6FSZ
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![BU of 6fsz by Molmil](/molmil-images/mine/6fsz) | Structure of the nuclear RNA exosome | Descriptor: | ATP-dependent RNA helicase DOB1, Exosome complex component CSL4, Exosome complex component MTR3, ... | Authors: | Schuller, J.M, Falk, S, Conti, E. | Deposit date: | 2018-02-20 | Release date: | 2018-03-21 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | Structure of the nuclear exosome captured on a maturing preribosome. Science, 360, 2018
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4U21
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![BU of 4u21 by Molmil](/molmil-images/mine/4u21) | GluA2flip sLBD complexed with FW and (R,R)-2b crystal form E | Descriptor: | 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID, Glutamate receptor 2,Glutamate receptor 2, N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide | Authors: | Chen, L, Gouaux, E. | Deposit date: | 2014-07-16 | Release date: | 2014-08-20 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.3908 Å) | Cite: | Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States. Cell, 158, 2014
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6FUG
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![BU of 6fug by Molmil](/molmil-images/mine/6fug) | Complement factor D in complex with the inhibitor 3-((3-((3-(aminomethyl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)phenol | Descriptor: | 3-[[3-[[3-(aminomethyl)phenyl]amino]-1~{H}-pyrazolo[3,4-d]pyrimidin-4-yl]amino]phenol, Complement factor D | Authors: | Mac Sweeney, A, Ostermann, N, Vulpetti, A, Maibaum, J, Erbel, P, Lorthiois, E, Yoon, T, Randl, S, Ruedisser, S. | Deposit date: | 2018-02-27 | Release date: | 2018-06-06 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Discovery and Design of First Benzylamine-Based Ligands Binding to an Unlocked Conformation of the Complement Factor D. ACS Med Chem Lett, 9, 2018
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5F7L
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![BU of 5f7l by Molmil](/molmil-images/mine/5f7l) | Blood group antigen binding adhesin BabA of Helicobacter pylori strain 17875 in complex with Nanobody Nb-ER14 | Descriptor: | Adhesin binding fucosylated histo-blood group antigen, Nanobody Nb-ER14, SULFATE ION | Authors: | Moonens, K, Gideonsson, P, Subedi, S, Romao, E, Oscarson, S, Muyldermans, S, Boren, T, Remaut, H. | Deposit date: | 2015-12-08 | Release date: | 2016-01-20 | Last modified: | 2016-01-27 | Method: | X-RAY DIFFRACTION (2.74 Å) | Cite: | Structural Insights into Polymorphic ABO Glycan Binding by Helicobacter pylori. Cell Host Microbe, 19, 2016
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8DFO
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![BU of 8dfo by Molmil](/molmil-images/mine/8dfo) | type I-C Cascade bound to AcrIC4 | Descriptor: | AcrIC4, CRISPR-associated protein, CT1133 family, ... | Authors: | O'Brien, R.E, Bravo, J.P.K, Ramos, D, Hibshman, G.N, Wright, J.T, Taylor, D.W. | Deposit date: | 2022-06-22 | Release date: | 2023-02-15 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural snapshots of R-loop formation by a type I-C CRISPR Cascade. Mol.Cell, 83, 2023
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1G1O
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![BU of 1g1o by Molmil](/molmil-images/mine/1g1o) | CRYSTAL STRUCTURE OF THE HIGHLY AMYLOIDOGENIC TRANSTHYRETIN MUTANT TTR G53S/E54D/L55S | Descriptor: | TRANSTHYRETIN | Authors: | Eneqvist, T, Andersson, K, Olofsson, A, Lundgren, E, Sauer-Eriksson, A.E. | Deposit date: | 2000-10-13 | Release date: | 2001-10-17 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The beta-slip: a novel concept in transthyretin amyloidosis. Mol.Cell, 6, 2000
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8DFA
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![BU of 8dfa by Molmil](/molmil-images/mine/8dfa) | type I-C Cascade bound to ssDNA target | Descriptor: | CRISPR-associated protein, CT1133 family, TM1801 family, ... | Authors: | O'Brien, R.E, Bravo, J.P.K, Ramos, D, Hibshman, G.N, Wright, J.T, Taylor, D.W. | Deposit date: | 2022-06-21 | Release date: | 2023-02-22 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural snapshots of R-loop formation by a type I-C CRISPR Cascade. Mol.Cell, 83, 2023
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4ZKD
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4ZHG
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![BU of 4zhg by Molmil](/molmil-images/mine/4zhg) | Siderocalin-mediated recognition and cellular uptake of actinides | Descriptor: | AMERICIUM ION, CHLORIDE ION, GLYCEROL, ... | Authors: | Allred, B.E, Rupert, P.B, Gauny, S.S, An, D.D, Ralston, C.Y, Sturzbecher-Hoehne, M, Strong, R.K, Abergel, R.J. | Deposit date: | 2015-04-24 | Release date: | 2015-08-05 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Siderocalin-mediated recognition, sensitization, and cellular uptake of actinides. Proc.Natl.Acad.Sci.USA, 112, 2015
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4TV8
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![BU of 4tv8 by Molmil](/molmil-images/mine/4tv8) | Tubulin-Maytansine complex | Descriptor: | (3beta,4beta,5beta,10beta,11E,13E)-maytansine, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | Authors: | Prota, A.E, Bargsten, K, Diaz, J.F, Marsh, M, Cuevas, C, Liniger, M, Neuhaus, C, Andreu, J.M, Altmann, K.H, Steinmetz, M.O. | Deposit date: | 2014-06-26 | Release date: | 2014-08-27 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.103 Å) | Cite: | A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs. Proc.Natl.Acad.Sci.USA, 111, 2014
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2XX9
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![BU of 2xx9 by Molmil](/molmil-images/mine/2xx9) | Crystal structure of 1-((2-fluoro-4-(3-(trifluoromethyl)-4,5,6,7- tetrahydro-1H-indazol-1-yl)phenyl)methyl)-2-pyrrolidinone in complex with the ligand binding domain of the Rat GluA2 receptor and glutamate at 2.2A resolution. | Descriptor: | GLUTAMATE RECEPTOR 2, GLUTAMIC ACID, N,N-DIMETHYL-4-[3-(TRIFLUOROMETHYL)-4,5,6,7-TETRAHYDRO-1H-INDAZOL-1-YL]BENZAMIDE, ... | Authors: | Ward, S.E, Harries, M, Aldegheri, L, Austin, N.E, Ballantine, S, Ballini, E, Bradley, D.M, Bax, B.D, Clarke, B.P, Harris, A.J, Harrison, S.A, Melarange, R.A, Mookherjee, C, Mosley, J, DalNegro, G, Oliosi, B, Smith, K.J, Thewlis, K.M, Woollard, P.M, Yusaf, S.P. | Deposit date: | 2010-11-09 | Release date: | 2011-04-06 | Last modified: | 2011-09-28 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Integration of Lead Optimization with Crystallography for a Membrane-Bound Ion Channel Target: Discovery of a New Class of Ampa Receptor Positive Allosteric Modulators. J.Med.Chem., 54, 2011
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8DAJ
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![BU of 8daj by Molmil](/molmil-images/mine/8daj) | Structure and Biochemistry of a Promiscuous Thermophilic Polyhydroxybutyrate Depolymerase from Lihuaxuella thermophilia | Descriptor: | 1,2-ETHANEDIOL, Esterase, PHB depolymerase family, ... | Authors: | Thomas, G.M, Quirk, S, Huard, D.J.E, Lieberman, R.L. | Deposit date: | 2022-06-13 | Release date: | 2023-02-15 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Bioplastic degradation by a polyhydroxybutyrate depolymerase from a thermophilic soil bacterium. Protein Sci., 31, 2022
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8DEJ
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![BU of 8dej by Molmil](/molmil-images/mine/8dej) | D. vulgaris type I-C Cascade bound to dsDNA target | Descriptor: | CRISPR-associated protein, CT1133 family, TM1801 family, ... | Authors: | O'Brien, R.E, Bravo, J.P.K, Ramos, D, Hibshman, G.N, Wright, J.T, Taylor, D.W. | Deposit date: | 2022-06-20 | Release date: | 2023-02-22 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.86 Å) | Cite: | Structural snapshots of R-loop formation by a type I-C CRISPR Cascade. Mol.Cell, 83, 2023
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1RLO
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![BU of 1rlo by Molmil](/molmil-images/mine/1rlo) | Phospho-aspartyl Intermediate Analogue of ybiV from E. coli K12 | Descriptor: | GLYCEROL, MAGNESIUM ION, Phosphatase | Authors: | Roberts, A, Lee, S.Y, McCullagh, E, Silversmith, R.E, Wemmer, D.E. | Deposit date: | 2003-11-26 | Release date: | 2004-12-07 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Ybiv from Escherichia coli K12 is a HAD phosphatase. Proteins, 58, 2005
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8DEX
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![BU of 8dex by Molmil](/molmil-images/mine/8dex) | type I-C Cascade | Descriptor: | CRISPR-associated protein, CT1133 family, TM1801 family, ... | Authors: | O'Brien, R.E, Bravo, J.P.K, Ramos, D, Hibshman, G.N, Wright, J.T, Taylor, D.W. | Deposit date: | 2022-06-21 | Release date: | 2023-02-15 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structural snapshots of R-loop formation by a type I-C CRISPR Cascade. Mol.Cell, 83, 2023
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2XX7
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![BU of 2xx7 by Molmil](/molmil-images/mine/2xx7) | Crystal structure of 1-(4-(1-pyrrolidinylcarbonyl)phenyl)-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole in complex with the ligand binding domain of the Rat GluA2 receptor and glutamate at 2.2A resolution. | Descriptor: | 1-[4-(1-PYRROLIDINYLCARBONYL)PHENYL]-3-(TRIFLUOROMETHYL)-4,5,6,7-TETRAHYDRO-1H-INDAZOLE, GLUTAMATE RECEPTOR 2, GLUTAMIC ACID, ... | Authors: | Ward, S.E, Harries, M, Aldegheri, L, Austin, N.E, Ballantine, S, Ballini, E, Bradley, D.M, Bax, B.D, Clarke, B.P, Harris, A.J, Harrison, S.A, Melarange, R.A, Mookherjee, C, Mosley, J, DalNegro, G, Oliosi, B, Smith, K.J, Thewlis, K.M, Woollard, P.M, Yusaf, S.P. | Deposit date: | 2010-11-09 | Release date: | 2011-04-06 | Last modified: | 2011-09-28 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Integration of Lead Optimization with Crystallography for a Membrane-Bound Ion Channel Target: Discovery of a New Class of Ampa Receptor Positive Allosteric Modulators. J.Med.Chem., 54, 2011
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5J6T
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![BU of 5j6t by Molmil](/molmil-images/mine/5j6t) | |
5J6V
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5J6W
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![BU of 5j6w by Molmil](/molmil-images/mine/5j6w) | |
2XXH
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![BU of 2xxh by Molmil](/molmil-images/mine/2xxh) | Crystal structure of 1-(4-(2-oxo-2-(1-pyrrolidinyl)ethyl)phenyl)-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole in complex with the ligand binding domain of the Rat GluA2 receptor and glutamate at 1.5A resolution. | Descriptor: | 1-{4-[2-OXO-2-(1-PYRROLIDINYL)ETHYL]PHENYL}-3-( TRIFLUOROMETHYL)-4,5,6,7-TETRAHYDRO-1H-INDAZOLE, GLUTAMATE RECEPTOR 2, GLUTAMIC ACID, ... | Authors: | Ward, S.E, Harries, M, Aldegheri, L, Austin, N.E, Ballantine, S, Ballini, E, Bradley, D.M, Bax, B.D, Clarke, B.P, Harris, A.J, Harrison, S.A, Melarange, R.A, Mookherjee, C, Mosley, J, DalNegro, G, Oliosi, B, Smith, K.J, Thewlis, K.M, Woollard, P.M, Yusaf, S.P. | Deposit date: | 2010-11-10 | Release date: | 2011-04-06 | Last modified: | 2011-09-28 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Integration of Lead Optimization with Crystallography for a Membrane-Bound Ion Channel Target: Discovery of a New Class of Ampa Receptor Positive Allosteric Modulators. J.Med.Chem., 54, 2011
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7OGP
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![BU of 7ogp by Molmil](/molmil-images/mine/7ogp) | Structure of the apo-state of the bacteriophage PhiKZ non-virion RNA polymerase - class including clamp | Descriptor: | DNA-directed RNA polymerase, PHIKZ055, PHIKZ068, ... | Authors: | de Martin Garrido, N, Lai Wan Loong, Y.T.E, Yakunina, M, Aylett, C.H.S. | Deposit date: | 2021-05-07 | Release date: | 2021-07-07 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structure of the bacteriophage PhiKZ non-virion RNA polymerase. Nucleic Acids Res., 49, 2021
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8DFT
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![BU of 8dft by Molmil](/molmil-images/mine/8dft) | Cryo-EM structure of conjugative pili from Pyrobaculum calidifontis | Descriptor: | Pilin protein, [(2~{S},7~{S},11~{S},15~{S},19~{R},22~{R},26~{S},30~{R},34~{R},38~{S},43~{S},47~{S},51~{S},55~{R},58~{R},62~{S},66~{R},70~{R})-38-(hydroxymethyl)-7,11,15,19,22,26,30,34,43,47,51,55,58,62,66,70-hexadecamethyl-1,4,37,40-tetraoxacyclodoheptacont-2-yl]methanol | Authors: | Beltran, L.C, Egelman, E.H. | Deposit date: | 2022-06-22 | Release date: | 2023-03-22 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Archaeal DNA-import apparatus is homologous to bacterial conjugation machinery. Nat Commun, 14, 2023
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7OGR
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![BU of 7ogr by Molmil](/molmil-images/mine/7ogr) | Structure of the apo-state of the bacteriophage PhiKZ non-virion RNA polymerase | Descriptor: | DNA-directed RNA polymerase, PHIKZ055, PHIKZ068, ... | Authors: | de Martin Garrido, N, Lai Wan Loong, Y.T.E, Yakunina, M, Aylett, C.H.S. | Deposit date: | 2021-05-07 | Release date: | 2021-07-07 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structure of the bacteriophage PhiKZ non-virion RNA polymerase. Nucleic Acids Res., 49, 2021
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8HQR
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![BU of 8hqr by Molmil](/molmil-images/mine/8hqr) | |
2XX8
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![BU of 2xx8 by Molmil](/molmil-images/mine/2xx8) | Crystal structure of N,N-dimethyl-4-(3-(trifluoromethyl)-4,5,6,7- tetrahydro-1H-indazol-1-yl)benzamide in complex with the ligand binding domain of the Rat GluA2 receptor and glutamate at 2.2A resolution. | Descriptor: | GLUTAMATE RECEPTOR 2, GLUTAMIC ACID, N,N-DIMETHYL-4-[3-(TRIFLUOROMETHYL)-4,5,6,7-TETRAHYDRO-1H-INDAZOL-1-YL]BENZAMIDE, ... | Authors: | Ward, S.E, Harries, M, Aldegheri, L, Austin, N.E, Ballantine, S, Ballini, E, Bradley, D.M, Bax, B.D, Clarke, B.P, Harris, A.J, Harrison, S.A, Melarange, R.A, Mookherjee, C, Mosley, J, DalNegro, G, Oliosi, B, Smith, K.J, Thewlis, K.M, Woollard, P.M, Yusaf, S.P. | Deposit date: | 2010-11-09 | Release date: | 2011-04-27 | Last modified: | 2011-09-28 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Integration of Lead Optimization with Crystallography for a Membrane-Bound Ion Channel Target: Discovery of a New Class of Ampa Receptor Positive Allosteric Modulators. J.Med.Chem., 54, 2011
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