7MX3
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![BU of 7mx3 by Molmil](/molmil-images/mine/7mx3) | Crystal structure of human RIPK3 complexed with GSK'843 | Descriptor: | 1,2-ETHANEDIOL, 3-(1,3-benzothiazol-5-yl)-7-(1,3-dimethyl-1H-pyrazol-5-yl)thieno[3,2-c]pyridin-4-amine, Receptor-interacting serine/threonine-protein kinase 3 | Authors: | Davies, K.A, Czabotar, P.E. | Deposit date: | 2021-05-18 | Release date: | 2021-11-24 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.23 Å) | Cite: | Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis. Nat Commun, 12, 2021
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6VBZ
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![BU of 6vbz by Molmil](/molmil-images/mine/6vbz) | Crystal structure of the rat MLKL pseudokinase domain | Descriptor: | MANGANESE (II) ION, Mixed lineage kinase domain-like pseudokinase | Authors: | Davies, K.A, Czabotar, P.E. | Deposit date: | 2019-12-19 | Release date: | 2020-07-08 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.192 Å) | Cite: | Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues. Nat Commun, 11, 2020
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6VC0
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![BU of 6vc0 by Molmil](/molmil-images/mine/6vc0) | Crystal structure of the horse MLKL pseudokinase domain | Descriptor: | GLYCEROL, Mixed lineage kinase domain like pseudokinase | Authors: | Davies, K.A, Czabotar, P.E. | Deposit date: | 2019-12-19 | Release date: | 2020-07-08 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.746 Å) | Cite: | Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues. Nat Commun, 11, 2020
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8SLZ
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![BU of 8slz by Molmil](/molmil-images/mine/8slz) | |
7MON
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![BU of 7mon by Molmil](/molmil-images/mine/7mon) | Structure of human RIPK3-MLKL complex | Descriptor: | Mixed lineage kinase domain-like protein, N-[4-({2-[(cyclopropanecarbonyl)amino]pyridin-4-yl}oxy)-3-fluorophenyl]-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide, Receptor-interacting serine/threonine-protein kinase 3 | Authors: | Meng, Y, Davies, K.A, Czabotar, P.E, Murphy, J.M. | Deposit date: | 2021-05-03 | Release date: | 2021-11-17 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.23 Å) | Cite: | Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis. Nat Commun, 12, 2021
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