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PDB: 274 件
4Z91
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BU of 4z91 by Molmil
ELIC cocrystallized with isofluorane in a desensitized state
分子名称: (2R)-2-chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane, 1.7.6 3-bromanylpropan-1-amine, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
著者Chen, Q, Kinde, M.N, Arjunan, P, Cohen, A, Xu, Y, Tang, P.
登録日2015-04-09
公開日2015-09-16
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.3915 Å)
主引用文献Direct Pore Binding as a Mechanism for Isoflurane Inhibition of the Pentameric Ligand-gated Ion Channel ELIC.
Sci Rep, 5, 2015
4Z90
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BU of 4z90 by Molmil
ELIC bound with the anesthetic isoflurane in the resting state
分子名称: (2R)-2-chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Gamma-aminobutyric-acid receptor subunit beta-1
著者Chen, Q, Kinde, M, Arjunan, P, Cohen, A, Xu, Y, Tang, P.
登録日2015-04-09
公開日2015-09-16
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Direct Pore Binding as a Mechanism for Isoflurane Inhibition of the Pentameric Ligand-gated Ion Channel ELIC.
Sci Rep, 5, 2015
6LP7
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BU of 6lp7 by Molmil
Crystal structure of human DHODH in complex with inhibitor 0944
分子名称: 3-[3,5-bis(fluoranyl)-4-(3-methoxyphenyl)phenyl]benzo[f]benzotriazole-4,9-dione, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ...
著者Chen, Q, Yu, Y.
登録日2020-01-09
公開日2020-09-30
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.802 Å)
主引用文献Bifunctional Naphtho[2,3- d ][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production.
J.Med.Chem., 63, 2020
3LCY
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BU of 3lcy by Molmil
Titin Ig tandem domains A164-A165
分子名称: Titin
著者Chen, Q, Groves, M.R, Wilmanns, M.
登録日2010-01-12
公開日2011-05-25
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural investigation of the Titin A-band tandem Ig domains A164-A165
To be Published
6LP6
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BU of 6lp6 by Molmil
Crystal structure of human DHODH in complex with inhibitor 1214
分子名称: 3-[3,5-bis(fluoranyl)-4-[2-fluoranyl-5-(hydroxymethyl)phenyl]phenyl]benzo[f]benzotriazole-4,9-dione, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ...
著者Chen, Q, Yu, Y.
登録日2020-01-09
公開日2020-09-30
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.795 Å)
主引用文献Bifunctional Naphtho[2,3- d ][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production.
J.Med.Chem., 63, 2020
3LAF
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BU of 3laf by Molmil
Structure of DCC, a netrin-1 receptor
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Deleted in Colorectal Cancer, SULFATE ION, ...
著者Chen, Q, Liu, J.-H, Wang, J.-H.
登録日2010-01-06
公開日2011-03-02
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献N-terminal horseshoe conformation of DCC is functionally required for axon guidance and might be shared by other neural receptors.
J.Cell.Sci., 126, 2013
6J2B
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BU of 6j2b by Molmil
CTX-M-64 beta-lactamase S130T sulbactam complex
分子名称: Beta-lactamase, GLYCEROL, TRANS-ENAMINE INTERMEDIATE OF SULBACTAM
著者Cheng, Q, Chen, S.
登録日2018-12-31
公開日2019-10-30
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.44 Å)
主引用文献Structural Insight into the Mechanism of Inhibitor Resistance in CTX-M-199, a CTX-M-64 Variant Carrying the S130T Substitution.
Acs Infect Dis., 6, 2020
6J2O
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BU of 6j2o by Molmil
Crystal structure of CTX-M-64 clavulanic acid complex
分子名称: (2E)-3-[(4-hydroxy-2-oxobutyl)amino]prop-2-enal, Beta-lactamase
著者Cheng, Q, Chen, S.
登録日2019-01-02
公開日2019-10-30
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural Insight into the Mechanism of Inhibitor Resistance in CTX-M-199, a CTX-M-64 Variant Carrying the S130T Substitution.
Acs Infect Dis., 6, 2020
6J25
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BU of 6j25 by Molmil
CTX-M-64 beta-lactamase mutant-S130T
分子名称: Beta-lactamase
著者Cheng, Q, Chen, S.
登録日2018-12-30
公開日2019-10-30
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Structural Insight into the Mechanism of Inhibitor Resistance in CTX-M-199, a CTX-M-64 Variant Carrying the S130T Substitution.
Acs Infect Dis., 6, 2020
5TV1
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BU of 5tv1 by Molmil
active arrestin-3 with inositol hexakisphosphate
分子名称: Beta-arrestin-2, GLYCEROL, INOSITOL HEXAKISPHOSPHATE
著者Chen, Q, Gilbert, N.C, Perry, N.A, Vishniveteskiy, S, Gurevich, V.V, Iverson, T.M.
登録日2016-11-07
公開日2017-11-22
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural basis of arrestin-3 activation and signaling.
Nat Commun, 8, 2017
6JV4
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BU of 6jv4 by Molmil
Crystal structure of metallo-beta-lactamase VMB-1
分子名称: CITRIC ACID, VMB-1, ZINC ION
著者Cheng, Q, Chen, S.
登録日2019-04-15
公開日2019-11-27
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Genetic and Biochemical Characterization of VMB-1, a Novel Metallo-beta-Lactamase Encoded by a Conjugative, Broad-Host Range IncC Plasmid from Vibrio spp.
Adv Biosyst, 4, 2020
6ITY
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BU of 6ity by Molmil
CTX-M-64 sulbactam complex
分子名称: ACRYLIC ACID, Beta-lactamase, TRANS-ENAMINE INTERMEDIATE OF SULBACTAM
著者Cheng, Q, Chen, S.
登録日2018-11-26
公開日2019-10-30
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献Structural Insight into the Mechanism of Inhibitor Resistance in CTX-M-199, a CTX-M-64 Variant Carrying the S130T Substitution.
Acs Infect Dis., 6, 2020
6J2K
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BU of 6j2k by Molmil
CTX-M-64 beta-lactamase S130T clavulanic acid complex
分子名称: (2E)-3-[(4-hydroxy-2-oxobutyl)amino]prop-2-enal, Beta-lactamase
著者Cheng, Q, Chen, S.
登録日2019-01-01
公開日2019-10-30
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.44 Å)
主引用文献Structural Insight into the Mechanism of Inhibitor Resistance in CTX-M-199, a CTX-M-64 Variant Carrying the S130T Substitution.
Acs Infect Dis., 6, 2020
5WPT
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BU of 5wpt by Molmil
Cryo-EM structure of mammalian endolysosomal TRPML1 channel in nanodiscs in closed II conformation at 3.75 Angstrom resolution
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Mucolipin-1, SODIUM ION
著者Chen, Q, She, J, Guo, J, Bai, X, Jiang, Y.
登録日2017-08-07
公開日2017-10-18
最終更新日2024-10-16
実験手法ELECTRON MICROSCOPY (3.75 Å)
主引用文献Structure of mammalian endolysosomal TRPML1 channel in nanodiscs.
Nature, 550, 2017
5ZB7
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BU of 5zb7 by Molmil
CTX-M-64 apoenzyme
分子名称: Beta-lactamase
著者Cheng, Q, Chen, S.
登録日2018-02-10
公開日2019-02-13
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献Structural Insight into the Mechanism of Inhibitor Resistance in CTX-M-199, a CTX-M-64 Variant Carrying the S130T Substitution.
Acs Infect Dis., 6, 2020
4IRE
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BU of 4ire by Molmil
Crystal structure of GLIC with mutations at the loop C region
分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ACETATE ION, OXALATE ION, ...
著者Chen, Q, Pan, J, Liang, Y.H, Xu, Y, Tang, P.
登録日2013-01-14
公開日2013-04-24
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.19 Å)
主引用文献Signal transduction pathways in the pentameric ligand-gated ion channels.
Plos One, 8, 2013
4QH9
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BU of 4qh9 by Molmil
Crystal structure of Mn2+ bound human APE1
分子名称: 1,2-ETHANEDIOL, DNA-(apurinic or apyrimidinic site) lyase, MANGANESE (II) ION
著者Chen, Q, He, H, Georgiadis, M.M.
登録日2014-05-27
公開日2014-11-12
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.175 Å)
主引用文献High-resolution crystal structures reveal plasticity in the metal binding site of apurinic/apyrimidinic endonuclease I.
Biochemistry, 53, 2014
2GEB
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BU of 2geb by Molmil
Crystal structure of the Thermoanaerobacter tengcongensis hypoxanthine-guanine phosphoribosyltransferase L160I mutant: insights into the inhibitor design
分子名称: CALCIUM ION, Hypoxanthine-guanine phosphoribosyltransferase
著者Chen, Q, Luo, M.
登録日2006-03-19
公開日2007-04-03
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal structure of Thermoanaerobacter tengcongensis hypoxanthine-guanine phosphoribosyl transferase L160I mutant--insights into inhibitor design.
Febs J., 274, 2007
7EPW
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BU of 7epw by Molmil
Crystal structure of monooxygenase Tet(X4) with tigecycline
分子名称: DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, Flavin-dependent monooxygenase, TIGECYCLINE
著者Cheng, Q, Chen, S.
登録日2021-04-28
公開日2021-11-10
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.23 Å)
主引用文献Structural and mechanistic basis of the high catalytic activity of monooxygenase Tet(X4) on tigecycline.
Bmc Biol., 19, 2021
7EPV
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BU of 7epv by Molmil
Crystal structure of tigecycline degrading monooxygenase Tet(X4)
分子名称: DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, Flavin-dependent monooxygenase, GLYCEROL
著者Cheng, Q, Chen, S.
登録日2021-04-27
公開日2021-11-10
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Structural and mechanistic basis of the high catalytic activity of monooxygenase Tet(X4) on tigecycline.
Bmc Biol., 19, 2021
6LP8
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BU of 6lp8 by Molmil
Crystal structure of human DHODH in complex with inhibitor 1243
分子名称: 3-[4-[3-(dimethylamino)phenyl]-3,5-bis(fluoranyl)phenyl]benzo[f]benzotriazole-4,9-dione, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ...
著者Chen, Q, Yu, Y.
登録日2020-01-09
公開日2020-09-30
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Bifunctional Naphtho[2,3- d ][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production.
J.Med.Chem., 63, 2020
6D1S
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BU of 6d1s by Molmil
Crystal structure of an apo chimeric human alpha1GABAA receptor
分子名称: chimeric alpha1GABAA receptor
著者Chen, Q, Arjunan, P, Cohen, A.E, Xu, Y, Tang, P.
登録日2018-04-12
公開日2018-08-22
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structural basis of neurosteroid anesthetic action on GABAAreceptors.
Nat Commun, 9, 2018
6CNE
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BU of 6cne by Molmil
Selenomethionine variant (V29SeM) of protein GB1
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Immunoglobulin G-binding protein G, PHOSPHATE ION
著者Chen, Q.
登録日2018-03-08
公開日2019-07-10
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献77Se NMR Probes the Protein Environment of Selenomethionine.
J.Phys.Chem.B, 124, 2020
6CDU
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BU of 6cdu by Molmil
Crystal structure of a chimeric human alpha1GABAA receptor in complex with alphaxalone
分子名称: (3a,5a)-3-Hydroxypregnane-11,20-dione, chimeric alpha1GABAA receptor
著者Chen, Q, Arjunan, P, Cohen, A.E, Xu, Y, Tang, P.
登録日2018-02-09
公開日2018-08-22
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.45 Å)
主引用文献Structural basis of neurosteroid anesthetic action on GABAAreceptors.
Nat Commun, 9, 2018
6CTE
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BU of 6cte by Molmil
77Se-NMR probes the protein environment of selenomethionine
分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, ...
著者Chen, Q, Rozovsky, S.
登録日2018-03-22
公開日2019-07-10
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献77Se NMR Probes the Protein Environment of Selenomethionine.
J.Phys.Chem.B, 124, 2020

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