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PDB: 5 件
7MX3
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BU of 7mx3 by Molmil
Crystal structure of human RIPK3 complexed with GSK'843
分子名称: 1,2-ETHANEDIOL, 3-(1,3-benzothiazol-5-yl)-7-(1,3-dimethyl-1H-pyrazol-5-yl)thieno[3,2-c]pyridin-4-amine, Receptor-interacting serine/threonine-protein kinase 3
著者Davies, K.A, Czabotar, P.E.
登録日2021-05-18
公開日2021-11-24
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (3.23 Å)
主引用文献Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis.
Nat Commun, 12, 2021
6VBZ
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BU of 6vbz by Molmil
Crystal structure of the rat MLKL pseudokinase domain
分子名称: MANGANESE (II) ION, Mixed lineage kinase domain-like pseudokinase
著者Davies, K.A, Czabotar, P.E.
登録日2019-12-19
公開日2020-07-08
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.192 Å)
主引用文献Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues.
Nat Commun, 11, 2020
6VC0
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BU of 6vc0 by Molmil
Crystal structure of the horse MLKL pseudokinase domain
分子名称: GLYCEROL, Mixed lineage kinase domain like pseudokinase
著者Davies, K.A, Czabotar, P.E.
登録日2019-12-19
公開日2020-07-08
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.746 Å)
主引用文献Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues.
Nat Commun, 11, 2020
8SLZ
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BU of 8slz by Molmil
Crystal structure of phosphorylated (T357/S358) human MLKL pseudokinase domain
分子名称: Mixed lineage kinase domain-like protein
著者Meng, Y, Davies, K.A, Czabotar, P.E, Murphy, J.M.
登録日2023-04-25
公開日2023-11-08
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Phosphorylation-dependent pseudokinase domain dimerization drives full-length MLKL oligomerization.
Nat Commun, 14, 2023
7MON
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BU of 7mon by Molmil
Structure of human RIPK3-MLKL complex
分子名称: Mixed lineage kinase domain-like protein, N-[4-({2-[(cyclopropanecarbonyl)amino]pyridin-4-yl}oxy)-3-fluorophenyl]-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide, Receptor-interacting serine/threonine-protein kinase 3
著者Meng, Y, Davies, K.A, Czabotar, P.E, Murphy, J.M.
登録日2021-05-03
公開日2021-11-17
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.23 Å)
主引用文献Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis.
Nat Commun, 12, 2021

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件を2024-08-28に公開中

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