3JD3
| Glutamate dehydrogenase in complex with NADH and GTP, open conformation | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, GUANOSINE-5'-TRIPHOSPHATE, Glutamate dehydrogenase 1, ... | 著者 | Borgnia, M.J, Banerjee, S, Merk, A, Matthies, D, Bartesaghi, A, Rao, P, Pierson, J, Earl, L.A, Falconieri, V, Subramaniam, S, Milne, J.L.S. | 登録日 | 2016-03-28 | 公開日 | 2016-04-27 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Using Cryo-EM to Map Small Ligands on Dynamic Metabolic Enzymes: Studies with Glutamate Dehydrogenase. Mol.Pharmacol., 89, 2016
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3J31
| Life in the extremes: atomic structure of Sulfolobus Turreted Icosahedral Virus | 分子名称: | A223 penton base, A55 membrane protein, C381 turret protein, ... | 著者 | Veesler, D, Ng, T.S, Sendamarai, A.K, Eilers, B.J, Lawrence, C.M, Lok, S.M, Young, M.J, Johnson, J.E, Fu, C.-Y. | 登録日 | 2013-02-18 | 公開日 | 2013-05-01 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Atomic structure of the 75 MDa extremophile Sulfolobus turreted icosahedral virus determined by CryoEM and X-ray crystallography. Proc.Natl.Acad.Sci.USA, 110, 2013
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6SZL
| Crystal structure of YTHDC1 with fragment 7 (DHU_DC1_021) | 分子名称: | 6-phenyl-1~{H}-pyrimidine-2,4-dione, SULFATE ION, YTH domain-containing protein 1 | 著者 | Bedi, R.K, Huang, D, Sledz, P, Caflisch, A. | 登録日 | 2019-10-02 | 公開日 | 2020-03-04 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Selectively Disrupting m6A-Dependent Protein-RNA Interactions with Fragments. Acs Chem.Biol., 15, 2020
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6SZQ
| Crystal structure of human DDAH-1 | 分子名称: | N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 | 著者 | Hennig, S, Vetter, I.R, Schade, D. | 登録日 | 2019-10-02 | 公開日 | 2019-12-25 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.412 Å) | 主引用文献 | Discovery ofN-(4-Aminobutyl)-N'-(2-methoxyethyl)guanidine as the First Selective, Nonamino Acid, Catalytic Site Inhibitor of Human Dimethylarginine Dimethylaminohydrolase-1 (hDDAH-1). J.Med.Chem., 63, 2020
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6T09
| Crystal structure of YTHDC1 with fragment 24 (PSI_DC1_003) | 分子名称: | SULFATE ION, YTHDC1, ~{N}-pyridin-3-ylethanamide | 著者 | Bedi, R.K, Huang, D, Sledz, P, Caflisch, A. | 登録日 | 2019-10-02 | 公開日 | 2020-03-04 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Selectively Disrupting m6A-Dependent Protein-RNA Interactions with Fragments. Acs Chem.Biol., 15, 2020
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6SGS
| Cryo-EM structure of Escherichia coli AcrBZ and DARPin in Saposin A-nanodisc | 分子名称: | DARPin, Multidrug efflux pump accessory protein AcrZ, Multidrug efflux pump subunit AcrB | 著者 | Szewczak-Harris, A, Du, D, Newman, C, Neuberger, A, Luisi, B.F. | 登録日 | 2019-08-05 | 公開日 | 2020-05-13 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Interactions of a Bacterial RND Transporter with a Transmembrane Small Protein in a Lipid Environment. Structure, 28, 2020
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6SKO
| Cryo-EM Structure of the Fork Protection Complex Bound to CMG at a Replication Fork - conformation 2 MCM CTD:ssDNA | 分子名称: | DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, DNA replication licensing factor MCM4, ... | 著者 | Yeeles, J, Baretic, D, Jenkyn-Bedford, M. | 登録日 | 2019-08-16 | 公開日 | 2020-05-06 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Cryo-EM Structure of the Fork Protection Complex Bound to CMG at a Replication Fork. Mol.Cell, 78, 2020
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6FCZ
| Model of gC1q-Fc complex based on 7A EM map | 分子名称: | Complement C1q subcomponent subunit A, Complement C1q subcomponent subunit B, Complement C1q subcomponent subunit C, ... | 著者 | Ugurlar, D, Howes, S.C, de Kreuk, B.J.K, de Jong, R.N, Beurskens, F.J, Koster, A.J, Parren, P.W.H.I, Sharp, T.H, Gros, P, Koning, R.I. | 登録日 | 2017-12-21 | 公開日 | 2018-02-28 | 最終更新日 | 2018-10-24 | 実験手法 | ELECTRON MICROSCOPY (10 Å) | 主引用文献 | Structures of C1-IgG1 provide insights into how danger pattern recognition activates complement. Science, 359, 2018
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6SPB
| Pseudomonas aeruginosa 50s ribosome from a clinical isolate with a mutation in uL6 | 分子名称: | 23S ribosomal RNA, 50S ribosomal protein L11, 50S ribosomal protein L13, ... | 著者 | Halfon, Y, Jimenez-Fernande, A, La Ros, R, Espinos, R, Krogh Johansen, H, Matzov, D, Eyal, Z, Bashan, A, Zimmerman, E, Belousoff, M, Molin, S, Yonath, A. | 登録日 | 2019-09-01 | 公開日 | 2019-10-16 | 最終更新日 | 2019-11-06 | 実験手法 | ELECTRON MICROSCOPY (2.82 Å) | 主引用文献 | Structure ofPseudomonas aeruginosaribosomes from an aminoglycoside-resistant clinical isolate. Proc.Natl.Acad.Sci.USA, 116, 2019
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3JRE
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6SPC
| Pseudomonas aeruginosa 30s ribosome from an aminoglycoside resistant clinical isolate | 分子名称: | 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | 著者 | Halfon, Y, Jimenez-Fernande, A, La Ros, R, Espinos, R, Krogh Johansen, H, Matzov, D, Eyal, Z, Bashan, A, Zimmerman, E, Belousoff, M, Molin, S, Yonath, A. | 登録日 | 2019-09-01 | 公開日 | 2019-10-16 | 最終更新日 | 2019-11-06 | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | 主引用文献 | Structure ofPseudomonas aeruginosaribosomes from an aminoglycoside-resistant clinical isolate. Proc.Natl.Acad.Sci.USA, 116, 2019
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3JVC
| Crystal Structure of the Lipoprotein_17 domain from Q9PRA0_UREPA protein of Ureaplasma parvum. Northeast Structural Genomics Consortium Target UuR17a. | 分子名称: | Conserved hypothetical membrane lipoprotein | 著者 | Vorobiev, S, Neely, H, Lee, D, Ciccosanti, C, Mao, L, Xiao, R, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2009-09-16 | 公開日 | 2009-09-29 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | Crystal Structure of the Lipoprotein_17 domain from Q9PRA0_UREPA protein of Ureaplasma parvum. To be Published
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6SRV
| Structure of the arginase-2-inhibitory human antigen-binding fragment Fab C0021144 | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... | 著者 | Burschowsky, D, Addyman, A, Fiedler, S, Groves, M, Haynes, S, Seewooruthun, C, Carr, M. | 登録日 | 2019-09-06 | 公開日 | 2020-06-10 | 最終更新日 | 2020-09-16 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action. Mabs, 12
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4F7B
| Structure of the lysosomal domain of limp-2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Neculai, D, Ravichandran, M, Seitova, A, Neculai, M, Pizzaro, J.C, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Dhe-Paganon, D, Structural Genomics Consortium (SGC) | 登録日 | 2012-05-15 | 公開日 | 2013-10-09 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36. Nature, 504, 2013
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6SRU
| Structure of Ig-like V-type domian of mouse Programmed cell death 1 ligand 1 (PD-L1) | 分子名称: | Programmed cell death 1 ligand 1 | 著者 | Magiera-Mularz, K, Sala, D, Grudnik, P, Holak, T.A. | 登録日 | 2019-09-06 | 公開日 | 2021-02-03 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.532 Å) | 主引用文献 | Human and mouse PD-L1: similar molecular structure, but different druggability profiles. Iscience, 24, 2021
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3JV6
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6SUQ
| Crystal Structure of TcdB2-TccC3-TEV | 分子名称: | TcdB2,TccC3,Genome polyprotein | 著者 | Roderer, D, Schubert, E, Sitsel, O, Raunser, S. | 登録日 | 2019-09-16 | 公開日 | 2019-12-04 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | 主引用文献 | Towards the application of Tc toxins as a universal protein translocation system. Nat Commun, 10, 2019
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3JYQ
| Quinate dehydrogenase from Corynebacterium glutamicum in complex with shikimate and NADH | 分子名称: | (3R,4S,5R)-3,4,5-TRIHYDROXYCYCLOHEX-1-ENE-1-CARBOXYLIC ACID, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Quinate/shikimate dehydrogenase | 著者 | Hoeppner, A, Schomburg, D, Niefind, K. | 登録日 | 2009-09-22 | 公開日 | 2010-10-27 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.16 Å) | 主引用文献 | Enzyme-substrate complexes of the quinate/shikimate dehydrogenase from Corynebacterium glutamicum enable new insights in substrate and cofactor binding, specificity, and discrimination. Biol.Chem., 394, 2013
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6FH7
| Crystal Structure of BAZ2B bromodomain in complex with 1-methylpyridinone compound 2 | 分子名称: | Bromodomain adjacent to zinc finger domain protein 2B, ~{N}-[3-[(4-fluorophenyl)carbonylamino]propyl]-1-methyl-6-oxidanylidene-pyridine-3-carboxamide | 著者 | Dalle Vedove, A, Spiliotopoulos, D, Lolli, G, Caflisch, A. | 登録日 | 2018-01-12 | 公開日 | 2018-05-30 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural Analysis of Small-Molecule Binding to the BAZ2A and BAZ2B Bromodomains. ChemMedChem, 13, 2018
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3JXD
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6FHS
| CryoEM Structure of INO80core | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Arp5, ... | 著者 | Eustermann, S, Schall, K, Kostrewa, D, Strauss, M, Hopfner, K. | 登録日 | 2018-01-15 | 公開日 | 2018-04-25 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.754 Å) | 主引用文献 | Structural basis for ATP-dependent chromatin remodelling by the INO80 complex. Nature, 556, 2018
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6SX5
| Full length Mutant Open-form Sodium Channel NavMs | 分子名称: | DODECAETHYLENE GLYCOL, HEGA-10, Ion transport protein, ... | 著者 | Sula, A, Hollingworth, D, Wallace, B.A. | 登録日 | 2019-09-25 | 公開日 | 2021-02-03 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | A tamoxifen receptor within a voltage-gated sodium channel. Mol.Cell, 81, 2021
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3K1F
| Crystal structure of RNA Polymerase II in complex with TFIIB | 分子名称: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... | 著者 | Kostrewa, D, Zeller, M.E, Armache, K.-J, Seizl, M, Leike, K, Thomm, M, Cramer, P. | 登録日 | 2009-09-27 | 公開日 | 2009-11-10 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (4.3 Å) | 主引用文献 | RNA polymerase II-TFIIB structure and mechanism of transcription initiation. Nature, 462, 2009
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6SXC
| Crystal structure of the Voltage-Gated Sodium Channel NavMs (F208L) in complex with 4-hydroxytamoxifen (2.5 Angstrom resolution) | 分子名称: | 4-HYDROXYTAMOXIFEN, DODECAETHYLENE GLYCOL, HEGA-10, ... | 著者 | Sula, A, Hollingworth, D, Wallace, B.A. | 登録日 | 2019-09-25 | 公開日 | 2021-02-03 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | A tamoxifen receptor within a voltage-gated sodium channel. Mol.Cell, 81, 2021
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6SXF
| Crystal Structure of the Voltage-Gated Sodium Channel NavMs (F208L) in complex with Tamoxifen (2.8 Angstrom resolution) | 分子名称: | (Z)-2-[4-(1,2)-DIPHENYL-1-BUTENYL)-PHENOXY]-N,N-DIMETHYLETHANAMINE, DODECAETHYLENE GLYCOL, HEGA-10, ... | 著者 | Sula, A, Hollingworth, D, Wallace, B.A. | 登録日 | 2019-09-25 | 公開日 | 2021-02-03 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.839 Å) | 主引用文献 | A tamoxifen receptor within a voltage-gated sodium channel. Mol.Cell, 81, 2021
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