5LVL
 
 | | Human PDK1 Kinase Domain in Complex with Compound PS653 Bound to the ATP-Binding Site | | 分子名称: | 2,6-DIHYDROANTHRA/1,9-CD/PYRAZOL-6-ONE, 3-phosphoinositide-dependent protein kinase 1, DIMETHYL SULFOXIDE, ... | | 著者 | Schulze, J.O, Saladino, G, Busschots, K, Neimanis, S, Suess, E, Odadzic, D, Zeuzem, S, Hindie, V, Herbrand, A.K, Lisa, M.N, Alzari, P.M, Gervasio, F.L, Biondi, R.M. | | 登録日 | 2016-09-14 | | 公開日 | 2016-10-19 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase.
Cell Chem Biol, 23, 2016
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5CCV
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6YEG
 | | Hybrid structure of the SPP1 tail tube by solid-state NMR and cryo EM - Final EM Refinement | | 分子名称: | Tail tube protein gp17.1* | | 著者 | Zinke, M, Sachowsky, K.A.A, Zinn-Justin, S, Ravelli, R, Schroder, G.F, Habeck, M, Lange, A. | | 登録日 | 2020-03-24 | | 公開日 | 2020-10-14 | | 最終更新日 | 2023-09-13 | | 実験手法 | ELECTRON MICROSCOPY (4 Å), SOLID-STATE NMR | | 主引用文献 | Architecture of the flexible tail tube of bacteriophage SPP1.
Nat Commun, 11, 2020
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8F2N
 | | Phi-29 partially-expanded fiberless prohead | | 分子名称: | Major capsid protein | | 著者 | Woodson, M.E, Morais, M.C, Scott, S.D, Choi, K.H, Jardine, P.J, Zhang, W. | | 登録日 | 2022-11-08 | | 公開日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Phi-29 partially-expanded fiberless prohead
To Be Published
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5ZR3
 | | Crystal structure of Hsp90-alpha N-terminal domain in complex with 4-(3-isopropyl-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl)-3-methylbenzamide | | 分子名称: | 3-methyl-4-{4-[4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzamide, Heat shock protein HSP 90-alpha | | 著者 | Uno, T, Chong, K.T, Suzuki, T. | | 登録日 | 2018-04-23 | | 公開日 | 2019-01-02 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Discovery of 3-Ethyl-4-(3-isopropyl-4-(4-(1-methyl-1 H-pyrazol-4-yl)-1 H-imidazol-1-yl)-1 H-pyrazolo[3,4- b]pyridin-1-yl)benzamide (TAS-116) as a Potent, Selective, and Orally Available HSP90 Inhibitor.
J. Med. Chem., 62, 2019
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6YQ5
 | | Hybrid structure of the SPP1 tail tube by solid-state NMR and cryo EM - NMR Ensemble | | 分子名称: | Tail tube protein gp17.1* | | 著者 | Zinke, M, Sachowsky, K.A.A, Zinn-Justin, S, Ravelli, R, Schroder, G.F, Habeck, M, Lange, A. | | 登録日 | 2020-04-16 | | 公開日 | 2020-10-14 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (4 Å), SOLID-STATE NMR | | 主引用文献 | Architecture of the flexible tail tube of bacteriophage SPP1.
Nat Commun, 11, 2020
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1WUT
 | | Acyl Ureas as Human Liver Glycogen Phosphorylase Inhibitors for the Treatment of Type 2 Diabetes | | 分子名称: | 7-[2,6-DICHLORO-4-({[(2-CHLOROBENZOYL)AMINO]CARBONYL}AMINO)PHENOXY]HEPTANOIC ACID, Glycogen phosphorylase, muscle form, ... | | 著者 | Klabunde, T, Wendt, K.U, Kadereit, D, Brachvogel, V, Burger, H.-J, Herling, A.W, Oikonomakos, N.G, Kosmopoulou, M.N, Schmoll, D, Sarubbi, E, von Roedern, E, Schonafinger, K, Defossa, E. | | 登録日 | 2004-12-08 | | 公開日 | 2005-12-08 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | | 主引用文献 | Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs
Protein Sci., 14, 2005
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1W02
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1W00
 | | Crystal structure of mutant enzyme D103L of Ketosteroid Isomerase from Pseudomonas putida biotype B | | 分子名称: | STEROID DELTA-ISOMERASE | | 著者 | Kim, D.H, Jang, D.S, Nam, G.H, Oh, B.H, Choi, K.Y. | | 登録日 | 2004-05-30 | | 公開日 | 2005-05-26 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural Double-Mutant Cycle Analysis of a Hydrogen Bond Network in Ketosteroid Isomerase from Pseudomonas Putida Biotype B
Biochem.J., 382, 2004
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2O23
 | | The structure of wild-type human HADH2 (17beta-hydroxysteroid dehydrogenase type 10) bound to NAD+ at 1.2 A | | 分子名称: | GLYCEROL, HADH2 protein, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | 著者 | Kavanagh, K.L, Shafqat, N, Scholer, K, Debreczeni, J, Zschocke, J, von Delft, F, Weigelt, J, Arrowsmith, C, Sundstrom, M, Edwards, A, Oppermann, U, Structural Genomics Consortium (SGC) | | 登録日 | 2006-11-29 | | 公開日 | 2006-12-12 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | The structure of wild-type human HADH2 (17beta-hydroxysteroid dehydrogenase type 10) bound to NAD+ at 1.2 A
To be Published
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1BDI
 | | PURINE REPRESSOR MUTANT-HYPOXANTHINE-PALINDROMIC OPERATOR COMPLEX | | 分子名称: | DNA (5'-D(*TP*AP*CP*GP*CP*AP*AP*AP*CP*GP*TP*TP*TP*GP*CP*GP*T )-3'), HYPOXANTHINE, PROTEIN (PURINE REPRESSOR) | | 著者 | Glasfeld, A, Schumacher, M.A, Choi, K.Y, Zalkin, H, Brennan, R.G. | | 登録日 | 1996-07-25 | | 公開日 | 1997-04-21 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | A Positively Charged Residue Bound in the Minor Groove Does not Alter the Bending of a DNA Duplex
J.Am.Chem.Soc., 118, 1996
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1BDH
 | | PURINE REPRESSOR MUTANT-HYPOXANTHINE-PALINDROMIC OPERATOR COMPLEX | | 分子名称: | DNA (5'-D(*TP*AP*CP*GP*CP*AP*AP*AP*CP*GP*TP*TP*TP*GP*CP*GP*T )-3'), HYPOXANTHINE, PROTEIN (PURINE REPRESSOR) | | 著者 | Glasfeld, A, Schumacher, M.A, Choi, K.Y, Zalkin, H, Brennan, R.G. | | 登録日 | 1996-07-25 | | 公開日 | 1997-04-21 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | A Positively Charged Residue Bound in the Minor Groove Does not Alter the Bending of a DNA Duplex
J.Am.Chem.Soc., 118, 1996
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1EA2
 | | Pseudoreversion of the Catalytic Activity of Y14F by the Additional Tyrosine-to-Phenylalanine Substitution(s) in the Hydrogen Bond Network of Delta-5-3-Ketosteroid Isomerase from Pheudomonas putida Biotype B | | 分子名称: | STEROID DELTA-ISOMERASE | | 著者 | Choi, G, Ha, N.-C, Kim, M.-S, Hong, B.-H, Choi, K.Y. | | 登録日 | 2000-11-03 | | 公開日 | 2001-11-01 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Pseudoreversion of the Catalytic Activity of Y14F by the Additional Substitution(S) of Tyrosine with Phenylalanine in the Hydrogen Bond Network of Delta (5)-3-Ketosteroid Isomerase from Pseudomonas Putida Biotype B
Biochemistry, 40, 2001
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1W6Y
 | | crystal structure of a mutant W92A in ketosteroid isomerase (KSI) from Pseudomonas putida biotype B | | 分子名称: | BETA-MERCAPTOETHANOL, EQUILENIN, STEROID DELTA-ISOMERASE | | 著者 | Yun, Y.S, Nam, G.H, Kim, Y.-G, Oh, B.-H, Choi, K.Y. | | 登録日 | 2004-08-25 | | 公開日 | 2005-04-14 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Small Exterior Hydrophobic Cluster Contributes to Conformational Stability and Steroid Binding in Ketosteroid Isomerase from Pseudomonas Putida Biotype B
FEBS J., 272, 2005
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1CQS
 | | CRYSTAL STRUCTURE OF D103E MUTANT WITH EQUILENINEOF KSI IN PSEUDOMONAS PUTIDA | | 分子名称: | EQUILENIN, PROTEIN : KETOSTEROID ISOMERASE | | 著者 | Choi, G, Ha, N.C, Kim, S.W, Kim, D.H, Park, S, Oh, B.H, Choi, K.Y. | | 登録日 | 1999-08-11 | | 公開日 | 2003-06-17 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Asp-99 donates a hydrogen bond not to Tyr-14 but to the steroid directly
in the catalytic mechanism of Delta 5-3-ketosteroid isomerase from
Pseudomonas putida biotype B
Biochemistry, 39, 2000
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6VTX
 | | Crystal structure of human KLF4 zinc finger DNA binding domain in complex with NANOG DNA | | 分子名称: | DNA (5'-D(*AP*GP*GP*GP*GP*GP*TP*GP*TP*GP*CP*C)-3'), DNA (5'-D(*GP*GP*CP*AP*CP*AP*CP*CP*CP*CP*CP*T)-3'), Krueppel-like factor 4, ... | | 著者 | Sharma, R, Sharma, S, Choi, K.J, Ferreon, A.C.M, Ferreon, J.C, Sankaran, B, MacKenzie, K.R, Kim, C. | | 登録日 | 2020-02-13 | | 公開日 | 2021-09-01 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | | 主引用文献 | Liquid condensation of reprogramming factor KLF4 with DNA provides a mechanism for chromatin organization.
Nat Commun, 12, 2021
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8TSV
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1YXN
 | | Pseudo-atomic model of a fiberless isometric variant of bacteriophage phi29 | | 分子名称: | Major head protein | | 著者 | Morais, M.C, Choi, K.H, Koti, J.S, Chipman, P.R, Anderson, D.L, Rossmann, M.G. | | 登録日 | 2005-02-22 | | 公開日 | 2005-04-26 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (7.9 Å) | | 主引用文献 | Conservation of the Capsid Structure in Tailed dsDNA Bacteriophages: the Pseudoatomic Structure of phi29
Mol.Cell, 18, 2005
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8S95
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8SP9
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8TQX
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3L1N
 | | Crystal structure of Mp1p ligand binding domain 2 complexd with palmitic acid | | 分子名称: | Cell wall antigen, PALMITIC ACID | | 著者 | Liao, S, Tung, E.T, Zheng, W, Chong, K, Xu, Y, Bartlam, M, Rao, Z, Yuen, K.Y. | | 登録日 | 2009-12-14 | | 公開日 | 2010-01-05 | | 最終更新日 | 2021-11-10 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Crystal structure of the Mp1p ligand binding domain 2 reveals its function as a fatty acid-binding protein.
J.Biol.Chem., 285, 2010
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3MDC
 | | DNA polymerase lambda in complex with dFdCTP | | 分子名称: | 2'-deoxy-2',2'-difluorocytidine 5'-(tetrahydrogen triphosphate), DNA (5'-D(*CP*AP*GP*TP*AP*C)-3'), DNA (5'-D(*CP*GP*GP*CP*GP*GP*TP*AP*CP*TP*G)-3'), ... | | 著者 | Garcia-Diaz, M, Murray, M, Kunkel, T, Chou, K.M. | | 登録日 | 2010-03-30 | | 公開日 | 2010-04-28 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.999 Å) | | 主引用文献 | Interaction between DNA Polymerase lambda and anticancer nucleoside analogs.
J.Biol.Chem., 285, 2010
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4K1V
 | | Crystal structure of delta5-3-ketosteroid isomerase containing Y16F and Y57F mutations | | 分子名称: | Steroid Delta-isomerase | | 著者 | Cha, H.J, Jang, D.S, Kim, Y.G, Hong, B.H, Woo, J.S, Choi, K.Y. | | 登録日 | 2013-04-05 | | 公開日 | 2013-07-31 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Rescue of deleterious mutations by the compensatory Y30F mutation in ketosteroid isomerase
Mol.Cells, 36, 2013
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2E0Z
 | | Crystal structure of virus-like particle from Pyrococcus furiosus | | 分子名称: | Virus-like particle | | 著者 | Akita, F, Chong, K.T, Tanaka, H, Yamashita, E, Miyazaki, N, Nakaishi, Y, Namba, K, Ono, Y, Suzuki, M, Tsukihara, T, Nakagawa, A. | | 登録日 | 2006-10-16 | | 公開日 | 2007-04-17 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | | 主引用文献 | The Crystal Structure of a Virus-like Particle from the Hyperthermophilic Archaeon Pyrococcus furiosus Provides Insight into the Evolution of Viruses
J.Mol.Biol., 368, 2007
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