2WDO
 
 | | Crystal structure of the S. coelicolor AcpS in complex with acetyl- CoA at 1.5 A | | 分子名称: | ACETYL COENZYME *A, COENZYME A, GLYCEROL, ... | | 著者 | Dall'Aglio, P, Arthur, C, Crump, M.P, Crosby, J, Hadfield, A.T. | | 登録日 | 2009-03-25 | | 公開日 | 2010-04-21 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | | 主引用文献 | Analysis of Streptomyces Coelicolor Phosphopantetheinyl Transferase, Acps, Reveals the Basis for Relaxed Substrate Specificity.
Biochemistry, 50, 2011
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2WDY
 | | Crystal structure of the Streptomyces coelicolor D111A AcpS mutant in complex with cofactor CoA at 1.4 A | | 分子名称: | COENZYME A, HOLO-[ACYL-CARRIER-PROTEIN] SYNTHASE, MAGNESIUM ION, ... | | 著者 | Dall'Aglio, P, Arthur, C, Crump, M.P, Crosby, J, Hadfield, A.T. | | 登録日 | 2009-03-27 | | 公開日 | 2010-04-21 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Analysis of Streptomyces Coelicolor Phosphopantetheinyl Transferase, Acps, Reveals the Basis for Relaxed Substrate Specificity.
Biochemistry, 50, 2011
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1NQ4
 | | Solution Structure of Oxytetracycline Acyl Carrier Protein | | 分子名称: | Oxytetracycline polyketide synthase acyl carrier protein | | 著者 | Findlow, S.C, Winsor, C, Simpson, T.J, Crosby, J, Crump, M.P. | | 登録日 | 2003-01-21 | | 公開日 | 2003-11-04 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure and dynamics of oxytetracycline polyketide synthase acyl carrier protein from Streptomyces rimosus
Biochemistry, 42, 2003
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2JCA
 | | Crystal structure of the streptomyces coelicolor holo- [Acyl-carrier-protein] Synthase (AcpS) at 2 A. | | 分子名称: | GLYCEROL, HOLO-[ACYL-CARRIER-PROTEIN] SYNTHASE, SODIUM ION, ... | | 著者 | Dall'Aglio, P, Arthur, C, Crump, M.P, Crosby, J, Hadfield, A.T. | | 登録日 | 2006-12-21 | | 公開日 | 2007-01-30 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | | 主引用文献 | Analysis of Streptomyces Coelicolor Phosphopantetheinyl Transferase, Acps, Reveals the Basis for Relaxed Substrate Specificity.
Biochemistry, 50, 2011
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2M68
 | | NMR solution structure ensemble of 3-4D mutant domain 11 IGF2R in complex with IGF2 (domain 11 structure only) | | 分子名称: | Insulin-like growth factor 2 receptor variant | | 著者 | Strickland, M, Williams, C, Richards, E, Minnall, L, Crump, M.P, Frago, S, Hughes, J, Garner, L, Hoppe, H, Rezgui, D, Zaccheo, O.J, Prince, S.N, Hassan, A.B, Whittaker, S. | | 登録日 | 2013-03-27 | | 公開日 | 2014-10-15 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist.
Proc.Natl.Acad.Sci.USA, 113, 2016
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4CRP
 | | Solution structure of a TrkAIg2 domain construct for use in drug discovery | | 分子名称: | HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR | | 著者 | Shoemark, D.K, Fahey, M, Williams, C, Sessions, R.B, Crump, M.P, Allen-Birt, S.J. | | 登録日 | 2014-02-28 | | 公開日 | 2015-01-14 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Design and Nuclear Magnetic Resonance (NMR) Structure Determination of the Second Extracellular Immunoglobulin Tyrosine Kinase a (Trkaig2) Domain Construct for Binding Site Elucidation in Drug Discovery
J.Med.Chem., 58, 2015
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6GWX
 | | Stabilising and Understanding a Miniprotein by Rational Design. | | 分子名称: | Optimised PPa-TYR | | 著者 | Porter Goff, K.L, Williams, C, Baker, E.G, Nicol, D, Samphire, J.L, Zieleniewski, F.L, Crump, M.P, Woolfson, D.N. | | 登録日 | 2018-06-26 | | 公開日 | 2019-07-10 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Stabilizing and Understanding a Miniprotein by Rational Redesign.
Biochemistry, 58, 2019
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2M6T
 | | NMR solution structure ensemble of 3-4D mutant domain 11 IGF2R | | 分子名称: | Insulin-like growth factor 2 receptor variant | | 著者 | Strickland, M, Williams, C, Richards, E, Minnall, L, Crump, M.P, Frago, S, Hughes, J, Garner, L, Hoppe, H, Rezgui, D, Zaccheo, O.J, Prince, S.N, Hassan, A.B, Whittaker, S. | | 登録日 | 2013-04-09 | | 公開日 | 2014-10-15 | | 最終更新日 | 2016-06-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist.
Proc.Natl.Acad.Sci.USA, 113, 2016
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2L29
 | | Complex structure of E4 mutant human IGF2R domain 11 bound to IGF-II | | 分子名称: | Insulin-like growth factor 2 receptor variant, Insulin-like growth factor II | | 著者 | Williams, C, Hoppe, H, Rezgui, D, Strickland, M, Frago, S, Ellis, R.Z, Wattana-Amorn, P, Prince, S.N, Zaccheo, O.J, Forbes, B, Jones, E.Y, Crump, M.P, Hassan, A.B. | | 登録日 | 2010-08-13 | | 公開日 | 2012-02-15 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution.
Science, 338, 2012
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2L2A
 | | Mutated Domain 11 of the Cytoplasmic region of the Cation-independent mannose-6-phosphate receptor | | 分子名称: | Insulin-like growth factor 2 receptor variant | | 著者 | Williams, C, Hoppe, H, Rezgui, D, Strickland, M, Frago, S, Ellis, R.Z, Wattana-Amorn, P, Prince, S.N, Zaccheo, O.J, Forbes, B, Jones, E.Y, Crump, M.P, Hassan, A.B. | | 登録日 | 2010-08-13 | | 公開日 | 2012-02-15 | | 最終更新日 | 2012-12-12 | | 実験手法 | SOLUTION NMR | | 主引用文献 | An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution.
Science, 338, 2012
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2L2G
 | | Solution structure of Opossum Domain 11 | | 分子名称: | IGF2R DOMAIN 11 | | 著者 | Williams, C, Hoppe, H, Rezgui, D, Rezgui, M, Frago, S, Ellis, R.Z, Wattana-Amorn, P, Prince, S.N, Zaccheo, O.J, Forbes, B, Jones, E.Y, Crump, M.P, Bassim, A.H. | | 登録日 | 2010-08-18 | | 公開日 | 2012-02-15 | | 最終更新日 | 2015-02-25 | | 実験手法 | SOLUTION NMR | | 主引用文献 | An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution.
Science, 338, 2012
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2PNG
 | | Type I rat fatty acid synthase acyl carrier protein (ACP) domain | | 分子名称: | Fatty acid synthase (EC 2.3.1.85) | | 著者 | Ploskon, E.A, Arthur, C.J, Evans, S.E, Williams, C, Crosby, J, Crump, M.P. | | 登録日 | 2007-04-24 | | 公開日 | 2007-06-05 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | A Mammalian type I Fatty Acid synthase acyl carrier protein domain does not sequester acyl chains.
J.Biol.Chem., 283, 2008
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2LLA
 | | NMR solution structure ensemble of domain 11 of the echidna M6P/IGF2R receptor | | 分子名称: | Mannose-6-phosphate/insulin-like growth factor II receptor | | 著者 | Strickland, M, Crump, M.P, Williams, C, Rezgui, D, Ellis, R.Z, Hoppe, H, Frago, S, Prince, S.N, Zaccheo, O.J, Forbes, B.E, Jones, E, Hassan, A.Z, Wattana-Amorn, P. | | 登録日 | 2011-11-05 | | 公開日 | 2012-11-07 | | 最終更新日 | 2012-12-12 | | 実験手法 | SOLUTION NMR | | 主引用文献 | An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution.
Science, 338, 2012
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2CNR
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2L21
 | | chicken IGF2R domain 11 | | 分子名称: | Cation-independent mannose-6-phosphate receptor | | 著者 | Williams, C, Hoppe, H, Strickland, M, Frago, S, Ellis, R.Z, Wattana-Amorn, P, Prince, S.N, Zaccheo, O.J, Forbes, B, Jones, E.Y, Rezgui, D.Z, Crump, M.P, Hassan, A.B. | | 登録日 | 2010-08-10 | | 公開日 | 2012-02-15 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | CD loop dependency of the IGF2: M6P/IGF2 receptor binding interaction predates imprinting
To be Published
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2L22
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1GVT
 | | Endothiapepsin complex with CP-80,794 | | 分子名称: | ENDOTHIAPEPSIN, N-(morpholin-4-ylcarbonyl)-L-phenylalanyl-N-[(1R,2S)-1-(cyclohexylmethyl)-2-hydroxy-3-(1-methylethoxy)-3-oxopropyl]-S-methyl-L-cysteinamide, SULFATE ION | | 著者 | Coates, L, Erskine, P.T, Crump, M.P, Wood, S.P, Cooper, J.B. | | 登録日 | 2002-02-27 | | 公開日 | 2002-07-04 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (0.98 Å) | | 主引用文献 | Five Atomic Resolution Structures of Endothiapepsin Inhibitor Complexes: Implications for the Aspartic Proteinase Mechanism
J.Mol.Biol., 318, 2002
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1GVU
 | | Endothiapepsin complex with H189 | | 分子名称: | ENDOTHIAPEPSIN, INHIBITOR, H189, ... | | 著者 | Coates, L, Erskine, P.T, Crump, M.P, Wood, S.P, Cooper, J.B. | | 登録日 | 2002-02-27 | | 公開日 | 2002-07-04 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (0.94 Å) | | 主引用文献 | Five Atomic Resolution Structures of Endothiapepsin Inhibitor Complexes: Implications for the Aspartic Proteinase Mechanism
J.Mol.Biol., 318, 2002
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1GVX
 | | Endothiapepsin complexed with H256 | | 分子名称: | ENDOTHIAPEPSIN, INHIBITOR H256, SULFATE ION | | 著者 | Coates, L, Erskine, P.T, Crump, M.P, Wood, S.P, Cooper, J.B. | | 登録日 | 2002-02-27 | | 公開日 | 2002-07-04 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1 Å) | | 主引用文献 | Five Atomic Resolution Structures of Endothiapepsin Inhibitor Complexes: Implications for the Aspartic Proteinase Mechanism
J.Mol.Biol., 318, 2002
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1GVW
 | | Endothiapepsin complex with PD-130,328 | | 分子名称: | ENDOTHIAPEPSIN, N-(tert-butoxycarbonyl)-L-phenylalanyl-N-{(1S)-1-[(R)-hydroxy(2-{[(2S)-2-methylbutyl]amino}-2-oxoethyl)phosphoryl]-3-methylbutyl}-3-(1H-imidazol-3-ium-4-yl)-L-alaninamide, SULFATE ION | | 著者 | Coates, L, Erskine, P.T, Crump, M.P, Wood, S.P, Cooper, J.B. | | 登録日 | 2002-02-27 | | 公開日 | 2002-07-04 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1 Å) | | 主引用文献 | Five Atomic Resolution Structures of Endothiapepsin Inhibitor Complexes: Implications for the Aspartic Proteinase Mechanism
J.Mol.Biol., 318, 2002
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1GVV
 | | Five Atomic Resolution Structures of Endothiapepsin Inhibitor Complexes; implications for the Aspartic Proteinase Mechanism | | 分子名称: | ENDOTHIAPEPSIN, N-[(5S,9S,10S,13S)-9-hydroxy-5,10-bis(2-methylpropyl)-4,7,12,16-tetraoxo-3,6,11,17-tetraazabicyclo[17.3.1]tricosa-1(23),19,21-trien-13-yl]-3-(naphthalen-1-yl)-2-(naphthalen-1-ylmethyl)propanamide, SULFATE ION | | 著者 | Coates, L, Erskine, P.T, Crump, M.P, Wood, S.P, Cooper, J.B. | | 登録日 | 2002-02-27 | | 公開日 | 2002-07-04 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | | 主引用文献 | Five Atomic Resolution Structures of Endothiapepsin Inhibitor Complexes: Implications for the Aspartic Proteinase Mechanism
J.Mol.Biol., 318, 2002
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2LPC
 | | NMR STRUCTURE of Bcl-XL | | 分子名称: | Bcl-2-like protein 1 | | 著者 | Wysoczanski, P, Mart, R.J, Loveridge, J.E, Williams, C, Whittaker, S.B.-M, Crump, M.P, Allemann, R.K. | | 登録日 | 2012-02-09 | | 公開日 | 2012-03-21 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR Solution Structure of a Photoswitchable Apoptosis Activating Bak Peptide Bound to Bcl-x(L).
J.Am.Chem.Soc., 134, 2012
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2LP8
 | | SOLUTION STRUCTURE OF AN APOPTOSIS ACTIVATING PHOTOSWITCHABLE BAK PEPTIDE BOUND to BCL-XL | | 分子名称: | 3,3'-(E)-diazene-1,2-diylbis{6-[(chloroacetyl)amino]benzenesulfonic acid}, Bcl-2 homologous antagonist/killer, Bcl-2-like protein 1 | | 著者 | Wysoczanski, P, Mart, R.J, Loveridge, J.E, Williams, C, Whittaker, S.B.-M, Crump, M.P, Allemann, R.K. | | 登録日 | 2012-02-03 | | 公開日 | 2012-04-18 | | 最終更新日 | 2021-08-18 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR Solution Structure of a Photoswitchable Apoptosis Activating Bak Peptide Bound to Bcl-x(L).
J.Am.Chem.Soc., 134, 2012
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2JBZ
 | | Crystal structure of the Streptomyces coelicolor holo-[Acyl-carrier-protein] Synthase (AcpS) in complex with coenzyme A at 1.6 A | | 分子名称: | COENZYME A, HOLO-[ACYL-CARRIER-PROTEIN] SYNTHASE, MAGNESIUM ION, ... | | 著者 | Dall'Aglio, P, Arthur, C, Law, C.K.E, Crump, M.P, Crosby, J, Hadfield, A.T. | | 登録日 | 2006-12-15 | | 公開日 | 2007-01-23 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | | 主引用文献 | Analysis of Streptomyces Coelicolor Phosphopantetheinyl Transferase, Acps, Reveals the Basis for Relaxed Substrate Specificity.
Biochemistry, 50, 2011
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2MVV
 | | Solution Structure of the 5-phenyl-3-oxo-pentyl Actinorhodin Acyl Carrier Protein from Streptomyces coelicolor | | 分子名称: | Actinorhodin polyketide synthase acyl carrier protein, N~3~-{(2S)-4-[(dihydroxyphosphanyl)oxy]-2-hydroxy-3,3-dimethylbutanoyl}-N-{2-[(3-oxo-5-phenylpentyl)sulfanyl]ethyl}-beta-alaninamide | | 著者 | Dong, X, Bailey, C, Williams, C, Crosby, J, Simpson, T.J, Willis, C.L, Crump, M.P. | | 登録日 | 2014-10-15 | | 公開日 | 2015-10-21 | | 実験手法 | SOLUTION NMR | | 主引用文献 | ACP-ligand recognition: Selection of derivatized aromatic biosynthetic intermediates
To be Published
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