8DPV
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8DPS
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![BU of 8dps by Molmil](/molmil-images/mine/8dps) | The structure of the interleukin 11 signalling complex, truncated gp130 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-11, ... | Authors: | Metcalfe, R.D, Hanssen, E, Griffin, M.D.W. | Deposit date: | 2022-07-17 | Release date: | 2023-11-29 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.47 Å) | Cite: | Structures of the interleukin 11 signalling complex reveal gp130 dynamics and the inhibitory mechanism of a cytokine variant. Nat Commun, 14, 2023
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8DPT
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![BU of 8dpt by Molmil](/molmil-images/mine/8dpt) | The structure of the IL-11 signalling complex, with full-length extracellular gp130 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-11, ... | Authors: | Metcalfe, R.D, Hanssen, E, Griffin, M.D.W. | Deposit date: | 2022-07-17 | Release date: | 2023-11-29 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structures of the interleukin 11 signalling complex reveal gp130 dynamics and the inhibitory mechanism of a cytokine variant. Nat Commun, 14, 2023
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8DPW
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![BU of 8dpw by Molmil](/molmil-images/mine/8dpw) | The structure of Interleukin-11 Mutein | Descriptor: | Interleukin-11, SULFATE ION | Authors: | Metcalfe, R.D, Griffin, M.D.W. | Deposit date: | 2022-07-17 | Release date: | 2023-11-29 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structures of the interleukin 11 signalling complex reveal gp130 dynamics and the inhibitory mechanism of a cytokine variant. Nat Commun, 14, 2023
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8SFJ
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![BU of 8sfj by Molmil](/molmil-images/mine/8sfj) | WT CRISPR-Cas12a with a 10bp R-loop | Descriptor: | CRISPR-associated endonuclease Cas12a, DNA (5'-D(P*CP*AP*CP*TP*TP*AP*TP*CP*AP*CP*TP*AP*AP*AP*AP*GP*AP*TP*CP*GP*GP*AP*AP*G)-3'), DNA (5'-D(P*CP*TP*TP*CP*CP*GP*AP*TP*CP*TP*TP*TP*TP*AP*GP*TP*GP*AP*T)-3'), ... | Authors: | Strohkendl, I, Taylor, D.W. | Deposit date: | 2023-04-11 | Release date: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | WT CRISPR-Cas12a with a 10bp R-loop To Be Published
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8SFH
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8SFL
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8SFR
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![BU of 8sfr by Molmil](/molmil-images/mine/8sfr) | WT CRISPR-Cas12a post nontarget strand cleavage. | Descriptor: | CRISPR-associated endonuclease Cas12a, DNA (34-MER), DNA (5'-D(P*CP*TP*TP*CP*CP*GP*AP*TP*CP*TP*TP*TP*TP*AP*GP*TP*GP*AP*T)-3'), ... | Authors: | Strohkendl, I, Taylor, D.W. | Deposit date: | 2023-04-11 | Release date: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | WT CRISPR-Cas12a post nontarget strand cleavage. To Be Published
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4PTD
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![BU of 4ptd by Molmil](/molmil-images/mine/4ptd) | PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C MUTANT D274N | Descriptor: | PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C | Authors: | Heinz, D.W. | Deposit date: | 1997-07-18 | Release date: | 1998-01-21 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Probing the roles of active site residues in phosphatidylinositol-specific phospholipase C from Bacillus cereus by site-directed mutagenesis. Biochemistry, 36, 1997
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8SFP
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4PEE
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![BU of 4pee by Molmil](/molmil-images/mine/4pee) | Crystal structure of a bacterial fucosidase with inhibitor 1-phenyl-4-[(2S,3S,4R,5S)-3,4-dihydroxy-5-methylpyrrolidin-2-yl]triazole | Descriptor: | (2S,3R,4S,5S)-2-methyl-5-(1-phenyl-1H-1,2,3-triazol-4-yl)pyrrolidine-3,4-diol, Alpha-L-fucosidase, IMIDAZOLE, ... | Authors: | Wright, D.W, Davies, G.J, Behr, J.B. | Deposit date: | 2014-04-23 | Release date: | 2014-07-09 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Exploiting the Hydrophobic Terrain in Fucosidases with Aryl-Substituted Pyrrolidine Iminosugars. Chembiochem, 16, 2015
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8SYF
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![BU of 8syf by Molmil](/molmil-images/mine/8syf) | Homology model of Acto-HMM complex in ADP-state. Chicken smooth muscle HMM and chicken pectoralis actin | Descriptor: | Actin, alpha skeletal muscle, Myosin light polypeptide 6, ... | Authors: | Hojjatian, A, Taylor, D.W, Daneshparvar, N, Trybus, K.M, Taylor, K.A. | Deposit date: | 2023-05-25 | Release date: | 2023-08-30 | Last modified: | 2024-08-07 | Method: | ELECTRON MICROSCOPY (19 Å) | Cite: | Double-headed binding of myosin II to F-actin shows the effect of strain on head structure. J.Struct.Biol., 215, 2023
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8SZT
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![BU of 8szt by Molmil](/molmil-images/mine/8szt) | Structure of Kdac1 from Acinetobacter baumannii | Descriptor: | CHLORIDE ION, Histone deacetylase domain-containing protein, POTASSIUM ION, ... | Authors: | Watson, P.R, Christianson, D.W. | Deposit date: | 2023-05-30 | Release date: | 2023-09-06 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure and Function of Kdac1, a Class II Deacetylase from the Multidrug-Resistant Pathogen Acinetobacter baumannii . Biochemistry, 62, 2023
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8SZU
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8TQ0
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8DAY
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![BU of 8day by Molmil](/molmil-images/mine/8day) | Crystal Structure of DMATS1 prenyltransferase in complex with L-Tyr and DMSPP | Descriptor: | DIMETHYLALLYL S-THIOLODIPHOSPHATE, Dimethylallyltryptophan synthase 1, TYROSINE | Authors: | Eaton, S.A, Ronnebaum, T.A, Roose, B.W, Christianson, D.W. | Deposit date: | 2022-06-14 | Release date: | 2022-09-28 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Structural Basis of Substrate Promiscuity and Catalysis by the Reverse Prenyltransferase N -Dimethylallyl-l-tryptophan Synthase from Fusarium fujikuroi . Biochemistry, 61, 2022
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8DAZ
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![BU of 8daz by Molmil](/molmil-images/mine/8daz) | Crystal structure of DMATS1 prenyltransferase in complex with L-Trp and GSPP | Descriptor: | Dimethylallyltryptophan synthase 1, GERANYL S-THIOLODIPHOSPHATE, TRYPTOPHAN | Authors: | Eaton, S.A, Ronnebaum, T.A, Roose, B.W, Christianson, D.W. | Deposit date: | 2022-06-14 | Release date: | 2022-09-28 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Structural Basis of Substrate Promiscuity and Catalysis by the Reverse Prenyltransferase N -Dimethylallyl-l-tryptophan Synthase from Fusarium fujikuroi . Biochemistry, 61, 2022
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8D9C
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![BU of 8d9c by Molmil](/molmil-images/mine/8d9c) | Crystal Structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with fluorinated inhibitor 10 | Descriptor: | 2,3,4,5,6-pentafluoro-N-hydroxybenzamide, Hdac6 protein, POTASSIUM ION, ... | Authors: | Watson, P.R, Christianson, D.W. | Deposit date: | 2022-06-09 | Release date: | 2022-09-28 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Aromatic Ring Fluorination Patterns Modulate Inhibitory Potency of Fluorophenylhydroxamates Complexed with Histone Deacetylase 6. Biochemistry, 61, 2022
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8TID
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![BU of 8tid by Molmil](/molmil-images/mine/8tid) | Combined linker domain of N-DRC and associated proteins Tetrahymena | Descriptor: | AAA family ATPase CDC48 subfamily protein, CFAP20, Calmodulin 7-2, ... | Authors: | Ghanaeian, A.G, Majhi, S.M, McCaffrey, C.M, Nami, B.N, Black, C.B, Yang, S.K, Legal, T.L, Papoulas, O.P, Janowska, M.J, Valente-Paterno, M.V, Marcotte, E.M, Wloga, D.W, Bui, K.H. | Deposit date: | 2023-07-19 | Release date: | 2023-09-27 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Integrated modeling of the Nexin-dynein regulatory complex reveals its regulatory mechanism. Nat Commun, 14, 2023
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8D99
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![BU of 8d99 by Molmil](/molmil-images/mine/8d99) | Crystal Structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with fluorinated inhibitor 7 | Descriptor: | 2,3,6-trifluoro-N-hydroxybenzamide, Hdac6 protein, POTASSIUM ION, ... | Authors: | Watson, P.R, Christianson, D.W. | Deposit date: | 2022-06-09 | Release date: | 2022-09-28 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Aromatic Ring Fluorination Patterns Modulate Inhibitory Potency of Fluorophenylhydroxamates Complexed with Histone Deacetylase 6. Biochemistry, 61, 2022
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8D9B
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![BU of 8d9b by Molmil](/molmil-images/mine/8d9b) | Crystal Structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with fluorinated inhibitor 9 | Descriptor: | 2,3,5,6-tetrafluoro-N-hydroxybenzamide, Hdac6 protein, POTASSIUM ION, ... | Authors: | Watson, P.R, Christianson, D.W. | Deposit date: | 2022-06-09 | Release date: | 2022-09-28 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.63 Å) | Cite: | Aromatic Ring Fluorination Patterns Modulate Inhibitory Potency of Fluorophenylhydroxamates Complexed with Histone Deacetylase 6. Biochemistry, 61, 2022
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4Q3R
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![BU of 4q3r by Molmil](/molmil-images/mine/4q3r) | Crystal structure of Schistosoma mansoni arginase in complex with inhibitor ABHDP | Descriptor: | (R)-2-amino-6-borono-2-(1-(3,4-dichlorobenzyl)piperidin-4-yl)hexanoic acid, Arginase, CESIUM ION, ... | Authors: | Hai, Y, Edwards, J.E, Van Zandt, M.C, Hoffmann, K.F, Christianson, D.W. | Deposit date: | 2014-04-12 | Release date: | 2014-07-16 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.169 Å) | Cite: | Crystal Structure of Schistosoma mansoni Arginase, a Potential Drug Target for the Treatment of Schistosomiasis. Biochemistry, 53, 2014
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8DB0
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![BU of 8db0 by Molmil](/molmil-images/mine/8db0) | Crystal structure of DMATS1 prenyltransferase in complex with L-Trp and DMSPP | Descriptor: | 1,2-ETHANEDIOL, 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, DIMETHYLALLYL S-THIOLODIPHOSPHATE, ... | Authors: | Eaton, S.A, Ronnebaum, T.A, Roose, B.W, Christianson, D.W. | Deposit date: | 2022-06-14 | Release date: | 2022-09-28 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | Structural Basis of Substrate Promiscuity and Catalysis by the Reverse Prenyltransferase N -Dimethylallyl-l-tryptophan Synthase from Fusarium fujikuroi . Biochemistry, 61, 2022
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4Q40
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![BU of 4q40 by Molmil](/molmil-images/mine/4q40) | Crystal structure of Schistosoma mansoni arginase in complex with L-valine | Descriptor: | Arginase, GLYCEROL, IMIDAZOLE, ... | Authors: | Hai, Y, Edwards, J.E, Van Zandt, M.C, Hoffmann, K.F, Christianson, D.W. | Deposit date: | 2014-04-12 | Release date: | 2014-07-16 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.831 Å) | Cite: | Crystal Structure of Schistosoma mansoni Arginase, a Potential Drug Target for the Treatment of Schistosomiasis. Biochemistry, 53, 2014
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4Q3U
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![BU of 4q3u by Molmil](/molmil-images/mine/4q3u) | Crystal structure of Schistosoma mansoni arginase in complex with inhibitor nor-NOHA | Descriptor: | Arginase, GLYCEROL, MANGANESE (II) ION, ... | Authors: | Hai, Y, Edwards, J.E, Van Zandt, M.C, Hoffmann, K.F, Christianson, D.W. | Deposit date: | 2014-04-12 | Release date: | 2014-07-16 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal Structure of Schistosoma mansoni Arginase, a Potential Drug Target for the Treatment of Schistosomiasis. Biochemistry, 53, 2014
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