4TXD
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![BU of 4txd by Molmil](/molmil-images/mine/4txd) | Crystal structure of Thermofilum pendens Csc2 | Descriptor: | Csc2, ZINC ION | Authors: | Hrle, A, Conti, E. | Deposit date: | 2014-07-03 | Release date: | 2014-08-27 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.818 Å) | Cite: | Structural analyses of the CRISPR protein Csc2 reveal the RNA-binding interface of the type I-D Cas7 family. Rna Biol., 11, 2014
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5NKM
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![BU of 5nkm by Molmil](/molmil-images/mine/5nkm) | SMG8-SMG9 complex | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, ... | Authors: | Li, L, Basquin, J, Conti, E. | Deposit date: | 2017-03-31 | Release date: | 2017-04-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.493 Å) | Cite: | Structure of a SMG8-SMG9 complex identifies a G-domain heterodimer in the NMD effector proteins. RNA, 23, 2017
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2C37
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![BU of 2c37 by Molmil](/molmil-images/mine/2c37) | RNASE PH CORE OF THE ARCHAEAL EXOSOME IN COMPLEX WITH U8 RNA | Descriptor: | 5-O-phosphono-beta-D-ribofuranose, CHLORIDE ION, PROBABLE EXOSOME COMPLEX EXONUCLEASE 1, ... | Authors: | Lorentzen, E, Conti, E. | Deposit date: | 2005-10-04 | Release date: | 2005-11-23 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural Basis of 3' End RNA Recognition and Exoribonucleolytic Cleavage by an Exosome Rnase Ph Core. Mol.Cell, 20, 2005
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1OL6
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![BU of 1ol6 by Molmil](/molmil-images/mine/1ol6) | |
5NKK
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![BU of 5nkk by Molmil](/molmil-images/mine/5nkk) | SMG8-SMG9 complex GDP bound | Descriptor: | 1,2-ETHANEDIOL, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Li, L, Basquin, J, Conti, E. | Deposit date: | 2017-03-31 | Release date: | 2017-04-19 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.64 Å) | Cite: | Structure of a SMG8-SMG9 complex identifies a G-domain heterodimer in the NMD effector proteins. RNA, 23, 2017
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2C38
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![BU of 2c38 by Molmil](/molmil-images/mine/2c38) | RNase PH core of the archaeal exosome in complex with A5 RNA | Descriptor: | ADENOSINE MONOPHOSPHATE, CHLORIDE ION, PROBABLE EXOSOME COMPLEX EXONUCLEASE 1, ... | Authors: | Lorentzen, E, Conti, E. | Deposit date: | 2005-10-04 | Release date: | 2005-11-23 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural Basis of 3' End RNA Recognition and Exoribonucleolytic Cleavage by an Exosome Rnase Ph Core. Mol.Cell, 20, 2005
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2C39
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![BU of 2c39 by Molmil](/molmil-images/mine/2c39) | RNase PH core of the archaeal exosome in complex with ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, PROBABLE EXOSOME COMPLEX EXONUCLEASE 1, PROBABLE EXOSOME COMPLEX EXONUCLEASE 2 | Authors: | Lorentzen, E, Conti, E. | Deposit date: | 2005-10-05 | Release date: | 2005-11-23 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structural Basis of 3' End RNA Recognition and Exoribonucleolytic Cleavage by an Exosome Rnase Ph Core. Mol.Cell, 20, 2005
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7QE0
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![BU of 7qe0 by Molmil](/molmil-images/mine/7qe0) | 80S-bound human SKI complex in the open state | Descriptor: | Helicase SKI2W, RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') | Authors: | Koegel, A, Keidel, A, Bonneau, F, Schaefer, I.B, Conti, E. | Deposit date: | 2021-12-01 | Release date: | 2022-02-09 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (6.5 Å) | Cite: | The human SKI complex regulates channeling of ribosome-bound RNA to the exosome via an intrinsic gatekeeping mechanism. Mol.Cell, 82, 2022
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1A0E
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![BU of 1a0e by Molmil](/molmil-images/mine/1a0e) | XYLOSE ISOMERASE FROM THERMOTOGA NEAPOLITANA | Descriptor: | COBALT (II) ION, XYLOSE ISOMERASE | Authors: | Gallay, O, Chopra, R, Conti, E, Brick, P, Blow, D. | Deposit date: | 1997-11-28 | Release date: | 1998-06-03 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal Structures of Class II Xylose Isomerases from Two Thermophiles and a Hyperthermophile To be Published
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5C0X
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5C0W
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![BU of 5c0w by Molmil](/molmil-images/mine/5c0w) | |
5MC6
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![BU of 5mc6 by Molmil](/molmil-images/mine/5mc6) | Cryo-EM structure of a native ribosome-Ski2-Ski3-Ski8 complex from S. cerevisiae | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | Authors: | Schmidt, C, Kowalinski, E, Shanmuganathan, V, Defenouillere, Q, Braunger, K, Heuer, A, Pech, M, Namane, A, Berninghausen, O, Fromont-Racine, M, Jacquier, A, Conti, E, Becker, T, Beckmann, R. | Deposit date: | 2016-11-09 | Release date: | 2017-01-18 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | The cryo-EM structure of a ribosome-Ski2-Ski3-Ski8 helicase complex. Science, 354, 2016
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7QDR
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![BU of 7qdr by Molmil](/molmil-images/mine/7qdr) | Apo human SKI complex in the closed state | Descriptor: | Helicase SKI2W, Tetratricopeptide repeat protein 37, WD repeat-containing protein 61 | Authors: | Koegel, A, Keidel, A, Bonneau, F, Schaefer, I.B, Conti, E. | Deposit date: | 2021-11-29 | Release date: | 2022-02-02 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | The human SKI complex regulates channeling of ribosome-bound RNA to the exosome via an intrinsic gatekeeping mechanism. Mol.Cell, 82, 2022
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7QDS
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![BU of 7qds by Molmil](/molmil-images/mine/7qds) | Apo human SKI complex in the open state | Descriptor: | Helicase SKI2W, Tetratricopeptide repeat protein 37, WD repeat-containing protein 61 | Authors: | Koegel, A, Keidel, A, Bonneau, A, Schaefer, I.B, Conti, E. | Deposit date: | 2021-11-30 | Release date: | 2022-02-02 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | The human SKI complex regulates channeling of ribosome-bound RNA to the exosome via an intrinsic gatekeeping mechanism. Mol.Cell, 82, 2022
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5C0Y
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![BU of 5c0y by Molmil](/molmil-images/mine/5c0y) | |
7PW6
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![BU of 7pw6 by Molmil](/molmil-images/mine/7pw6) | Human SMG1-8-9 kinase complex bound to a SMG1 inhibitor - SMG1 body | Descriptor: | 1-[4-[4-[2-[[4-chloranyl-3-(diethylsulfamoyl)phenyl]amino]pyrimidin-4-yl]pyridin-2-yl]phenyl]-3-methyl-urea, INOSITOL HEXAKISPHOSPHATE, Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1 | Authors: | Langer, L.M, Conti, E. | Deposit date: | 2021-10-06 | Release date: | 2021-12-01 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.05 Å) | Cite: | Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8. Elife, 10, 2021
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5AOR
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![BU of 5aor by Molmil](/molmil-images/mine/5aor) | Structure of MLE RNA ADP AlF4 complex | Descriptor: | 5'-R(*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP)-3', ADENOSINE-5'-DIPHOSPHATE, DOSAGE COMPENSATION REGULATOR, ... | Authors: | Prabu, J.R, Conti, E. | Deposit date: | 2015-09-11 | Release date: | 2015-11-18 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Structure of the RNA Helicase Mle Reveals the Molecular Mechanisms for Uridine Specificity and RNA-ATP Coupling. Mol.Cell, 60, 2015
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5ANR
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![BU of 5anr by Molmil](/molmil-images/mine/5anr) | Structure of a human 4E-T - DDX6 - CNOT1 complex | Descriptor: | CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TRANSPORTER, PROBABLE ATP-DEPENDENT RNA HELICASE DDX6 | Authors: | Basquin, J, Oezguer, S, Conti, E. | Deposit date: | 2015-09-08 | Release date: | 2015-10-21 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.102 Å) | Cite: | Structure of a Human 4E-T/Ddx6/Cnot1 Complex Reveals the Different Interplay of Ddx6-Binding Proteins with the Ccr4-not Complex. Cell Rep., 13, 2015
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5LXY
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![BU of 5lxy by Molmil](/molmil-images/mine/5lxy) | Structure of the minimal RBM7 - ZCCHC8 Complex | Descriptor: | BROMIDE ION, RNA-binding protein 7, Zinc finger CCHC domain-containing protein 8 | Authors: | Falk, S, Finogenova, K, Benda, C, Conti, E. | Deposit date: | 2016-09-23 | Release date: | 2016-12-14 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Structure of the RBM7-ZCCHC8 core of the NEXT complex reveals connections to splicing factors. Nat Commun, 7, 2016
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1HL6
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![BU of 1hl6 by Molmil](/molmil-images/mine/1hl6) | A novel mode of RBD-protein recognition in the Y14-mago complex | Descriptor: | CG8781 PROTEIN, MAGO NASHI PROTEIN | Authors: | Fribourg, S, Gatfield, D, Yao, W, Izaurralde, E, Conti, E. | Deposit date: | 2003-03-13 | Release date: | 2003-05-08 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | A Novel Mode of Rbd-Protein Recognition in the Y14-Mago Complex Nat.Struct.Biol., 10, 2003
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5MZN
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![BU of 5mzn by Molmil](/molmil-images/mine/5mzn) | Helicase Sen1 | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, DI(HYDROXYETHYL)ETHER, ... | Authors: | Leonaite, B, Basquin, J, Conti, E. | Deposit date: | 2017-02-01 | Release date: | 2017-04-19 | Last modified: | 2017-06-14 | Method: | X-RAY DIFFRACTION (1.787 Å) | Cite: | Sen1 has unique structural features grafted on the architecture of the Upf1-like helicase family. EMBO J., 36, 2017
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5LXR
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![BU of 5lxr by Molmil](/molmil-images/mine/5lxr) | Structure of the minimal RBM7 - ZCCHC8 Complex | Descriptor: | BROMIDE ION, CHLORIDE ION, RNA-binding protein 7, ... | Authors: | Falk, S, Finogenova, K, Benda, C, Conti, E. | Deposit date: | 2016-09-22 | Release date: | 2016-12-14 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of the RBM7-ZCCHC8 core of the NEXT complex reveals connections to splicing factors. Nat Commun, 7, 2016
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1JN5
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![BU of 1jn5 by Molmil](/molmil-images/mine/1jn5) | Structural basis for the recognition of a nucleoporin FG-repeat by the NTF2-like domain of TAP-p15 mRNA export factor | Descriptor: | FG-repeat, TAP, p15 | Authors: | Fribourg, S, Braun, I.C, Izaurralde, E, Conti, E. | Deposit date: | 2001-07-23 | Release date: | 2001-10-17 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factor. Mol.Cell, 8, 2001
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1JKG
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![BU of 1jkg by Molmil](/molmil-images/mine/1jkg) | Structural basis for the recognition of a nucleoporin FG-repeat by the NTF2-like domain of TAP-p15 mRNA nuclear export factor | Descriptor: | TAP, p15 | Authors: | Fribourg, S, Braun, I.C, Izaurralde, E, Conti, E. | Deposit date: | 2001-07-12 | Release date: | 2001-10-17 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factor. Mol.Cell, 8, 2001
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2VNU
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![BU of 2vnu by Molmil](/molmil-images/mine/2vnu) | Crystal structure of Sc Rrp44 | Descriptor: | 5'-R(*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP)-3', EXOSOME COMPLEX EXONUCLEASE RRP44, MAGNESIUM ION, ... | Authors: | Lorentzen, E, Basquin, J, Conti, E. | Deposit date: | 2008-02-07 | Release date: | 2008-04-08 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of the Active Subunit of the Yeast Exosome Core, Rrp44: Diverse Modes of Substrate Recruitment in the Rnase II Nuclease Family Mol.Cell, 29, 2008
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