6BZO
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![BU of 6bzo by Molmil](/molmil-images/mine/6bzo) | Mtb RNAP Holo/RbpA/Fidaxomicin/upstream fork DNA | Descriptor: | DNA (26-MER), DNA (32-MER), DNA-directed RNA polymerase subunit alpha, ... | Authors: | Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J. | Deposit date: | 2017-12-25 | Release date: | 2018-03-28 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.38 Å) | Cite: | Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts. Elife, 7, 2018
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6XEZ
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![BU of 6xez by Molmil](/molmil-images/mine/6xez) | Structure of SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, CHAPSO, ... | Authors: | Chen, J, Malone, B, Llewellyn, E.C, Campbell, E.A, Darst, S.A. | Deposit date: | 2020-06-14 | Release date: | 2020-07-29 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex. Cell, 182, 2020
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4OZ6
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![BU of 4oz6 by Molmil](/molmil-images/mine/4oz6) | Structure of the Branched Intermediate in Protein Splicing | Descriptor: | ALA-MET-ARG-TYR, MAGNESIUM ION, Mxe gyrA intein | Authors: | Bick, M.J, Liu, Z, Frutos, S, Vila-Perello, M, Debelouchina, G.T, Darst, S.A, Muir, T.W. | Deposit date: | 2014-02-14 | Release date: | 2014-05-14 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.786 Å) | Cite: | Structure of the branched intermediate in protein splicing. Proc.Natl.Acad.Sci.USA, 111, 2014
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6DCF
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![BU of 6dcf by Molmil](/molmil-images/mine/6dcf) | Crystal structure of a Mycobacterium smegmatis transcription initiation complex with Rifampicin-resistant RNA polymerase and bound to kanglemycin A | Descriptor: | 1,2-ETHANEDIOL, DNA (26-MER), DNA (31-MER), ... | Authors: | Lilic, M, Darst, S.A, Campbell, E.A. | Deposit date: | 2018-05-06 | Release date: | 2018-09-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.45 Å) | Cite: | Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism. Nat Commun, 9, 2018
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1BDF
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![BU of 1bdf by Molmil](/molmil-images/mine/1bdf) | |
3UGP
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![BU of 3ugp by Molmil](/molmil-images/mine/3ugp) | |
3UGO
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![BU of 3ugo by Molmil](/molmil-images/mine/3ugo) | |
7UO4
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![BU of 7uo4 by Molmil](/molmil-images/mine/7uo4) | SARS-CoV-2 replication-transcription complex bound to Remdesivir triphosphate, in a pre-catalytic state | Descriptor: | MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ... | Authors: | Malone, B.F, Perry, J.K, Appleby, T.C, Feng, J.Y, Campbell, E.A, Darst, S.A. | Deposit date: | 2022-04-12 | Release date: | 2022-11-30 | Last modified: | 2023-03-08 | Method: | ELECTRON MICROSCOPY (3.38 Å) | Cite: | Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature, 614, 2023
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7UOB
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![BU of 7uob by Molmil](/molmil-images/mine/7uob) | SARS-CoV-2 replication-transcription complex bound to GTP, in a pre-catalytic state | Descriptor: | 3'-DEOXYURIDINE-5'-MONOPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Malone, B.F, Perry, J.K, Appleby, T.C, Feng, J.Y, Campbell, E.A, Darst, S.A. | Deposit date: | 2022-04-12 | Release date: | 2022-11-30 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.68 Å) | Cite: | Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature, 614, 2023
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7UO9
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![BU of 7uo9 by Molmil](/molmil-images/mine/7uo9) | SARS-CoV-2 replication-transcription complex bound to UTP, in a pre-catalytic state | Descriptor: | MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ... | Authors: | Malone, B.F, Perry, J.K, Appleby, T.C, Feng, J.Y, Campbell, E.A, Darst, S.A. | Deposit date: | 2022-04-12 | Release date: | 2022-11-30 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.13 Å) | Cite: | Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature, 614, 2023
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7UO7
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![BU of 7uo7 by Molmil](/molmil-images/mine/7uo7) | SARS-CoV-2 replication-transcription complex bound to ATP, in a pre-catalytic state | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Non-structural protein 7, ... | Authors: | Malone, B.F, Perry, J.K, Appleby, T.C, Feng, J.Y, Campbell, E.A, Darst, S.A. | Deposit date: | 2022-04-12 | Release date: | 2022-11-30 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.09 Å) | Cite: | Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature, 614, 2023
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7UOE
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![BU of 7uoe by Molmil](/molmil-images/mine/7uoe) | SARS-CoV-2 replication-transcription complex bound to CTP, in a pre-catalytic state | Descriptor: | 3'-DEOXYURIDINE-5'-MONOPHOSPHATE, CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Malone, B.F, Perry, J.K, Appleby, T.C, Feng, J.Y, Campbell, E.A, Darst, S.A. | Deposit date: | 2022-04-12 | Release date: | 2022-11-30 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.67 Å) | Cite: | Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature, 614, 2023
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5VT0
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![BU of 5vt0 by Molmil](/molmil-images/mine/5vt0) | |
5VI8
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![BU of 5vi8 by Molmil](/molmil-images/mine/5vi8) | Structure of a mycobacterium smegmatis transcription initiation complex with an upstream-fork promoter fragment | Descriptor: | 1,2-ETHANEDIOL, DNA (26-MER), DNA (31-MER), ... | Authors: | Hubin, E.A, Campbell, E.A, Darst, S.A. | Deposit date: | 2017-04-14 | Release date: | 2017-04-26 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.76 Å) | Cite: | Structural insights into the mycobacteria transcription initiation complex from analysis of X-ray crystal structures. Nat Commun, 8, 2017
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6X4Y
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![BU of 6x4y by Molmil](/molmil-images/mine/6x4y) | Mfd-bound E.coli RNA polymerase elongation complex - IV state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA (64-MER), DNA-directed RNA polymerase subunit alpha, ... | Authors: | Llewellyn, E, Chen, J, Kang, J.Y, Darst, S.A. | Deposit date: | 2020-05-24 | Release date: | 2021-02-03 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural basis for transcription complex disruption by the Mfd translocase. Elife, 10, 2021
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6X50
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![BU of 6x50 by Molmil](/molmil-images/mine/6x50) | Mfd-bound E.coli RNA polymerase elongation complex - V state | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, DNA (64-MER), DNA-directed RNA polymerase subunit alpha, ... | Authors: | Llewelyn, E, Chen, J, Kang, J.Y, Darst, S.A. | Deposit date: | 2020-05-24 | Release date: | 2021-02-03 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural basis for transcription complex disruption by the Mfd translocase. Elife, 10, 2021
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6X26
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![BU of 6x26 by Molmil](/molmil-images/mine/6x26) | Mfd-bound E.coli RNA polymerase elongation complex - L1 state | Descriptor: | DNA (64-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Llewellyn, E, Chen, J, Kang, J.Y, Darst, S.A. | Deposit date: | 2020-05-20 | Release date: | 2021-02-03 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structural basis for transcription complex disruption by the Mfd translocase. Elife, 10, 2021
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6X43
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![BU of 6x43 by Molmil](/molmil-images/mine/6x43) | Mfd-bound E.coli RNA polymerase elongation complex - II state | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, DNA (64-MER), DNA-directed RNA polymerase subunit alpha, ... | Authors: | Llewellyn, E, Chen, J, Kang, J.Y, Darst, S.A. | Deposit date: | 2020-05-22 | Release date: | 2021-02-03 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural basis for transcription complex disruption by the Mfd translocase. Elife, 10, 2021
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1OR7
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![BU of 1or7 by Molmil](/molmil-images/mine/1or7) | Crystal Structure of Escherichia coli sigmaE with the Cytoplasmic Domain of its Anti-sigma RseA | Descriptor: | RNA polymerase sigma-E factor, Sigma-E factor negative regulatory protein | Authors: | Campbell, E.A, Tupy, J.L, Gruber, T.M, Wang, S, Sharp, M.M, Gross, C.A, Darst, S.A. | Deposit date: | 2003-03-12 | Release date: | 2003-04-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of Escherichia coli sigmaE with the cytoplasmic domain of its anti-sigma RseA. Mol.Cell, 11, 2003
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3TBI
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![BU of 3tbi by Molmil](/molmil-images/mine/3tbi) | |
2AUJ
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![BU of 2auj by Molmil](/molmil-images/mine/2auj) | Structure of Thermus aquaticus RNA polymerase beta'-subunit insert | Descriptor: | DNA-directed RNA polymerase beta' chain | Authors: | Chlenov, M, Masuda, S, Murakami, K.S, Nikiforov, V, Darst, S.A, Mustaev, A. | Deposit date: | 2005-08-27 | Release date: | 2005-10-04 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structure and Function of Lineage-specific Sequence Insertions in the Bacterial RNA Polymerase beta' Subunit J.Mol.Biol., 353, 2005
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2AUK
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![BU of 2auk by Molmil](/molmil-images/mine/2auk) | Structure of E. coli RNA polymerase beta' G/G' insert | Descriptor: | DNA-directed RNA polymerase beta' chain | Authors: | Chlenov, M, Masuda, S, Murakami, K.S, Nikiforov, V, Darst, S.A, Mustaev, A. | Deposit date: | 2005-08-28 | Release date: | 2005-10-04 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure and Function of Lineage-specific Sequence Insertions in the Bacterial RNA Polymerase beta' Subunit J.Mol.Biol., 353, 2005
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2EYQ
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![BU of 2eyq by Molmil](/molmil-images/mine/2eyq) | |
2ETN
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![BU of 2etn by Molmil](/molmil-images/mine/2etn) | Crystal structure of Thermus aquaticus Gfh1 | Descriptor: | anti-cleavage anti-GreA transcription factor Gfh1 | Authors: | Lamour, V, Hogan, B.P, Erie, D.A, Darst, S.A. | Deposit date: | 2005-10-27 | Release date: | 2006-02-14 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Crystal structure of Thermus aquaticus Gfh1, a Gre-factor paralog that inhibits rather than stimulates transcript cleavage. J.Mol.Biol., 356, 2006
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8E74
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![BU of 8e74 by Molmil](/molmil-images/mine/8e74) | Mycobacterium tuberculosis RNAP paused elongation complex with NusG transcription factor | Descriptor: | DNA (54-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Delbeau, M, Darst, S.A, Campbell, E.A. | Deposit date: | 2022-08-23 | Release date: | 2023-03-22 | Last modified: | 2023-10-11 | Method: | ELECTRON MICROSCOPY (2.94 Å) | Cite: | Structural and functional basis of the universal transcription factor NusG pro-pausing activity in Mycobacterium tuberculosis. Mol.Cell, 83, 2023
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