6QTY

Non-phosphorylated human CLK1 in complex with an indole inhibitor to 1.65 Ang

Summary for 6QTY

Entry DOI	10.2210/pdb6qty/pdb
Related	2VAG
Descriptor	Dual specificity protein kinase CLK1, ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate (3 entities in total)
Functional Keywords	clk1, splicing, kinase, viral infection, signaling protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	39787.54
Authors	Livnah, O.,Domovich, Y. (deposition date: 2019-02-26, release date: 2020-03-18, Last modification date: 2024-01-24)
Primary citation	Dekel, N.,Eisenberg-Domovich, Y.,Karlas, A.,Meyer, T.F.,Bracher, F.,Lebendiker, M.,Danieli, T.,Livnah, O. Expression, purification and crystallization of CLK1 kinase - A potential target for antiviral therapy. Protein Expr.Purif., 176:105742-105742, 2020 Cited by PubMed: 32866611 DOI: 10.1016/j.pep.2020.105742 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation