7ZZ2
 
 | | Cryo-EM structure of "CT pyr" conformation of Lactococcus lactis pyruvate carboxylase with acetyl-CoA | | 分子名称: | MAGNESIUM ION, MANGANESE (II) ION, PYRUVIC ACID, ... | | 著者 | Lopez-Alonso, J.P, Lazaro, M, Gil, D, Choi, P.H, Tong, L, Valle, M. | | 登録日 | 2022-05-25 | | 公開日 | 2022-10-12 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (2.48 Å) | | 主引用文献 | CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase.
Nat Commun, 13, 2022
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8D2V
 | | Zebrafish MFSD2A isoform B in inward open ligand 1B conformation | | 分子名称: | DODECYL-BETA-D-MALTOSIDE, FAB heavy chain, FAB light chain, ... | | 著者 | Nguyen, C, Lei, H.T, Lai, L.T.F, Gallentino, M.J, Mu, X, Matthies, D, Gonen, T. | | 登録日 | 2022-05-30 | | 公開日 | 2023-05-10 | | 最終更新日 | 2023-05-24 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Lipid flipping in the omega-3 fatty-acid transporter.
Nat Commun, 14, 2023
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7ZZ0
 | | Cryo-EM structure of "CT empty" conformation of Lactococcus lactis pyruvate carboxylase with acetyl-CoA | | 分子名称: | MAGNESIUM ION, MANGANESE (II) ION, Pyruvate carboxylase | | 著者 | Lopez-Alonso, J.P, Lazaro, M, Gil, D, Choi, P.H, Tong, L, Valle, M. | | 登録日 | 2022-05-25 | | 公開日 | 2022-10-12 | | 最終更新日 | 2022-11-02 | | 実験手法 | ELECTRON MICROSCOPY (2.26 Å) | | 主引用文献 | CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase.
Nat Commun, 13, 2022
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4RF3
 | | Crystal Structure of ketoreductase from Lactobacillus kefir, mutant A94F | | 分子名称: | GLYCEROL, MAGNESIUM ION, NADPH dependent R-specific alcohol dehydrogenase | | 著者 | Tang, Y, Tibrewal, N, Cascio, D. | | 登録日 | 2014-09-24 | | 公開日 | 2015-09-30 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.694 Å) | | 主引用文献 | Origins of stereoselectivity in evolved ketoreductases.
Proc.Natl.Acad.Sci.USA, 112, 2015
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8CWK
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4QRG
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7ZYY
 | | Cryo-EM structure of Lactococcus lactis pyruvate carboxylase with acetyl-CoA | | 分子名称: | ACETYL COENZYME *A, ADENOSINE-5'-DIPHOSPHATE, BICARBONATE ION, ... | | 著者 | Lopez-Alonso, J.P, Lazaro, M, Gil, D, Choi, P.H, Tong, L, Valle, M. | | 登録日 | 2022-05-25 | | 公開日 | 2022-10-12 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (2.12 Å) | | 主引用文献 | CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase.
Nat Commun, 13, 2022
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8D02
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4QRV
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7ZZ4
 | | Cryo-EM structure of "BC closed" conformation of Lactococcus lactis pyruvate carboxylase with acetyl-CoA | | 分子名称: | ACETYL COENZYME *A, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Lopez-Alonso, J.P, Lazaro, M, Gil, D, Choi, P.H, Tong, L, Valle, M. | | 登録日 | 2022-05-25 | | 公開日 | 2022-10-12 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (2.63 Å) | | 主引用文献 | CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase.
Nat Commun, 13, 2022
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7C1K
 | | Crystal structure of the starter condensation domain of rhizomide synthetase RzmA mutant R148A | | 分子名称: | Non-ribosomal peptide synthetase modules | | 著者 | Zhong, L, Diao, X, Zhang, N, Li, F.W, Zhou, H.B, Chen, H.N, Ren, X, Zhang, Y, Wu, D, Bian, X. | | 登録日 | 2020-05-04 | | 公開日 | 2020-11-25 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.755 Å) | | 主引用文献 | Engineering and elucidation of the lipoinitiation process in nonribosomal peptide biosynthesis.
Nat Commun, 12, 2021
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5NEN
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7B9O
 | | Crystal structure of Retinoic Acid Receptor alpha (RXRA) in complexed with S169 inhibitor | | 分子名称: | 3-(5-(3,5-bis(trifluoromethyl)phenyl)-4-phenyloxazol-2-yl)propanoic acid, Nuclear receptor coactivator 2, Retinoic acid receptor RXR-alpha | | 著者 | Ni, X, Chaikuad, A, Schierle, S, Merk, D, Knapp, S, Structural Genomics Consortium (SGC) | | 登録日 | 2020-12-14 | | 公開日 | 2021-02-10 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Oxaprozin Analogues as Selective RXR Agonists with Superior Properties and Pharmacokinetics.
J.Med.Chem., 64, 2021
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5NIK
 | | Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump | | 分子名称: | Macrolide export ATP-binding/permease protein MacB, Macrolide export protein MacA, Outer membrane protein TolC | | 著者 | Fitzpatrick, A.W.P, Llabres, S, Neuberger, A, Blaza, J.N, Bai, X.-C, Okada, U, Murakami, S, van Veen, H.W, Zachariae, U, Scheres, S.H.W, Luisi, B.F, Du, D. | | 登録日 | 2017-03-24 | | 公開日 | 2017-05-24 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump.
Nat Microbiol, 2, 2017
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8D2U
 | | Zebrafish MFSD2A isoform B in inward open ligand 1A conformation | | 分子名称: | DODECYL-BETA-D-MALTOSIDE, FAB heavy chain, FAB light chain, ... | | 著者 | Nguyen, C, Lei, H.T, Lai, L.T.F, Gallentino, M.J, Mu, X, Matthies, D, Gonen, T. | | 登録日 | 2022-05-30 | | 公開日 | 2023-05-10 | | 最終更新日 | 2023-05-24 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Lipid flipping in the omega-3 fatty-acid transporter.
Nat Commun, 14, 2023
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7ZXK
 | | Human IL-27 in complex with neutralizing SRF388 FAb fragment | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-27 subunit alpha, Interleukin-27 subunit beta, ... | | 著者 | Bloch, Y, Skladanowska, K, Strand, J, Welin, M, Logan, D, Hill, J, Savvides, S.N. | | 登録日 | 2022-05-21 | | 公開日 | 2022-11-02 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural basis of activation and antagonism of receptor signaling mediated by interleukin-27.
Cell Rep, 41, 2022
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5NK5
 | | Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 1m | | 分子名称: | 2-[[3-[(3-aminophenyl)carbamoyl]phenyl]amino]-~{N}-(2-chloranyl-6-methyl-phenyl)-1,3-thiazole-5-carboxamide, Ephrin type-A receptor 2 | | 著者 | Kudlinzki, D, Linhard, V.L, Witt, K, Gande, S.L, Saxena, K, Heinzlmeir, S, Medard, G, Kuester, B, Schwalbe, H. | | 登録日 | 2017-03-31 | | 公開日 | 2017-06-07 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.329 Å) | | 主引用文献 | Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors.
ChemMedChem, 12, 2017
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5NKD
 | | Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 2i | | 分子名称: | 1,2-ETHANEDIOL, 2-[(3~{R})-1-[3-[[5-[(2-chloranyl-6-methyl-phenyl)carbamoyl]-1,3-thiazol-2-yl]amino]phenyl]carbonylpyrrolidin-3-yl]ethanoic acid, Ephrin type-A receptor 2 | | 著者 | Kudlinzki, D, Linhard, V.L, Witt, K, Gande, S.L, Saxena, K, Heinzlmeir, S, Medard, G, Kuester, B, Schwalbe, H. | | 登録日 | 2017-03-31 | | 公開日 | 2017-06-07 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.408 Å) | | 主引用文献 | Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors.
ChemMedChem, 12, 2017
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8D2S
 | | Zebrafish MFSD2A isoform B in inward open ligand bound conformation | | 分子名称: | DODECYL-BETA-D-MALTOSIDE, FAB heavy chain, FAB light chain, ... | | 著者 | Nguyen, C, Lei, H.T, Lai, L.T.F, Gallentino, M.J, Mu, X, Matthies, D, Gonen, T. | | 登録日 | 2022-05-30 | | 公開日 | 2023-05-10 | | 最終更新日 | 2023-05-24 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Lipid flipping in the omega-3 fatty-acid transporter.
Nat Commun, 14, 2023
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5NMW
 | | Crystal Structure of the pyrrolizidine alkaloid N-oxygenase from Zonocerus variegatus in complex with FAD | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Flavin-containing monooxygenase, MAGNESIUM ION | | 著者 | Scheidig, A, Kubitza, C, Faust, A, Ober, D. | | 登録日 | 2017-04-07 | | 公開日 | 2018-03-14 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | | 主引用文献 | Crystal structure of pyrrolizidine alkaloid N-oxygenase from the grasshopper Zonocerus variegatus.
Acta Crystallogr D Struct Biol, 74, 2018
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5NGM
 | | 2.9S structure of the 70S ribosome composing the S. aureus 100S complex | | 分子名称: | 16S ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Matzov, D, Aibara, S, Zimmerman, E, Bashan, A, Amunts, A, Yonath, A. | | 登録日 | 2017-03-18 | | 公開日 | 2017-10-04 | | 最終更新日 | 2018-11-28 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | The cryo-EM structure of hibernating 100S ribosome dimer from pathogenic Staphylococcus aureus.
Nat Commun, 8, 2017
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6ZXJ
 | | Fully-loaded anthrax lethal toxin in its heptameric pre-pore state, in which the third lethal factor is masked out (PA7LF3-masked) | | 分子名称: | Lethal factor, Protective antigen | | 著者 | Quentin, D, Antoni, C, Gatsogiannis, C, Raunser, S. | | 登録日 | 2020-07-29 | | 公開日 | 2020-09-02 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Cryo-EM structure of the fully-loaded asymmetric anthrax lethal toxin in its heptameric pre-pore state.
Plos Pathog., 16, 2020
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8D2W
 | | Zebrafish MFSD2A isoform B in inward open ligand 2B conformation | | 分子名称: | DODECYL-BETA-D-MALTOSIDE, FAB heavy chain, FAB light chain, ... | | 著者 | Nguyen, C, Lei, H.T, Lai, L.T.F, Gallentino, M.J, Mu, X, Matthies, D, Gonen, T. | | 登録日 | 2022-05-30 | | 公開日 | 2023-05-10 | | 最終更新日 | 2023-05-24 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Lipid flipping in the omega-3 fatty-acid transporter.
Nat Commun, 14, 2023
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5NG5
 | | multi-drug efflux; membrane transport; RND superfamily; Drug resistance | | 分子名称: | 6-[2-(3,4-dimethoxyphenyl)ethylsulfanyl]-8-[4-(2-methoxyethyl)piperazin-1-yl]-3,3-dimethyl-1,4-dihydropyrano[3,4-c]pyridine-5-carbonitrile, Multidrug efflux pump accessory protein AcrZ, Multidrug efflux pump subunit AcrA, ... | | 著者 | Wang, Z, Fan, G, Hryc, C.F, Blaza, J.N, Serysheva, I.I, Schmid, M.F, Chiu, W, Luisi, B.F, Du, D. | | 登録日 | 2017-03-16 | | 公開日 | 2017-04-19 | | 最終更新日 | 2017-08-02 | | 実験手法 | ELECTRON MICROSCOPY (6.5 Å) | | 主引用文献 | An allosteric transport mechanism for the AcrAB-TolC Multidrug Efflux Pump.
Elife, 6, 2017
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8D2T
 | | Zebrafish MFSD2A isoform B in inward open ligand-free conformation | | 分子名称: | DODECYL-BETA-D-MALTOSIDE, FAB heavy chain, FAB light chain, ... | | 著者 | Nguyen, C, Lei, H.T, Lai, L.T.F, Gallentino, M.J, Mu, X, Matthies, D, Gonen, T. | | 登録日 | 2022-05-30 | | 公開日 | 2023-05-10 | | 最終更新日 | 2023-05-24 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Lipid flipping in the omega-3 fatty-acid transporter.
Nat Commun, 14, 2023
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