6TKG

Tsetse thrombin inhibitor in complex with human alpha-thrombin - orthorhombic form at 12keV

Summary for 6TKG

Entry DOI	10.2210/pdb6tkg/pdb
Descriptor	Prothrombin, Tsetse thrombin inhibitor, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywords	anticoagulant tyrosine sulfation posttranslational modification complex, blood clotting
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	40175.79
Authors	Calisto, B.M.,Ripoll-Rozada, J.,de Sanctis, D.,Pereira, P.J.B. (deposition date: 2019-11-28, release date: 2020-11-04, Last modification date: 2024-01-24)
Primary citation	Calisto, B.M.,Ripoll-Rozada, J.,Dowman, L.J.,Franck, C.,Agten, S.M.,Parker, B.L.,Veloso, R.C.,Vale, N.,Gomes, P.,de Sanctis, D.,Payne, R.J.,Pereira, P.J.B. Sulfotyrosine-Mediated Recognition of Human Thrombin by a Tsetse Fly Anticoagulant Mimics Physiological Substrates. Cell Chem Biol, 28:26-, 2021 Cited by PubMed: 33096052 DOI: 10.1016/j.chembiol.2020.10.002 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.35 Å)

Structure validation