7FQA
| DHFR:NADP+:FOL complex (crystal 1, pass 4, 280 K) | 分子名称: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | 著者 | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | 登録日 | 2022-09-12 | 公開日 | 2023-09-20 | 最終更新日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (1.08 Å) | 主引用文献 | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
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7FPU
| DHFR:NADP+:FOL complex at 290 K (crystal 4) | 分子名称: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | 著者 | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | 登録日 | 2022-09-10 | 公開日 | 2023-09-20 | 最終更新日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | 主引用文献 | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
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7FQD
| DHFR:NADP+:FOL complex (crystal 2, pass 2, 280 K) | 分子名称: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | 著者 | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | 登録日 | 2022-09-12 | 公開日 | 2023-09-20 | 最終更新日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (1.17 Å) | 主引用文献 | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
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7FPP
| DHFR:NADP+:FOL complex at 280 K (crystal 5) | 分子名称: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | 著者 | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | 登録日 | 2022-09-09 | 公開日 | 2023-09-20 | 最終更新日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (1.03 Å) | 主引用文献 | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
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7FPV
| DHFR:NADP+:FOL complex at 290 K (crystal 5) | 分子名称: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | 著者 | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | 登録日 | 2022-09-10 | 公開日 | 2023-09-20 | 最終更新日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (1.04 Å) | 主引用文献 | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
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7FPY
| DHFR:NADP+:FOL complex at 300 K (crystal 2) | 分子名称: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | 著者 | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | 登録日 | 2022-09-10 | 公開日 | 2023-09-20 | 最終更新日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (1.12 Å) | 主引用文献 | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
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7FQ0
| DHFR:NADP+:FOL complex at 300 K (crystal 4) | 分子名称: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | 著者 | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | 登録日 | 2022-09-10 | 公開日 | 2023-09-20 | 最終更新日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | 主引用文献 | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
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7FPZ
| DHFR:NADP+:FOL complex at 300 K (crystal 3) | 分子名称: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | 著者 | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | 登録日 | 2022-09-10 | 公開日 | 2023-09-20 | 最終更新日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (1.32 Å) | 主引用文献 | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
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7FPQ
| DHFR:NADP+:FOL complex at 280 K (multi-crystal) | 分子名称: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | 著者 | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | 登録日 | 2022-09-09 | 公開日 | 2023-09-20 | 最終更新日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (1.03 Å) | 主引用文献 | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
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7FQ4
| DHFR:NADP+:FOL complex at 310 K (crystal 2) | 分子名称: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | 著者 | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | 登録日 | 2022-09-12 | 公開日 | 2023-09-20 | 最終更新日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (1.33 Å) | 主引用文献 | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
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7FPL
| DHFR:NADP+:FOL complex at 280 K (crystal 1) | 分子名称: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | 著者 | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | 登録日 | 2022-09-09 | 公開日 | 2023-09-20 | 最終更新日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (1.17 Å) | 主引用文献 | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
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7FQ3
| DHFR:NADP+:FOL complex at 310 K (crystal 1) | 分子名称: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | 著者 | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | 登録日 | 2022-09-12 | 公開日 | 2023-09-20 | 最終更新日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
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7FQ7
| DHFR:NADP+:FOL complex (crystal 1, pass 1, 295 K) | 分子名称: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | 著者 | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | 登録日 | 2022-09-12 | 公開日 | 2023-09-20 | 最終更新日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
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7FQ9
| DHFR:NADP+:FOL complex (crystal 1, pass 3, 295 K) | 分子名称: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | 著者 | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | 登録日 | 2022-09-12 | 公開日 | 2023-09-20 | 最終更新日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (1.11 Å) | 主引用文献 | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
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7FQB
| DHFR:NADP+:FOL complex (crystal 1, pass 5, 295 K) | 分子名称: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | 著者 | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | 登録日 | 2022-09-12 | 公開日 | 2023-09-20 | 最終更新日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (1.14 Å) | 主引用文献 | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
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7FQC
| DHFR:NADP+:FOL complex (crystal 2, pass 1, 295 K) | 分子名称: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | 著者 | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | 登録日 | 2022-09-12 | 公開日 | 2023-09-20 | 最終更新日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (1.18 Å) | 主引用文献 | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
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7JQD
| Crystal Structure of PAC1r in complex with peptide antagonist | 分子名称: | Peptide-43, Pituitary adenylate cyclase-activating polypeptide type I receptor | 著者 | Piper, D.E, Hu, E, Fang-Tsao, H. | 登録日 | 2020-08-10 | 公開日 | 2021-03-24 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Discovery of Selective Pituitary Adenylate Cyclase 1 Receptor (PAC1R) Antagonist Peptides Potent in a Maxadilan/PACAP38-Induced Increase in Blood Flow Pharmacodynamic Model. J.Med.Chem., 64, 2021
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7JTU
| Cytidine deaminase T6S toxin from Pseudomonas syringae | 分子名称: | SsdA, SsdAI | 著者 | Bosch, D.E, Hsu, F, de Moraes, M.H, Mougous, J.D. | 登録日 | 2020-08-18 | 公開日 | 2021-03-31 | 最終更新日 | 2021-04-07 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | An interbacterial DNA deaminase toxin directly mutagenizes surviving target populations. Elife, 10, 2021
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7JYO
| JAK2 JH2 in complex with JAK064 | 分子名称: | 3-({4-amino-6-[(4-cyanophenyl)amino]-1,3,5-triazin-2-yl}oxy)benzoic acid, GLYCEROL, Tyrosine-protein kinase JAK2 | 著者 | Puleo, D.E, Krimmer, S.G, Newton, A.S, Schlessinger, J, Jorgensen, W.L. | 登録日 | 2020-08-31 | 公開日 | 2021-07-14 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.16127229 Å) | 主引用文献 | Indoloxytriazines as binding molecules for the JAK2 JH2 pseudokinase domain and its V617F variant Tetrahedron Lett., 77, 2021
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7JYQ
| JAK2 JH2 in complex with JAK020 | 分子名称: | GLYCEROL, N~2~-(4-fluorophenyl)-6-{[(5-{[(oxolan-2-yl)methyl]amino}-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-1,3,5-triazine-2,4-diamine, Tyrosine-protein kinase JAK2 | 著者 | Puleo, D.E, Krimmer, S.G, Newton, A.S, Schlessinger, J, Jorgensen, W.L. | 登録日 | 2020-08-31 | 公開日 | 2021-07-14 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.85941613 Å) | 主引用文献 | Indoloxytriazines as binding molecules for the JAK2 JH2 pseudokinase domain and its V617F variant Tetrahedron Lett., 77, 2021
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7KG3
| Crystal structure of CoV-2 Nsp3 Macrodomain | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, MALONATE ION, ... | 著者 | Arvai, A, Brosey, C.A, Link, T, Jones, D.E, Ahmed, Z, Tainer, J.A. | 登録日 | 2020-10-15 | 公開日 | 2020-10-28 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors. Prog.Biophys.Mol.Biol., 163, 2021
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7KIR
| Crystal structure of inositol polyphosphate 1-phosphatase (INPP1) D54A mutant in complex with inositol (1,4)-bisphosphate | 分子名称: | CALCIUM ION, D-MYO-INOSITOL-1,4-BISPHOSPHATE, Inositol polyphosphate 1-phosphatase | 著者 | Dollins, D.E, Xiong, J.-P, Ren, Y, York, J.D. | 登録日 | 2020-10-24 | 公開日 | 2020-11-25 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | A structural basis for lithium and substrate binding of an inositide phosphatase. J.Biol.Chem., 296, 2020
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7KIO
| Crystal structure of inositol polyphosphate 1-phosphatase (INPP1) D54A mutant | 分子名称: | CALCIUM ION, Inositol polyphosphate 1-phosphatase, SULFATE ION | 著者 | Xiong, J.-P, Dollins, D.E, Ren, Y, York, J.D. | 登録日 | 2020-10-24 | 公開日 | 2020-11-25 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | A structural basis for lithium and substrate binding of an inositide phosphatase. J.Biol.Chem., 296, 2020
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2DYN
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1XIL
| HYDROGEN BONDING IN HUMAN MANGANESE SUPEROXIDE DISMUTASE CONTAINING 3-FLUOROTYROSINE | 分子名称: | MANGANESE (II) ION, Superoxide dismutase [Mn], mitochondrial | 著者 | Ayala, I, Perry, J.J, Szczepanski, J, Cabelli, D.E, Tainer, J.A, Vala, M.T, Nick, H.S, Silverman, D.N. | 登録日 | 2004-09-21 | 公開日 | 2005-03-08 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | 主引用文献 | Hydrogen bonding in human manganese superoxide dismutase containing 3-fluorotyrosine Biophys.J., 89, 2005
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