4WAT
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7YNK
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7YNJ
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7YNI
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![BU of 7yni by Molmil](/molmil-images/mine/7yni) | Structure of human SGLT1-MAP17 complex bound with substrate 4D4FDG in the occluded conformation | Descriptor: | (2R,3R,4R,5S,6R)-5-fluoranyl-6-(hydroxymethyl)oxane-2,3,4-triol, PDZK1-interacting protein 1, Sodium/glucose cotransporter 1 | Authors: | Chen, L, Niu, Y, Cui, W. | Deposit date: | 2022-07-31 | Release date: | 2023-05-31 | Last modified: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (3.26 Å) | Cite: | Structures of human SGLT in the occluded state reveal conformational changes during sugar transport. Nat Commun, 14, 2023
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1MDA
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![BU of 1mda by Molmil](/molmil-images/mine/1mda) | CRYSTAL STRUCTURE OF AN ELECTRON-TRANSFER COMPLEX BETWEEN METHYLAMINE DEHYDROGENASE AND AMICYANIN | Descriptor: | AMICYANIN, COPPER (II) ION, METHYLAMINE DEHYDROGENASE (HEAVY SUBUNIT), ... | Authors: | Chen, L, Durley, R, Mathews, F.S. | Deposit date: | 1992-03-02 | Release date: | 1993-10-31 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of an electron-transfer complex between methylamine dehydrogenase and amicyanin. Biochemistry, 31, 1992
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2BBK
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1Y6J
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![BU of 1y6j by Molmil](/molmil-images/mine/1y6j) | L-Lactate Dehydrogenase from Clostridium Thermocellum Cth-1135 | Descriptor: | L-lactate dehydrogenase | Authors: | Chen, L, Yang, H, Kataeva, I, Chen, L.R, Tempel, W, Lee, D, Habel, J, Zhou, W, Lin, D, Ljungdahl, L, Liu, Z.-J, Rose, J, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG) | Deposit date: | 2004-12-06 | Release date: | 2004-12-14 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3.01 Å) | Cite: | L-Lactate Dehydrogenase from Clostridium Thermocellum Cth-1135 To be Published
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7D4P
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![BU of 7d4p by Molmil](/molmil-images/mine/7d4p) | Structure of human TRPC5 in complex with clemizole | Descriptor: | (2S)-2-(hexadecanoyloxy)-3-hydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole, ... | Authors: | Chen, L, Song, K, Wei, M, Guo, W. | Deposit date: | 2020-09-24 | Release date: | 2021-03-31 | Last modified: | 2021-10-13 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structural basis for human TRPC5 channel inhibition by two distinct inhibitors. Elife, 10, 2021
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7D4Q
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![BU of 7d4q by Molmil](/molmil-images/mine/7d4q) | Structure of human TRPC5 in complex with HC-070 | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 8-(3-chloranylphenoxy)-7-[(4-chlorophenyl)methyl]-3-methyl-1-(3-oxidanylpropyl)purine-2,6-dione, CALCIUM ION, ... | Authors: | Chen, L, Song, K, Wei, M, Guo, W. | Deposit date: | 2020-09-24 | Release date: | 2021-03-31 | Last modified: | 2021-10-13 | Method: | ELECTRON MICROSCOPY (2.74 Å) | Cite: | Structural basis for human TRPC5 channel inhibition by two distinct inhibitors. Elife, 10, 2021
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3WL0
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![BU of 3wl0 by Molmil](/molmil-images/mine/3wl0) | Crystal structure of Ostrinia furnacalis Group I chitinase catalytic domain E148A mutant in complex with a(GlcNAc)2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Chitinase | Authors: | Chen, L, Liu, T, Zhou, Y, Chen, Q, Shen, X, Yang, Q. | Deposit date: | 2013-11-05 | Release date: | 2014-04-09 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.204 Å) | Cite: | Structural characteristics of an insect group I chitinase, an enzyme indispensable to moulting. Acta Crystallogr.,Sect.D, 70, 2014
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3WKZ
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![BU of 3wkz by Molmil](/molmil-images/mine/3wkz) | Crystal Structure of the Ostrinia furnacalis Group I Chitinase catalytic domain E148Q mutant | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Chitinase | Authors: | Chen, L, Liu, T, Zhou, Y, Chen, Q, Shen, X, Yang, Q. | Deposit date: | 2013-11-05 | Release date: | 2014-04-09 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.001 Å) | Cite: | Structural characteristics of an insect group I chitinase, an enzyme indispensable to moulting. Acta Crystallogr.,Sect.D, 70, 2014
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1R7J
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![BU of 1r7j by Molmil](/molmil-images/mine/1r7j) | Crystal structure of the DNA-binding protein Sso10a from Sulfolobus solfataricus | Descriptor: | Conserved hypothetical protein Sso10a | Authors: | Chen, L, Chen, L.R, Zhou, X.E, Wang, Y, Kahsai, M.A, Clark, A.T, Edmondson, S.P, Liu, Z.-J, Rose, J.P, Wang, B.C, Shriver, J.W, Meehan, E.J, Southeast Collaboratory for Structural Genomics (SECSG) | Deposit date: | 2003-10-21 | Release date: | 2004-07-20 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | The hyperthermophile protein Sso10a is a dimer of winged helix DNA-binding domains linked by an antiparallel coiled coil rod. J.Mol.Biol., 341, 2004
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3WL1
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![BU of 3wl1 by Molmil](/molmil-images/mine/3wl1) | Crystal structure of Ostrinia furnacalis Group I chitinase catalytic domain in complex with reaction products (GlcNAc)2,3 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Chen, L, Liu, T, Zhou, Y, Chen, Q, Shen, X, Yang, Q. | Deposit date: | 2013-11-05 | Release date: | 2014-04-09 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.772 Å) | Cite: | Structural characteristics of an insect group I chitinase, an enzyme indispensable to moulting. Acta Crystallogr.,Sect.D, 70, 2014
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3W4R
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![BU of 3w4r by Molmil](/molmil-images/mine/3w4r) | Crystal structure of an insect chitinase from the Asian corn borer, Ostrinia furnacalis | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Chitinase | Authors: | Chen, L, Liu, T, Zhou, Y, Shen, X, Yang, Q. | Deposit date: | 2013-01-10 | Release date: | 2014-02-12 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural characteristics of an insect group I chitinase, an enzyme indispensable to moulting Acta Crystallogr.,Sect.D, 70, 2014
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7D3F
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![BU of 7d3f by Molmil](/molmil-images/mine/7d3f) | Cryo-EM structure of human DUOX1-DUOXA1 in high-calcium state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Dual oxidase 1, ... | Authors: | Chen, L, Wu, J.X. | Deposit date: | 2020-09-19 | Release date: | 2020-12-09 | Last modified: | 2021-06-23 | Method: | ELECTRON MICROSCOPY (2.3 Å) | Cite: | Structures of human dual oxidase 1 complex in low-calcium and high-calcium states. Nat Commun, 12, 2021
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7D9R
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![BU of 7d9r by Molmil](/molmil-images/mine/7d9r) | Structure of huamn soluble guanylate cyclase in the riociguat and NO-bound state | Descriptor: | Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, MAGNESIUM ION, ... | Authors: | Chen, L, Liu, R, Kang, Y. | Deposit date: | 2020-10-14 | Release date: | 2021-08-11 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Activation mechanism of human soluble guanylate cyclase by stimulators and activators. Nat Commun, 12, 2021
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7D9U
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![BU of 7d9u by Molmil](/molmil-images/mine/7d9u) | Structure of human soluble guanylate cyclase in the cinciguat-bound activated state | Descriptor: | 4-({(4-carboxybutyl)[2-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)ethyl]amino}methyl)benzoic acid, Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, ... | Authors: | Chen, L, Liu, R, Kang, Y. | Deposit date: | 2020-10-14 | Release date: | 2021-08-11 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Activation mechanism of human soluble guanylate cyclase by stimulators and activators. Nat Commun, 12, 2021
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7D9S
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![BU of 7d9s by Molmil](/molmil-images/mine/7d9s) | Structure of huamn soluble guanylate cyclase in the YC1 and NO-bound state | Descriptor: | Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, MAGNESIUM ION, ... | Authors: | Chen, L, Liu, R, Kang, Y. | Deposit date: | 2020-10-14 | Release date: | 2021-08-11 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Activation mechanism of human soluble guanylate cyclase by stimulators and activators. Nat Commun, 12, 2021
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7D9T
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![BU of 7d9t by Molmil](/molmil-images/mine/7d9t) | Structure of human soluble guanylate cyclase in the cinciguat-bound inactive state | Descriptor: | 4-({(4-carboxybutyl)[2-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)ethyl]amino}methyl)benzoic acid, Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1 | Authors: | Chen, L, Liu, R, Kang, Y. | Deposit date: | 2020-10-14 | Release date: | 2021-08-11 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Activation mechanism of human soluble guanylate cyclase by stimulators and activators. Nat Commun, 12, 2021
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3BWH
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![BU of 3bwh by Molmil](/molmil-images/mine/3bwh) | Atomic resolution structure of cucurmosin, a novel type 1 RIP from the sarcocarp of Cucurbita moschata | Descriptor: | 1,2-ETHANEDIOL, PHOSPHATE ION, beta-D-xylopyranose-(1-2)-[alpha-D-mannopyranose-(1-3)][alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Chen, L. | Deposit date: | 2008-01-09 | Release date: | 2008-10-07 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | Atomic resolution structure of cucurmosin, a novel type 1 ribosome-inactivating protein from the sarcocarp of Cucurbita moschata. J.Struct.Biol., 164, 2008
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3WMC
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![BU of 3wmc by Molmil](/molmil-images/mine/3wmc) | Crystal structure of insect beta-N-acetyl-D-hexosaminidase OfHex1 complexed with naphthalimide derivative Q2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-(dimethylamino)-2-(2-{[(5-methyl-1,3,4-thiadiazol-2-yl)methyl]amino}ethyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione, Beta-hexosaminidase | Authors: | Chen, L, Zhou, Y, Chen, L, Yang, Q. | Deposit date: | 2013-11-16 | Release date: | 2014-11-05 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.095 Å) | Cite: | A crystal structure-guided rational design switching non-carbohydrate inhibitors' specificity between two beta-GlcNAcase homologs Sci Rep, 4, 2014
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8YJC
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![BU of 8yjc by Molmil](/molmil-images/mine/8yjc) | Structure of Vibrio vulnificus MARTX cysteine protease domain C3727A | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, INOSITOL HEXAKISPHOSPHATE, Multifunctional autoprocessing repeat-in-toxin (MARTX), ... | Authors: | Chen, L, Khan, H, Tan, L, Li, X, Zhang, G, Im, Y.J. | Deposit date: | 2024-03-01 | Release date: | 2024-07-10 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Structural basis of the activation of MARTX cysteine protease from Vibrio vunificus To Be Published
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8YJA
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![BU of 8yja by Molmil](/molmil-images/mine/8yja) | Structure of Vibrio vulnificus MARTX cysteine protease domain lacking beta-flap | Descriptor: | INOSITOL HEXAKISPHOSPHATE, MARTX cysteine protease domain, SODIUM ION | Authors: | Chen, L, Khan, H, Tan, L, Li, X, Zhang, G, Im, Y.J. | Deposit date: | 2024-03-01 | Release date: | 2024-07-10 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural basis of the activation of MARTX cysteine protease from Vibrio vunificus To Be Published
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1PN9
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![BU of 1pn9 by Molmil](/molmil-images/mine/1pn9) | Crystal structure of an insect delta-class glutathione S-transferase from a DDT-resistant strain of the malaria vector Anopheles gambiae | Descriptor: | Glutathione S-transferase 1-6, S-HEXYLGLUTATHIONE | Authors: | Chen, L, Hall, P.R, Zhou, X.E, Ranson, H, Hemingway, J, Meehan, E.J. | Deposit date: | 2003-06-12 | Release date: | 2003-12-09 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of an insect delta-class glutathione S-transferase from a DDT-resistant strain of the malaria vector Anopheles gambiae. Acta Crystallogr.,Sect.D, 59, 2003
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1PSA
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![BU of 1psa by Molmil](/molmil-images/mine/1psa) | STRUCTURE OF A PEPSIN(SLASH)RENIN INHIBITOR COMPLEX REVEALS A NOVEL CRYSTAL PACKING INDUCED BY MINOR CHEMICAL ALTERATIONS IN THE INHIBITOR | Descriptor: | N-(ethoxycarbonyl)-L-leucyl-N-[(1R,2S,3S)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-L-leucinamide, PEPSIN A | Authors: | Chen, L, Abad-Zapatero, C. | Deposit date: | 1991-10-22 | Release date: | 1994-01-31 | Last modified: | 2017-11-29 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structure of a pepsin/renin inhibitor complex reveals a novel crystal packing induced by minor chemical alterations in the inhibitor. Acta Crystallogr.,Sect.B, 48, 1992
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