4CAC
| REFINED STRUCTURE OF HUMAN CARBONIC ANHYDRASE II AT 2.0 ANGSTROMS RESOLUTION | 分子名称: | CARBONIC ANHYDRASE FORM C, ZINC ION | 著者 | Lindahl, M, Habash, D, Harrop, S, Helliwell, D.R, Liljas, A. | 登録日 | 1991-09-05 | 公開日 | 1994-01-31 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Refined structure of human carbonic anhydrase II at 2.0 A resolution. Proteins, 4, 1988
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4JOI
| Crystal structure of the human telomeric Stn1-Ten1 complex | 分子名称: | CST complex subunit STN1, CST complex subunit TEN1 | 著者 | Bryan, C, Rice, C, Harkisheimer, M, Schultz, D, Skordalakes, E. | 登録日 | 2013-03-18 | 公開日 | 2013-05-29 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structure of the human telomeric stn1-ten1 capping complex. Plos One, 8, 2013
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4JQF
| Structure of the C-terminal domain of human telomeric Stn1 | 分子名称: | CST complex subunit STN1 | 著者 | Bryan, C.F, Rice, C.T, Harkisheimer, M, Schultz, D, Skordalakes, E. | 登録日 | 2013-03-20 | 公開日 | 2013-06-05 | 最終更新日 | 2013-07-24 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structure of the human telomeric stn1-ten1 capping complex. Plos One, 8, 2013
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4BKN
| Human Dihydropyrimidinase-related protein 3 (DPYSL3) | 分子名称: | DIHYDROPYRIMIDINASE-RELATED PROTEIN 3 | 著者 | Mathea, S, Elkins, J.M, Alegre-Abarrategui, J, Shrestha, L, Burgess-Brown, N, Puranik, S, Coutandin, D, Bradley, A, Vollmar, M, von Delft, F, Bountra, C, Arrowsmith, C, Edwards, A, Knapp, S. | 登録日 | 2013-04-26 | 公開日 | 2013-05-08 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure of Dpysl3 To be Published
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4JKO
| Crystal structure of a catalytic mutant of Axe2 (Axe2_S15A), an acetylxylan esterase from Geobacillus stearothermophilus | 分子名称: | Acetyl xylan esterase, GLYCEROL, PHOSPHATE ION | 著者 | Azulay, D, Lansky, S, Alalouf, O, Solomon, V, Alhassid, A, Belrahli, H, Govada, L, Chayan, N.E, Shoham, Y, Shoham, G. | 登録日 | 2013-03-11 | 公開日 | 2014-02-12 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | A unique octameric structure of Axe2, an intracellular acetyl-xylooligosaccharide esterase from Geobacillus stearothermophilus. Acta Crystallogr.,Sect.D, 70, 2014
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4F4J
| Conversion of the enzyme guanylate kinase into a mitotic spindle orienting protein by a single mutation that inhibits gmp- induced closing | 分子名称: | Guanylate kinase, SULFATE ION | 著者 | Johnston, C.A, Whitney, D, Volkman, B.F, Prehoda, K.E. | 登録日 | 2012-05-10 | 公開日 | 2012-06-13 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Conversion of the enzyme guanylate kinase into a mitotic-spindle orienting protein by a single mutation that inhibits GMP-induced closing. Proc.Natl.Acad.Sci.USA, 108, 2011
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4EYW
| Crystal structure of rat carnitine palmitoyltransferase 2 in complex with 1-[(R)-2-(3,4-Dihydro-1H-isoquinoline-2-carbonyl)-piperidin-1-yl]-2-phenoxy-ethanone | 分子名称: | 1-[(2R)-2-(3,4-dihydroisoquinolin-2(1H)-ylcarbonyl)piperidin-1-yl]-2-phenoxyethanone, Carnitine O-palmitoyltransferase 2, mitochondrial, ... | 著者 | Rudolph, M.G, Benz, J, Burger, D, Thoma, R, Rufer, A, Joseph, C. | 登録日 | 2012-05-02 | 公開日 | 2013-04-24 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.885 Å) | 主引用文献 | Isothermal titration calorimetry with micelles: Thermodynamics of inhibitor binding to carnitine palmitoyltransferase 2 membrane protein. FEBS Open Bio, 3, 2013
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3PNW
| Crystal Structure of the tudor domain of human TDRD3 in complex with an anti-TDRD3 FAB | 分子名称: | FAB heavy chain, FAB light chain, Tudor domain-containing protein 3, ... | 著者 | Loppnau, P, Tempel, W, Wernimont, A.K, Lam, R, Ravichandran, M, Adams-Cioaba, M.A, Persson, H, Sidhu, S.S, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Cossar, D, Structural Genomics Consortium (SGC) | 登録日 | 2010-11-19 | 公開日 | 2010-12-01 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | CDR-H3 Diversity Is Not Required for Antigen Recognition by Synthetic Antibodies. J.Mol.Biol., 425, 2013
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3QKI
| Crystal structure of Glucose-6-Phosphate Isomerase (PF14_0341) from Plasmodium falciparum 3D7 | 分子名称: | Glucose-6-phosphate isomerase | 著者 | Gileadi, T, Wernimont, A.K, Hutchinson, A, Weadge, J, Cossar, D, Lew, J, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Hui, R, Hills, T, Pizarro, J.C, Structural Genomics Consortium (SGC) | 登録日 | 2011-02-01 | 公開日 | 2011-02-16 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Crystal structure of Glucose-6-Phosphate Isomerase (PF14_0341) from Plasmodium falciparum 3D7 TO BE PUBLISHED
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3RZ2
| Crystal of Prl-1 complexed with peptide | 分子名称: | Prl-1 (PTP4A1), Protein tyrosine phosphatase type IVA 1 | 著者 | Zhang, Z.-Y, Liu, D, Bai, Y. | 登録日 | 2011-05-11 | 公開日 | 2011-10-26 | 最終更新日 | 2014-10-29 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | PRL-1 protein promotes ERK1/2 and RhoA protein activation through a non-canonical interaction with the Src homology 3 domain of p115 Rho GTPase-activating protein. J.Biol.Chem., 286, 2011
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3PO6
| Crystal structure of human carbonic anhydrase II with 6,7-Dimethoxy-1-methyl-3,4-dihydroisoquinoline-2(1H)-sulfonamide | 分子名称: | (1R)-6,7-dimethoxy-1-methyl-3,4-dihydroisoquinoline-2(1H)-sulfonamide, (1S)-6,7-dimethoxy-1-methyl-3,4-dihydroisoquinoline-2(1H)-sulfonamide, ACETATE ION, ... | 著者 | Mader, P, Brynda, J, Gitto, R, Agnello, S, Ferro, S, De Luca, L, Vullo, D, Supuran, C.T, Chimirri, A. | 登録日 | 2010-11-22 | 公開日 | 2011-04-06 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | Structural basis for the interaction between carbonic anhydrase and 1,2,3,4-tetrahydroisoquinolin-2-ylsulfonamides. J.Med.Chem., 54, 2011
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3PYM
| Structure of GAPDH 3 from S.cerevisiae at 2.0 A resolution | 分子名称: | Glyceraldehyde-3-phosphate dehydrogenase 3, MESO-ERYTHRITOL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | 著者 | Garcia-Saez, I, Kozielski, F, Job, D, Boscheron, C. | 登録日 | 2010-12-13 | 公開日 | 2012-01-11 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 |
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7JUK
| Crystal structure of PTEN with a tetra-phosphorylated tail (4p-crPTEN-13sp-T2, SDTTDSDPENEG) | 分子名称: | PHOSPHATE ION, Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN | 著者 | Dempsey, D, Phan, K, Cole, P, Gabelli, S.B. | 登録日 | 2020-08-19 | 公開日 | 2021-10-13 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | 主引用文献 | The structural basis of PTEN regulation by multi-site phosphorylation. Nat.Struct.Mol.Biol., 28, 2021
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7KH2
| Structure of N-citrylornithine decarboxylase bound with PLP | 分子名称: | GLYCEROL, N-citrylornithine decarboxylase, PYRIDOXAL-5'-PHOSPHATE, ... | 著者 | Deng, X, Tomchick, D, Phillips, M, Michael, A. | 登録日 | 2020-10-19 | 公開日 | 2020-12-16 | 最終更新日 | 2021-07-28 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Alternative pathways utilize or circumvent putrescine for biosynthesis of putrescine-containing rhizoferrin. J.Biol.Chem., 296, 2020
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7L4U
| Crystal structure of human monoacylglycerol lipase in complex with compound 1h | 分子名称: | (5S)-5-(3-{4-[(2-chloro-4-fluorophenoxy)methyl]piperidin-1-yl}-3-oxopropyl)pyrrolidin-2-one, CHLORIDE ION, Monoglyceride lipase | 著者 | Qin, L, Lane, W, Skene, R.J, Dougan, D. | 登録日 | 2020-12-21 | 公開日 | 2021-08-11 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3-Oxo-3,4-dihydro-2 H -benzo[ b ][1,4]oxazin-6-yl Moiety. J.Med.Chem., 64, 2021
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7KC4
| Human WLS in complex with WNT8A | 分子名称: | 1-CIS-9-OCTADECANOYL-2-CIS-9-HEXADECANOYL PHOSPHATIDYL GLYCEROL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Nygaard, R, Jia, Y, Kim, J, Ross, D, Parisi, G, Clarke, O.B, Virshup, D.M, Mancia, F. | 登録日 | 2020-10-05 | 公開日 | 2021-01-06 | 最終更新日 | 2021-01-20 | 実験手法 | ELECTRON MICROSCOPY (3.19 Å) | 主引用文献 | Structural Basis of WLS/Evi-Mediated Wnt Transport and Secretion. Cell, 184, 2021
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3RPL
| D-fructose 1,6-bisphosphatase class 2/sedoheptulose 1,7-bisphosphatase of Synechocystis sp. PCC 6803 in complex with FRUCTOSE-1,6-BISPHOSPHATE | 分子名称: | 1,6-di-O-phosphono-beta-D-fructofuranose, ADENOSINE MONOPHOSPHATE, CHLORIDE ION, ... | 著者 | Hu, X, Hui, D, Lingling, F, Jian, W. | 登録日 | 2011-04-26 | 公開日 | 2012-05-02 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | New insights into the structural and interactional basis for a promising route towards fructose-1,6-/sedoheptulose-1,7-bisphosphatases controlling To be Published
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3T9I
| Pim1 complexed with a novel 3,6-disubstituted indole at 2.6 Ang Resolution | 分子名称: | 2-methoxy-4-(3-phenyl-2H-pyrazolo[3,4-b]pyridin-6-yl)phenol, Proto-oncogene serine/threonine-protein kinase pim-1 | 著者 | Bellamacina, C, Shu, W, Le, V, Nishiguchi, G, Bussiere, D. | 登録日 | 2011-08-02 | 公開日 | 2011-10-12 | 最終更新日 | 2011-11-02 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Discovery of novel 3,5-disubstituted indole derivatives as potent inhibitors of Pim-1, Pim-2, and Pim-3 protein kinases. Bioorg.Med.Chem.Lett., 21, 2011
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3SWM
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7LHG
| Cryo-EM structure of E. coli P pilus tip assembly intermediate PapC-PapD-PapK-PapG in the first conformation | 分子名称: | Chaperone protein PapD, Fimbrial adapter PapK, P fimbria tip G-adhesin PapG-II, ... | 著者 | Du, M, Yuan, Z, Werneburg, G, Henderson, N, Chauhan, H, Kovach, A, Zhao, G, Johl, J, Li, H, Thanassi, D. | 登録日 | 2021-01-23 | 公開日 | 2021-08-11 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Processive dynamics of the usher assembly platform during uropathogenic Escherichia coli P pilus biogenesis. Nat Commun, 12, 2021
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7LHH
| Cryo-EM structure of E. coli P pilus tip assembly intermediate PapC-PapD-PapK-PapG in the second conformation | 分子名称: | Chaperone protein PapD, Fimbrial adapter PapK, P fimbria tip G-adhesin PapG-II, ... | 著者 | Du, M, Yuan, Z, Werneburg, G, Henderson, N, Chauhan, H, Kovach, A, Zhao, G, Johl, J, Li, H, Thanassi, D. | 登録日 | 2021-01-23 | 公開日 | 2021-08-11 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (7.2 Å) | 主引用文献 | Processive dynamics of the usher assembly platform during uropathogenic Escherichia coli P pilus biogenesis. Nat Commun, 12, 2021
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3PR3
| Crystal structure of Plasmodium falciparum glucose-6-phosphate isomerase (PF14_0341) in complex with fructose-6-phosphate | 分子名称: | 6-O-phosphono-beta-D-fructofuranose, Glucose-6-phosphate isomerase, PHOSPHATE ION | 著者 | Gileadi, T, Wernimont, A.K, Hutchinson, A, Weadge, J, Cossar, D, Lew, J, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Hui, R, Hills, T, Pizarro, J.C, Structural Genomics Consortium (SGC) | 登録日 | 2010-11-29 | 公開日 | 2011-02-09 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Crystal structure of Plasmodium falciparum glucose-6-phosphate isomerase (PF14_0341) in complex with fructose-6-phosphate To be Published
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3Q4L
| Structure of a small peptide ligand bound to E.coli DNA sliding clamp | 分子名称: | DNA polymerase III subunit beta, SODIUM ION, peptide ligand | 著者 | Wolff, P, Olieric, V, Briand, J.P, Chaloin, O, Dejaegere, A, Dumas, P, Ennifar, E, Guichard, G, Wagner, J, Burnouf, D. | 登録日 | 2010-12-23 | 公開日 | 2011-12-28 | 最終更新日 | 2013-03-20 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structure-based design of short peptide ligands binding onto the E. coli processivity ring. J.Med.Chem., 54, 2011
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3T29
| TMAO-grown trigonal trypsin (bovine) | 分子名称: | BENZAMIDINE, CALCIUM ION, Cationic trypsin, ... | 著者 | Cahn, J, Venkat, M, Marshall, H, Juers, D. | 登録日 | 2011-07-22 | 公開日 | 2011-12-28 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | The use of trimethylamine N-oxide as a primary precipitating agent and related methylamine osmolytes as cryoprotective agents for macromolecular crystallography. Acta Crystallogr.,Sect.D, 68, 2012
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7L0K
| Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM784 (3-(1-(3-methyl-4-((6-(trifluoromethyl)pyridin-3-yl)methyl)-1H-pyrrole-2-carboxamido)ethyl)-1H-pyrazole-5-carboxamide) | 分子名称: | 3-{(1R)-1-[(3-methyl-4-{[6-(trifluoromethyl)pyridin-3-yl]methyl}-1H-pyrrole-2-carbonyl)amino]ethyl}-1H-pyrazole-5-carboxamide, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... | 著者 | Deng, X, Phillips, M, Tomchick, D. | 登録日 | 2020-12-11 | 公開日 | 2021-05-19 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series. J.Med.Chem., 64, 2021
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