7NVH
 
 | | Cryo-EM structure of the mycolic acid transporter MmpL3 from M. tuberculosis | | 分子名称: | 2-decyl-2-{[(4-O-alpha-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]methyl}dodecyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, Trehalose monomycolate exporter MmpL3 | | 著者 | Adams, O, Deme, J.C, Parker, J.L, Lea, S.M, Newstead, S. | | 登録日 | 2021-03-15 | | 公開日 | 2021-06-16 | | 最終更新日 | 2022-12-21 | | 実験手法 | ELECTRON MICROSCOPY (3.02 Å) | | 主引用文献 | Cryo-EM structure and resistance landscape of M. tuberculosis MmpL3: An emergent therapeutic target.
Structure, 29, 2021
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6YS8
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7AKV
 | | The cryo-EM structure of the Vag8-C1 inhibitor complex | | 分子名称: | Plasma protease C1 inhibitor, Vag8 | | 著者 | Johnson, S, Lea, S.M, Deme, J.C, Furlong, E, Dhillon, A. | | 登録日 | 2020-10-02 | | 公開日 | 2021-06-16 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Molecular Basis for Bordetella pertussis Interference with Complement, Coagulation, Fibrinolytic, and Contact Activation Systems: the Cryo-EM Structure of the Vag8-C1 Inhibitor Complex.
Mbio, 12, 2021
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8SAH
 | | Huntingtin C-HEAT domain in complex with HAP40 | | 分子名称: | 40-kDa huntingtin-associated protein, Huntingtin | | 著者 | Harding, R.J, Deme, J.C, Alteen, M.G, Arrowsmith, C.H, Lea, S.M, Structural Genomics Consortium (SGC) | | 登録日 | 2023-03-31 | | 公開日 | 2023-04-26 | | 最終更新日 | 2023-09-20 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Delineation of functional subdomains of Huntingtin protein and their interaction with HAP40.
Structure, 31, 2023
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8HCN
 | | CryoEM Structure of Klebsiella pneumoniae UreD/urease complex | | 分子名称: | Urease accessory protein UreD, Urease subunit alpha, Urease subunit beta, ... | | 著者 | Nim, Y.S, Fong, I.Y.H, Deme, J, Tsang, K.L, Caesar, J, Johnson, S, Wong, K.B, Lea, S.M. | | 登録日 | 2022-11-02 | | 公開日 | 2023-05-03 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Delivering a toxic metal to the active site of urease.
Sci Adv, 9, 2023
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8HC1
 | | CryoEM structure of Helicobacter pylori UreFD/urease complex | | 分子名称: | Urease accessory protein UreF, Urease accessory protein UreH, Urease subunit alpha, ... | | 著者 | Nim, Y.S, Fong, I.Y.H, Deme, J, Tsang, K.L, Caesar, J, Johnson, S, Wong, K.B, Lea, S.M. | | 登録日 | 2022-11-01 | | 公開日 | 2023-05-03 | | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | | 主引用文献 | Delivering a toxic metal to the active site of urease.
Sci Adv, 9, 2023
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7BC6
 | | Cryo-EM structure of the outward open proton coupled folate transporter at pH 7.5 | | 分子名称: | Proton-coupled folate transporter, nanobody | | 著者 | Parker, J.L, Deme, J.C, Lea, S.M, Newstead, S. | | 登録日 | 2020-12-18 | | 公開日 | 2021-05-12 | | 最終更新日 | 2021-08-11 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural basis of antifolate recognition and transport by PCFT.
Nature, 595, 2021
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7BC7
 | | Cryo-EM structure of the proton coupled folate transporter at pH 6.0 bound to pemetrexed | | 分子名称: | 2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC ACID, Proton-coupled folate transporter, nanobody | | 著者 | Parker, J.L, Deme, J.C, Lea, S.M, Newstead, S. | | 登録日 | 2020-12-18 | | 公開日 | 2021-05-12 | | 最終更新日 | 2021-08-11 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structural basis of antifolate recognition and transport by PCFT.
Nature, 595, 2021
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8UOX
 | | Cryo-EM structure of a Counterclockwise locked form of the Salmonella enterica Typhimurium flagellar C-ring, with C34 symmetry applied | | 分子名称: | Flagellar M-ring protein, Flagellar motor switch protein FliG, Flagellar motor switch protein FliM, ... | | 著者 | Johnson, S, Deme, J.C, Lea, S.M. | | 登録日 | 2023-10-20 | | 公開日 | 2024-01-24 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | | 主引用文献 | Structural basis of directional switching by the bacterial flagellum.
Nat Microbiol, 9, 2024
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8UPL
 | | Cryo-EM structure of a Clockwise locked form of the Salmonella enterica Typhimurium flagellar C-ring, with C34 symmetry applied | | 分子名称: | Flagellar M-ring protein, Flagellar motor switch protein FliG, Flagellar motor switch protein FliM, ... | | 著者 | Johnson, S, Deme, J.C, Lea, S.M. | | 登録日 | 2023-10-22 | | 公開日 | 2024-01-24 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (5.4 Å) | | 主引用文献 | Structural basis of directional switching by the bacterial flagellum.
Nat Microbiol, 9, 2024
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8UMX
 | | Cryo-EM structure of a single subunit of a Clockwise-locked form of the Salmonella enterica Typhimurium flagellar C-ring. | | 分子名称: | Flagellar M-ring protein, Flagellar motor switch protein FliG, Flagellar motor switch protein FliM, ... | | 著者 | Johnson, S, Deme, J.C, Lea, S.M. | | 登録日 | 2023-10-18 | | 公開日 | 2024-01-24 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Structural basis of directional switching by the bacterial flagellum.
Nat Microbiol, 9, 2024
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8UMD
 | | Cryo-EM structure of a single subunit of a Counterclockwise-locked form of the Salmonella enterica Typhimurium flagellar C-ring. | | 分子名称: | Flagellar M-ring protein, Flagellar motor switch protein FliG, Flagellar motor switch protein FliM, ... | | 著者 | Johnson, S, Deme, J.C, Lea, S.M. | | 登録日 | 2023-10-17 | | 公開日 | 2024-01-24 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structural basis of directional switching by the bacterial flagellum.
Nat Microbiol, 9, 2024
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8SA3
 | | Adenosylcobalamin-bound riboswitch dimer, form 2 | | 分子名称: | Adenosylcobalamin, adenosylcobalamin riboswitch form 2 | | 著者 | Ding, J, Deme, J.C, Stagno, J.R, Yu, P, Lea, S.M, Wang, Y.X. | | 登録日 | 2023-03-31 | | 公開日 | 2023-07-26 | | 最終更新日 | 2023-10-25 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Capturing heterogeneous conformers of cobalamin riboswitch by cryo-EM.
Nucleic Acids Res., 51, 2023
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8SA6
 | | apo form of adenosylcobalamin riboswitch dimer | | 分子名称: | apo form of adenosylcobalamin riboswitch dimer | | 著者 | Ding, J, Deme, J.C, Stagno, J.R, Yu, P, Lea, S.M, Wang, Y.X. | | 登録日 | 2023-03-31 | | 公開日 | 2023-07-26 | | 最終更新日 | 2023-10-25 | | 実験手法 | ELECTRON MICROSCOPY (5.3 Å) | | 主引用文献 | Capturing heterogeneous conformers of cobalamin riboswitch by cryo-EM.
Nucleic Acids Res., 51, 2023
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8SA4
 | | Adenosylcobalamin-bound riboswitch dimer, form 3 | | 分子名称: | Adenosylcobalamin, adenosylcobalamin riboswitch form 3 | | 著者 | Ding, J, Deme, J.C, Stagno, J.R, Yu, P, Lea, S.M, Wang, Y.X. | | 登録日 | 2023-03-31 | | 公開日 | 2023-07-26 | | 最終更新日 | 2023-10-25 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Capturing heterogeneous conformers of cobalamin riboswitch by cryo-EM.
Nucleic Acids Res., 51, 2023
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8SA5
 | | Adenosylcobalamin-bound riboswitch dimer, form 4 | | 分子名称: | Adenosylcobalamin, adenosylcobalamin riboswitch form 4 | | 著者 | Ding, J, Deme, J.C, Stagno, J.R, Yu, P, Lea, S.M, Wang, Y.X. | | 登録日 | 2023-03-31 | | 公開日 | 2023-07-26 | | 最終更新日 | 2023-10-25 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Capturing heterogeneous conformers of cobalamin riboswitch by cryo-EM.
Nucleic Acids Res., 51, 2023
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8SA2
 | | Adenosylcobalamin-bound riboswitch dimer, form 1 | | 分子名称: | Adenosylcobalamin, adenosylcobalamin riboswitch form 1 | | 著者 | Ding, J, Deme, J.C, Stagno, J.R, Yu, P, Lea, S.M, Wang, Y.X. | | 登録日 | 2023-03-31 | | 公開日 | 2023-07-26 | | 最終更新日 | 2023-10-25 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Capturing heterogeneous conformers of cobalamin riboswitch by cryo-EM.
Nucleic Acids Res., 51, 2023
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6S3S
 | | Structure of the FliPQR complex from the flagellar type 3 secretion system of Vibrio mimicus. | | 分子名称: | Flagellar biosynthetic protein FliP, Flagellar biosynthetic protein FliQ, Flagellar biosynthetic protein FliR | | 著者 | Kuhlen, L, Johnson, S, Deme, J.C, Lea, S.M. | | 登録日 | 2019-06-25 | | 公開日 | 2020-03-25 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | The substrate specificity switch FlhB assembles onto the export gate to regulate type three secretion.
Nat Commun, 11, 2020
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6S3L
 | | Structure of the core of the flagellar export apparatus from Vibrio mimicus, the FliPQR-FlhB complex. | | 分子名称: | Flagellar biosynthetic protein FlhB, Flagellar biosynthetic protein FliP, Flagellar biosynthetic protein FliQ, ... | | 著者 | Kuhlen, L, Johnson, S, Deme, J.C, Lea, S.M. | | 登録日 | 2019-06-25 | | 公開日 | 2020-03-25 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | The substrate specificity switch FlhB assembles onto the export gate to regulate type three secretion.
Nat Commun, 11, 2020
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6S3R
 | | Structure of the FliPQR complex from the flagellar type 3 secretion system of Pseudomonas savastanoi. | | 分子名称: | Flagellar biosynthetic protein FliP, Flagellar biosynthetic protein FliQ, Flagellar biosynthetic protein FliR | | 著者 | Kuhlen, L, Johnson, S, Deme, J.C, Lea, S.M. | | 登録日 | 2019-06-25 | | 公開日 | 2020-03-25 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | The substrate specificity switch FlhB assembles onto the export gate to regulate type three secretion.
Nat Commun, 11, 2020
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6SD1
 | | Structure of the RBM3/collar region of the Salmonella flagella MS-ring protein FliF with 33-fold symmetry applied | | 分子名称: | Flagellar M-ring protein | | 著者 | Johnson, S, Fong, Y.H, Deme, J.C, Furlong, E.J, Kuhlen, L, Lea, S.M. | | 登録日 | 2019-07-26 | | 公開日 | 2020-03-18 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Symmetry mismatch in the MS-ring of the bacterial flagellar rotor explains the structural coordination of secretion and rotation.
Nat Microbiol, 5, 2020
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6SCN
 | | 33mer structure of the Salmonella flagella MS-ring protein FliF | | 分子名称: | Flagellar M-ring protein | | 著者 | Johnson, S, Fong, Y.H, Deme, J.C, Furlong, E.J, Kuhlen, L, Lea, S.M. | | 登録日 | 2019-07-24 | | 公開日 | 2020-03-18 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Symmetry mismatch in the MS-ring of the bacterial flagellar rotor explains the structural coordination of secretion and rotation.
Nat Microbiol, 5, 2020
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6SD2
 | | Structure of the RBM2inner region of the Salmonella flagella MS-ring protein FliF with 21-fold symmetry applied. | | 分子名称: | Flagellar M-ring protein | | 著者 | Johnson, S, Fong, Y.H, Deme, J.C, Furlong, E.J, Kuhlen, L, Lea, S.M. | | 登録日 | 2019-07-26 | | 公開日 | 2020-03-18 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Symmetry mismatch in the MS-ring of the bacterial flagellar rotor explains the structural coordination of secretion and rotation.
Nat Microbiol, 5, 2020
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6SD3
 | | 34mer structure of the Salmonella flagella MS-ring protein FliF | | 分子名称: | Flagellar M-ring protein | | 著者 | Johnson, S, Fong, Y.H, Deme, J.C, Furlong, E.J, Kuhlen, L, Lea, S.M. | | 登録日 | 2019-07-26 | | 公開日 | 2020-03-18 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Symmetry mismatch in the MS-ring of the bacterial flagellar rotor explains the structural coordination of secretion and rotation.
Nat Microbiol, 5, 2020
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6SD5
 | | Structure of the RBM2 inner ring of Salmonella flagella MS-ring protein FliF with 22-fold symmetry applied | | 分子名称: | Flagellar M-ring protein | | 著者 | Johnson, S, Fong, Y.H, Deme, J.C, Furlong, E.J, Kuhlen, L, Lea, S.M. | | 登録日 | 2019-07-26 | | 公開日 | 2020-03-18 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Symmetry mismatch in the MS-ring of the bacterial flagellar rotor explains the structural coordination of secretion and rotation.
Nat Microbiol, 5, 2020
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