1LE1
 
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1LE0
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1LE3
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1VPP
 | | COMPLEX BETWEEN VEGF AND A RECEPTOR BLOCKING PEPTIDE | | 分子名称: | PROTEIN (PEPTIDE V108), PROTEIN (VASCULAR ENDOTHELIAL GROWTH FACTOR) | | 著者 | Wiesmann, C, Christinger, H.W, Cochran, A.G, Cunningham, B.C, Fairbrother, W.J, Keenan, C.J, Meng, G, de Vos, A.M. | | 登録日 | 1998-10-09 | | 公開日 | 1999-02-23 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal structure of the complex between VEGF and a receptor-blocking peptide.
Biochemistry, 37, 1998
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7TAB
 | | G-925 bound to the SMARCA4 (BRG1) Bromodomain | | 分子名称: | 2-(6-amino-5-phenylpyridazin-3-yl)phenol, Isoform 4 of Transcription activator BRG1 | | 著者 | Tang, Y, Poy, F, Taylor, A.M, Cochran, A.G, Bellon, S.F. | | 登録日 | 2021-12-20 | | 公開日 | 2022-08-17 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.16 Å) | | 主引用文献 | GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1.
J.Med.Chem., 65, 2022
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7TD9
 | | G-059 bound to the SMARCA4 (BRG1) Bromodomain | | 分子名称: | 4-phenyl-5H-pyridazino[4,3-b]indol-3-amine, Isoform 4 of Transcription activator BRG1 | | 著者 | Tang, Y, Poy, F, Taylor, A.M, Cochran, A.G, Bellon, S.F. | | 登録日 | 2021-12-30 | | 公開日 | 2022-08-17 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | | 主引用文献 | GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1.
J.Med.Chem., 65, 2022
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3SOV
 | | The structure of a beta propeller domain in complex with peptide S | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Low-density lipoprotein receptor-related protein 6, ... | | 著者 | Wang, W, Bourhis, E, Zhang, Y, Rouge, L, Wu, Y, Franke, Y, Cochran, A.G. | | 登録日 | 2011-06-30 | | 公開日 | 2011-09-21 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (1.27 Å) | | 主引用文献 | Wnt antagonists bind through a short peptide to the first beta-propeller domain of LRP5/6.
Structure, 19, 2011
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4S3O
 | | PCGF5-RING1B-UbcH5c complex | | 分子名称: | E3 ubiquitin-protein ligase RING2, Polycomb group RING finger protein 5, Ubiquitin-conjugating enzyme E2 D3, ... | | 著者 | Taherbhoy, A.M, Cochran, A.G. | | 登録日 | 2015-03-23 | | 公開日 | 2015-07-15 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | BMI1-RING1B is an autoinhibited RING E3 ubiquitin ligase.
Nat Commun, 6, 2015
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6OXB
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1OSG
 | | Complex between BAFF and a BR3 derived peptide presented in a beta-hairpin scaffold | | 分子名称: | BR3 derived PEPTIDE, MAGNESIUM ION, Tumor necrosis factor ligand superfamily member 13B | | 著者 | Gordon, N.C, Pan, B, Hymowitz, S.G, Yin, J.P, Kelley, R.F, Cochran, A.G, Yan, M, Dixit, V.M, Fairbrother, W.J, Starovasnik, M.A. | | 登録日 | 2003-03-19 | | 公開日 | 2003-05-27 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site
Biochemistry, 42, 2003
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1N09
 | | A minimal beta-hairpin peptide scaffold for beta-turn display | | 分子名称: | bhpW, disulfide cyclized beta-hairpin peptide | | 著者 | Russell, S.J, Blandl, T, Skelton, N.J, Cochran, A.G. | | 登録日 | 2002-10-11 | | 公開日 | 2003-02-04 | | 最終更新日 | 2022-02-23 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Stability of cyclic beta-hairpins: asymmetric contributions from side chains of a hydrogen-bonded cross-strand residue pair
J.Am.Chem.Soc., 125, 2003
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1MPV
 | | Structure of bhpBR3, the BAFF-binding loop of BR3 embedded in a beta-hairpin peptide | | 分子名称: | BLyS Receptor 3 | | 著者 | Kayagaki, N, Yan, M, Seshasayee, D, Wang, H, Lee, W, French, D.M, Grewal, I.S, Cochran, A.G, Gordon, N.C, Yin, J, Starovasnik, M.A, Dixit, V.M. | | 登録日 | 2002-09-12 | | 公開日 | 2002-10-30 | | 最終更新日 | 2022-02-23 | | 実験手法 | SOLUTION NMR | | 主引用文献 | BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2.
Immunity, 17, 2002
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1OSX
 | | Solution Structure of the Extracellular Domain of BLyS Receptor 3 (BR3) | | 分子名称: | Tumor necrosis factor receptor superfamily member 13C | | 著者 | Gordon, N.C, Pan, B, Hymowitz, S.G, Yin, J.P, Kelley, R.F, Cochran, A.G, Yan, M, Dixit, V.M, Fairbrother, W.J, Starovasnik, M.A. | | 登録日 | 2003-03-20 | | 公開日 | 2003-05-27 | | 最終更新日 | 2022-02-23 | | 実験手法 | SOLUTION NMR | | 主引用文献 | BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site
Biochemistry, 42, 2003
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3H0Z
 | | Aurora A in complex with a bisanilinopyrimidine | | 分子名称: | 4-{[2-({4-[2-(4-acetylpiperazin-1-yl)-2-oxoethyl]phenyl}amino)-5-fluoropyrimidin-4-yl]amino}-N-(2-chlorophenyl)benzamide, Serine/threonine-protein kinase 6 | | 著者 | Wiesmann, C, Ultsch, M.H, Cochran, A.G. | | 登録日 | 2009-04-10 | | 公開日 | 2009-07-07 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.92 Å) | | 主引用文献 | A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B.
J.Med.Chem., 52, 2009
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3H10
 | | Aurora A inhibitor complex | | 分子名称: | 9-chloro-7-(2,6-difluorophenyl)-N-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}-5H-pyrimido[5,4-d][2]benzazepin-2-amine, Serine/threonine-protein kinase 6 | | 著者 | Wiesmann, C, Ultsch, M.H, Cochran, A.G. | | 登録日 | 2009-04-10 | | 公開日 | 2009-07-07 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B.
J.Med.Chem., 52, 2009
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3H0Y
 | | Aurora A in complex with a bisanilinopyrimidine | | 分子名称: | 2-chloro-N-[4-({5-fluoro-2-[(4-hydroxyphenyl)amino]pyrimidin-4-yl}amino)phenyl]benzamide, SULFATE ION, Serine/threonine-protein kinase 6 | | 著者 | Wiesmann, C, Ultsch, M.H, Cochran, A.G. | | 登録日 | 2009-04-10 | | 公開日 | 2009-07-07 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B.
J.Med.Chem., 52, 2009
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3RPG
 | | Bmi1/Ring1b-UbcH5c complex structure | | 分子名称: | E3 ubiquitin-protein ligase RING2, Polycomb complex protein BMI-1, Ubiquitin-conjugating enzyme E2 D3, ... | | 著者 | Bentley, M.L, Dong, K.C, Cochran, A.G. | | 登録日 | 2011-04-26 | | 公開日 | 2011-08-17 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.6485 Å) | | 主引用文献 | Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex.
Embo J., 30, 2011
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3SOB
 | | The structure of the first YWTD beta propeller domain of LRP6 in complex with a FAB | | 分子名称: | CALCIUM ION, Low-density lipoprotein receptor-related protein 6, antibody heavy chain, ... | | 著者 | Wang, W, Bourhis, E, Tam, C, Zhang, Y, Rouge, L, Wu, Y, Franke, Y, Cochran, A.G. | | 登録日 | 2011-06-30 | | 公開日 | 2011-09-21 | | 最終更新日 | 2014-05-14 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Wnt antagonists bind through a short peptide to the first beta-propeller domain of LRP5/6.
Structure, 19, 2011
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3SOQ
 | | The structure of the first YWTD beta propeller domain of LRP6 in complex with a DKK1 peptide | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Dickkopf-related protein 1, ... | | 著者 | Wang, W, Bourhis, E, Zhang, Y, Rouge, L, Wu, Y, Franke, Y, Cochran, A.G. | | 登録日 | 2011-06-30 | | 公開日 | 2011-09-21 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Wnt antagonists bind through a short peptide to the first beta-propeller domain of LRP5/6.
Structure, 19, 2011
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1N0D
 | | Stability of cyclic beta-hairpins: Asymmetric contibutions from side chains of hydrogen bonded cross-strand residue pair | | 分子名称: | bhp_VWLH, disulfide cyclized beta-hairpin peptide | | 著者 | Russell, S.J, Blandl, T, Skelton, N.J, Cochran, A.G. | | 登録日 | 2002-10-11 | | 公開日 | 2003-02-04 | | 最終更新日 | 2022-02-23 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Stability of Cyclic Beta-Hairpins: Asymmetric Contributions From Side Chains of Hydrogen Bonded Cross-Strand Residue Pair
J.Am.Chem.Soc., 125, 2003
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1N0A
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1N0C
 | | Stability of cyclic beta-hairpins: Asymmetric contibutions from side chains of hydrogen bonded cross-strand residue pair | | 分子名称: | bhp_HWLV, disulfide cyclized beta-hairpin peptide | | 著者 | Russel, S.J, Blandl, T, Skelton, N.J, Cochran, A.G. | | 登録日 | 2002-10-11 | | 公開日 | 2003-10-21 | | 最終更新日 | 2022-02-23 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Stability of cyclic beta-hairpins: asymmetric contributions from side chains of
a hydrogen-bonded cross-strand residue pair
J.AM.CHEM.SOC., 125, 2003
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1GJG
 | | Peptide Antagonist of IGFBP1, (i,i+8) Covalently Restrained Analog, Minimized Average Structure | | 分子名称: | IGFBP-1 antagonist, PENTANE | | 著者 | Skelton, N.J, Chen, Y.M, Dubree, N, Quan, C, Jackson, D.Y, Cochran, A.G, Zobel, K, Deshayes, K, Baca, M, Pisabarro, M.T, Lowman, H.B. | | 登録日 | 2001-05-11 | | 公開日 | 2001-05-30 | | 最終更新日 | 2023-12-27 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure-function analysis of a phage display-derived peptide that binds to insulin-like growth factor binding protein 1.
Biochemistry, 40, 2001
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1GJF
 | | Peptide Antagonist of IGFBP1, (i,i+7) Covalently Restrained Analog, Minimized Average Structure | | 分子名称: | IGFBP-1 antagonist, PENTANE | | 著者 | Skelton, N.J, Chen, Y.M, Dubree, N, Quan, C, Jackson, D.Y, Cochran, A.G, Zobel, K, Deshayes, K, Baca, M, Pisabarro, M.T, Lowman, H.B. | | 登録日 | 2001-05-11 | | 公開日 | 2001-05-30 | | 最終更新日 | 2023-12-27 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure-function analysis of a phage display-derived peptide that binds to insulin-like growth factor binding protein 1.
Biochemistry, 40, 2001
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2KDD
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