4OOA

CRYSTAL STRUCTURE of NAF1 (MINER1): H114C THE REDOX-ACTIVE 2FE-2S PROTEIN

Summary for 4OOA

Entry DOI	10.2210/pdb4ooa/pdb
Related	4OO7
Descriptor	CDGSH iron-sulfur domain-containing protein 2, FE2/S2 (INORGANIC) CLUSTER (3 entities in total)
Functional Keywords	membrane bound, thiazolidinedione, oxidative stress, metal binding protein
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Single-pass membrane protein: Q8N5K1
Total number of polymer chains	6
Total formula weight	46995.95
Authors	Tamir, S.,Eisenberg-Domovich, Y.,Conlan, A.R.,Stofleth, J.T.,Lipper, C.H.,Paddock, M.L.,Mittler, R.,Jennings, P.A.,Livnah, O.,Nechushtai, R. (deposition date: 2014-01-31, release date: 2014-07-02, Last modification date: 2024-02-28)
Primary citation	Tamir, S.,Eisenberg-Domovich, Y.,Conlan, A.R.,Stofleth, J.T.,Lipper, C.H.,Paddock, M.L.,Mittler, R.,Jennings, P.A.,Livnah, O.,Nechushtai, R. A point mutation in the [2Fe-2S] cluster binding region of the NAF-1 protein (H114C) dramatically hinders the cluster donor properties. Acta Crystallogr.,Sect.D, 70:1572-1578, 2014 Cited by PubMed: 24914968 DOI: 10.1107/S1399004714005458 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.58 Å)

Structure validation