6YSL
 
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6YSF
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8SAH
 | | Huntingtin C-HEAT domain in complex with HAP40 | | Descriptor: | 40-kDa huntingtin-associated protein, Huntingtin | | Authors: | Harding, R.J, Deme, J.C, Alteen, M.G, Arrowsmith, C.H, Lea, S.M, Structural Genomics Consortium (SGC) | | Deposit date: | 2023-03-31 | | Release date: | 2023-04-26 | | Last modified: | 2023-09-20 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Delineation of functional subdomains of Huntingtin protein and their interaction with HAP40.
Structure, 31, 2023
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8UPL
 | | Cryo-EM structure of a Clockwise locked form of the Salmonella enterica Typhimurium flagellar C-ring, with C34 symmetry applied | | Descriptor: | Flagellar M-ring protein, Flagellar motor switch protein FliG, Flagellar motor switch protein FliM, ... | | Authors: | Johnson, S, Deme, J.C, Lea, S.M. | | Deposit date: | 2023-10-22 | | Release date: | 2024-01-24 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (5.4 Å) | | Cite: | Structural basis of directional switching by the bacterial flagellum.
Nat Microbiol, 9, 2024
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8UOX
 | | Cryo-EM structure of a Counterclockwise locked form of the Salmonella enterica Typhimurium flagellar C-ring, with C34 symmetry applied | | Descriptor: | Flagellar M-ring protein, Flagellar motor switch protein FliG, Flagellar motor switch protein FliM, ... | | Authors: | Johnson, S, Deme, J.C, Lea, S.M. | | Deposit date: | 2023-10-20 | | Release date: | 2024-01-24 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (4.6 Å) | | Cite: | Structural basis of directional switching by the bacterial flagellum.
Nat Microbiol, 9, 2024
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8UMD
 | | Cryo-EM structure of a single subunit of a Counterclockwise-locked form of the Salmonella enterica Typhimurium flagellar C-ring. | | Descriptor: | Flagellar M-ring protein, Flagellar motor switch protein FliG, Flagellar motor switch protein FliM, ... | | Authors: | Johnson, S, Deme, J.C, Lea, S.M. | | Deposit date: | 2023-10-17 | | Release date: | 2024-01-24 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structural basis of directional switching by the bacterial flagellum.
Nat Microbiol, 9, 2024
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8UMX
 | | Cryo-EM structure of a single subunit of a Clockwise-locked form of the Salmonella enterica Typhimurium flagellar C-ring. | | Descriptor: | Flagellar M-ring protein, Flagellar motor switch protein FliG, Flagellar motor switch protein FliM, ... | | Authors: | Johnson, S, Deme, J.C, Lea, S.M. | | Deposit date: | 2023-10-18 | | Release date: | 2024-01-24 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Structural basis of directional switching by the bacterial flagellum.
Nat Microbiol, 9, 2024
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6YS8
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7NQK
 | | Cryo-EM structure of the mammalian peptide transporter PepT2 | | Descriptor: | Solute carrier family 15 member 2, nanobody | | Authors: | Parker, J.L, Deme, J.C, Lea, S.M, Newstead, S. | | Deposit date: | 2021-03-01 | | Release date: | 2021-07-07 | | Last modified: | 2021-10-13 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Cryo-EM structure of PepT2 reveals structural basis for proton-coupled peptide and prodrug transport in mammals.
Sci Adv, 7, 2021
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8SA2
 | | Adenosylcobalamin-bound riboswitch dimer, form 1 | | Descriptor: | Adenosylcobalamin, adenosylcobalamin riboswitch form 1 | | Authors: | Ding, J, Deme, J.C, Stagno, J.R, Yu, P, Lea, S.M, Wang, Y.X. | | Deposit date: | 2023-03-31 | | Release date: | 2023-07-26 | | Last modified: | 2023-10-25 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Capturing heterogeneous conformers of cobalamin riboswitch by cryo-EM.
Nucleic Acids Res., 51, 2023
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8SA4
 | | Adenosylcobalamin-bound riboswitch dimer, form 3 | | Descriptor: | Adenosylcobalamin, adenosylcobalamin riboswitch form 3 | | Authors: | Ding, J, Deme, J.C, Stagno, J.R, Yu, P, Lea, S.M, Wang, Y.X. | | Deposit date: | 2023-03-31 | | Release date: | 2023-07-26 | | Last modified: | 2023-10-25 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Capturing heterogeneous conformers of cobalamin riboswitch by cryo-EM.
Nucleic Acids Res., 51, 2023
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8SA3
 | | Adenosylcobalamin-bound riboswitch dimer, form 2 | | Descriptor: | Adenosylcobalamin, adenosylcobalamin riboswitch form 2 | | Authors: | Ding, J, Deme, J.C, Stagno, J.R, Yu, P, Lea, S.M, Wang, Y.X. | | Deposit date: | 2023-03-31 | | Release date: | 2023-07-26 | | Last modified: | 2023-10-25 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Capturing heterogeneous conformers of cobalamin riboswitch by cryo-EM.
Nucleic Acids Res., 51, 2023
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8SA6
 | | apo form of adenosylcobalamin riboswitch dimer | | Descriptor: | apo form of adenosylcobalamin riboswitch dimer | | Authors: | Ding, J, Deme, J.C, Stagno, J.R, Yu, P, Lea, S.M, Wang, Y.X. | | Deposit date: | 2023-03-31 | | Release date: | 2023-07-26 | | Last modified: | 2023-10-25 | | Method: | ELECTRON MICROSCOPY (5.3 Å) | | Cite: | Capturing heterogeneous conformers of cobalamin riboswitch by cryo-EM.
Nucleic Acids Res., 51, 2023
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8SA5
 | | Adenosylcobalamin-bound riboswitch dimer, form 4 | | Descriptor: | Adenosylcobalamin, adenosylcobalamin riboswitch form 4 | | Authors: | Ding, J, Deme, J.C, Stagno, J.R, Yu, P, Lea, S.M, Wang, Y.X. | | Deposit date: | 2023-03-31 | | Release date: | 2023-07-26 | | Last modified: | 2023-10-25 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Capturing heterogeneous conformers of cobalamin riboswitch by cryo-EM.
Nucleic Acids Res., 51, 2023
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7NVH
 | | Cryo-EM structure of the mycolic acid transporter MmpL3 from M. tuberculosis | | Descriptor: | Lauryl Maltose Neopentyl Glycol, Trehalose monomycolate exporter MmpL3 | | Authors: | Adams, O, Deme, J.C, Parker, J.L, Lea, S.M, Newstead, S. | | Deposit date: | 2021-03-15 | | Release date: | 2021-06-16 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Cryo-EM structure and resistance landscape of M. tuberculosis MmpL3: An emergent therapeutic target.
Structure, 29, 2021
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7P9V
 | | Cryo EM structure of System XC- | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4F2 cell-surface antigen heavy chain, Cystine/glutamate transporter | | Authors: | Parker, J.L, Deme, J.C, Lea, S.M, Newstead, S. | | Deposit date: | 2021-07-28 | | Release date: | 2021-11-17 | | Last modified: | 2022-02-02 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Molecular basis for redox control by the human cystine/glutamate antiporter system xc .
Nat Commun, 12, 2021
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7P9U
 | | Cryo EM structure of System XC- in complex with glutamate | | Descriptor: | 4F2 cell-surface antigen heavy chain, Cystine/glutamate transporter, GLUTAMIC ACID | | Authors: | Parker, J.L, Deme, J.C, Lea, S.M, Newstead, S. | | Deposit date: | 2021-07-28 | | Release date: | 2021-11-17 | | Last modified: | 2022-02-02 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Molecular basis for redox control by the human cystine/glutamate antiporter system xc .
Nat Commun, 12, 2021
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7BC6
 | | Cryo-EM structure of the outward open proton coupled folate transporter at pH 7.5 | | Descriptor: | Proton-coupled folate transporter, nanobody | | Authors: | Parker, J.L, Deme, J.C, Lea, S.M, Newstead, S. | | Deposit date: | 2020-12-18 | | Release date: | 2021-05-12 | | Last modified: | 2021-08-11 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural basis of antifolate recognition and transport by PCFT.
Nature, 595, 2021
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7BC7
 | | Cryo-EM structure of the proton coupled folate transporter at pH 6.0 bound to pemetrexed | | Descriptor: | 2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC ACID, Proton-coupled folate transporter, nanobody | | Authors: | Parker, J.L, Deme, J.C, Lea, S.M, Newstead, S. | | Deposit date: | 2020-12-18 | | Release date: | 2021-05-12 | | Last modified: | 2021-08-11 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural basis of antifolate recognition and transport by PCFT.
Nature, 595, 2021
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8HC1
 | | CryoEM structure of Helicobacter pylori UreFD/urease complex | | Descriptor: | Urease accessory protein UreF, Urease accessory protein UreH, Urease subunit alpha, ... | | Authors: | Nim, Y.S, Fong, I.Y.H, Deme, J, Tsang, K.L, Caesar, J, Johnson, S, Wong, K.B, Lea, S.M. | | Deposit date: | 2022-11-01 | | Release date: | 2023-05-03 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (2.3 Å) | | Cite: | Delivering a toxic metal to the active site of urease.
Sci Adv, 9, 2023
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8HCN
 | | CryoEM Structure of Klebsiella pneumoniae UreD/urease complex | | Descriptor: | Urease accessory protein UreD, Urease subunit alpha, Urease subunit beta, ... | | Authors: | Nim, Y.S, Fong, I.Y.H, Deme, J, Tsang, K.L, Caesar, J, Johnson, S, Wong, K.B, Lea, S.M. | | Deposit date: | 2022-11-02 | | Release date: | 2023-05-03 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Delivering a toxic metal to the active site of urease.
Sci Adv, 9, 2023
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6S3S
 | | Structure of the FliPQR complex from the flagellar type 3 secretion system of Vibrio mimicus. | | Descriptor: | Flagellar biosynthetic protein FliP, Flagellar biosynthetic protein FliQ, Flagellar biosynthetic protein FliR | | Authors: | Kuhlen, L, Johnson, S, Deme, J.C, Lea, S.M. | | Deposit date: | 2019-06-25 | | Release date: | 2020-03-25 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | The substrate specificity switch FlhB assembles onto the export gate to regulate type three secretion.
Nat Commun, 11, 2020
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6S3L
 | | Structure of the core of the flagellar export apparatus from Vibrio mimicus, the FliPQR-FlhB complex. | | Descriptor: | Flagellar biosynthetic protein FlhB, Flagellar biosynthetic protein FliP, Flagellar biosynthetic protein FliQ, ... | | Authors: | Kuhlen, L, Johnson, S, Deme, J.C, Lea, S.M. | | Deposit date: | 2019-06-25 | | Release date: | 2020-03-25 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | The substrate specificity switch FlhB assembles onto the export gate to regulate type three secretion.
Nat Commun, 11, 2020
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6S3R
 | | Structure of the FliPQR complex from the flagellar type 3 secretion system of Pseudomonas savastanoi. | | Descriptor: | Flagellar biosynthetic protein FliP, Flagellar biosynthetic protein FliQ, Flagellar biosynthetic protein FliR | | Authors: | Kuhlen, L, Johnson, S, Deme, J.C, Lea, S.M. | | Deposit date: | 2019-06-25 | | Release date: | 2020-03-25 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | The substrate specificity switch FlhB assembles onto the export gate to regulate type three secretion.
Nat Commun, 11, 2020
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6SD1
 | | Structure of the RBM3/collar region of the Salmonella flagella MS-ring protein FliF with 33-fold symmetry applied | | Descriptor: | Flagellar M-ring protein | | Authors: | Johnson, S, Fong, Y.H, Deme, J.C, Furlong, E.J, Kuhlen, L, Lea, S.M. | | Deposit date: | 2019-07-26 | | Release date: | 2020-03-18 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Symmetry mismatch in the MS-ring of the bacterial flagellar rotor explains the structural coordination of secretion and rotation.
Nat Microbiol, 5, 2020
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