2KNO
 
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3LLP
 | | 1.8 Angstrom human fascin 1 crystal structure | | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, BROMIDE ION, Fascin, ... | | Authors: | Chen, L, Yang, S, Jakoncic, J, Zhang, J.J, Huang, X.-Y. | | Deposit date: | 2010-01-29 | | Release date: | 2010-04-07 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Migrastatin analogues target fascin to block tumour metastasis.
Nature, 464, 2010
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2LHK
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3MQ0
 | | Crystal Structure of Agobacterium tumefaciens repressor BlcR | | Descriptor: | Transcriptional repressor of the blcABC operon | | Authors: | Chen, L. | | Deposit date: | 2010-04-27 | | Release date: | 2011-03-30 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.793 Å) | | Cite: | The Agrobacterium tumefaciens Transcription Factor BlcR Is Regulated via Oligomerization.
J.Biol.Chem., 286, 2011
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3MCA
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2M1N
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1AAN
 | | CRYSTAL STRUCTURE ANALYSIS OF AMICYANIN AND APOAMICYANIN FROM PARACOCCUS DENITRIFICANS AT 2.0 ANGSTROMS AND 1.8 ANGSTROMS RESOLUTION | | Descriptor: | AMICYANIN, COPPER (II) ION | | Authors: | Chen, L, Durley, R.C.E, Lim, L.W, Mathews, F.S. | | Deposit date: | 1992-04-09 | | Release date: | 1993-10-31 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure analysis of amicyanin and apoamicyanin from Paracoccus denitrificans at 2.0 A and 1.8 A resolution.
Protein Sci., 2, 1993
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1A02
 | | STRUCTURE OF THE DNA BINDING DOMAINS OF NFAT, FOS AND JUN BOUND TO DNA | | Descriptor: | AP-1 FRAGMENT FOS, AP-1 FRAGMENT JUN, DNA (5'-D(*DAP*DAP*DCP*DTP*DAP*DTP*DGP*DAP*DAP*DAP*DCP*DAP*DAP*DAP*DTP*DTP*DTP*DTP*DCP*DC)-3'), ... | | Authors: | Chen, L, Glover, J.N.M, Hogan, P.G, Rao, A, Harrison, S.C. | | Deposit date: | 1997-12-08 | | Release date: | 1998-05-27 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA.
Nature, 392, 1998
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7E3X
 | | Crystal structure of SDR family NAD(P)-dependent oxidoreductase from exiguobacterium | | Descriptor: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Oxidoreductase | | Authors: | Chen, L, Tang, J, Yuan, S, Zhang, F, Chen, S. | | Deposit date: | 2021-02-09 | | Release date: | 2021-09-29 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.58 Å) | | Cite: | Structure-guided evolution of a ketoreductase forefficient and stereoselective bioreduction of bulkyalpha-aminobeta-keto esters
Catalysis Science And Technology, 2021
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1B3D
 | | STROMELYSIN-1 | | Descriptor: | CALCIUM ION, N-[[2-METHYL-4-HYDROXYCARBAMOYL]BUT-4-YL-N]-BENZYL-P-[PHENYL]-P-[METHYL]PHOSPHINAMID, STROMELYSIN-1, ... | | Authors: | Chen, L, Rydel, T.J, Dunaway, C.M, Pikul, S, Dunham, K.M, Gu, F, Barnett, B.L. | | Deposit date: | 1998-12-09 | | Release date: | 1999-12-10 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structure of the stromelysin catalytic domain at 2.0 A resolution: inhibitor-induced conformational changes.
J.Mol.Biol., 293, 1999
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7Y1M
 | | Structure of SUR2B in complex with Mg-ATP, Mg-ADP, and repaglinide in the inward-facing conformation | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Isoform SUR2B of ATP-binding cassette sub-family C member 9, ... | | Authors: | Chen, L, Ding, D, Hou, T. | | Deposit date: | 2022-06-08 | | Release date: | 2023-06-14 | | Last modified: | 2023-10-11 | | Method: | ELECTRON MICROSCOPY (3.57 Å) | | Cite: | The inhibition mechanism of the SUR2A-containing K ATP channel by a regulatory helix.
Nat Commun, 14, 2023
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7Y1J
 | | Structure of SUR2A in complex with Mg-ATP and repaglinide in the inward-facing conformation. | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 9, MAGNESIUM ION, ... | | Authors: | Chen, L, Ding, D, Hou, T. | | Deposit date: | 2022-06-08 | | Release date: | 2023-06-14 | | Last modified: | 2023-10-11 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | The inhibition mechanism of the SUR2A-containing K ATP channel by a regulatory helix.
Nat Commun, 14, 2023
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7Y1K
 | | Structure of SUR2A in complex with Mg-ATP, Mg-ADP and repaglinide in the inward-facing conformation | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 9, ... | | Authors: | Chen, L, Ding, D, Hou, T. | | Deposit date: | 2022-06-08 | | Release date: | 2023-06-14 | | Last modified: | 2023-10-11 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | The inhibition mechanism of the SUR2A-containing K ATP channel by a regulatory helix.
Nat Commun, 14, 2023
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7Y1N
 | | Structure of SUR2B in complex with Mg-ATP, Mg-ADP, and repaglinide in the partially occluded state | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Isoform SUR2B of ATP-binding cassette sub-family C member 9, ... | | Authors: | Chen, L, Ding, D, Hou, T. | | Deposit date: | 2022-06-08 | | Release date: | 2023-06-14 | | Last modified: | 2023-10-11 | | Method: | ELECTRON MICROSCOPY (3.61 Å) | | Cite: | The inhibition mechanism of the SUR2A-containing K ATP channel by a regulatory helix.
Nat Commun, 14, 2023
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7Y1L
 | | Structure of SUR2B in complex with Mg-ATP and repaglinide in the inward-facing conformation | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Isoform SUR2B of ATP-binding cassette sub-family C member 9, MAGNESIUM ION, ... | | Authors: | Chen, L, Ding, D, Hou, T. | | Deposit date: | 2022-06-08 | | Release date: | 2023-06-14 | | Last modified: | 2023-10-11 | | Method: | ELECTRON MICROSCOPY (3.73 Å) | | Cite: | The inhibition mechanism of the SUR2A-containing K ATP channel by a regulatory helix.
Nat Commun, 14, 2023
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7YNJ
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7YNI
 | | Structure of human SGLT1-MAP17 complex bound with substrate 4D4FDG in the occluded conformation | | Descriptor: | (2R,3R,4R,5S,6R)-5-fluoranyl-6-(hydroxymethyl)oxane-2,3,4-triol, PDZK1-interacting protein 1, Sodium/glucose cotransporter 1 | | Authors: | Chen, L, Niu, Y, Cui, W. | | Deposit date: | 2022-07-31 | | Release date: | 2023-05-31 | | Last modified: | 2023-12-13 | | Method: | ELECTRON MICROSCOPY (3.26 Å) | | Cite: | Structures of human SGLT in the occluded state reveal conformational changes during sugar transport.
Nat Commun, 14, 2023
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7YNK
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3RJ2
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3R0M
 | | Crystal structure of anti-HIV llama VHH antibody A12 | | Descriptor: | Llama VHH A12, SULFATE ION | | Authors: | Chen, L, McLellan, J.S, Kwon, Y.D, Schmidt, S, Wu, X, Zhou, T, Yang, Y, Zhang, B, Forsman, A, Weiss, R.A, Verrips, T, Mascola, J, Kwong, P.D. | | Deposit date: | 2011-03-08 | | Release date: | 2012-03-14 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Single-Headed Immunoglobulins Efficiently Penetrate CD4-Binding Site and Effectively Neutralize HIV-1
To be Published
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3RPT
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3RJQ
 | | Crystal structure of anti-HIV llama VHH antibody A12 in complex with C186 gp120 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, C186 gp120, Llama VHH A12 | | Authors: | Chen, L, McLellan, J.S, Kwon, Y.D, Schmidt, S, Wu, X, Zhou, T, Yang, Y, Zhang, B, Forsman, A, Weiss, R.A, Verrips, T, Mascola, J, Kwong, P.D. | | Deposit date: | 2011-04-15 | | Release date: | 2012-05-02 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.601 Å) | | Cite: | Crystal structure of anti-HIV A12 VHH of llama antibody in complex with C1086 gp120
To be Published
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7VLR
 | | Structure of SUR2B in complex with Mg-ATP/ADP | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL HEMISUCCINATE, ... | | Authors: | Chen, L, Ding, D. | | Deposit date: | 2021-10-05 | | Release date: | 2022-05-18 | | Last modified: | 2022-12-14 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structural identification of vasodilator binding sites on the SUR2 subunit.
Nat Commun, 13, 2022
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7VLT
 | | Structure of SUR2B in complex with Mg-ATP/ADP and levcromakalim | | Descriptor: | (3S,4R)-2,2-dimethyl-3-oxidanyl-4-(2-oxidanylidenepyrrolidin-1-yl)-3,4-dihydrochromene-6-carbonitrile, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Chen, L, Ding, D. | | Deposit date: | 2021-10-05 | | Release date: | 2022-05-18 | | Last modified: | 2022-12-14 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural identification of vasodilator binding sites on the SUR2 subunit.
Nat Commun, 13, 2022
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7VLS
 | | Structure of SUR2B in complex with MgATP/ADP and P1075 | | Descriptor: | 1-cyano-2-(2-methylbutan-2-yl)-3-pyridin-3-yl-guanidine, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Chen, L, Ding, D. | | Deposit date: | 2021-10-05 | | Release date: | 2022-05-18 | | Last modified: | 2022-12-14 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural identification of vasodilator binding sites on the SUR2 subunit.
Nat Commun, 13, 2022
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