03-24 | Last modified: | 2021-04-28 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN-1607. Acta Neuropathol, 141, 2021
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8BGV
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![BU of 8bgv by Molmil](/molmil-images/mine/8bgv) | |
7NRT
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![BU of 7nrt by Molmil](/molmil-images/mine/7nrt) | Conformation 2 of straight filament from primary age-related tauopathy brain | Descriptor: | Microtubule-associated protein tau | Authors: | Shi, Y, Murzin, A.G, Falcon, B, Epstein, A, Machin, J, Tempest, P, Newell, K.L, Vidal, R, Garringer, H.J, Sahara, N, Higuchi, M, Ghetti, B, Jang, M, Scheres, S.H.W, Goedert, M. | Deposit date: | 2021-03-04 | Release date: | 2021-03-24 | Last modified: | 2021-04-28 | Method: | ELECTRON MICROSCOPY (2.68 Å) | Cite: | Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN-1607. Acta Neuropathol, 141, 2021
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7NRX
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![BU of 7nrx by Molmil](/molmil-images/mine/7nrx) | Straight filament from Alzheimer's disease with PET ligand APN-1607 | Descriptor: | Microtubule-associated protein tau | Authors: | Shi, Y, Murzin, A.G, Falcon, B, Epstein, A, Machin, J, Tempest, P, Newell, K.L, Vidal, R, Garringer, H.J, Sahara, N, Higuchi, M, Ghetti, B, Jang, M, Scheres, S.H.W, Goedert, M. | Deposit date: | 2021-03-04 | Release date: | 2021-03-24 | Last modified: | 2021-04-28 | Method: | ELECTRON MICROSCOPY (3.55 Å) | Cite: | Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN-1607. Acta Neuropathol, 141, 2021
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7NRS
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![BU of 7nrs by Molmil](/molmil-images/mine/7nrs) | Conformation 1 of straight filament from primary age-related tauopathy brain | Descriptor: | Microtubule-associated protein tau | Authors: | Shi, Y, Murzin, A.G, Falcon, B, Epstein, A, Machin, J, Tempest, P, Newell, K.L, Vidal, R, Garringer, H.J, Sahara, N, Higuchi, M, Ghetti, B, Jang, M, Scheres, S.H.W, Goedert, M. | Deposit date: | 2021-03-04 | Release date: | 2021-03-24 | Last modified: | 2021-04-28 | Method: | ELECTRON MICROSCOPY (2.68 Å) | Cite: | Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN-1607. Acta Neuropathol, 141, 2021
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7NRQ
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![BU of 7nrq by Molmil](/molmil-images/mine/7nrq) | Paired helical filament from primary age-related tauopathy brain | Descriptor: | Microtubule-associated protein tau | Authors: | Shi, Y, Murzin, A.G, Falcon, B, Epstein, A, Machin, J, Tempest, P, Newell, K.L, Vidal, R, Garringer, H.J, Sahara, N, Higuchi, M, Ghetti, B, Jang, M, Scheres, S.H.W, Goedert, M. | Deposit date: | 2021-03-04 | Release date: | 2021-03-24 | Last modified: | 2021-04-28 | Method: | ELECTRON MICROSCOPY (2.76 Å) | Cite: | Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN-1607. Acta Neuropathol, 141, 2021
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6QJQ
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![BU of 6qjq by Molmil](/molmil-images/mine/6qjq) | Cryo-EM structure of heparin-induced 2N3R tau filaments | Descriptor: | Microtubule-associated protein tau | Authors: | Zhang, W, Falcon, B, Murzin, A.G, Fan, J, Crowther, R.A, Goedert, M, Scheres, S.H.W. | Deposit date: | 2019-01-24 | Release date: | 2019-02-20 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases. Elife, 8, 2019
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8ONS
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![BU of 8ons by Molmil](/molmil-images/mine/8ons) | |
6TJO
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![BU of 6tjo by Molmil](/molmil-images/mine/6tjo) | Cryo-EM structure of TypeI tau filaments extracted from the brains of individuals with Corticobasal degeneration | Descriptor: | Microtubule-associated protein tau | Authors: | Zhang, W, Murzin, A.G, Falcon, B, Shi, Y, Goedert, M, Scheres, S.H.W. | Deposit date: | 2019-11-26 | Release date: | 2020-02-05 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Novel tau filament fold in corticobasal degeneration. Nature, 580, 2020
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6TJX
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![BU of 6tjx by Molmil](/molmil-images/mine/6tjx) | Cryo-EM structure of TypeII tau filaments extracted from the brains of individuals with Corticobasal degeneration | Descriptor: | Microtubule-associated protein tau | Authors: | Zhang, W, Murzin, A.G, Falcon, B, Shi, Y, Goedert, M, Scheres, S.H.W. | Deposit date: | 2019-11-27 | Release date: | 2020-02-05 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Novel tau filament fold in corticobasal degeneration. Nature, 580, 2020
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8OTI
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![BU of 8oti by Molmil](/molmil-images/mine/8oti) | CTE typeIII tau filament | Descriptor: | Microtubule-associated protein tau | Authors: | Tetter, S, Qi, C, Ryskeldi-Falcon, B, Scheres, S.H.W, Goedert, M. | Deposit date: | 2023-04-20 | Release date: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold. Proc.Natl.Acad.Sci.USA, 120, 2023
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