4PXA
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![BU of 4pxa by Molmil](/molmil-images/mine/4pxa) | DEAD-box RNA helicase DDX3X Cancer-associated mutant D354V | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase DDX3X, PHOSPHATE ION | Authors: | Epling, L.B, Grace, C.R, Lowe, B.R, Partridge, J.F, Enemark, E.J. | Deposit date: | 2014-03-22 | Release date: | 2015-03-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Cancer-Associated Mutants of RNA Helicase DDX3X Are Defective in RNA-Stimulated ATP Hydrolysis. J.Mol.Biol., 427, 2015
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4PX9
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![BU of 4px9 by Molmil](/molmil-images/mine/4px9) | DEAD-box RNA helicase DDX3X Domain 1 with N-terminal ATP-binding Loop | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase DDX3X | Authors: | Epling, L.B, Grace, C.R, Lowe, B.R, Partridge, J.F, Enemark, E.J. | Deposit date: | 2014-03-22 | Release date: | 2015-03-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Cancer-Associated Mutants of RNA Helicase DDX3X Are Defective in RNA-Stimulated ATP Hydrolysis. J.Mol.Biol., 427, 2015
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8UV0
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![BU of 8uv0 by Molmil](/molmil-images/mine/8uv0) | |
6MII
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![BU of 6mii by Molmil](/molmil-images/mine/6mii) | Crystal structure of minichromosome maintenance protein MCM/DNA complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), MAGNESIUM ION, ... | Authors: | Enemark, E.J, Meagher, M, Epling, L.B. | Deposit date: | 2018-09-19 | Release date: | 2019-07-24 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | DNA translocation mechanism of the MCM complex and implications for replication initiation. Nat Commun, 10, 2019
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4R7Z
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![BU of 4r7z by Molmil](/molmil-images/mine/4r7z) | PfMCM-AAA double-octamer | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 21, MAGNESIUM ION | Authors: | Miller, J.M, Arachea, B.T, Epling, L.B, Enemark, E.J. | Deposit date: | 2014-08-28 | Release date: | 2014-10-08 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Analysis of the crystal structure of an active MCM hexamer. Elife, 3, 2014
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4R7Y
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![BU of 4r7y by Molmil](/molmil-images/mine/4r7y) | Crystal structure of an active MCM hexamer | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, MAGNESIUM ION, ... | Authors: | Miller, J.M, Arachea, B.T, Epling, L.B, Enemark, E.J. | Deposit date: | 2014-08-28 | Release date: | 2014-10-08 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Analysis of the crystal structure of an active MCM hexamer. Elife, 3, 2014
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8E1X
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![BU of 8e1x by Molmil](/molmil-images/mine/8e1x) | FGFR2 kinase domain in complex with a Pyrazolo[1,5-a]pyrimidine analog (Compound 29) | Descriptor: | (5M)-N-methyl-5-{(6M,8S)-5-{[(3S)-oxolan-3-yl]amino}-6-[1-(propan-2-yl)-1H-pyrazol-3-yl]pyrazolo[1,5-a]pyrimidin-3-yl}pyridine-3-carboxamide, Fibroblast growth factor receptor 2 | Authors: | Lei, H.-T, Epling, L.B, Deller, M.C. | Deposit date: | 2022-08-11 | Release date: | 2022-11-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.68 Å) | Cite: | Discovery of Potent and Selective Inhibitors of Wild-Type and Gatekeeper Mutant Fibroblast Growth Factor Receptor (FGFR) 2/3. J.Med.Chem., 65, 2022
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4POF
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![BU of 4pof by Molmil](/molmil-images/mine/4pof) | PfMCM N-terminal domain without DNA | Descriptor: | Cell division control protein 21, ZINC ION | Authors: | Froelich, C.A, Kang, S, Epling, L.B, Bell, S.P, Enemark, E.J. | Deposit date: | 2014-02-25 | Release date: | 2014-04-09 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.648 Å) | Cite: | A conserved MCM single-stranded DNA binding element is essential for replication initiation. Elife, 3, 2014
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4POG
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![BU of 4pog by Molmil](/molmil-images/mine/4pog) | MCM-ssDNA co-crystal structure | Descriptor: | 30-mer oligo(dT), Cell division control protein 21, ZINC ION | Authors: | Froelich, C.A, Kang, S, Epling, L.B, Bell, S.P, Enemark, E.J. | Deposit date: | 2014-02-25 | Release date: | 2014-04-09 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.203 Å) | Cite: | A conserved MCM single-stranded DNA binding element is essential for replication initiation. Elife, 3, 2014
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