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PDB: 25 件

6OTA
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THREE-DIMENSIONAL STRUCTURE IN SOLUTION OF THE RIBBON DISULFIDE ISOMER OF THE NICOTINIC ACETYLCHOLINE RECEPTOR ANTAGONIST ALPHA-CONOTOXIN TxIA
分子名称: Alpha-conotoxin TxIA
著者Clark, R.J, Nicke, A.
登録日2019-05-02
公開日2020-05-06
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Structural and functional analysis of E. Coli-expressed 4/7 alpha-conotoxin analogues reveals preferential formation of ribbon isomers
To Be Published
2AK0
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Structure of cyclic conotoxin MII-7
分子名称: Alpha-conotoxin MII
著者Clark, R.J, Fischer, H, Dempster, L, Daly, N.L, Rosengren, K.J, Nevin, S.T, Meunier, F.A, Adams, D.J, Craik, D.J.
登録日2005-08-02
公開日2005-09-06
最終更新日2022-03-09
実験手法SOLUTION NMR
主引用文献Engineering stable peptide toxins by means of backbone cyclization: Stabilization of the {alpha}-conotoxin MII.
Proc.Natl.Acad.Sci.USA, 102, 2005
2AJW
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Structure of the cyclic conotoxin MII-6
分子名称: Alpha-conotoxin MII
著者Clark, R.J, Fischer, H, Dempster, L, Daly, N.L, Rosengren, K.J, Nevin, S.T, Meunier, F.A, Adams, D.J, Craik, D.J.
登録日2005-08-02
公開日2005-09-06
最終更新日2022-03-09
実験手法SOLUTION NMR
主引用文献Engineering stable peptide toxins by means of backbone cyclization: Stabilization of the {alpha}-conotoxin MII.
Proc.Natl.Acad.Sci.USA, 102, 2005
2F2I
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Solution structure of [P20D,V21K]-kalata B1
分子名称: Kalata-B1
著者Clark, R.J, Daly, N.L, Craik, D.J.
登録日2005-11-17
公開日2006-01-31
最終更新日2021-11-10
実験手法SOLUTION NMR
主引用文献Structural plasticity of the cyclic cystine knot framework: implications for biological activity and drug design
Biochem.J., 394, 2006
2F2J
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Solution structure of [W19K, P20N, V21K]-kalata B1
分子名称: Kalata-B1
著者Clark, R.J, Daly, N.L, Craik, D.J.
登録日2005-11-17
公開日2006-01-31
最終更新日2021-11-10
実験手法SOLUTION NMR
主引用文献Structural plasticity of the cyclic cystine knot framework: implications for biological activity and drug design
Biochem.J., 394, 2006
6CGX
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Backbone cyclised conotoxin Vc1.1 mutant - D11A, E14A
分子名称: Alpha-conotoxin Vc1A
著者Clark, R.J.
登録日2018-02-21
公開日2018-05-23
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Structure-Activity Studies Reveal the Molecular Basis for GABAB-Receptor Mediated Inhibition of High Voltage-Activated Calcium Channels by alpha-Conotoxin Vc1.1.
ACS Chem. Biol., 13, 2018
2H8S
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Solution structure of alpha-conotoxin Vc1.1
分子名称: Alpha-conotoxin Vc1A
著者Clark, R.J, Fischer, H, Nevin, S.T, Adams, D.J, Craik, D.J.
登録日2006-06-07
公開日2006-06-27
最終更新日2022-03-09
実験手法SOLUTION NMR
主引用文献The Synthesis, Structural Characterization, and Receptor Specificity of the {alpha}-Conotoxin Vc1.1.
J.Biol.Chem., 281, 2006
2L1Q
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Solution structure of human Liver Expressed Antimicrobial Peptide 2
分子名称: Liver-expressed antimicrobial peptide 2
著者Clark, R.J.
登録日2010-08-03
公開日2010-09-22
最終更新日2020-01-01
実験手法SOLUTION NMR
主引用文献Structural and functional analysis of human liver-expressed antimicrobial peptide 2.
Chembiochem, 11, 2010
8UWF
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NMR structure of the funnel-web spider toxin Hc3a
分子名称: Pi-Hexatoxin-Hc1b_1
著者Budusan, E, Payne, C.D, Gonzalez, T.I, Clark, R.J, Rosengren, K.J, Rash, L.D, Cristofori-Armstrong, B.
登録日2023-11-06
公開日2024-03-13
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献The funnel-web spider venom derived single knot peptide Hc3a modulates acid-sensing ion channel 1a desensitisation.
Biochem Pharmacol, 2024
6DRI
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NMR solution structure of Acan1 from the Ancylostoma caninum hookworm
分子名称: Acan1
著者Smallwood, T.B, Rosengren, K.J, Clark, R.J.
登録日2018-06-11
公開日2019-06-19
最終更新日2020-01-01
実験手法SOLUTION NMR
主引用文献NMR solution structure of Acan1 from the Ancylostoma caninum hookworm
To Be Published
2M2Q
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Solution structure of MCh-1: A novel inhibitor cystine knot peptide from Momordica charantia
分子名称: Inhibitor cystine knot peptide MCh-1
著者He, W, Chan, L, Clark, R.J, Tang, J, Zeng, G, Franco, O.L, Cantacessi, C, Craik, D.J, Daly, N.L, Tan, N.
登録日2013-01-01
公開日2013-11-06
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Novel Inhibitor Cystine Knot Peptides from Momordica charantia.
Plos One, 8, 2013
2M2R
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Solution structure of MCh-2: A novel inhibitor cystine knot peptide from Momordica charantia
分子名称: Inhibitor cystine knot peptide MCh-2
著者He, W, Chan, L, Clark, R.J, Tang, J, Zeng, G, Franco, O.L, Cantacessi, C, Craik, D.J, Daly, N.L, Tan, N.
登録日2013-01-01
公開日2013-11-06
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Novel Inhibitor Cystine Knot Peptides from Momordica charantia.
Plos One, 8, 2013
2MSO
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Solution study of cGm9a
分子名称: Conotoxin Gm9.1
著者Akcan, M, Clark, R.J, Daly, N.L, Conibear, A.C, de Faoite, A.C, Heghinian, M.C, Adams, D.J, Mari, F, Craik, D.J.
登録日2014-08-05
公開日2015-07-22
最終更新日2023-12-27
実験手法SOLUTION NMR
主引用文献Transforming conotoxins into cyclotides: Backbone cyclization of P-superfamily conotoxins.
Biopolymers, 104, 2015
2NS3
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Solution structure of ribbon BuIA
分子名称: Alpha-conotoxin BuIA
著者Jin, A.H, Brandstaetter, H, Nevin, S.T, Tan, C.C, Clark, R.J, Adams, D.J, Alewood, P.F, Craik, D.J, Daly, N.L.
登録日2006-11-03
公開日2007-09-25
最終更新日2023-12-27
実験手法SOLUTION NMR
主引用文献Structure of alpha-conotoxin BuIA: influences of disulfide connectivity on structural dynamics
Bmc Struct.Biol., 7, 2007
7L2G
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NMR solution structure of Nak1 from the Necator americanus hookworm
分子名称: ShTK domain protein
著者Smallwood, T.B, Rosengren, K.J, Clark, R.J.
登録日2020-12-17
公開日2021-10-27
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Synthetic hookworm-derived peptides are potent modulators of primary human immune cell function that protect against experimental colitis in vivo.
J.Biol.Chem., 297, 2021
2MSQ
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Solution study of cBru9a
分子名称: Conotoxin cBru9a
著者Akcan, M, Clark, R.J, Daly, N.L, Conibear, A.C, de Faoite, A.C, Heghinian, M.C, Adams, D.J, Mari, F, Craik, D.J.
登録日2014-08-05
公開日2015-07-22
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Transforming conotoxins into cyclotides: Backbone cyclization of P-superfamily conotoxins.
Biopolymers, 104, 2015
1WN4
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NMR Structure of VoNTR
分子名称: VoNTR protein
著者Dutton, J.L, Renda, R.F, Waine, C, Clark, R.J, Daly, N.L, Jennings, C.V, Anderson, M.A, Craik, D.J.
登録日2004-07-27
公開日2004-09-14
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Conserved structural and sequence elements implicated in the processing of gene-encoded circular proteins
J.Biol.Chem., 279, 2004
1WN8
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NMR Structure of OaNTR
分子名称: Kalata B3/B6
著者Dutton, J.L, Renda, R.F, Waine, C, Clark, R.J, Daly, N.L, Jennings, C.V, Anderson, M.A, Craik, D.J.
登録日2004-07-28
公開日2004-09-14
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Conserved structural and sequence elements implicated in the processing of gene-encoded circular proteins
J.Biol.Chem., 279, 2004
2B38
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Solution structure of kalata B8
分子名称: kalata B8
著者Daly, N.L, Clark, R.J, Plan, M.R, Craik, D.J.
登録日2005-09-19
公開日2006-01-31
最終更新日2022-03-09
実験手法SOLUTION NMR
主引用文献Kalata B8, a novel antiviral circular protein, exhibits conformational flexibility in the cystine knot motif
Biochem.J., 393, 2006
1N1U
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NMR structure of [Ala1,15]kalata B1
分子名称: kalata B1
著者Daly, N.L, Clark, R.J, Craik, D.J.
登録日2002-10-20
公開日2003-02-25
最終更新日2022-02-23
実験手法SOLUTION NMR
主引用文献Disulfide Folding Pathways of Cystine Knot Proteins. TYING THE KNOT WITHIN THE CIRCULAR BACKBONE OF THE CYCLOTIDES
J.Biol.Chem., 278, 2003
1ORX
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Solution Structure of the acyclic permutant des-(24-28)-kalata B1.
分子名称: kalata B1
著者Barry, D.G, Daly, N.L, Clark, R.J, Sando, L, Craik, D.J.
登録日2003-03-17
公開日2003-06-24
最終更新日2022-02-23
実験手法SOLUTION NMR
主引用文献Linearization of a naturally occurring circular protein maintains structure but eliminates hemolytic activity
Biochemistry, 42, 2003
6CFB
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Isolation, Characterization, and Synthesis of the Barrettides: Disulfide-Containing Peptides from the Marine Sponge Geodia barretti
分子名称: barrettide A
著者Rosengren, K.J, Carstens, B.B, Clark, R.J, Goransson, U.
登録日2018-02-14
公開日2018-03-21
最終更新日2020-01-01
実験手法SOLUTION NMR
主引用文献Isolation, Characterization, and Synthesis of the Barrettides: Disulfide-Containing Peptides from the Marine Sponge Geodia barretti.
J. Nat. Prod., 78, 2015
1T9E
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NMR solution structure of a disulfide analogue of the cyclic sunflower trypsin inhibitor SFTI-1
分子名称: Trypsin inhibitor 1
著者Korsinczky, M.L.J, Clark, R.J, Craik, D.J.
登録日2004-05-16
公開日2005-05-03
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Disulfide bond mutagenesis and the structure and function of the head-to-tail macrocyclic trypsin inhibitor SFTI-1
Biochemistry, 44, 2005
3LX5
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Crystal structure of mGMPPNP-bound NFeoB from S. thermophilus
分子名称: 2-amino-9-(5-O-[(R)-hydroxy{[(R)-hydroxy(phosphonoamino)phosphoryl]oxy}phosphoryl]-3-O-{[2-(methylamino)phenyl]carbonyl}-beta-D-erythro-pentofuranosyl-2-ulose)-1,9-dihydro-6H-purin-6-one, Ferrous iron uptake transporter protein B, GLYCEROL, ...
著者Ash, M.R, Guilfoyle, A, Maher, M.J, Clarke, R.J, Guss, J.M, Jormakka, M.
登録日2010-02-24
公開日2010-03-09
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Potassium-activated GTPase reaction in the G Protein-coupled ferrous iron transporter B.
J.Biol.Chem., 285, 2010
3LX8
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Crystal structure of GDP-bound NFeoB from S. thermophilus
分子名称: Ferrous iron uptake transporter protein B, GUANOSINE-5'-DIPHOSPHATE
著者Ash, M.R, Guilfoyle, A, Maher, M.J, Clarke, R.J, Guss, J.M, Jormakka, M.
登録日2010-02-24
公開日2010-03-09
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Potassium-activated GTPase reaction in the G Protein-coupled ferrous iron transporter B.
J.Biol.Chem., 285, 2010

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