2M68
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2m68 by Molmil](/molmil-images/mine/2m68) | NMR solution structure ensemble of 3-4D mutant domain 11 IGF2R in complex with IGF2 (domain 11 structure only) | Descriptor: | Insulin-like growth factor 2 receptor variant | Authors: | Strickland, M, Williams, C, Richards, E, Minnall, L, Crump, M.P, Frago, S, Hughes, J, Garner, L, Hoppe, H, Rezgui, D, Zaccheo, O.J, Prince, S.N, Hassan, A.B, Whittaker, S. | Deposit date: | 2013-03-27 | Release date: | 2014-10-15 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist. Proc.Natl.Acad.Sci.USA, 113, 2016
|
|
2L29
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2l29 by Molmil](/molmil-images/mine/2l29) | Complex structure of E4 mutant human IGF2R domain 11 bound to IGF-II | Descriptor: | Insulin-like growth factor 2 receptor variant, Insulin-like growth factor II | Authors: | Williams, C, Hoppe, H, Rezgui, D, Strickland, M, Frago, S, Ellis, R.Z, Wattana-Amorn, P, Prince, S.N, Zaccheo, O.J, Forbes, B, Jones, E.Y, Crump, M.P, Hassan, A.B. | Deposit date: | 2010-08-13 | Release date: | 2012-02-15 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution. Science, 338, 2012
|
|
2WDS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2wds by Molmil](/molmil-images/mine/2wds) | Crystal structure of the Streptomyces coelicolor H110A AcpS mutant in complex with cofactor CoA at 1.3 A | Descriptor: | COENZYME A, HOLO-[ACYL-CARRIER-PROTEIN] SYNTHASE, MAGNESIUM ION | Authors: | Dall'Aglio, P, Arthur, C, Crump, M.P, Crosby, J, Hadfield, A.T. | Deposit date: | 2009-03-26 | Release date: | 2010-04-21 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Analysis of Streptomyces Coelicolor Phosphopantetheinyl Transferase, Acps, Reveals the Basis for Relaxed Substrate Specificity. Biochemistry, 50, 2011
|
|
2WDY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2wdy by Molmil](/molmil-images/mine/2wdy) | Crystal structure of the Streptomyces coelicolor D111A AcpS mutant in complex with cofactor CoA at 1.4 A | Descriptor: | COENZYME A, HOLO-[ACYL-CARRIER-PROTEIN] SYNTHASE, MAGNESIUM ION, ... | Authors: | Dall'Aglio, P, Arthur, C, Crump, M.P, Crosby, J, Hadfield, A.T. | Deposit date: | 2009-03-27 | Release date: | 2010-04-21 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Analysis of Streptomyces Coelicolor Phosphopantetheinyl Transferase, Acps, Reveals the Basis for Relaxed Substrate Specificity. Biochemistry, 50, 2011
|
|
2WDO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2wdo by Molmil](/molmil-images/mine/2wdo) | Crystal structure of the S. coelicolor AcpS in complex with acetyl- CoA at 1.5 A | Descriptor: | ACETYL COENZYME *A, COENZYME A, GLYCEROL, ... | Authors: | Dall'Aglio, P, Arthur, C, Crump, M.P, Crosby, J, Hadfield, A.T. | Deposit date: | 2009-03-25 | Release date: | 2010-04-21 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Analysis of Streptomyces Coelicolor Phosphopantetheinyl Transferase, Acps, Reveals the Basis for Relaxed Substrate Specificity. Biochemistry, 50, 2011
|
|
2L21
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2l21 by Molmil](/molmil-images/mine/2l21) | chicken IGF2R domain 11 | Descriptor: | Cation-independent mannose-6-phosphate receptor | Authors: | Williams, C, Hoppe, H, Strickland, M, Frago, S, Ellis, R.Z, Wattana-Amorn, P, Prince, S.N, Zaccheo, O.J, Forbes, B, Jones, E.Y, Rezgui, D.Z, Crump, M.P, Hassan, A.B. | Deposit date: | 2010-08-10 | Release date: | 2012-02-15 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | CD loop dependency of the IGF2: M6P/IGF2 receptor binding interaction predates imprinting To be Published
|
|
2L2G
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2l2g by Molmil](/molmil-images/mine/2l2g) | Solution structure of Opossum Domain 11 | Descriptor: | IGF2R DOMAIN 11 | Authors: | Williams, C, Hoppe, H, Rezgui, D, Rezgui, M, Frago, S, Ellis, R.Z, Wattana-Amorn, P, Prince, S.N, Zaccheo, O.J, Forbes, B, Jones, E.Y, Crump, M.P, Bassim, A.H. | Deposit date: | 2010-08-18 | Release date: | 2012-02-15 | Last modified: | 2015-02-25 | Method: | SOLUTION NMR | Cite: | An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution. Science, 338, 2012
|
|
1EL0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1el0 by Molmil](/molmil-images/mine/1el0) | SOLUTION STRUCTURE OF THE HUMAN CC CHEMOKINE, I-309 | Descriptor: | I-309 | Authors: | Keizer, D.W, Crump, M.P, Lee, T.W, Slupsky, C.M, Clark-Lewis, I, Sykes, B.D. | Deposit date: | 2000-03-11 | Release date: | 2000-09-01 | Last modified: | 2022-02-16 | Method: | SOLUTION NMR | Cite: | Human CC chemokine I-309, structural consequences of the additional disulfide bond. Biochemistry, 39, 2000
|
|
4CRP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4crp by Molmil](/molmil-images/mine/4crp) | Solution structure of a TrkAIg2 domain construct for use in drug discovery | Descriptor: | HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR | Authors: | Shoemark, D.K, Fahey, M, Williams, C, Sessions, R.B, Crump, M.P, Allen-Birt, S.J. | Deposit date: | 2014-02-28 | Release date: | 2015-01-14 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Design and Nuclear Magnetic Resonance (NMR) Structure Determination of the Second Extracellular Immunoglobulin Tyrosine Kinase a (Trkaig2) Domain Construct for Binding Site Elucidation in Drug Discovery J.Med.Chem., 58, 2015
|
|
6GWX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6gwx by Molmil](/molmil-images/mine/6gwx) | Stabilising and Understanding a Miniprotein by Rational Design. | Descriptor: | Optimised PPa-TYR | Authors: | Porter Goff, K.L, Williams, C, Baker, E.G, Nicol, D, Samphire, J.L, Zieleniewski, F.L, Crump, M.P, Woolfson, D.N. | Deposit date: | 2018-06-26 | Release date: | 2019-07-10 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Stabilizing and Understanding a Miniprotein by Rational Redesign. Biochemistry, 58, 2019
|
|
2L2A
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2l2a by Molmil](/molmil-images/mine/2l2a) | Mutated Domain 11 of the Cytoplasmic region of the Cation-independent mannose-6-phosphate receptor | Descriptor: | Insulin-like growth factor 2 receptor variant | Authors: | Williams, C, Hoppe, H, Rezgui, D, Strickland, M, Frago, S, Ellis, R.Z, Wattana-Amorn, P, Prince, S.N, Zaccheo, O.J, Forbes, B, Jones, E.Y, Crump, M.P, Hassan, A.B. | Deposit date: | 2010-08-13 | Release date: | 2012-02-15 | Last modified: | 2012-12-12 | Method: | SOLUTION NMR | Cite: | An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution. Science, 338, 2012
|
|
2LP8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2lp8 by Molmil](/molmil-images/mine/2lp8) | SOLUTION STRUCTURE OF AN APOPTOSIS ACTIVATING PHOTOSWITCHABLE BAK PEPTIDE BOUND to BCL-XL | Descriptor: | 3,3'-(E)-diazene-1,2-diylbis{6-[(chloroacetyl)amino]benzenesulfonic acid}, Bcl-2 homologous antagonist/killer, Bcl-2-like protein 1 | Authors: | Wysoczanski, P, Mart, R.J, Loveridge, J.E, Williams, C, Whittaker, S.B.-M, Crump, M.P, Allemann, R.K. | Deposit date: | 2012-02-03 | Release date: | 2012-04-18 | Last modified: | 2021-08-18 | Method: | SOLUTION NMR | Cite: | NMR Solution Structure of a Photoswitchable Apoptosis Activating Bak Peptide Bound to Bcl-x(L). J.Am.Chem.Soc., 134, 2012
|
|
2LPC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2lpc by Molmil](/molmil-images/mine/2lpc) | NMR STRUCTURE of Bcl-XL | Descriptor: | Bcl-2-like protein 1 | Authors: | Wysoczanski, P, Mart, R.J, Loveridge, J.E, Williams, C, Whittaker, S.B.-M, Crump, M.P, Allemann, R.K. | Deposit date: | 2012-02-09 | Release date: | 2012-03-21 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | NMR Solution Structure of a Photoswitchable Apoptosis Activating Bak Peptide Bound to Bcl-x(L). J.Am.Chem.Soc., 134, 2012
|
|
1NQ4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1nq4 by Molmil](/molmil-images/mine/1nq4) | Solution Structure of Oxytetracycline Acyl Carrier Protein | Descriptor: | Oxytetracycline polyketide synthase acyl carrier protein | Authors: | Findlow, S.C, Winsor, C, Simpson, T.J, Crosby, J, Crump, M.P. | Deposit date: | 2003-01-21 | Release date: | 2003-11-04 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure and dynamics of oxytetracycline polyketide synthase acyl carrier protein from Streptomyces rimosus Biochemistry, 42, 2003
|
|
2CNR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2cnr by Molmil](/molmil-images/mine/2cnr) | |
2L22
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2l22 by Molmil](/molmil-images/mine/2l22) | Mupirocin didomain ACP | Descriptor: | Mupirocin didomain Acyl Carrier Protein | Authors: | Dong, X, Williams, C, Crump, M.P, Wattana-amorn, P. | Deposit date: | 2010-08-10 | Release date: | 2012-02-15 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | A conserved motif flags acyl carrier proteins for beta-branching in polyketide synthesis. Nat.Chem.Biol., 9, 2013
|
|
2MVU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2mvu by Molmil](/molmil-images/mine/2mvu) | Solution Structure of the 3,7-dioxo-octyl Actinorhodin Acyl Carrier Protein from Streptomyces coelicolor | Descriptor: | Actinorhodin polyketide synthase acyl carrier protein, N~3~-{(2S)-4-[(dihydroxyphosphanyl)oxy]-2-hydroxy-3,3-dimethylbutanoyl}-N-{2-[(3,7-dioxooctyl)sulfanyl]ethyl}-beta-alaninamide | Authors: | Dong, X, Bailey, C, Williams, C, Crosby, J, Simpson, T.J, Willis, C.L, Crump, M.P. | Deposit date: | 2014-10-15 | Release date: | 2015-10-21 | Method: | SOLUTION NMR | Cite: | ACP-ligand recognition: Selection of derivatized aromatic biosynthetic intermediates To be Published
|
|
1GVW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1gvw by Molmil](/molmil-images/mine/1gvw) | Endothiapepsin complex with PD-130,328 | Descriptor: | ENDOTHIAPEPSIN, N-(tert-butoxycarbonyl)-L-phenylalanyl-N-{(1S)-1-[(R)-hydroxy(2-{[(2S)-2-methylbutyl]amino}-2-oxoethyl)phosphoryl]-3-methylbutyl}-3-(1H-imidazol-3-ium-4-yl)-L-alaninamide, SULFATE ION | Authors: | Coates, L, Erskine, P.T, Crump, M.P, Wood, S.P, Cooper, J.B. | Deposit date: | 2002-02-27 | Release date: | 2002-07-04 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | Five Atomic Resolution Structures of Endothiapepsin Inhibitor Complexes: Implications for the Aspartic Proteinase Mechanism J.Mol.Biol., 318, 2002
|
|
1GVV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1gvv by Molmil](/molmil-images/mine/1gvv) | Five Atomic Resolution Structures of Endothiapepsin Inhibitor Complexes; implications for the Aspartic Proteinase Mechanism | Descriptor: | ENDOTHIAPEPSIN, N-[(5S,9S,10S,13S)-9-hydroxy-5,10-bis(2-methylpropyl)-4,7,12,16-tetraoxo-3,6,11,17-tetraazabicyclo[17.3.1]tricosa-1(23),19,21-trien-13-yl]-3-(naphthalen-1-yl)-2-(naphthalen-1-ylmethyl)propanamide, SULFATE ION | Authors: | Coates, L, Erskine, P.T, Crump, M.P, Wood, S.P, Cooper, J.B. | Deposit date: | 2002-02-27 | Release date: | 2002-07-04 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.05 Å) | Cite: | Five Atomic Resolution Structures of Endothiapepsin Inhibitor Complexes: Implications for the Aspartic Proteinase Mechanism J.Mol.Biol., 318, 2002
|
|
1GVT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1gvt by Molmil](/molmil-images/mine/1gvt) | Endothiapepsin complex with CP-80,794 | Descriptor: | ENDOTHIAPEPSIN, N-(morpholin-4-ylcarbonyl)-L-phenylalanyl-N-[(1R,2S)-1-(cyclohexylmethyl)-2-hydroxy-3-(1-methylethoxy)-3-oxopropyl]-S-methyl-L-cysteinamide, SULFATE ION | Authors: | Coates, L, Erskine, P.T, Crump, M.P, Wood, S.P, Cooper, J.B. | Deposit date: | 2002-02-27 | Release date: | 2002-07-04 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (0.98 Å) | Cite: | Five Atomic Resolution Structures of Endothiapepsin Inhibitor Complexes: Implications for the Aspartic Proteinase Mechanism J.Mol.Biol., 318, 2002
|
|
1GVU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1gvu by Molmil](/molmil-images/mine/1gvu) | Endothiapepsin complex with H189 | Descriptor: | ENDOTHIAPEPSIN, INHIBITOR, H189, ... | Authors: | Coates, L, Erskine, P.T, Crump, M.P, Wood, S.P, Cooper, J.B. | Deposit date: | 2002-02-27 | Release date: | 2002-07-04 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (0.94 Å) | Cite: | Five Atomic Resolution Structures of Endothiapepsin Inhibitor Complexes: Implications for the Aspartic Proteinase Mechanism J.Mol.Biol., 318, 2002
|
|
1GVX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1gvx by Molmil](/molmil-images/mine/1gvx) | Endothiapepsin complexed with H256 | Descriptor: | ENDOTHIAPEPSIN, INHIBITOR H256, SULFATE ION | Authors: | Coates, L, Erskine, P.T, Crump, M.P, Wood, S.P, Cooper, J.B. | Deposit date: | 2002-02-27 | Release date: | 2002-07-04 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | Five Atomic Resolution Structures of Endothiapepsin Inhibitor Complexes: Implications for the Aspartic Proteinase Mechanism J.Mol.Biol., 318, 2002
|
|
2PNG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2png by Molmil](/molmil-images/mine/2png) | Type I rat fatty acid synthase acyl carrier protein (ACP) domain | Descriptor: | Fatty acid synthase (EC 2.3.1.85) | Authors: | Ploskon, E.A, Arthur, C.J, Evans, S.E, Williams, C, Crosby, J, Crump, M.P. | Deposit date: | 2007-04-24 | Release date: | 2007-06-05 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | A Mammalian type I Fatty Acid synthase acyl carrier protein domain does not sequester acyl chains. J.Biol.Chem., 283, 2008
|
|
2MVV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2mvv by Molmil](/molmil-images/mine/2mvv) | Solution Structure of the 5-phenyl-3-oxo-pentyl Actinorhodin Acyl Carrier Protein from Streptomyces coelicolor | Descriptor: | Actinorhodin polyketide synthase acyl carrier protein, N~3~-{(2S)-4-[(dihydroxyphosphanyl)oxy]-2-hydroxy-3,3-dimethylbutanoyl}-N-{2-[(3-oxo-5-phenylpentyl)sulfanyl]ethyl}-beta-alaninamide | Authors: | Dong, X, Bailey, C, Williams, C, Crosby, J, Simpson, T.J, Willis, C.L, Crump, M.P. | Deposit date: | 2014-10-15 | Release date: | 2015-10-21 | Method: | SOLUTION NMR | Cite: | ACP-ligand recognition: Selection of derivatized aromatic biosynthetic intermediates To be Published
|
|
2JCA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2jca by Molmil](/molmil-images/mine/2jca) | Crystal structure of the streptomyces coelicolor holo- [Acyl-carrier-protein] Synthase (AcpS) at 2 A. | Descriptor: | GLYCEROL, HOLO-[ACYL-CARRIER-PROTEIN] SYNTHASE, SODIUM ION, ... | Authors: | Dall'Aglio, P, Arthur, C, Crump, M.P, Crosby, J, Hadfield, A.T. | Deposit date: | 2006-12-21 | Release date: | 2007-01-30 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Analysis of Streptomyces Coelicolor Phosphopantetheinyl Transferase, Acps, Reveals the Basis for Relaxed Substrate Specificity. Biochemistry, 50, 2011
|
|