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PDB: 53012 results

7U4W
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BU of 7u4w by Molmil
The ubiquitin-associated domain of human thirty-eight negative kinase-1 flexibly fused to the 1TEL crystallization chaperone via a 2-glycine linker and crystallized at traditional protein concentration
Descriptor: Transcription factor ETV6,Non-receptor tyrosine-protein kinase TNK1
Authors:Nawarathnage, S, Pedroza Romo, M.J, Smith, T, Bunn, D, Stewart, C, Doukov, T, Moody, J.D.
Deposit date:2022-03-01
Release date:2023-03-08
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Fusion crystallization reveals the behavior of both the 1TEL crystallization chaperone and the TNK1 UBA domain.
Structure, 31, 2023
8ANA
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BU of 8ana by Molmil
Cryo-EM structure of the proline-rich antimicrobial peptide drosocin bound to the 50S ribosomal subunit
Descriptor: 2-acetamido-2-deoxy-alpha-D-galactopyranose, 23S ribosomal RNA, 50S ribosomal protein L13, ...
Authors:Koller, T.O, Morici, M, Wilson, D.N.
Deposit date:2022-08-05
Release date:2023-03-08
Last modified:2023-09-06
Method:ELECTRON MICROSCOPY (2.1 Å)
Cite:Structural basis for translation inhibition by the glycosylated drosocin peptide.
Nat.Chem.Biol., 19, 2023
5L6S
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BU of 5l6s by Molmil
Crystal structure of E. coli ADP-glucose pyrophosphorylase (AGPase) in complex with a positive allosteric regulator beta-fructose-1,6-diphosphate (FBP) - AGPase*FBP
Descriptor: 1,6-di-O-phosphono-beta-D-fructofuranose, Glucose-1-phosphate adenylyltransferase, SULFATE ION
Authors:Cifuente, J.O, Albesa-Jove, D, Comino, N, Madariaga-Marcos, J, Agirre, J, Lopez-Fernandez, S, Garcia-Alija, M, Guerin, M.E.
Deposit date:2016-05-31
Release date:2016-09-07
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.04 Å)
Cite:Structural Basis of Glycogen Biosynthesis Regulation in Bacteria.
Structure, 24, 2016
4YW2
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BU of 4yw2 by Molmil
Crystal Structure of Streptococcus pneumoniae NanC, complex 6'SL
Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose, ...
Authors:Owen, C.D, Lukacik, P, Potter, J.A, Walsh, M, Taylor, G.L.
Deposit date:2015-03-20
Release date:2015-09-23
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Streptococcus pneumoniae NanC: STRUCTURAL INSIGHTS INTO THE SPECIFICITY AND MECHANISM OF A SIALIDASE THAT PRODUCES A SIALIDASE INHIBITOR.
J.Biol.Chem., 290, 2015
6G31
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BU of 6g31 by Molmil
Crystal structure of human geranylgeranyl diphosphate synthase mutant D188Y bound to zoledronate
Descriptor: Geranylgeranyl pyrophosphate synthase, MAGNESIUM ION, ZOLEDRONIC ACID
Authors:Lisnyansky, M, Kapelushnik, N, Ben-Bassat, A, Marom, M, Loewenstein, A, Khananshvili, D, Giladi, M, Haitin, Y.
Deposit date:2018-03-24
Release date:2018-10-17
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3 Å)
Cite:Reduced Activity of Geranylgeranyl Diphosphate Synthase Mutant Is Involved in Bisphosphonate-Induced Atypical Fractures.
Mol. Pharmacol., 94, 2018
8PVZ
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BU of 8pvz by Molmil
Manganese-dependent transcriptional repressor DR2539 complexed with cadmium
Descriptor: CADMIUM ION, Iron dependent repressor, putative
Authors:Mota, C, De Sanctis, D.
Deposit date:2023-07-18
Release date:2024-05-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Metal ion activation and DNA recognition by the Deinococcus radiodurans manganese sensor DR2539.
Febs J., 2024
5NLX
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BU of 5nlx by Molmil
A2A Adenosine receptor room-temperature structure determined by serial millisecond crystallography
Descriptor: 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, CHOLESTEROL, ...
Authors:Weinert, T, Cheng, R, James, D, Gashi, D, Nogly, P, Jaeger, K, Dore, A.S, Geng, T, Cooke, R, Hennig, M, Standfuss, J.
Deposit date:2017-04-05
Release date:2017-09-27
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons.
Nat Commun, 8, 2017
5NMG
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BU of 5nmg by Molmil
868 TCR in complex with HLA A02 presenting SLYFNTIAVL
Descriptor: 1,2-ETHANEDIOL, Beta-2-microglobulin, GLYCEROL, ...
Authors:Rizkallah, P.J, Cole, D.K, Fuller, A, Sewell, A.K.
Deposit date:2017-04-05
Release date:2017-11-15
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Dual Molecular Mechanisms Govern Escape at Immunodominant HLA A2-Restricted HIV Epitope.
Front Immunol, 8, 2017
6G2U
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BU of 6g2u by Molmil
Crystal structure of the human glutamate dehydrogenase 2 (hGDH2)
Descriptor: CHLORIDE ION, Glutamate dehydrogenase 2, mitochondrial, ...
Authors:Fadouloglou, V.F, Dimovasili, C, Providaki, M, Kotsifaki, D, Sarrou, I, Plaitakis, A, Zaganas, I, Kokkinidis, M.
Deposit date:2018-03-23
Release date:2019-04-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.934287 Å)
Cite:Crystal structure of glutamate dehydrogenase 2, a positively selected novel human enzyme involved in brain biology and cancer pathophysiology.
J.Neurochem., 2021
6D4M
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BU of 6d4m by Molmil
Crystal Structure of a Fc Fragment of Rhesus macaque (Macaca mulatta) IgG3
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Fc fragment of IgG3
Authors:Gohain, N, Tolbert, W.D, Pazgier, M.
Deposit date:2018-04-18
Release date:2019-05-01
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.47 Å)
Cite:From Rhesus macaque to human: structural evolutionary pathways for immunoglobulin G subclasses.
Mabs, 11, 2019
6GJ8
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BU of 6gj8 by Molmil
CRYSTAL STRUCTURE OF KRAS G12D (GPPCP) IN COMPLEX WITH BI 2852
Descriptor: (3~{S})-3-[2-[[[1-[(1-methylimidazol-4-yl)methyl]indol-6-yl]methylamino]methyl]-1~{H}-indol-3-yl]-5-oxidanyl-2,3-dihydroisoindol-1-one, GTPase KRas, MAGNESIUM ION, ...
Authors:Kessler, D, Mcconnell, D.M, Mantoulidis, A.
Deposit date:2018-05-16
Release date:2019-07-31
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Drugging an undruggable pocket on KRAS.
Proc.Natl.Acad.Sci.USA, 116, 2019
7LSA
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BU of 7lsa by Molmil
Ruminococcus bromii Amy12 with maltoheptaose
Descriptor: CALCIUM ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Koropatkin, N.M, Cockburn, D.W, Brown, H.A, Kibler, R.D.
Deposit date:2021-02-18
Release date:2021-07-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Structure and substrate recognition by the Ruminococcus bromii amylosome pullulanases.
J.Struct.Biol., 213, 2021
7LST
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BU of 7lst by Molmil
Ruminococcus bromii Amy12-D392A with 63-a-D-glucosyl-maltotriosyl-maltotriose
Descriptor: ACETATE ION, CALCIUM ION, GLYCEROL, ...
Authors:Koropatkin, N.M, Cockburn, D.W, Brown, H.A, Kibler, R.D.
Deposit date:2021-02-18
Release date:2021-07-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure and substrate recognition by the Ruminococcus bromii amylosome pullulanases.
J.Struct.Biol., 213, 2021
6GOS
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BU of 6gos by Molmil
E. coli Microcin synthetase McbBCD complex with pro-MccB17 bound
Descriptor: 1,2-ETHANEDIOL, Bacteriocin microcin B17, CHLORIDE ION, ...
Authors:Ghilarov, D, Stevenson, C.E.M, Travin, D.Y, Piskunova, J, Serebryakova, M, Maxwell, A, Lawson, D.M, Severinov, K.
Deposit date:2018-06-04
Release date:2019-01-30
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Architecture of Microcin B17 Synthetase: An Octameric Protein Complex Converting a Ribosomally Synthesized Peptide into a DNA Gyrase Poison.
Mol. Cell, 73, 2019
6T8W
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BU of 6t8w by Molmil
Complement factor B in complex with (-)-4-(1-((5,7-Dimethyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic acid
Descriptor: 5,7-dimethyl-4-[[(2~{S})-2-phenylpiperidin-1-yl]methyl]-1~{H}-indole, Complement factor B, SULFATE ION, ...
Authors:Mainolfi, N, Ehara, T, Karki, R.G, Anderson, K, Sweeney, A.M, Wiesmann, C, Adams, C, Mainolfi, N, Liao, S.M, Argikar, U.A, Jendza, K, Zhang, C, Powers, J, Klosowski, D.W, Crowley, M, Kawanami, T, Ding, J, April, M, Forster, C, Wu, M.S, Capparelli, M, Ramqaj, R, Solovay, C, Cumin, F, Smith, T.M, Ferrara, L, Lee, W, Long, D, Prentiss, M, Erkenez, A.D, Yang, L, Fang, L, Sellner, H, Sirockin, F, Valeur, E, Erbel, P, Ramage, P, Gerhartz, B, Schubart, A, Flohr, S, Gradoux, N, Feifel, R, Vogg, B, Wiesmann, C, Maibaum, J, Eder, J, Sedrani, R, Harrison, R.A, Mogi, M, Jaffee, B.D, Adams, C.M.
Deposit date:2019-10-25
Release date:2020-03-04
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases.
J.Med.Chem., 63, 2020
7LSU
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BU of 7lsu by Molmil
Ruminococcus bromii Amy12-D392A with 63-a-D-glucosyl-maltotriose
Descriptor: ACETATE ION, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Koropatkin, N.M, Cockburn, D.W, Brown, H.A, Kibler, R.D.
Deposit date:2021-02-18
Release date:2021-07-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure and substrate recognition by the Ruminococcus bromii amylosome pullulanases.
J.Struct.Biol., 213, 2021
7LSR
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BU of 7lsr by Molmil
Ruminococcus bromii Amy12-D392A with maltoheptaose
Descriptor: CALCIUM ION, GLYCEROL, Pullulanase, ...
Authors:Koropatkin, N.M, Cockburn, D.W, Brown, H.A, Kibler, R.D.
Deposit date:2021-02-18
Release date:2021-07-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Structure and substrate recognition by the Ruminococcus bromii amylosome pullulanases.
J.Struct.Biol., 213, 2021
5L8G
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BU of 5l8g by Molmil
Crystal structure of Rhodospirillum rubrum Rru_A0973 mutant H65A
Descriptor: CALCIUM ION, Uncharacterized protein
Authors:He, D, Hughes, S, Vanden-Hehir, S, Georgiev, A, Altenbach, K, Tarrant, E, Mackay, C.L, Waldron, K.J, Clarke, D.J, Marles-Wright, J.
Deposit date:2016-06-07
Release date:2016-08-31
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.974 Å)
Cite:Structural characterization of encapsulated ferritin provides insight into iron storage in bacterial nanocompartments.
Elife, 5, 2016
8ARC
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BU of 8arc by Molmil
Heterologous Complex of Aeromonas hydrophila Type III secretion substrate AscX with Photorhabdus luminescens subsp. laumondii LscY
Descriptor: AscX, BROMIDE ION, Type III secretion protein SctY
Authors:Gilzer, D, Niemann, H.H.
Deposit date:2022-08-16
Release date:2023-04-26
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The type III secretion chaperone SctY may shield the hydrophobic export gate-binding C-terminus of its substrate SctX.
Acta Crystallogr D Struct Biol, 79, 2023
4Z0N
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BU of 4z0n by Molmil
Crystal Structure of a Periplasmic Solute binding protein (IPR025997) from Streptobacillus moniliformis DSM-12112 (Smon_0317, TARGET EFI-511281) with bound D-Galactose
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, CALCIUM ION, ...
Authors:Yadava, U, Vetting, M.W, Al Obaidi, N.F, Toro, R, Morisco, L.L, Benach, J, Koss, J, Wasserman, S.R, Attonito, J.D, Scott Glenn, A, Chamala, S, Chowdhury, S, Lafleur, J, Love, J, Seidel, R.D, Whalen, K.L, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI)
Deposit date:2015-03-26
Release date:2015-04-15
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.26 Å)
Cite:Crystal Structure of a Periplasmic Solute binding protein (IPR025997) from Streptobacillus moniliformis DSM-12112 (Smon_0317, TARGET EFI-511281) with bound D-Galactose
To be published
6D58
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BU of 6d58 by Molmil
Crystal structure of a Fc fragment of Human IgG3
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoglobulin heavy constant gamma 3
Authors:Gohain, N, Tolbert, W.D, Pazgier, M.
Deposit date:2018-04-19
Release date:2019-05-15
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Crystal structure of a Fc fragment of Human IgG3.
To Be Published
6TDH
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BU of 6tdh by Molmil
Crystal structure of Aspergillus fumigatus Glucosamine-6-phosphate N-acetyltransferase 1 in complex with compound 1
Descriptor: 3-(2-chlorophenyl)-4~{H}-1,2,4-triazole, ACETYL COENZYME *A, Glucosamine 6-phosphate N-acetyltransferase
Authors:Raimi, O.G, Stanley, M, Lockhart, D.
Deposit date:2019-11-08
Release date:2020-04-29
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Targeting a critical step in fungal hexosamine biosynthesis.
J.Biol.Chem., 295, 2020
5L8C
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BU of 5l8c by Molmil
Crystal structure of T. brucei PDE-B1 catalytic domain with inhibitor NPD-039
Descriptor: 4-[5-[(4~{a}~{R},8~{a}~{S})-4-oxidanylidene-3-propan-2-yl-4~{a},5,8,8~{a}-tetrahydrophthalazin-1-yl]-2-methoxy-phenyl]-~{N}-(2-azanyl-2-oxidanylidene-ethyl)benzamide, DI(HYDROXYETHYL)ETHER, FORMIC ACID, ...
Authors:Singh, A.K, Anthonyrajah, E.S, Brown, D.G.
Deposit date:2016-06-07
Release date:2018-03-14
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity.
J. Med. Chem., 61, 2018
7KY7
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BU of 7ky7 by Molmil
Structure of the S. cerevisiae phosphatidylcholine flippase Dnf2-Lem3 complex in the apo E1 state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alkylphosphocholine resistance protein LEM3, CHOLESTEROL, ...
Authors:Bai, L, You, Q, Jain, B.K, Duan, H.D, Kovach, A, Graham, T.R, Li, H.
Deposit date:2020-12-07
Release date:2021-01-06
Method:ELECTRON MICROSCOPY (3.08 Å)
Cite:Transport mechanism of P4 ATPase phosphatidylcholine flippases.
Elife, 9, 2020
6TKG
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BU of 6tkg by Molmil
Tsetse thrombin inhibitor in complex with human alpha-thrombin - orthorhombic form at 12keV
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Prothrombin, ...
Authors:Calisto, B.M, Ripoll-Rozada, J, de Sanctis, D, Pereira, P.J.B.
Deposit date:2019-11-28
Release date:2020-11-04
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Sulfotyrosine-Mediated Recognition of Human Thrombin by a Tsetse Fly Anticoagulant Mimics Physiological Substrates.
Cell Chem Biol, 28, 2021

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數據於2024-07-31公開中

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