5W3W
 
 | | Crystal structure of SsoPox AsD6 mutant (V27A-Y97W-L228M-W263M) - open form | | 分子名称: | 1,2-ETHANEDIOL, Aryldialkylphosphatase, COBALT (II) ION, ... | | 著者 | Hiblot, J, Gotthard, G, Jacquet, P, Daude, D, Bergonzi, C, Chabriere, E, Elias, M. | | 登録日 | 2017-06-08 | | 公開日 | 2018-01-10 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Rational engineering of a native hyperthermostable lactonase into a broad spectrum phosphotriesterase.
Sci Rep, 7, 2017
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2EHU
 | | Crystal analysis of 1-pyrroline-5-carboxylate dehydrogenase from thermus with bound NAD and Inhibitor L-serine | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1-pyrroline-5-carboxylate dehydrogenase, ACETATE ION, ... | | 著者 | Inagaki, E, Sakamoto, K, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2007-03-09 | | 公開日 | 2007-09-11 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal Structure Analysis of delta1-pyrroline-5-carboxylate dehydrogenase in ternary complex with inhibitor and NAD.
To be Published
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5W50
 | | Crystal structure of the segment, LIIKGI, from the RRM2 of TDP-43, residues 248-253 | | 分子名称: | TAR DNA-binding protein 43 | | 著者 | Guenther, E.L, Trinh, H, Sawaya, M.R, Eisenberg, D.S. | | 登録日 | 2017-06-13 | | 公開日 | 2018-02-21 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2.
Nat. Struct. Mol. Biol., 25, 2018
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2EJ6
 | | Crystal analysis of delta1-pyrroline-5-carboxylate dehydrogenase from Thermus thermophilus with bound D-proline | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1-pyrroline-5-carboxylate dehydrogenase, ACETATE ION, ... | | 著者 | Inagaki, E, Sakamoto, K, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2007-03-15 | | 公開日 | 2007-09-18 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | | 主引用文献 | Crystal structure analysis of delta1-pyrroline-5-carboxylate dehydrogenase in ternary complex with inhibitor and NAD
To be Published
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4N9M
 | | Joint neutron/x-ray structure of urate oxidase in complex with 8-hydroxyxanthine | | 分子名称: | 8-hydroxy-3,9-dihydro-1H-purine-2,6-dione, CHLORIDE ION, SODIUM ION, ... | | 著者 | Oksanen, E, Blakeley, M.P, Budayova-Spano, M. | | 登録日 | 2013-10-21 | | 公開日 | 2014-02-05 | | 最終更新日 | 2018-06-13 | | 実験手法 | NEUTRON DIFFRACTION (2.023 Å), X-RAY DIFFRACTION | | 主引用文献 | The neutron structure of urate oxidase resolves a long-standing mechanistic conundrum and reveals unexpected changes in protonation.
Plos One, 9, 2014
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2EII
 | | Crystal analysis of delta1-pyrroline-5-carboxylate dehydrogenase from Thermus thermophilus with bound L-valine and NAD. | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1-pyrroline-5-carboxylate dehydrogenase, ACETATE ION, ... | | 著者 | Inagaki, E, Sakamoto, K, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2007-03-13 | | 公開日 | 2007-09-18 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | | 主引用文献 | Crystal structure analysis of delta1-pyrroline-5-carboxylate dehydrogenase in ternary complex with inhibitor and NAD.
To be Published
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5W4F
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8ALO
 | | Heterodimer formation of sensory domains of Vibrio cholerae regulators ToxR and ToxS | | 分子名称: | Cholera toxin transcriptional activator, Transmembrane regulatory protein ToxS | | 著者 | Gubensaek, N, Sagmeister, T, Pavkov-Keller, T, Zangger, K, Buhlheller, C, Wagner, G.E. | | 登録日 | 2022-08-01 | | 公開日 | 2023-09-13 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (3.002 Å) | | 主引用文献 | Vibrio cholerae's ToxRS bile sensing system.
Elife, 12, 2023
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2DYK
 | | Crystal structure of N-terminal GTP-binding domain of EngA from Thermus thermophilus HB8 | | 分子名称: | GTP-binding protein, GUANOSINE-5'-DIPHOSPHATE | | 著者 | Kawazoe, M, Takemoto, C, Fusatomi, E, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2006-09-14 | | 公開日 | 2007-03-14 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | Crystal structure of N-terminal GTP-binding domain of EngA from Thermus thermophilus HB8
to be published
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7ROY
 | | The structure of the Fem1B:FNIP1 complex | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Folliculin-interacting protein 1, Protein fem-1 homolog B, ... | | 著者 | Gee, C.L, Mena, E.L, Manford, A.G, Rape, M. | | 登録日 | 2021-08-02 | | 公開日 | 2021-10-13 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural basis and regulation of the reductive stress response.
Cell, 184, 2021
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2E3T
 | | Crystal structure of rat xanthine oxidoreductase mutant (W335A and F336L) | | 分子名称: | BICARBONATE ION, CALCIUM ION, FE2/S2 (INORGANIC) CLUSTER, ... | | 著者 | Asai, R, Nishino, T, Matsumura, T, Okamoto, K, Pai, E.F, Nishino, T. | | 登録日 | 2006-11-28 | | 公開日 | 2007-09-25 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | | 主引用文献 | Two mutations convert mammalian xanthine oxidoreductase to highly superoxide-productive xanthine oxidase
J.Biochem.(Tokyo), 141, 2007
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3TBL
 | | Structure of Mono-ubiquitinated PCNA: Implications for DNA Polymerase Switching and Okazaki Fragment Maturation | | 分子名称: | Proliferating cell nuclear antigen, Ubiquitin | | 著者 | Zhang, Z, Lee, M, Lee, E, Zhang, S. | | 登録日 | 2011-08-07 | | 公開日 | 2012-05-23 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.903 Å) | | 主引用文献 | Structure of monoubiquitinated PCNA: Implications for DNA polymerase switching and Okazaki fragment maturation.
Cell Cycle, 11, 2012
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5VSA
 | | Crystal structure of SsoPox AsA1 mutant (C258L-I261F-W263A) | | 分子名称: | Aryldialkylphosphatase, COBALT (II) ION, FE (II) ION, ... | | 著者 | Hiblot, J, Gotthard, G, Jacquet, P, Daude, D, Bergonzi, C, Chabriere, E, Elias, M. | | 登録日 | 2017-05-11 | | 公開日 | 2018-01-10 | | 最終更新日 | 2021-08-18 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Rational engineering of a native hyperthermostable lactonase into a broad spectrum phosphotriesterase.
Sci Rep, 7, 2017
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5VSM
 | | Crystal structure of viperin with bound [4Fe-4S] cluster, 5'-deoxyadenosine, and L-methionine | | 分子名称: | 5'-DEOXYADENOSINE, IRON/SULFUR CLUSTER, METHIONINE, ... | | 著者 | Fenwick, M.K, Li, Y, Cresswell, P, Modis, Y, Ealick, S.E. | | 登録日 | 2017-05-11 | | 公開日 | 2017-06-14 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structural studies of viperin, an antiviral radical SAM enzyme.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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3TG0
 | | E. coli alkaline phosphatase with bound inorganic phosphate | | 分子名称: | Alkaline phosphatase, MAGNESIUM ION, PHOSPHATE ION, ... | | 著者 | Bobyr, E, Lassila, J.K, Wiersma-Koch, H.I, Fenn, T.D, Lee, J.J, Nikolic-Hughes, I, Hodgson, K.O, Rees, D.C, Hedman, B, Herschlag, D. | | 登録日 | 2011-08-16 | | 公開日 | 2011-11-09 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | High-resolution analysis of Zn(2+) coordination in the alkaline phosphatase superfamily by EXAFS and x-ray crystallography.
J.Mol.Biol., 415, 2012
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3THH
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5VVS
 | | RNA pol II elongation complex | | 分子名称: | DNA (NTS), DNA (TS), DNA-directed RNA polymerase II subunit RPB1, ... | | 著者 | Lahiri, I, Leschziner, A.E. | | 登録日 | 2017-05-20 | | 公開日 | 2017-11-22 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (6.4 Å) | | 主引用文献 | Structural basis for the initiation of eukaryotic transcription-coupled DNA repair.
Nature, 551, 2017
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8AZ5
 | | IAPP S20G plateau-phase fibril polymorph 4PF-CU | | 分子名称: | Islet amyloid polypeptide | | 著者 | Wilkinson, M, Xu, Y, Gallardo, R, Radford, S.E, Ranson, N.A. | | 登録日 | 2022-09-05 | | 公開日 | 2024-01-10 | | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | | 主引用文献 | Structural evolution of fibril polymorphs during amyloid assembly.
Cell, 186, 2023
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8AZ4
 | | IAPP S20G plateau-phase fibril polymorph 2PF-L | | 分子名称: | Islet amyloid polypeptide | | 著者 | Wilkinson, M, Xu, Y, Gallardo, R, Radford, S.E, Ranson, N.A. | | 登録日 | 2022-09-05 | | 公開日 | 2024-01-10 | | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | | 主引用文献 | Structural evolution of fibril polymorphs during amyloid assembly.
Cell, 186, 2023
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2EHQ
 | | Crystal analysis of 1-pyrroline-5-carboxylate dehydrogenase from thermus with bound NADP | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1-pyrroline-5-carboxylate dehydrogenase, ACETATE ION, ... | | 著者 | Inagaki, E, Sakamoto, K, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2007-03-07 | | 公開日 | 2007-05-01 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | New insights into the binding mode of coenzymes: structure of Thermus thermophilus Delta1-pyrroline-5-carboxylate dehydrogenase complexed with NADP+.
Acta Crystallogr.,Sect.F, 63, 2007
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7RSJ
 | | Structure of the VPS34 kinase domain with compound 14 | | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, N-{4-[(7R,8R)-4-oxo-7-(propan-2-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-yl]pyridin-2-yl}cyclopropanecarboxamide, ... | | 著者 | Hu, D.X, Patel, S, Chen, H, Wang, S, Staben, S, Dimitrova, Y.N, Wallweber, H.A, Lee, J.Y, Chan, G.K.Y, Sneeringer, C.J, Prangley, M.S, Moffat, J.G, Wu, C, Schutt, L.K, Salphati, L, Pang, J, McNamara, E, Huang, H, Chen, Y, Wang, Y, Zhao, W, Lim, J, Murthy, A, Siu, M. | | 登録日 | 2021-08-11 | | 公開日 | 2021-11-24 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.881 Å) | | 主引用文献 | Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors.
J.Med.Chem., 65, 2022
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7RKH
 | | Yeast CTP Synthase (URA8) tetramer bound to ATP/UTP at neutral pH | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CTP synthase, MAGNESIUM ION, ... | | 著者 | Hansen, J.M, Lynch, E.M, Farrell, D.P, DiMaio, F, Quispe, J, Kollman, J.M. | | 登録日 | 2021-07-22 | | 公開日 | 2021-11-24 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Cryo-EM structures of CTP synthase filaments reveal mechanism of pH-sensitive assembly during budding yeast starvation.
Elife, 10, 2021
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7RSP
 | | Structure of the VPS34 kinase domain with compound 14 | | 分子名称: | (7R,8R)-2-[(3R)-3-methylmorpholin-4-yl]-7-(propan-2-yl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one, GLYCEROL, Phosphatidylinositol 3-kinase catalytic subunit type 3 | | 著者 | Hu, D.X, Patel, S, Chen, H, Wang, S, Staben, S, Dimitrova, Y.N, Wallweber, H.A, Lee, J.Y, Chan, G.K.Y, Sneeringer, C.J, Prangley, M.S, Moffat, J.G, Wu, C, Schutt, L.K, Salphati, L, Pang, J, McNamara, E, Huang, H, Chen, Y, Wang, Y, Zhao, W, Lim, J, Murthy, A, Siu, M. | | 登録日 | 2021-08-11 | | 公開日 | 2021-11-24 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | | 主引用文献 | Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors.
J.Med.Chem., 65, 2022
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6LHW
 | | Structure of N-terminal and C-terminal domains of FANCA | | 分子名称: | Fanconi anemia complementation group A | | 著者 | Jeong, E, Lee, S, Shin, J, Kim, Y, Kim, J, Scharer, O, Kim, Y, Kim, H, Cho, Y. | | 登録日 | 2019-12-10 | | 公開日 | 2020-03-25 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (4.84 Å) | | 主引用文献 | Structural basis of the fanconi anemia-associated mutations within the FANCA and FANCG complex.
Nucleic Acids Res., 48, 2020
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5W2L
 | | Structure of a central domain of human Ctc1 | | 分子名称: | CST complex subunit CTC1, MERCURY (II) ION | | 著者 | Rice, C, Skordalakes, E. | | 登録日 | 2017-06-06 | | 公開日 | 2017-11-29 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | | 主引用文献 | Structural and functional analysis of an OB-fold in human Ctc1 implicated in telomere maintenance and bone marrow syndromes.
Nucleic Acids Res., 46, 2018
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