4EYW
Crystal structure of rat carnitine palmitoyltransferase 2 in complex with 1-[(R)-2-(3,4-Dihydro-1H-isoquinoline-2-carbonyl)-piperidin-1-yl]-2-phenoxy-ethanone
Summary for 4EYW
Entry DOI | 10.2210/pdb4eyw/pdb |
Descriptor | Carnitine O-palmitoyltransferase 2, mitochondrial, 1-[(2R)-2-(3,4-dihydroisoquinolin-2(1H)-ylcarbonyl)piperidin-1-yl]-2-phenoxyethanone, HEXAETHYLENE GLYCOL, ... (4 entities in total) |
Functional Keywords | acyltransferase, mitochondrial protein, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Rattus norvegicus (brown rat,rat,rats) |
Cellular location | Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side : P18886 |
Total number of polymer chains | 2 |
Total formula weight | 144387.37 |
Authors | Rudolph, M.G.,Benz, J.,Burger, D.,Thoma, R.,Rufer, A.,Joseph, C. (deposition date: 2012-05-02, release date: 2013-04-24, Last modification date: 2024-04-03) |
Primary citation | Perspicace, S.,Rufer, A.C.,Thoma, R.,Mueller, F.,Hennig, M.,Ceccarelli, S.,Schulz-Gasch, T.,Seelig, J. Isothermal titration calorimetry with micelles: Thermodynamics of inhibitor binding to carnitine palmitoyltransferase 2 membrane protein. FEBS Open Bio, 3:204-211, 2013 Cited by PubMed: 23772395DOI: 10.1016/j.fob.2013.04.003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.885 Å) |
Structure validation
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