8EDJ
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![BU of 8edj by Molmil](/molmil-images/mine/8edj) | Crystal structure of rA3G-ssRNA-GA | Descriptor: | DNA dC->dU-editing enzyme APOBEC-3G, RNA (5'-R(P*UP*GP*AP*UP*UP*U)-3'), SULFATE ION, ... | Authors: | Pacheco, J, Yang, H.J, Li, S.-X, Chen, X.S. | Deposit date: | 2022-09-04 | Release date: | 2023-01-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Structural basis of sequence-specific RNA recognition by the antiviral factor APOBEC3G. Nat Commun, 13, 2022
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6P3X
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![BU of 6p3x by Molmil](/molmil-images/mine/6p3x) | Crystal Structure of Full Length APOBEC3G E/Q (pH 7.0) | Descriptor: | Apolipoprotein B mRNA editing enzyme, catalytic peptide-like 3G, ZINC ION | Authors: | Yang, H.J, Li, S.X, Chen, X.S. | Deposit date: | 2019-05-25 | Release date: | 2020-02-12 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.402 Å) | Cite: | Understanding the structural basis of HIV-1 restriction by the full length double-domain APOBEC3G. Nat Commun, 11, 2020
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6P3Z
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![BU of 6p3z by Molmil](/molmil-images/mine/6p3z) | Crystal Structure of Full Length APOBEC3G E/Q (pH 5.2) | Descriptor: | Apolipoprotein B mRNA editing enzyme, catalytic peptide-like 3G, ZINC ION | Authors: | Yang, H.J, Li, S.X, Chen, X.S. | Deposit date: | 2019-05-25 | Release date: | 2020-02-12 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.844 Å) | Cite: | Understanding the structural basis of HIV-1 restriction by the full length double-domain APOBEC3G. Nat Commun, 11, 2020
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6P3Y
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![BU of 6p3y by Molmil](/molmil-images/mine/6p3y) | Crystal Structure of Full Length APOBEC3G E/Q (pH 7.4) | Descriptor: | Apolipoprotein B mRNA editing enzyme, catalytic peptide-like 3G, ZINC ION | Authors: | Yang, H.J, Li, S.X, Chen, X.S. | Deposit date: | 2019-05-25 | Release date: | 2020-02-12 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.57 Å) | Cite: | Understanding the structural basis of HIV-1 restriction by the full length double-domain APOBEC3G. Nat Commun, 11, 2020
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6P40
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![BU of 6p40 by Molmil](/molmil-images/mine/6p40) | Crystal Structure of Full Length APOBEC3G FKL | Descriptor: | Apolipoprotein B mRNA editing enzyme, catalytic peptide-like 3G, ZINC ION | Authors: | Yang, H.J, Li, S.X, Chen, X.S. | Deposit date: | 2019-05-25 | Release date: | 2020-02-12 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.452 Å) | Cite: | Understanding the structural basis of HIV-1 restriction by the full length double-domain APOBEC3G. Nat Commun, 11, 2020
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4E2I
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![BU of 4e2i by Molmil](/molmil-images/mine/4e2i) | The Complex Structure of the SV40 Helicase Large T Antigen and p68 Subunit of DNA Polymerase Alpha-Primase | Descriptor: | DNA polymerase alpha subunit B, Large T antigen, ZINC ION | Authors: | Zhou, B, Arnett, D.R, Yu, X, Brewster, A, Sowd, G.A, Xie, C.L, Vila, S, Gai, D, Fanning, E, Chen, X.S. | Deposit date: | 2012-03-08 | Release date: | 2012-06-13 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (5 Å) | Cite: | Structural basis for the interaction of a hexameric replicative helicase with the regulatory subunit of human DNA polymerase alpha-primase. J.Biol.Chem., 287, 2012
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3BGW
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![BU of 3bgw by Molmil](/molmil-images/mine/3bgw) | The Structure Of A DnaB-Like Replicative Helicase And Its Interactions With Primase | Descriptor: | DNAB-Like Replicative Helicase | Authors: | Wang, G, Klein, M.G, Tokonzaba, E, Zhang, Y, Holden, L.G, Chen, X.S. | Deposit date: | 2007-11-27 | Release date: | 2007-12-25 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (3.91 Å) | Cite: | The structure of a DnaB-family replicative helicase and its interactions with primase. Nat.Struct.Mol.Biol., 15, 2008
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3BH0
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![BU of 3bh0 by Molmil](/molmil-images/mine/3bh0) | ATPase Domain of G40P | Descriptor: | DNAB-LIKE REPLICATIVE HELICASE | Authors: | Wang, G, Klein, M.G, Tokonzaba, E, Zhang, Y, Holden, L.G, Chen, X.S. | Deposit date: | 2007-11-27 | Release date: | 2007-12-25 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | The structure of a DnaB-family replicative helicase and its interactions with primase. Nat.Struct.Mol.Biol., 15, 2008
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5K83
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![BU of 5k83 by Molmil](/molmil-images/mine/5k83) | Crystal Structure of a Primate APOBEC3G N-Domain, in Complex with ssDNA | Descriptor: | Apolipoprotein B mRNA editing enzyme, catalytic peptide-like 3G,Apolipoprotein B mRNA editing enzyme, catalytic peptide-like 3G, ... | Authors: | Xiao, X, Li, S.-X, Yang, H, Chen, X.S. | Deposit date: | 2016-05-27 | Release date: | 2016-08-10 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.39 Å) | Cite: | Crystal structures of APOBEC3G N-domain alone and its complex with DNA. Nat Commun, 7, 2016
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2H1L
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![BU of 2h1l by Molmil](/molmil-images/mine/2h1l) | |
2Q9Q
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![BU of 2q9q by Molmil](/molmil-images/mine/2q9q) | The crystal structure of full length human GINS complex | Descriptor: | DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, GINS complex subunit 3, ... | Authors: | Chang, Y.P, Wang, G, Chen, X.S. | Deposit date: | 2007-06-13 | Release date: | 2007-08-07 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.36 Å) | Cite: | Crystal structure of the GINS complex and functional insights into its role in DNA replication. Proc.Natl.Acad.Sci.Usa, 104, 2007
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4GDF
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![BU of 4gdf by Molmil](/molmil-images/mine/4gdf) | A Crystal Structure of SV40 Large T Antigen | Descriptor: | DNA (32-MER), Large T antigen, ZINC ION | Authors: | Chang, Y.P, Xu, M, Chen, X.S. | Deposit date: | 2012-07-31 | Release date: | 2013-04-10 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Mechanism of Origin DNA Recognition and Assembly of an Initiator-Helicase Complex by SV40 Large Tumor Antigen. Cell Rep, 3, 2013
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5TKM
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![BU of 5tkm by Molmil](/molmil-images/mine/5tkm) | Crystal structure of human APOBEC3B N-terminal Domain | Descriptor: | DNA dC->dU-editing enzyme APOBEC-3B, ZINC ION | Authors: | Xiao, X, Yang, H, Arutiunian, V, Besse, G, Morimoto, C, Zirkle, B, Chen, X.S. | Deposit date: | 2016-10-07 | Release date: | 2017-06-14 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural determinants of APOBEC3B non-catalytic domain for molecular assembly and catalytic regulation. Nucleic Acids Res., 45, 2017
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4IGO
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![BU of 4igo by Molmil](/molmil-images/mine/4igo) | Histone H3 Lysine 4 Demethylating rice Rice JMJ703 in complex with alpha-KG | Descriptor: | 2-OXOGLUTARIC ACID, FE (III) ION, Os05g0196500 protein | Authors: | Chen, Q.F, Chen, X.S, Wang, Q, Zhang, F.B, Lou, Z.Y, Zhang, Q.F, Zhou, D.X. | Deposit date: | 2012-12-17 | Release date: | 2013-04-03 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis of a histone H3 lysine 4 demethylase required for stem elongation in rice. PLoS Genet., 9, 2013
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4IGQ
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![BU of 4igq by Molmil](/molmil-images/mine/4igq) | Histone H3 Lysine 4 Demethylating Rice JMJ703 in complex with methylated H3K4 substrate | Descriptor: | FE (III) ION, N-OXALYLGLYCINE, Os05g0196500 protein, ... | Authors: | Chen, Q.F, Chen, X.S, Wang, Q, Zhang, F.B, Lou, Z.Y, Zhang, Q.F, Zhou, D.X. | Deposit date: | 2012-12-17 | Release date: | 2013-04-03 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structural basis of a histone H3 lysine 4 demethylase required for stem elongation in rice. PLoS Genet., 9, 2013
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4IGP
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![BU of 4igp by Molmil](/molmil-images/mine/4igp) | Histone H3 Lysine 4 Demethylating Rice JMJ703 apo enzyme | Descriptor: | FE (III) ION, Os05g0196500 protein | Authors: | Chen, Q.F, Chen, X.S, Wang, Q, Zhang, F.B, Lou, Z.Y, Zhang, Q.F, Zhou, D.X. | Deposit date: | 2012-12-17 | Release date: | 2013-04-03 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.003 Å) | Cite: | Structural basis of a histone H3 lysine 4 demethylase required for stem elongation in rice. PLoS Genet., 9, 2013
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3E1U
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![BU of 3e1u by Molmil](/molmil-images/mine/3e1u) | The Crystal Structure of the Anti-Viral APOBEC3G Catalytic Domain | Descriptor: | DNA dC->dU-editing enzyme APOBEC-3G, ZINC ION | Authors: | Holden, L, Prochnow, C, Chang, Y.P, Bransteitter, R, Chelico, L, Sen, U, Stevens, R.C, Goodman, R.F, Chen, X.S. | Deposit date: | 2008-08-04 | Release date: | 2008-10-07 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications. Nature, 456, 2008
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8FVJ
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![BU of 8fvj by Molmil](/molmil-images/mine/8fvj) | Dimeric form of HIV-1 Vif in complex with human CBF-beta, ELOB, ELOC, and CUL5 | Descriptor: | Core-binding factor subunit beta, Cullin-5, Elongin-B, ... | Authors: | Ito, F, Alvarez-Cabrera, A.L, Zhou, Z.H, Chen, X.S. | Deposit date: | 2023-01-19 | Release date: | 2023-09-06 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.54 Å) | Cite: | Structural basis of HIV-1 Vif-mediated E3 ligase targeting of host APOBEC3H. Nat Commun, 14, 2023
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8FY7
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![BU of 8fy7 by Molmil](/molmil-images/mine/8fy7) | SARS-CoV-2 main protease in complex with covalent inhibitor | Descriptor: | 3C-like proteinase nsp5, 4-methoxy-N-[(2S)-4-methyl-1-oxo-1-({(2S)-1-[(3S)-2-oxopyrrolidin-3-yl]but-3-en-2-yl}amino)pentan-2-yl]-1H-indole-2-carboxamide | Authors: | Fried, W, Chen, X.S. | Deposit date: | 2023-01-25 | Release date: | 2023-08-30 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Alkyne as a Latent Warhead to Covalently Target SARS-CoV-2 Main Protease. J.Med.Chem., 66, 2023
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8FY6
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![BU of 8fy6 by Molmil](/molmil-images/mine/8fy6) | SARS-CoV-2 main protease in complex with covalent inhibitor | Descriptor: | (1R,2S,5S)-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-N-{(2R)-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl}-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5 | Authors: | Fried, W, Chen, X.S. | Deposit date: | 2023-01-25 | Release date: | 2023-08-30 | Last modified: | 2024-07-24 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Alkyne as a Latent Warhead to Covalently Target SARS-CoV-2 Main Protease. J.Med.Chem., 66, 2023
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8FVI
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![BU of 8fvi by Molmil](/molmil-images/mine/8fvi) | Human APOBEC3H bound to HIV-1 Vif in complex with CBF-beta, ELOB, ELOC, and CUL5 | Descriptor: | Core-binding factor subunit beta, Cullin 5, DNA dC->dU-editing enzyme APOBEC-3H, ... | Authors: | Ito, F, Alvarez-Cabrera, A.L, Zhou, Z.H, Chen, X.S. | Deposit date: | 2023-01-19 | Release date: | 2023-09-06 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.24 Å) | Cite: | Structural basis of HIV-1 Vif-mediated E3 ligase targeting of host APOBEC3H. Nat Commun, 14, 2023
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6LKA
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![BU of 6lka by Molmil](/molmil-images/mine/6lka) | Crystal Structure of EV71-3C protease with a Novel Macrocyclic Compounds | Descriptor: | 3C proteinase, ~{N}-[(2~{S})-1-[[(2~{S},3~{S},6~{S},7~{Z},12~{E})-4,9-bis(oxidanylidene)-6-[[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]methyl]-2-phenyl-1,10-dioxa-5-azacyclopentadeca-7,12-dien-3-yl]amino]-3-methyl-1-oxidanylidene-butan-2-yl]-5-methyl-1,2-oxazole-3-carboxamide | Authors: | Li, P, Wu, S.Q, Xiao, T.Y.C, Li, Y.L, Su, Z.M, Hao, F, Hu, G.P, Hu, J, Lin, F.S, Chen, X.S, Gu, Z.X, He, H.Y, Li, J, Chen, S.H. | Deposit date: | 2019-12-18 | Release date: | 2020-06-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.033 Å) | Cite: | Design, synthesis, and evaluation of a novel macrocyclic anti-EV71 agent. Bioorg.Med.Chem., 28, 2020
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8UD5
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![BU of 8ud5 by Molmil](/molmil-images/mine/8ud5) | SARS-CoV-2 Nsp15 bound to poly(A/U) RNA, state 2 | Descriptor: | Non-structural protein 15, RNA (35-MER) | Authors: | Ito, F, Yang, H, Zhou, Z.H, Chen, X.S. | Deposit date: | 2023-09-28 | Release date: | 2024-04-24 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.13 Å) | Cite: | Structural basis for polyuridine tract recognition by SARS-CoV-2 Nsp15. Protein Cell, 15, 2024
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8UD4
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![BU of 8ud4 by Molmil](/molmil-images/mine/8ud4) | SARS-CoV-2 Nsp15 bound to poly(A/U) RNA, state 1 | Descriptor: | Non-structural protein 15, RNA (35-MER) | Authors: | Ito, F, Yang, H, Zhou, Z.H, Chen, X.S. | Deposit date: | 2023-09-28 | Release date: | 2024-04-24 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.25 Å) | Cite: | Structural basis for polyuridine tract recognition by SARS-CoV-2 Nsp15. Protein Cell, 15, 2024
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8UD2
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![BU of 8ud2 by Molmil](/molmil-images/mine/8ud2) | SARS-CoV-2 Nsp15, apo-form | Descriptor: | Non-structural protein 15 | Authors: | Ito, F, Yang, H, Zhou, Z.H, Chen, X.S. | Deposit date: | 2023-09-28 | Release date: | 2024-04-24 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (2.33 Å) | Cite: | Structural basis for polyuridine tract recognition by SARS-CoV-2 Nsp15. Protein Cell, 15, 2024
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