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PDB: 214 件
1M7W
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BU of 1m7w by Molmil
HNF4a ligand binding domain with bound fatty acid
分子名称: Hepatocyte nuclear factor 4-alpha, LAURIC ACID
著者Dhe-Paganon, S, Duda, K, Iwamoto, M, Chi, Y.I, Shoelson, S.E.
登録日2002-07-22
公開日2003-07-01
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligand
J.Biol.Chem., 277, 2002
1EKG
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BU of 1ekg by Molmil
MATURE HUMAN FRATAXIN
分子名称: FRATAXIN
著者Dhe-Paganon, S, Shigeta, R, Chi, Y.I, Ristow, M, Shoelson, S.E.
登録日2000-03-08
公開日2000-11-08
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of human frataxin.
J.Biol.Chem., 275, 2000
1IFR
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BU of 1ifr by Molmil
Structure of Lamin A/C Globular Domain
分子名称: GLYCEROL, Lamin A/C
著者Dhe-Paganon, S, Werner, E.D, Shoelson, S.E.
登録日2001-04-13
公開日2002-07-17
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structure of the globular tail of nuclear lamin.
J.Biol.Chem., 277, 2002
1QQG
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BU of 1qqg by Molmil
CRYSTAL STRUCTURE OF THE PH-PTB TARGETING REGION OF IRS-1
分子名称: INSULIN RECEPTOR SUBSTRATE 1
著者Dhe-Paganon, S, Shoelson, S.E.
登録日1999-06-04
公開日1999-08-01
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1.
Proc.Natl.Acad.Sci.USA, 96, 1999
1Q2H
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BU of 1q2h by Molmil
Phenylalanine Zipper Mediates APS Dimerization
分子名称: adaptor protein with pleckstrin homology and src homology 2 domains
著者Dhe-Paganon, S, Werner, E.D, Nishi, M, Chi, Y.-I, Shoelson, S.E.
登録日2003-07-24
公開日2004-08-03
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献A phenylalanine zipper mediates APS dimerization.
Nat.Struct.Mol.Biol., 11, 2004
6VQM
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BU of 6vqm by Molmil
Crystal Structure Analysis of human ACK1
分子名称: 2-({4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-2-methoxyphenyl}amino)-9-methyl-5,7-dihydro-6H-pyrimido[5,4-d][1,3]benzodiazepin-6-one, Activated CDC42 kinase 1, SULFATE ION
著者Seo, H.-S, Dhe-Paganon, S.
登録日2020-02-05
公開日2021-02-10
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.87 Å)
主引用文献Crystal Structure Analysis of human ACK1
To Be Published
2I7A
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BU of 2i7a by Molmil
Domain IV of Human Calpain 13
分子名称: CALCIUM ION, Calpain 13, GLYCEROL, ...
著者Walker, J.R, Ng, K, Davis, T.L, Ravulapalli, R, Butler-cole, C, Finerty Jr, P.J, Newman, E.M, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
登録日2006-08-30
公開日2006-09-12
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure of Human Calpain 13
To be Published
5K5F
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BU of 5k5f by Molmil
NMR structure of the HLTF HIRAN domain
分子名称: Helicase-like transcription factor
著者Bezsonova, I, Neculai, D, Korzhnev, D, Weigelt, J, Bountra, C, Edwards, A, Arrowsmith, C, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
登録日2016-05-23
公開日2016-06-08
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献NMR structure of the HLTF HIRAN domain
To Be Published
3EPZ
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BU of 3epz by Molmil
Structure of the replication foci-targeting sequence of human DNA cytosine methyltransferase DNMT1
分子名称: DNA (cytosine-5)-methyltransferase 1, GLYCEROL, SODIUM ION, ...
著者Walker, J.R, Avvakumov, G.V, Xue, S, Li, Y, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
登録日2008-09-30
公開日2008-11-25
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献The replication focus targeting sequence (RFTS) domain is a DNA-competitive inhibitor of Dnmt1.
J.Biol.Chem., 286, 2011
3EBB
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BU of 3ebb by Molmil
PLAP/P97 complex
分子名称: MAGNESIUM ION, PHOSPHOLIPASE A2-ACTIVATING PROTEIN, TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE (TER ATP
著者Walker, J.R, Qiu, L, Akutsu, M, Slessarev, Y, Amaya, M.F, Li, Y, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
登録日2008-08-27
公開日2009-02-24
最終更新日2014-04-02
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure and function of the PLAA/Ufd3-p97/Cdc48 complex.
J.Biol.Chem., 285, 2010
7S7G
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BU of 7s7g by Molmil
Crystal Structure Analysis of Human VLCAD
分子名称: FLAVIN-ADENINE DINUCLEOTIDE, Very long-chain specific acyl-CoA dehydrogenase, mitochondrial
著者Seo, H.-S, Dhe-Paganon, S.
登録日2021-09-15
公開日2022-09-28
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (1.34 Å)
主引用文献Structural basis for defective membrane targeting of mutant enzyme in human VLCAD deficiency.
Nat Commun, 13, 2022
5JWM
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BU of 5jwm by Molmil
Bivalent BET Bromodomain Inhibition
分子名称: 2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]-~{N}-[2-[2-[2-[2-[2-[2-[2-[2-[2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]ethanamide, Bromodomain-containing protein 4
著者Seo, H.-S, Dhe-Paganon, S.
登録日2016-05-12
公開日2016-07-06
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献Design and characterization of bivalent BET inhibitors.
Nat.Chem.Biol., 12, 2016
6DUN
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BU of 6dun by Molmil
Crystal Structure Analysis of PIN1
分子名称: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, TRIHYDROXYARSENITE(III)
著者Seo, H.-S, Dhe-Paganon, S.
登録日2018-06-21
公開日2019-03-06
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells.
Nat Commun, 9, 2018
3EBQ
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BU of 3ebq by Molmil
Crystal structure of human PPPDE1
分子名称: MERCURY (II) ION, MOLECULE: PPPDE1 (PERMUTED PAPAIN FOLD PEPTIDASES OF DSRNA VIRUSES AND EUKARYOTES 1), UPF0326 protein FAM152B
著者Walker, J.R, Akutsu, M, Qiu, L, Li, Y, Slessarev, Y, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Botchkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
登録日2008-08-28
公開日2008-11-04
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure of Human PPPDE1
To be Published
4WVL
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BU of 4wvl by Molmil
Structure-Guided DOT1L Probe Optimization by Label-Free Ligand Displacement
分子名称: 1,2-ETHANEDIOL, GLYCEROL, Histone-lysine N-methyltransferase, ...
著者Xu, X, Dhe-Paganon, S, Blacklow, S.
登録日2014-11-06
公開日2014-12-03
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Structure-Guided DOT1L Probe Optimization by Label-Free Ligand Displacement.
Acs Chem.Biol., 10, 2015
8ECM
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BU of 8ecm by Molmil
Crystal Structure Analysis of Acetyl-CoA acetyltransferase from Firmicutes bacterium
分子名称: Acetyl-CoA acetyltransferase
著者Seo, H.S, Dhe-Paganon, S.
登録日2022-09-02
公開日2023-05-31
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Gut microbial metabolism of 5-ASA diminishes its clinical efficacy in inflammatory bowel disease.
Nat Med, 29, 2023
4WJL
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BU of 4wjl by Molmil
Structure of human dipeptidyl peptidase 10 (DPPY): a modulator of neuronal Kv4 channels
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Inactive dipeptidyl peptidase 10, ...
著者Bezerra, G.A, Dobrovetsky, E, Seitova, A, Fedosyuk, S, Dhe-Paganon, S, Gruber, K.
登録日2014-09-30
公開日2015-03-18
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Structure of human dipeptidyl peptidase 10 (DPPY): a modulator of neuronal Kv4 channels.
Sci Rep, 5, 2015
8CUC
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BU of 8cuc by Molmil
Crystal structure analysis of SALL4 zinc finger domain in complex with DNA
分子名称: DNA (5'-D(P*CP*GP*AP*AP*AP*TP*AP*TP*TP*AP*GP*C)-3'), DNA (5'-D(P*GP*CP*TP*AP*AP*TP*AP*TP*TP*TP*CP*G)-3'), Sal-like protein 4, ...
著者Seo, H.S, Dhe-Paganon, S.
登録日2022-05-17
公開日2023-05-24
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Crystal Structure Analysis of SALL4 Zinc Finger domain in complex with DNA
To Be Published
8EBK
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Crystal Structure Analysis of xHDMX in complex with the stapled peptide PROTAC analog
分子名称: ACE-LEU-THR-PHE-0EH-GLU-TYR-TRP-ALA-GLN-LEU-MK8-SER-ALA-ALA, HDMX
著者Seo, H.-S, Dhe-Paganon, S.
登録日2022-08-31
公開日2023-10-04
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.29 Å)
主引用文献Crystal Structure Analysis of xHDMX in complex with the stapled peptide PROTAC analog
To Be Published
6MBW
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Structure of Transcription Factor
分子名称: Signal transducer and activator of transcription 5B
著者Seo, H.-S, Dhe-Paganon, S.
登録日2018-08-30
公開日2019-06-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.29 Å)
主引用文献Structural and functional consequences of the STAT5BN642H driver mutation.
Nat Commun, 10, 2019
6MBZ
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Structure of Transcription Factor
分子名称: Signal transducer and activator of transcription 5B
著者Seo, H.-S, Dhe-Paganon, S.
登録日2018-08-30
公開日2019-06-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.21 Å)
主引用文献Structural and functional consequences of the STAT5BN642Hdriver mutation.
Nat Commun, 10, 2019
2Z5D
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BU of 2z5d by Molmil
Human ubiquitin-conjugating enzyme E2 H
分子名称: SODIUM ION, Ubiquitin-conjugating enzyme E2 H
著者Bochkarev, A, Cui, H, Walker, J.R, Newman, E.M, Mackenzie, F, Battaile, K.P, Sundstrom, M, Arrowsmith, C, Edwards, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
登録日2007-07-06
公開日2007-10-09
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.
MOL.CELL PROTEOMICS, 11, 2012
4PYZ
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BU of 4pyz by Molmil
Crystal structure of the first two Ubl domains of Deubiquitylase USP7
分子名称: UNKNOWN ATOM OR ION, Ubiquitin carboxyl-terminal hydrolase 7
著者Walker, J.R, Dong, A, Ong, M.S, Dhe-Paganon, S, Kania, J, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Tong, Y, Structural Genomics Consortium (SGC)
登録日2014-03-28
公開日2014-04-16
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.84 Å)
主引用文献Crystal structure of the first two Ubl domains of Deubiquitylase USP7
to be published
7KMR
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BU of 7kmr by Molmil
Crystal structure analysis of human KRAS mutant
分子名称: GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas
著者Seo, H.-S, Dhe-Paganon, S.
登録日2020-11-03
公開日2021-11-10
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.51 Å)
主引用文献Regulation of GTPase function by autophosphorylation.
Mol.Cell, 82, 2022
7LI5
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BU of 7li5 by Molmil
Crystal Structure Analysis of human TEAD1
分子名称: 1-[(3R,4R)-3-[4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl]-4-{[4-(trifluoromethyl)phenyl]methoxy}pyrrolidin-1-yl]prop-2-en-1-one, SULFATE ION, Transcriptional enhancer factor TEF-1
著者Seo, H.-S, Dhe-Paganon, S.
登録日2021-01-26
公開日2022-02-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.68 Å)
主引用文献Crystal Structure Analysis of human TEAD1
To Be Published

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