7DFY
 
 | | Novel motif for left-handed G-quadruplex formation | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2xMotif2, POTASSIUM ION, ... | | 著者 | Das, P, Winnerdy, F.R, Maity, A, Mechulam, Y, Phan, A.T. | | 登録日 | 2020-11-10 | | 公開日 | 2021-09-01 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | | 主引用文献 | A novel minimal motif for left-handed G-quadruplex formation.
Chem.Commun.(Camb.), 57, 2021
|
|
2MS9
 | | Solution structure of a G-quadruplex | | 分子名称: | DNA (28-MER) | | 著者 | Chung, W.J, Heddi, B, Schmitt, E, Lim, K.W, Mechulam, Y, Phan, A.T. | | 登録日 | 2014-07-25 | | 公開日 | 2015-02-18 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of a left-handed DNA G-quadruplex
Proc.Natl.Acad.Sci.USA, 2015
|
|
6JCE
 | | NMR solution and X-ray crystal structures of a DNA containing both right-and left-handed parallel-stranded G-quadruplexes | | 分子名称: | 29-mer DNA | | 著者 | Winnerdy, F.R, Bakalar, B, Maity, A, Vandana, J.J, Mechulam, Y, Schmitt, E, Phan, A.T. | | 登録日 | 2019-01-28 | | 公開日 | 2019-07-10 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR solution and X-ray crystal structures of a DNA molecule containing both right- and left-handed parallel-stranded G-quadruplexes.
Nucleic Acids Res., 47, 2019
|
|
7ZKI
 | | Cryo-EM structure of aIF1A:aIF5B:Met-tRNAiMet complex from a Pyrococcus abyssi 30S initiation complex | | 分子名称: | MAGNESIUM ION, METHIONINE, Met-tRNAiMet, ... | | 著者 | Coureux, P.D, Bourgeois, G, Mechulam, Y, Schmitt, E, Kazan, R. | | 登録日 | 2022-04-13 | | 公開日 | 2022-07-20 | | 最終更新日 | 2022-08-31 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Role of aIF5B in archaeal translation initiation.
Nucleic Acids Res., 50, 2022
|
|
4ZTT
 | | Crystal structures of ferritin mutants reveal diferric-peroxo intermediates | | 分子名称: | FE (II) ION, FE (III) ION, GLYCEROL, ... | | 著者 | Kim, S, Park, Y.H, Jung, S.W, Seok, J.H, Chung, Y.B, Lee, D.B, Gowda, G, Lee, J.H, Han, H.R, Cho, A.E, Lee, C, Chung, M.S, Kim, K.H. | | 登録日 | 2015-05-15 | | 公開日 | 2016-06-15 | | 最終更新日 | 2024-10-02 | | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | | 主引用文献 | Structural Basis of Novel Iron-Uptake Route and Reaction Intermediates in Ferritins from Gram-Negative Bacteria.
J. Mol. Biol., 428, 2016
|
|
3B2R
 | | Crystal Structure of PDE5A1 catalytic domain in complex with Vardenafil | | 分子名称: | 2-{2-ETHOXY-5-[(4-ETHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-5-METHYL-7-PROPYLIMIDAZO[5,1-F][1,2,4]TRIAZIN-4(1H)-ONE, cGMP-specific 3',5'-cyclic phosphodiesterase | | 著者 | Huanchen, W, Mengchun, Y, Howard, R, Sharron, H.F, Hengming, K. | | 登録日 | 2007-10-19 | | 公開日 | 2008-05-20 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | | 主引用文献 | Conformational variations of both phosphodiesterase-5 and inhibitors provide the structural basis for the physiological effects of vardenafil and sildenafil.
Mol.Pharmacol., 73, 2008
|
|
7CJR
 | | Crystal structure of a periplasmic sensor domain of histidine kinase VbrK | | 分子名称: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, Histidine kinase | | 著者 | Goh, B.C, Chua, Y.K, Qian, X, Savko, M, Lescar, J. | | 登録日 | 2020-07-12 | | 公開日 | 2020-09-16 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | | 主引用文献 | Crystal structure of the periplasmic sensor domain of histidine kinase VbrK suggests indirect sensing of beta-lactam antibiotics.
J.Struct.Biol., 212, 2020
|
|
7D5E
 | | Left-handed G-quadruplex containing two bulges | | 分子名称: | 2xBulge-LHG4motif, POTASSIUM ION, SODIUM ION, ... | | 著者 | Das, P, Maity, A, Ngo, K.H, Winnerdy, F.R, Bakalar, B, Mechulam, Y, Schmitt, E, Phan, A.T. | | 登録日 | 2020-09-25 | | 公開日 | 2021-02-10 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.296 Å) | | 主引用文献 | Bulges in left-handed G-quadruplexes.
Nucleic Acids Res., 49, 2021
|
|
8B9P
 | | ACE2 in complex with bicyclic peptide inhibitor | | 分子名称: | 1-[3,5-bis(3-bromanylpropanoyl)-1,3,5-triazinan-1-yl]-3-bromanyl-propan-1-one, ALA-CYS-GLY-ARG-GLN-PHE-CYS-HIS-THR-LEU-MET-PRO-ARG-HIS-LEU-CYS-ALA-NH2, Processed angiotensin-converting enzyme 2 | | 著者 | Brear, P, Lulla, A, Harman, M, Dods, R, Chen, L, Bezerra, G, Demydchuk, Y, Stanway, S, Hyvonen, M. | | 登録日 | 2022-10-06 | | 公開日 | 2023-09-20 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | | 主引用文献 | Structure-Guided Chemical Optimization of Bicyclic Peptide ( Bicycle ) Inhibitors of Angiotensin-Converting Enzyme 2.
J.Med.Chem., 66, 2023
|
|
6QJO
 | | DNA containing both right- and left-handed parallel-stranded G-quadruplexes | | 分子名称: | DNA (28-MER), POTASSIUM ION | | 著者 | Winnerdy, F.R, Bakalar, B, Maity, A, Vandana, J.J, Schmitt, E, Mechulam, Y, Phan, A.T. | | 登録日 | 2019-01-24 | | 公開日 | 2019-07-03 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | NMR solution and X-ray crystal structures of a DNA molecule containing both right- and left-handed parallel-stranded G-quadruplexes.
Nucleic Acids Res., 47, 2019
|
|
8BN1
 | | The structures of Ace2 in complex with bicyclic peptide inhibitor | | 分子名称: | 1-[3,5-bis(3-bromanylpropanoyl)-1,3,5-triazinan-1-yl]-3-bromanyl-propan-1-one, ALA-CYS-VAL-ARG-SER-4PH-CYS-SER-SER-LEU-LEU-PRO-ARG-ILE-HIS-CYS-ALA-NH2, Processed angiotensin-converting enzyme 2, ... | | 著者 | Brear, P, Lulla, A, Harman, M, Dods, R, Chen, L, Bezerra, G, Demydchuk, Y, Stanway, S, Hyvonen, M. | | 登録日 | 2022-11-11 | | 公開日 | 2023-09-20 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | | 主引用文献 | Structure-Guided Chemical Optimization of Bicyclic Peptide ( Bicycle ) Inhibitors of Angiotensin-Converting Enzyme 2.
J.Med.Chem., 66, 2023
|
|
8BFW
 | | The structures of Ace2 in complex with bicyclic peptide inhibitor | | 分子名称: | 1-[3,5-bis(3-bromanylpropanoyl)-1,3,5-triazinan-1-yl]-3-bromanyl-propan-1-one, ALA-CYS-VAL-ARG-SER-HIS-CYS-SER-SER-LEU-LEU-PRO-ARG-ILE-HIS-CYS-ALA-NH2, Processed angiotensin-converting enzyme 2 | | 著者 | Brear, P, Lulla, A, Harman, M, Dods, R, Chen, L, Bezerra, G, Demydchuk, Y, Stanway, S, Hyvonen, M. | | 登録日 | 2022-10-27 | | 公開日 | 2023-10-04 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | | 主引用文献 | Structure-Guided Chemical Optimization of Bicyclic Peptide ( Bicycle ) Inhibitors of Angiotensin-Converting Enzyme 2.
J.Med.Chem., 66, 2023
|
|
8BYJ
 | | The structures of Ace2 in complex with bicyclic peptide inhibitor | | 分子名称: | 1-[3,5-bis(3-bromanylpropanoyl)-1,3,5-triazinan-1-yl]-3-bromanyl-propan-1-one, ALA-CYS-VAL-ARG-SER-HIS-CYS-SER-SER-LEU-LEU-PRO-ARG-ILE-HIS-CYS-ALA, Processed angiotensin-converting enzyme 2, ... | | 著者 | Brear, P, Lulla, A, Harman, M, Dods, R, Chen, L, Bezerra, G, Demydchuk, Y, Stanway, S, Hyvonen, M. | | 登録日 | 2022-12-13 | | 公開日 | 2023-09-20 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | | 主引用文献 | Structure-Guided Chemical Optimization of Bicyclic Peptide ( Bicycle ) Inhibitors of Angiotensin-Converting Enzyme 2.
J.Med.Chem., 66, 2023
|
|
8PHV
 | | Structure of Human selenomethionylated Cdc123 bound to domain 3 of eIF2 gamma | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cell division cycle protein 123 homolog, Eukaryotic translation initiation factor 2 subunit 3 | | 著者 | Schmitt, E, Mechulam, Y, Cardenal Peralta, C, Fagart, J, Seufert, W. | | 登録日 | 2023-06-20 | | 公開日 | 2023-08-16 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | | 主引用文献 | Binding of human Cdc123 to eIF2 gamma.
J.Struct.Biol., 215, 2023
|
|
8PHD
 | | Structure of Human Cdc123 bound to domain 3 of eIF2 gamma and ATP | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cell division cycle protein 123 homolog, Eukaryotic translation initiation factor 2 subunit 3, ... | | 著者 | Schmitt, E, Mechulam, Y, Cardenal Peralta, C, Fagart, J, Seufert, W. | | 登録日 | 2023-06-19 | | 公開日 | 2023-08-16 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | | 主引用文献 | Binding of human Cdc123 to eIF2 gamma.
J.Struct.Biol., 215, 2023
|
|
5C6F
 | | Crystal structures of ferritin mutants reveal side-on binding to diiron and end-on cleavage of oxygen | | 分子名称: | Bacterial non-heme ferritin, FE (III) ION, IMIDAZOLE | | 著者 | Kim, S, Kim, K.H, Seok, J.H, Park, Y.H, Jung, S.W, Chung, Y.B, Lee, D.B, Lee, J.H, Han, K.R, Cho, A.E, Lee, C, Chung, M.S. | | 登録日 | 2015-06-23 | | 公開日 | 2016-07-27 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural Basis of Novel Iron-Uptake Route and Reaction Intermediates in Ferritins from Gram-Negative Bacteria.
J. Mol. Biol., 428, 2016
|
|
5OCD
 | |
7ZHG
 | | High-resolution cryo-EM structure of Pyrococcus abyssi 30S ribosomal subunit bound to mRNA and initiator tRNA anticodon stem-loop | | 分子名称: | 30S ribosomal protein S10, 30S ribosomal protein S11, 30S ribosomal protein S12, ... | | 著者 | Kazan, R, Bourgeois, G, Mechulam, Y, Coureux, P.D, Schmitt, E. | | 登録日 | 2022-04-06 | | 公開日 | 2022-06-29 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (2.25 Å) | | 主引用文献 | Role of aIF5B in archaeal translation initiation.
Nucleic Acids Res., 50, 2022
|
|
7YYP
 | | Structure of aIF5B from Pyrococcus abyssi complexed with GDP | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, NITRATE ION, Probable translation initiation factor IF-2 | | 著者 | Bourgeois, G, Schmitt, E, Mechulam, Y, Coureux, P.D, Kazan, R. | | 登録日 | 2022-02-18 | | 公開日 | 2022-06-29 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Role of aIF5B in archaeal translation initiation.
Nucleic Acids Res., 50, 2022
|
|
1FMT
 | |
7ZAG
 | | Cryo-EM structure of a Pyrococcus abyssi 30S bound to Met-initiator tRNA,mRNA, aIF1A and the C-terminal domain of aIF5B. | | 分子名称: | 30S ribosomal protein S10, 30S ribosomal protein S11, 30S ribosomal protein S12, ... | | 著者 | Coureux, P.D, Bourgeois, G, Mechulam, Y, Schmitt, E, Kazan, R. | | 登録日 | 2022-03-22 | | 公開日 | 2022-08-03 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (2.77 Å) | | 主引用文献 | Role of aIF5B in archaeal translation initiation.
Nucleic Acids Res., 50, 2022
|
|
7ZAH
 | | Cryo-EM structure of a Pyrococcus abyssi 30S bound to Met-initiator tRNA, mRNA, aIF1A and aIF5B | | 分子名称: | 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | 著者 | Coureux, P.D, Bourgeois, G, Mechulam, Y, Schmitt, E, Kazan, R. | | 登録日 | 2022-03-22 | | 公開日 | 2022-08-03 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Role of aIF5B in archaeal translation initiation.
Nucleic Acids Res., 50, 2022
|
|
7ZAI
 | | Cryo-EM structure of a Pyrococcus abyssi 30S bound to Met-initiator tRNA, mRNA and aIF1A. | | 分子名称: | 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | 著者 | Coureux, P.D, Bourgeois, G, Mechulam, Y, Schmitt, E, Kazan, R. | | 登録日 | 2022-03-22 | | 公開日 | 2022-07-13 | | 最終更新日 | 2024-11-13 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Role of aIF5B in archaeal translation initiation.
Nucleic Acids Res., 50, 2022
|
|
6SPN
 | | Structure of the Escherichia coli methionyl-tRNA synthetase complexed with beta-methionine | | 分子名称: | (3R)-3-amino-5-(methylsulfanyl)pentanoic acid, CITRIC ACID, GLYCEROL, ... | | 著者 | Nigro, G, Schmitt, E, Mechulam, Y. | | 登録日 | 2019-09-02 | | 公開日 | 2020-01-01 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Use of beta3-methionine as an amino acid substrate of Escherichia coli methionyl-tRNA synthetase.
J.Struct.Biol., 209, 2020
|
|
5MLQ
 | | Structure of CDPS from Nocardia brasiliensis | | 分子名称: | CDPS, CITRIC ACID | | 著者 | Bourgeois, G, Seguin, J, Moutiez, M, Babin, M, Belin, P, Mechulam, Y, Gondry, M, Schmitt, E. | | 登録日 | 2016-12-07 | | 公開日 | 2018-05-02 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (3.18 Å) | | 主引用文献 | Structural basis for partition of the cyclodipeptide synthases into two subfamilies.
J.Struct.Biol., 203, 2018
|
|
