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PDB: 1609 results

1FQR
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X-RAY CRYSTAL STRUCTURE OF COBALT-BOUND F93I/F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT
Descriptor: CARBONIC ANHYDRASE, COBALT (II) ION
Authors:Cox, J.D, Hunt, J.A, Compher, K.M, Fierke, C.A, Christianson, D.W.
Deposit date:2000-09-06
Release date:2001-01-17
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II.
Biochemistry, 39, 2000
5ERN
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Crystal structure of elongation domain of Phomopsis amygdali fusicoccadiene synthase
Descriptor: Fusicoccadiene synthase
Authors:Chen, M, Christianson, D.W.
Deposit date:2015-11-14
Release date:2016-01-20
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.434 Å)
Cite:Structure and Function of Fusicoccadiene Synthase, a Hexameric Bifunctional Diterpene Synthase.
Acs Chem.Biol., 11, 2016
5ELW
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A. thaliana IGPD2 in complex with the triazole-phosphonate inhibitor, (R)-C348, to 1.36A resolution
Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ...
Authors:Bisson, C, Britton, K.L, Sedelnikova, S.E, Rodgers, H.F, Eadsforth, T.C, Viner, R.C, Hawkes, T.R, Baker, P.J, Rice, D.W.
Deposit date:2015-11-05
Release date:2016-10-05
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Mirror-Image Packing Provides a Molecular Basis for the Nanomolar Equipotency of Enantiomers of an Experimental Herbicide.
Angew.Chem.Int.Ed.Engl., 55, 2016
6VNR
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BU of 6vnr by Molmil
Crystal Structure of Danio rerio Histone Deacetylase 6 Catalytic Domain 2 (CD2) Complexed with Bishydroxamic Acid Inhibitor
Descriptor: 1,2-ETHANEDIOL, Hdac6 protein, N-hydroxy-1-{[4-(hydroxycarbamoyl)phenyl]methyl}-1H-indole-6-carboxamide, ...
Authors:Osko, J.D, Porter, N.J, Christianson, D.W.
Deposit date:2020-01-29
Release date:2020-05-13
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.94301319 Å)
Cite:Design and Synthesis of Dihydroxamic Acids as HDAC6/8/10 Inhibitors.
Chemmedchem, 15, 2020
6WYQ
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Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 1 (CD1) K330L mutant complexed with 4-iodo-SAHA
Descriptor: Histone deacetylase 6, N~1~-hydroxy-N~8~-(4-iodophenyl)octanediamide, POTASSIUM ION, ...
Authors:Osko, J.D, Christianson, D.W.
Deposit date:2020-05-13
Release date:2020-09-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.90001464 Å)
Cite:Binding of inhibitors to active-site mutants of CD1, the enigmatic catalytic domain of histone deacetylase 6.
Acta Crystallogr.,Sect.F, 76, 2020
6WQF
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Structural Plasticity of the SARS-CoV-2 3CL Mpro Active Site Cavity Revealed by Room Temperature X-ray Crystallography
Descriptor: 3C-like proteinase
Authors:Kneller, D.W, Kovalevsky, A, Coates, L.
Deposit date:2020-04-28
Release date:2020-05-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural plasticity of SARS-CoV-2 3CL Mproactive site cavity revealed by room temperature X-ray crystallography.
Nat Commun, 11, 2020
5EW4
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Crystal structure of C9ORF72 Antisense CCCCGG repeat RNA associated with Lou Gehrig's disease and frontotemporal dementia, crystallized with Sr2+
Descriptor: CHLORIDE ION, MAGNESIUM ION, POTASSIUM ION, ...
Authors:Tomchick, D.R, Dodd, D.W, Gagnon, K.T, Corey, D.R.
Deposit date:2015-11-20
Release date:2016-02-24
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Pathogenic C9ORF72 Antisense Repeat RNA Forms a Double Helix with Tandem C:C Mismatches.
Biochemistry, 55, 2016
5EXU
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BU of 5exu by Molmil
Reversibly photoswitching protein Dathail, Ensemble refinement
Descriptor: Reversibly photoswitching protein Dathail
Authors:Close, D.W, Langan, P.S, Bradbury, A.R.M.
Deposit date:2015-11-24
Release date:2016-04-06
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Evolution and characterization of a new reversibly photoswitching chromogenic protein, Dathail.
J.Mol.Biol., 428, 2016
5DC6
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Crystal structure of D176N-Y306F HDAC8 in complex with a tetrapeptide substrate
Descriptor: Fluor-de-Lys tetrapeptide assay substrate, GLYCEROL, Histone deacetylase 8, ...
Authors:Decroos, C, Lee, M.S, Christianson, D.W.
Deposit date:2015-08-23
Release date:2016-02-03
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1.553 Å)
Cite:General Base-General Acid Catalysis in Human Histone Deacetylase 8.
Biochemistry, 55, 2016
5EB7
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Crystal Structure of the Reversibly photoswitching chromoprotein Dathail, Metastable State
Descriptor: Reversibly photoswitching chromoprotein Dathail
Authors:Close, D.W, Langan, P.S, Bradbury, A.R.M.
Deposit date:2015-10-18
Release date:2016-04-06
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Evolution and characterization of a new reversibly photoswitching chromogenic protein, Dathail.
J.Mol.Biol., 428, 2016
5EW7
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BU of 5ew7 by Molmil
Crystal structure of C9ORF72 Antisense CCCCGG repeat RNA associated with Lou Gehrig's disease and frontotemporal dementia, crystallized with Ba2+
Descriptor: BARIUM ION, MAGNESIUM ION, POTASSIUM ION, ...
Authors:Tomchick, D.R, Dodd, D.W, Gagnon, K.T, Corey, D.R.
Deposit date:2015-11-20
Release date:2016-02-24
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Pathogenic C9ORF72 Antisense Repeat RNA Forms a Double Helix with Tandem C:C Mismatches.
Biochemistry, 55, 2016
1UGF
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BU of 1ugf by Molmil
HUMAN CARBONIC ANHYDRASE II [HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY THR (A65T)
Descriptor: AZIDE ION, CARBONIC ANHYDRASE II, MERCURY (II) ION, ...
Authors:Scolnick, L.R, Christianson, D.W.
Deposit date:1996-07-24
Release date:1997-04-01
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:X-ray crystallographic studies of alanine-65 variants of carbonic anhydrase II reveal the structural basis of compromised proton transfer in catalysis.
Biochemistry, 35, 1996
1UGA
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BU of 1uga by Molmil
HUMAN CARBONIC ANHYDRASE II[HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY PHE (A65F)
Descriptor: CARBONIC ANHYDRASE II, ZINC ION
Authors:Scolnick, L.R, Christianson, D.W.
Deposit date:1996-07-24
Release date:1997-01-27
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:X-ray crystallographic studies of alanine-65 variants of carbonic anhydrase II reveal the structural basis of compromised proton transfer in catalysis.
Biochemistry, 35, 1996
1UGG
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HUMAN CARBONIC ANHYDRASE II[HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY SER (A65S)-ORTHORHOMBIC FORM
Descriptor: CARBONIC ANHYDRASE II, ZINC ION
Authors:Scolnick, L.R, Christianson, D.W.
Deposit date:1996-07-24
Release date:1997-01-27
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:X-ray crystallographic studies of alanine-65 variants of carbonic anhydrase II reveal the structural basis of compromised proton transfer in catalysis.
Biochemistry, 35, 1996
1TNR
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BU of 1tnr by Molmil
CRYSTAL STRUCTURE OF THE SOLUBLE HUMAN 55 KD TNF RECEPTOR-HUMAN TNF-BETA COMPLEX: IMPLICATIONS FOR TNF RECEPTOR ACTIVATION
Descriptor: TUMOR NECROSIS FACTOR BETA, TUMOR NECROSIS FACTOR RECEPTOR P55
Authors:Banner, D.W.
Deposit date:1994-05-09
Release date:1994-07-31
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation.
Cell(Cambridge,Mass.), 73, 1993
1UGE
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BU of 1uge by Molmil
HUMAN CARBONIC ANHYDRASE II [HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY LEU (A65L)
Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION
Authors:Scolnick, L.R, Christianson, D.W.
Deposit date:1996-07-24
Release date:1997-04-01
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:X-ray crystallographic studies of alanine-65 variants of carbonic anhydrase II reveal the structural basis of compromised proton transfer in catalysis.
Biochemistry, 35, 1996
1URW
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BU of 1urw by Molmil
CDK2 IN COMPLEX WITH AN IMIDAZO[1,2-b]PYRIDAZINE
Descriptor: 2-[4-(N-(3-DIMETHYLAMINOPROPYL)SULPHAMOYL)ANILINO]-, CELL DIVISION PROTEIN KINASE 2
Authors:Byth, K.F, Cooper, N, Culshaw, J.D, Heaton, D.W, Oakes, S.E, Minshull, C.A, Norman, R.A, Pauptit, R.A, Tucker, J.A, Breed, J, Pannifer, A, Rowsell, S, Stanway, J.J, Valentine, A.L, Thomas, A.P.
Deposit date:2003-11-11
Release date:2004-04-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Imidazo[1,2-B]Pyridazines: A Potent and Selective Class of Cyclin-Dependent Kinase Inhibitors
Bioorg.Med.Chem.Lett., 14, 2004
1W7X
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BU of 1w7x by Molmil
Factor7 - 413 complex
Descriptor: (S)-[(R)-2-(4-BENZYLOXY-3-METHOXY-PHENYL)-2-(4-CARBAMIMIDOYL-PHENYLAMINO)-ACETYLAMINO]-PHENYL-ACETIC ACID, BLOOD COAGULATION FACTOR VIIA, CALCIUM ION, ...
Authors:Ackermann, J, Alig, L, Banner, D.W, Boehm, H.-J, Groebke-Zbinden, K, Hilpert, K, Lave, T, Kuehne, H, Obst-Sander, U, Riederer, M.A, Stahl, M, Tschopp, T.B, Weber, L, Wessel, H.P.
Deposit date:2004-09-14
Release date:2005-10-25
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Selective and Orally Bioavailable Phenylglycine Tissue Factor/Factor Viia Inhibitors.
Bioorg.Med.Chem.Lett., 15, 2005
1WVA
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BU of 1wva by Molmil
Crystal structure of human arginase I from twinned crystal
Descriptor: Arginase 1, MANGANESE (II) ION, S-2-(BORONOETHYL)-L-CYSTEINE
Authors:Di Costanzo, L, Sabio, G, Mora, A, Rodriguez, P.C, Ochoa, A.C, Centeno, F, Christianson, D.W.
Deposit date:2004-12-14
Release date:2005-09-06
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Crystal structure of human arginase I at 1.29 A resolution and exploration of inhibition in the immune response
Proc.Natl.Acad.Sci.Usa, 102, 2005
1WVB
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Crystal structure of human arginase I: the mutant E256Q
Descriptor: Arginase 1, MANGANESE (II) ION, S-2-(BORONOETHYL)-L-CYSTEINE
Authors:Di Costanzo, L, Guadalupe, S, Mora, A, Centeno, F, Christianson, D.W.
Deposit date:2004-12-14
Release date:2005-09-06
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of human arginase I: the mutant E256Q
To be Published
1XFI
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X-ray structure of gene product from Arabidopsis thaliana At2g17340
Descriptor: MAGNESIUM ION, unknown protein
Authors:Wesenberg, G.E, Smith, D.W, Phillips Jr, G.N, Bitto, E, Bingman, C.A, Allard, S.T.M, Center for Eukaryotic Structural Genomics (CESG)
Deposit date:2004-09-14
Release date:2004-09-28
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The structure at 1.7 A resolution of the protein product of the At2g17340 gene from Arabidopsis thaliana.
Acta Crystallogr.,Sect.F, 61, 2005
1VM9
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The X-ray Structure of the cys84ala cys85ala double mutant of the [2Fe-2S] Ferredoxin subunit of Toluene-4-Monooxygenase from Pseudomonas Mendocina KR1
Descriptor: 1,2-ETHANEDIOL, FE2/S2 (INORGANIC) CLUSTER, MAGNESIUM ION, ...
Authors:Wesenberg, G.E, Smith, D.W, Phillips Jr, G.N, Bingman, C.A, Allard, S.T.M, Moe, L.A, Fox, B.G, Center for Eukaryotic Structural Genomics (CESG)
Deposit date:2004-09-13
Release date:2004-09-21
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Structure of T4moC, the Rieske-type ferredoxin component of toluene 4-monooxygenase.
Acta Crystallogr.,Sect.D, 62, 2006
1W56
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Stepwise introduction of zinc binding site into porphobilinogen synthase of Pseudomonas aeruginosa (mutations A129C and D131C)
Descriptor: DELTA-AMINOLEVULINIC ACID DEHYDRATASE, FORMIC ACID, MAGNESIUM ION, ...
Authors:Frere, F, Reents, H, Schubert, W.-D, Heinz, D.W, Jahn, D.
Deposit date:2004-08-05
Release date:2005-01-19
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Tracking the Evolution of Porphobilinogen Synthase Metal Dependence in Vitro
J.Mol.Biol., 345, 2005
1X82
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CRYSTAL STRUCTURE OF PHOSPHOGLUCOSE ISOMERASE FROM PYROCOCCUS FURIOSUS WITH BOUND 5-phospho-D-arabinonate
Descriptor: 5-PHOSPHOARABINONIC ACID, Glucose-6-phosphate isomerase
Authors:Berrisford, J.M, Akerboom, J, Brouns, S, Sedelnikova, S.E, Turnbull, A.P, van der Oost, J, Salmon, L, Hardre, R, Murray, I.A, Blackburn, G.M, Rice, D.W, Baker, P.J.
Deposit date:2004-08-17
Release date:2004-10-12
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The structures of inhibitor complexes of Pyrococcus furiosus phosphoglucose isomerase provide insights into substrate binding and catalysis.
J.Mol.Biol., 343, 2004
1XKK
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EGFR kinase domain complexed with a quinazoline inhibitor- GW572016
Descriptor: Epidermal growth factor receptor, N-{3-CHLORO-4-[(3-FLUOROBENZYL)OXY]PHENYL}-6-[5-({[2-(METHYLSULFONYL)ETHYL]AMINO}METHYL)-2-FURYL]-4-QUINAZOLINAMINE, PHOSPHATE ION
Authors:Wood, E.R, Truesdale, A.T, McDonald, O.B, Yuan, D, Hassell, A, Dickerson, S.H, Ellis, B, Pennisi, C, Horne, E, Lackey, K, Alligood, K.J, Rusnak, D.W, Gilmer, T.M, Shewchuk, L.M.
Deposit date:2004-09-29
Release date:2004-12-07
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells.
Cancer Res., 64, 2004

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数据于2024-11-06公开中

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