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PDB: 1222 件
7S9Y
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Helicobacter Hepaticus CcsBA Open Conformation
分子名称: Cytochrome c biogenesis protein, HEME B/C, PHOSPHATIDYLETHANOLAMINE
著者Mendez, D.L, Lowder, E.P, Tillman, D.E, Sutherland, M.C, Collier, A.L, Rau, M.J, Fitzpatrick, J.A, Kranz, R.G.
登録日2021-09-21
公開日2021-12-22
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (3.56 Å)
主引用文献Cryo-EM of CcsBA reveals the basis for cytochrome c biogenesis and heme transport.
Nat.Chem.Biol., 18, 2022
6B8J
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Co-structure of human glycogen synthase kinase beta with a selective (5-imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine inhibitor
分子名称: CHIR99021, GLYCEROL, Glycogen synthase kinase-3 beta, ...
著者Bussiere, D.E.
登録日2017-10-08
公開日2017-11-08
実験手法X-RAY DIFFRACTION (2.595 Å)
主引用文献Synthesis, Binding Mode, and Antihyperglycemic Activity of Potent and Selective (5-Imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine Inhibitors of Glycogen Synthase Kinase 3.
J. Med. Chem., 60, 2017
6BFX
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BACE crystal structure with hydroxy pyrrolidine inhibitor
分子名称: Beta-secretase 1, GLYCEROL, N-{(1S,2S)-3-(3,5-difluorophenyl)-1-[(3R,5S,6R)-6-(2,2-dimethylpropoxy)-5-methylmorpholin-3-yl]-1-hydroxypropan-2-yl}acetamide
著者Timm, D.E.
登録日2017-10-27
公開日2017-11-15
最終更新日2017-12-27
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Optimization of Hydroxyethylamine Transition State Isosteres as Aspartic Protease Inhibitors by Exploiting Conformational Preferences.
J. Med. Chem., 60, 2017
6BFE
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BACE crystal structure with hydroxy pyrrolidine inhibitor
分子名称: Beta-secretase 1, GLYCEROL, N-[(1R,2S)-1-[(2R,4R)-4-(cyclohexylmethoxy)pyrrolidin-2-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]acetamide
著者Timm, D.E.
登録日2017-10-26
公開日2017-11-15
最終更新日2017-12-27
実験手法X-RAY DIFFRACTION (1.51 Å)
主引用文献Optimization of Hydroxyethylamine Transition State Isosteres as Aspartic Protease Inhibitors by Exploiting Conformational Preferences.
J. Med. Chem., 60, 2017
6BFD
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BACE crystal structure with hydroxy pyrrolidine inhibitor
分子名称: 2-{[(2S)-butan-2-yl]amino}-N-{(1R,2S)-1-hydroxy-3-phenyl-1-[(2R)-pyrrolidin-2-yl]propan-2-yl}-6-(methylsulfonyl)pyridine-4-carboxamide, Beta-secretase 1, GLYCEROL
著者Timm, D.E.
登録日2017-10-26
公開日2017-11-15
最終更新日2017-12-27
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献Optimization of Hydroxyethylamine Transition State Isosteres as Aspartic Protease Inhibitors by Exploiting Conformational Preferences.
J. Med. Chem., 60, 2017
6BFW
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BACE crystal structure with hydroxy morpholine inhibitor
分子名称: Beta-secretase 1, GLYCEROL, N-[(1S,2S)-1-[(3R,6R)-6-(cyclohexylmethoxy)morpholin-3-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]acetamide
著者Timm, D.E.
登録日2017-10-27
公開日2017-11-15
最終更新日2017-12-27
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献Optimization of Hydroxyethylamine Transition State Isosteres as Aspartic Protease Inhibitors by Exploiting Conformational Preferences.
J. Med. Chem., 60, 2017
1OY6
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Structural Basis of the Multiple Binding Capacity of the AcrB Multidrug Efflux Pump
分子名称: Acriflavine resistance protein B
著者Yu, E.W, McDermott, G, Zgurskaya, H.I, Nikaido, H, Koshland Jr, D.E.
登録日2003-04-03
公開日2003-05-13
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (3.68 Å)
主引用文献Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump.
Science, 300, 2003
1OY8
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Structural Basis of Multiple Drug Binding Capacity of the AcrB Multidrug Efflux Pump
分子名称: Acriflavine resistance protein B, RHODAMINE 6G
著者Yu, E.W, McDermott, G, Zgurskaya, H.I, Nikaido, H, Koshland Jr, D.E.
登録日2003-04-03
公開日2003-05-13
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (3.63 Å)
主引用文献Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump.
Science, 300, 2003
7XTB
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Serotonin 6 (5-HT6) receptor-Gs-Nb35 complex
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
著者Huang, S, Xu, P, Shen, D.D, Simon, I.A, Mao, C, Tan, Y, Zhang, H, Harpsoe, K, Li, H, Zhang, Y, You, C, Yu, X, Jiang, Y, Zhang, Y, Gloriam, D.E, Xu, H.E.
登録日2022-05-16
公開日2022-07-27
最終更新日2022-08-03
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors.
Mol.Cell, 82, 2022
7XTC
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Serotonin 7 (5-HT7) receptor-Gs-Nb35 complex
分子名称: 3-(2-azanylethyl)-1H-indole-5-carboxamide, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Huang, S, Xu, P, Shen, D.D, Simon, I.A, Mao, C, Tan, Y, Zhang, H, Harpsoe, K, Li, H, Zhang, Y, You, C, Yu, X, Jiang, Y, Zhang, Y, Gloriam, D.E, Xu, H.E.
登録日2022-05-16
公開日2022-07-27
最終更新日2022-08-03
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors.
Mol.Cell, 82, 2022
7XTA
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Serotonin 4 (5-HT4) receptor-Gi-scFv16 complex
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
著者Huang, S, Xu, P, Shen, D.D, Simon, I.A, Mao, C, Tan, Y, Zhang, H, Harpsoe, K, Li, H, Zhang, Y, You, C, Yu, X, Jiang, Y, Zhang, Y, Gloriam, D.E, Xu, H.E.
登録日2022-05-16
公開日2022-07-27
最終更新日2024-07-03
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors.
Mol.Cell, 82, 2022
7XT9
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Serotonin 4 (5-HT4) receptor-Gs complex
分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Huang, S, Xu, P, Shen, D.D, Simon, I.A, Mao, C, Tan, Y, Zhang, H, Harpsoe, K, Li, H, Zhang, Y, You, C, Yu, X, Jiang, Y, Zhang, Y, Gloriam, D.E, Xu, H.E.
登録日2022-05-16
公開日2022-07-27
最終更新日2022-08-03
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors.
Mol.Cell, 82, 2022
7XT8
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Serotonin 4 (5-HT4) receptor-Gs-Nb35 complex
分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Huang, S, Xu, P, Shen, D.D, Simon, I.A, Mao, C, Tan, Y, Zhang, H, Harpsoe, K, Li, H, Zhang, Y, You, C, Yu, X, Jiang, Y, Zhang, Y, Gloriam, D.E, Xu, H.E.
登録日2022-05-16
公開日2022-07-27
最終更新日2022-08-03
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors.
Mol.Cell, 82, 2022
1N2M
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The S53A Proenzyme Structure of Methanococcus jannaschii.
分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, Pyruvoyl-dependent arginine decarboxylase
著者Tolbert, W.D, Graham, D.E, White, R.H, Ealick, S.E.
登録日2002-10-23
公開日2003-03-25
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Pyruvoyl-Dependent Arginine Decarboxylase from Methanococcus jannaschii: Crystal Structures of the Self-Cleaved and S53A Proenzyme Forms
Structure, 11, 2003
7Z18
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E. coli C-P lyase bound to a PhnK ABC dimer and ATP
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P lyase, Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnG, ...
著者Amstrup, S.K, Sofos, N, Karlsen, J.L, Skjerning, R.B, Boesen, T, Enghild, J.J, Hove-Jensen, B, Brodersen, D.E.
登録日2022-02-24
公開日2022-05-25
最終更新日2024-07-17
実験手法ELECTRON MICROSCOPY (1.98 Å)
主引用文献Structural remodelling of the carbon-phosphorus lyase machinery by a dual ABC ATPase.
Nat Commun, 14, 2023
7Z19
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E. coli C-P lyase bound to a single PhnK ABC domain
分子名称: Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P lyase, Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnG, Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnH, ...
著者Amstrup, S.K, Sofos, N, Karlsen, J.L, Skjerning, R.B, Boesen, T, Enghild, J.J, Hove-Jensen, B, Brodersen, D.E.
登録日2022-02-24
公開日2022-05-25
最終更新日2024-07-17
実験手法ELECTRON MICROSCOPY (2.57 Å)
主引用文献Structural remodelling of the carbon-phosphorus lyase machinery by a dual ABC ATPase.
Nat Commun, 14, 2023
1PB3
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Sites of binding and orientation in a four location model for protein stereospecificity.
分子名称: GLYCEROL, Isocitrate dehydrogenase [NADP], SULFATE ION
著者Mesecar, A.D, Koshland Jr, D.E.
登録日2003-05-14
公開日2003-06-17
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Sites of Binding and Orientation in a Four-Location Model for Protein Stereospecificity.
IUBMB Life, 49, 2000
7Z17
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E. coli C-P lyase bound to a PhnK ABC dimer in an open conformation
分子名称: Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P lyase, Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnG, Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnH, ...
著者Amstrup, S.K, Sofos, N, Karlsen, J.L, Skjerning, R.B, Boesen, T, Enghild, J.J, Hove-Jensen, B, Brodersen, D.E.
登録日2022-02-24
公開日2022-05-25
最終更新日2024-07-17
実験手法ELECTRON MICROSCOPY (2.57 Å)
主引用文献Structural remodelling of the carbon-phosphorus lyase machinery by a dual ABC ATPase.
Nat Commun, 14, 2023
1PB1
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A four location model to explain the stereospecificity of proteins.
分子名称: GLYCEROL, ISOCITRIC ACID, Isocitrate dehydrogenase [NADP], ...
著者Mesecar, A.D, Koshland Jr, D.E.
登録日2003-05-14
公開日2003-06-17
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural Biology: A New Model for Protein Stereospecificity.
Nature, 403, 2000
7Z15
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E. coli C-P lyase bound to a PhnK/PhnL dual ABC dimer and ADP + Pi
分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P lyase, ...
著者Amstrup, S.K, Sofos, N, Karlsen, J.L, Skjerning, R.B, Boesen, T, Enghild, J.J, Hove-Jensen, B, Brodersen, D.E.
登録日2022-02-24
公開日2022-06-22
最終更新日2024-07-17
実験手法ELECTRON MICROSCOPY (1.93 Å)
主引用文献Structural remodelling of the carbon-phosphorus lyase machinery by a dual ABC ATPase.
Nat Commun, 14, 2023
7Z16
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E. coli C-P lyase bound to PhnK/PhnL dual ABC dimer with AMPPNP and PhnK E171Q mutation
分子名称: Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P lyase, Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnH, Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnI, ...
著者Amstrup, S.K, Sofus, N, Karlsen, J.L, Skjerning, R.B, Boesen, T, Enghild, J.J, Hove-Jensen, B, Brodersen, D.E.
登録日2022-02-24
公開日2022-06-22
最終更新日2024-07-17
実験手法ELECTRON MICROSCOPY (2.09 Å)
主引用文献Structural remodelling of the carbon-phosphorus lyase machinery by a dual ABC ATPase.
Nat Commun, 14, 2023
6BS0
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JAK2 JH2 in complex with 63552444
分子名称: 4-(5-aminopyrazin-2-yl)-1H-pyrrolo[2,3-b]pyridin-6-amine, GLYCEROL, Tyrosine-protein kinase JAK2
著者Puleo, D.E, Schlessinger, J.
登録日2017-12-01
公開日2018-08-22
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.541 Å)
主引用文献JAK2 JH2 Binders
To Be Published
7YWS
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Modified oligopeptidase B from S. proteomaculans in intermediate conformation with 3 spermine molecules at 1.7 A resolution
分子名称: Oligopeptidase B, SPERMINE
著者Petrenko, D.E, Boyko, K.M, Nikolaeva, A.Y, Vlaskina, A.V, Mikhailova, A.G, Timofeev, V.I, Rakitina, T.V.
登録日2022-02-14
公開日2023-01-18
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Elucidation of the Conformational Transition of Oligopeptidase B by an Integrative Approach Based on the Combination of X-ray, SAXS, and Essential Dynamics Sampling Simulation
Crystals, 12, 2022
7YX7
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Modified oligopeptidase B from S. proteomaculans in intermediate conformation with 1 spermine molecule at 1.72 A resolution
分子名称: Oligopeptidase B, SPERMINE
著者Petrenko, D.E, Boyko, K.M, Nikolaeva, A.Y, Vlaskina, A.V, Mikhailova, A.G, Timofeev, V.I, Rakitina, T.V.
登録日2022-02-15
公開日2023-01-18
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.72 Å)
主引用文献Elucidation of the Conformational Transition of Oligopeptidase B by an Integrative Approach Based on the Combination of X-ray, SAXS, and Essential Dynamics Sampling Simulation
Crystals, 12, 2022
6BRW
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JAK2 JH2 in complex with XMU-MP-1
分子名称: 4-[(5,10-dimethyl-6-oxo-6,10-dihydro-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]benzenesulfonamide, ACETATE ION, GLYCEROL, ...
著者Puleo, D.E, Schlessinger, J.
登録日2017-12-01
公開日2018-08-15
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.031 Å)
主引用文献JAK2 JH2 Binders
To Be Published

223532

件を2024-08-07に公開中

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