7P0P
 
 | | NAF-1 bound to M1 molecule | | 分子名称: | 2-benzamido-4-[(2~{R})-1,2,3,4-tetrahydronaphthalen-2-yl]thiophene-3-carboxylic acid, CDGSH iron-sulfur domain-containing protein 2, FE2/S2 (INORGANIC) CLUSTER | | 著者 | Livnah, O, Eisenberg-Domovich, Y, Marjault, H.B, Nechushtai, R. | | 登録日 | 2021-06-30 | | 公開日 | 2022-05-25 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | | 主引用文献 | An anti-diabetic drug targets NEET (CISD) proteins through destabilization of their [2Fe-2S] clusters.
Commun Biol, 5, 2022
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7P0O
 | | mitoNEET bound to M1 molecule | | 分子名称: | 2-benzamido-4-[(2~{R})-1,2,3,4-tetrahydronaphthalen-2-yl]thiophene-3-carboxylic acid, 2-benzamido-4-[(2~{S})-1,2,3,4-tetrahydronaphthalen-2-yl]thiophene-3-carboxylic acid, CDGSH iron-sulfur domain-containing protein 1, ... | | 著者 | Livnah, O, Eisenberg-Domovich, Y, Marjault, H.B, Nechushtai, R. | | 登録日 | 2021-06-30 | | 公開日 | 2022-05-25 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | An anti-diabetic drug targets NEET (CISD) proteins through destabilization of their [2Fe-2S] clusters.
Commun Biol, 5, 2022
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3MM0
 | | Crystal structure of chimeric avidin | | 分子名称: | Avidin, Avidin-related protein 4/5 | | 著者 | Livnah, O, Eisenberg-Domovich, Y, Maatta, J.A.E, Kulomaa, M.S, Hytonen, V.P, Nordlund, H.R. | | 登録日 | 2010-04-19 | | 公開日 | 2010-10-27 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Chimeric avidin shows stability against harsh chemical conditions-biochemical analysis and 3D structure.
Biotechnol.Bioeng., 108, 2011
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4OOA
 | | CRYSTAL STRUCTURE of NAF1 (MINER1): H114C THE REDOX-ACTIVE 2FE-2S PROTEIN | | 分子名称: | CDGSH iron-sulfur domain-containing protein 2, FE2/S2 (INORGANIC) CLUSTER | | 著者 | Tamir, S, Eisenberg-Domovich, Y, Conlan, A.R, Stofleth, J.T, Lipper, C.H, Paddock, M.L, Mittler, R, Jennings, P.A, Livnah, O, Nechushtai, R. | | 登録日 | 2014-01-31 | | 公開日 | 2014-07-02 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | | 主引用文献 | A point mutation in the [2Fe-2S] cluster binding region of the NAF-1 protein (H114C) dramatically hinders the cluster donor properties.
Acta Crystallogr.,Sect.D, 70, 2014
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4OO7
 | | THE 1.55A CRYSTAL STRUCTURE of NAF1 (MINER1): THE REDOX-ACTIVE 2FE-2S PROTEIN | | 分子名称: | CDGSH iron-sulfur domain-containing protein 2, FE2/S2 (INORGANIC) CLUSTER | | 著者 | Tamir, S, Eisenberg-Domovich, Y, Colman, A.R, Stofleth, J.T, Lipper, C.H, Paddock, M.L, Jenning, P.A, Livnah, O, Nechushtai, R. | | 登録日 | 2014-01-31 | | 公開日 | 2014-07-02 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | A point mutation in the [2Fe-2S] cluster binding region of the NAF-1 protein (H114C) dramatically hinders the cluster donor properties.
Acta Crystallogr.,Sect.D, 70, 2014
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6QTY
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3P63
 | | Structure of M. laminosus Ferredoxin with a shorter L1,2 loop | | 分子名称: | FE2/S2 (INORGANIC) CLUSTER, Ferredoxin | | 著者 | Livnah, O, Nechushtai, R, Eisenberg-Domovich, Y, Michaeli, D. | | 登録日 | 2010-10-11 | | 公開日 | 2011-02-09 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Allostery in the ferredoxin protein motif does not involve a conformational switch.
Proc.Natl.Acad.Sci.USA, 108, 2011
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1NQM
 | | Structure of Savm-W120K, streptavidin mutant | | 分子名称: | BIOTIN, Streptavidin | | 著者 | Pazy, Y, Eisenberg-Domovich, Y, Laitinen, O.H, Kulomaa, M.S, Bayer, E.A, Wilchek, M, Livnah, O. | | 登録日 | 2003-01-22 | | 公開日 | 2003-07-15 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Dimer-Tetramer Transition between Solution and Crystalline States of Streptavidin and Avidin Mutants.
J.Bacteriol., 185, 2003
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1NQN
 | | Structure of Avm-W110K (W110K mutant of avidin) | | 分子名称: | Avidin | | 著者 | Pazy, Y, Eisenberg-Domovich, Y, Laitinen, O.H, Kulomaa, M.S, Bayer, E.A, Wilchek, M, Livnah, O. | | 登録日 | 2003-01-22 | | 公開日 | 2003-07-15 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Dimer-Tetramer Transition between Solution and Crystalline States of Streptavidin and Avidin Mutants.
J.Bacteriol., 185, 2003
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1I9H
 | | CORE STREPTAVIDIN-BNA COMPLEX | | 分子名称: | 5-(2-OXO-HEXAHYDRO-THIENO[3,4-D]IMIDAZOL-6-YL)-PENTANOIC ACID (4-NITRO-PHENYL)-AMIDE, STREPTAVIDIN | | 著者 | Livnah, O, Huberman, T, Wilchek, M, Bayer, E.A, Eisenberg-Domovich, Y. | | 登録日 | 2001-03-20 | | 公開日 | 2001-09-12 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Chicken avidin exhibits pseudo-catalytic properties. Biochemical, structural, and electrostatic consequences.
J.Biol.Chem., 276, 2001
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1RXJ
 | | Crystal structure of streptavidin mutant (M2) where the L3,4 loop was replace by that of avidin | | 分子名称: | 5-(2-OXO-HEXAHYDRO-THIENO[3,4-D]IMIDAZOL-6-YL)-PENTANOIC ACID (4-NITRO-PHENYL)-AMIDE, Streptavidin | | 著者 | Eisenberg-Domovich, Y, Pazy, Y, Nir, O, Raboy, B, Bayer, E.A, Wilchek, M, Livnah, O. | | 登録日 | 2003-12-18 | | 公開日 | 2004-05-11 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.14 Å) | | 主引用文献 | Structural elements responsible for conversion of streptavidin to a pseudoenzyme
Proc.Natl.Acad.Sci.USA, 101, 2004
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1Y52
 | | structure of insect cell (Baculovirus) expressed AVR4 (C122S)-biotin complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Avidin-related protein 4/5, BIOTIN | | 著者 | Eisenberg-Domovich, Y, Hytonen, V.P, Wilchek, M, Bayer, E.A, Kulomaa, M.S, Livnah, O. | | 登録日 | 2004-12-02 | | 公開日 | 2005-05-24 | | 最終更新日 | 2024-01-03 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | High-resolution crystal structure of an avidin-related protein: insight into high-affinity biotin binding and protein stability.
Acta Crystallogr.,Sect.D, 61, 2005
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4E5B
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4E5A
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1RXH
 | | Crystal structure of streptavidin mutant L124R (M1) complexed with biotinyl p-nitroanilide (BNI) | | 分子名称: | 5-(2-OXO-HEXAHYDRO-THIENO[3,4-D]IMIDAZOL-6-YL)-PENTANOIC ACID (4-NITRO-PHENYL)-AMIDE, Streptavidin | | 著者 | Eisenberg-Domovich, Y, Pazy, Y, Nir, O, Raboy, B, Bayer, E.A, Wilchek, M, Livnah, O. | | 登録日 | 2003-12-18 | | 公開日 | 2004-05-11 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural elements responsible for conversion of streptavidin to a pseudoenzyme
Proc.Natl.Acad.Sci.USA, 101, 2004
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4E6C
 | | p38a-perifosine Complex | | 分子名称: | (1,1-dimethylpiperidin-1-ium-4-yl) octadecyl hydrogen phosphate, Mitogen-activated protein kinase 14 | | 著者 | Livnah, O, Tzarum, N, Eisenberg-Domovich, Y. | | 登録日 | 2012-03-15 | | 公開日 | 2012-10-31 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | | 主引用文献 | Lipid Molecules Induce p38 alpha Activation via a Novel Molecular Switch.
J.Mol.Biol., 424, 2012
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4E8A
 | | The crystal structure of p38a MAP kinase in complex with PIA24 | | 分子名称: | (1R,2S,3R,4S,6S)-6-(cyclohexylmethoxy)-2,3,4-trihydroxycyclohexyl (2R)-2-methoxy-3-(octadecyloxy)propyl hydrogen (S)-phosphate, Mitogen-activated protein kinase 14 | | 著者 | Livnah, O, Tzarum, N, Eisenberg-Domovich, Y. | | 登録日 | 2012-03-20 | | 公開日 | 2012-10-31 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Lipid Molecules Induce p38 alpha Activation via a Novel Molecular Switch.
J.Mol.Biol., 424, 2012
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1RXK
 | | crystal structure of streptavidin mutant (M3) a combination of M1+M2 | | 分子名称: | 5-(2-OXO-HEXAHYDRO-THIENO[3,4-D]IMIDAZOL-6-YL)-PENTANOIC ACID (4-NITRO-PHENYL)-AMIDE, Streptavidin | | 著者 | Eisenberg-Domovich, Y, Pazy, Y, Nir, O, Raboy, B, Bayer, E.A, Wilchek, M, Livnah, O. | | 登録日 | 2003-12-18 | | 公開日 | 2004-05-11 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structural elements responsible for conversion of streptavidin to a pseudoenzyme.
Proc.Natl.Acad.Sci.USA, 101, 2004
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4E6A
 | | p38a-PIA23 complex | | 分子名称: | (2S)-2-methoxy-3-(octadecyloxy)propyl (1R,2R,3R,4S,6S)-2,3,4-trihydroxy-6-(2-methylpropoxy)cyclohexyl hydrogen (S)-phosphate, Mitogen-activated protein kinase 14 | | 著者 | Livnah, O, Tzarum, N, Eisenberg-Domovich, Y. | | 登録日 | 2012-03-15 | | 公開日 | 2012-10-31 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | | 主引用文献 | Lipid Molecules Induce p38 alpha Activation via a Novel Molecular Switch.
J.Mol.Biol., 424, 2012
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2OF9
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7O9Y
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7OA0
 | | Crystal structure of di-phosphorylated human CLK1 in complex with 5-(6,7-dichloro-1H-indol-3-yl)pyrimidin-4-amine | | 分子名称: | 5-[6,7-bis(chloranyl)-1-methyl-indol-3-yl]pyrimidin-4-amine, Dual specificity protein kinase CLK1 | | 著者 | Livnah, O, Domovich, Y, Bracher, F, Aiger, C. | | 登録日 | 2021-04-18 | | 公開日 | 2022-05-04 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | | 主引用文献 | Development of novel CLK1 inhibitors as potential drugs for treatment of Chikungunya virus infections
To Be Published
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2OFA
 | | Crystal structure of apo AVR4 (R112L,C122S) | | 分子名称: | Avidin-related protein 4/5, FORMIC ACID | | 著者 | Livnah, O, Hayouka, R, Eisenberg-Domovich, Y. | | 登録日 | 2007-01-03 | | 公開日 | 2007-12-25 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Critical importance of loop conformation to avidin-enhanced hydrolysis of an active biotin ester.
Acta Crystallogr.,Sect.D, 64, 2008
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2OF8
 | | Crystal structure of AVR4 (D39A/C122S)-BNA complex | | 分子名称: | 5-(2-OXO-HEXAHYDRO-THIENO[3,4-D]IMIDAZOL-6-YL)-PENTANOIC ACID (4-NITRO-PHENYL)-AMIDE, Avidin-related protein 4/5, FORMIC ACID | | 著者 | Livnah, O, Hayouka, R, Eisenberg-Domovich, Y. | | 登録日 | 2007-01-03 | | 公開日 | 2007-12-25 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | | 主引用文献 | Critical importance of loop conformation to avidin-enhanced hydrolysis of an active biotin ester.
Acta Crystallogr.,Sect.D, 64, 2008
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2OFB
 | | Crystal structure of AVR4 (R112L/C122S)-BNA complex | | 分子名称: | 5-(2-OXO-HEXAHYDRO-THIENO[3,4-D]IMIDAZOL-6-YL)-PENTANOIC ACID (4-NITRO-PHENYL)-AMIDE, Avidin-related protein 4/5, FORMIC ACID | | 著者 | Livnah, O, Hayouka, R, Eisenberg-Domovich, Y. | | 登録日 | 2007-01-03 | | 公開日 | 2007-12-25 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.16 Å) | | 主引用文献 | Critical importance of loop conformation to avidin-enhanced hydrolysis of an active biotin ester.
Acta Crystallogr.,Sect.D, 64, 2008
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