2Q0O
| Crystal structure of an anti-activation complex in bacterial quorum sensing | 分子名称: | 3-OXO-OCTANOIC ACID (2-OXO-TETRAHYDRO-FURAN-3-YL)-AMIDE, Probable transcriptional activator protein traR, Probable transcriptional repressor traM | 著者 | Chen, G, Jeffrey, P.D, Fuqua, C, Shi, Y, Chen, L. | 登録日 | 2007-05-22 | 公開日 | 2007-09-25 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural basis for antiactivation in bacterial quorum sensing. Proc.Natl.Acad.Sci.Usa, 104, 2007
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5KYJ
| Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core | 分子名称: | (6~{R})-5-(5-fluoranyl-2-methoxy-pyrimidin-4-yl)-2-(3-methylsulfonylphenyl)-6-propan-2-yl-4,6-dihydropyrrolo[3,4-c]pyrazole, Oxysterols receptor LXR-beta, Retinoic acid receptor RXR-beta | 著者 | Chen, G, McKeever, B.M. | 登録日 | 2016-07-21 | 公開日 | 2016-09-21 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core. Bioorg.Med.Chem.Lett., 26, 2016
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5KYA
| Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core | 分子名称: | Oxysterols receptor LXR-beta, Retinoic acid receptor RXR-beta, [2-[(6~{R})-2-(3-methylsulfonylphenyl)-6-propan-2-yl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl]-4-(trifluoromethyl)pyrimidin-5-yl]methanol | 著者 | Chen, G, McKeever, B.M. | 登録日 | 2016-07-21 | 公開日 | 2016-09-21 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.598 Å) | 主引用文献 | Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core. Bioorg.Med.Chem.Lett., 26, 2016
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1RFY
| Crystal Structure of Quorum-Sensing Antiactivator TraM | 分子名称: | Transcriptional repressor traM | 著者 | Chen, G, Malenkos, J.W, Cha, M.R, Fuqua, C, Chen, L. | 登録日 | 2003-11-10 | 公開日 | 2004-11-23 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Quorum-sensing antiactivator TraM forms a dimer that dissociates to inhibit TraR Mol.Microbiol., 52, 2004
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7BW0
| Active human TGR5 complex with a synthetic agonist 23H | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Chen, G, Wang, X.K, Chen, Q, Hu, H.L, Ren, R.B. | 登録日 | 2020-04-12 | 公開日 | 2020-09-02 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Cryo-EM structure of activated bile acids receptor TGR5 in complex with stimulatory G protein. Signal Transduct Target Ther, 5, 2020
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3BJC
| Crystal structure of the PDE5A catalytic domain in complex with a novel inhibitor | 分子名称: | 5-ethoxy-4-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)thiophene-2-sulfonamide, MAGNESIUM ION, ZINC ION, ... | 著者 | Chen, G, Wang, H, Howard, R, Cai, J, Wan, Y, Ke, H. | 登録日 | 2007-12-03 | 公開日 | 2008-04-29 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | An insight into the pharmacophores of phosphodiesterase-5 inhibitors from synthetic and crystal structural studies BIOCHEM.PHARM., 75, 2008
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2DD1
| Three consecutive sheared GA pairs in 5'GGUGGAGGCU/3'PCCAAAGCCG | 分子名称: | 5'-R(*GP*CP*CP*GP*AP*AP*AP*CP*CP*(P5P))-3', 5'-R(*GP*GP*UP*GP*GP*AP*GP*GP*CP*U)-3' | 著者 | Chen, G, Kennedy, S.D, Krugh, T.R, Turner, D.H. | 登録日 | 2006-01-19 | 公開日 | 2006-06-13 | 最終更新日 | 2022-03-09 | 実験手法 | SOLUTION NMR | 主引用文献 | An Alternating Sheared AA Pair and Elements of Stability for a Single Sheared Purine-Purine Pair Flanked by Sheared GA Pairs in RNA Biochemistry, 45, 2006
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2DD3
| An alternating sheared AA pair in 5'GGUGAAGGCU/3'PCCGAAGCCG: II. The minor conformation with A6/A5/A16 stack | 分子名称: | 5'-R(*GP*CP*CP*GP*AP*AP*GP*CP*CP*(P5P))-3', 5'-R(*GP*GP*UP*GP*AP*AP*GP*GP*CP*U)-3' | 著者 | Chen, G, Kennedy, S.D, Krugh, T.R, Turner, D.H. | 登録日 | 2006-01-19 | 公開日 | 2006-06-13 | 最終更新日 | 2022-03-09 | 実験手法 | SOLUTION NMR | 主引用文献 | An Alternating Sheared AA Pair and Elements of Stability for a Single Sheared Purine-Purine Pair Flanked by Sheared GA Pairs in RNA Biochemistry, 45, 2006
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2DD2
| An alternating sheared AA pair in 5'GGUGAAGGCU/3'PCCGAAGCCG: I. The major conformation with A6/A15/A16 stack | 分子名称: | 5'-R(*GP*CP*CP*GP*AP*AP*GP*CP*CP*(P5P))-3', 5'-R(*GP*GP*UP*GP*AP*AP*GP*GP*CP*U)-3' | 著者 | Chen, G, Kennedy, S.D, Krugh, T.R, Turner, D.H. | 登録日 | 2006-01-19 | 公開日 | 2006-06-13 | 最終更新日 | 2022-03-09 | 実験手法 | SOLUTION NMR | 主引用文献 | An Alternating Sheared AA Pair and Elements of Stability for a Single Sheared Purine-Purine Pair Flanked by Sheared GA Pairs in RNA Biochemistry, 45, 2006
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1XV0
| Solution NMR structure of RNA internal loop with three consecutive sheared GA pairs in 5'GGUGGAGGCU/3'PCCGAAGCCG | 分子名称: | 5'-R(*GP*CP*CP*GP*AP*AP*GP*CP*CP*(P5P)-3', 5'-R(*GP*GP*UP*GP*GP*AP*GP*GP*CP*U)-3' | 著者 | Chen, G, Znosko, B.M, Kennedy, S.D, Krugh, T.R, Turner, D.H. | 登録日 | 2004-10-26 | 公開日 | 2004-11-09 | 最終更新日 | 2022-03-02 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution Structure of an RNA Internal Loop with Three Consecutive Sheared GA Pairs Biochemistry, 44, 2005
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5HCV
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5I4V
| Discovery of novel, orally efficacious Liver X Receptor (LXR) beta agonists | 分子名称: | Oxysterols receptor LXR-beta,Nuclear receptor coactivator 2, Retinoic acid receptor RXR-beta,Nuclear receptor coactivator 2, {2-[(2R)-4-[4-(hydroxymethyl)-3-(methylsulfonyl)phenyl]-2-(propan-2-yl)piperazin-1-yl]-4-(trifluoromethyl)pyrimidin-5-yl}methanol | 著者 | Chen, G, McKeever, B.M. | 登録日 | 2016-02-12 | 公開日 | 2016-06-29 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | 主引用文献 | Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR) beta Agonist. J.Med.Chem., 59, 2016
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6KMJ
| Crystal structure of Sth1 bromodomain in complex with H3K14Ac | 分子名称: | GLYCEROL, Histone H3, Nuclear protein STH1/NPS1 | 著者 | Chen, G, Li, W, Yan, F, Wang, D, Chen, Y. | 登録日 | 2019-07-31 | 公開日 | 2019-11-27 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | The Structural Basis for Specific Recognition of H3K14 Acetylation by Sth1 in the RSC Chromatin Remodeling Complex. Structure, 28, 2020
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6KMB
| Crystal structure of Sth1 bromodomain | 分子名称: | GLYCEROL, Nuclear protein STH1/NPS1 | 著者 | Chen, G, Li, W, Yan, F, Wang, D, Chen, Y. | 登録日 | 2019-07-31 | 公開日 | 2019-10-30 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | The Structural Basis for Specific Recognition of H3K14 Acetylation by Sth1 in the RSC Chromatin Remodeling Complex. Structure, 28, 2020
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3QP4
| Crystal structure of CviR ligand-binding domain bound to C10-HSL | 分子名称: | CviR transcriptional regulator, N-[(3S)-2-oxotetrahydrofuran-3-yl]decanamide | 著者 | Chen, G, Swem, L, Swem, D, Stauff, D, O'Loughlin, C, Jeffrey, P, Bassler, B, Hughson, F. | 登録日 | 2011-02-11 | 公開日 | 2011-03-30 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | A strategy for antagonizing quorum sensing. Mol.Cell, 42, 2011
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3QP2
| Crystal structure of CviR ligand-binding domain bound to C8-HSL | 分子名称: | CviR transcriptional regulator, N-(2-OXOTETRAHYDROFURAN-3-YL)OCTANAMIDE | 著者 | Chen, G, Swem, L, Swem, D, Stauff, D, O'Loughlin, C, Jeffrey, P, Bassler, B, Hughson, F. | 登録日 | 2011-02-11 | 公開日 | 2011-03-30 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.638 Å) | 主引用文献 | A strategy for antagonizing quorum sensing. Mol.Cell, 42, 2011
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3QP8
| Crystal structure of CviR (Chromobacterium violaceum 12472) ligand-binding domain bound to C10-HSL | 分子名称: | CviR transcriptional regulator, N-[(3S)-2-oxotetrahydrofuran-3-yl]decanamide | 著者 | Chen, G, Swem, L, Swem, D, Stauff, D, O'Loughlin, C, Jeffrey, P, Bassler, B, Hughson, F. | 登録日 | 2011-02-11 | 公開日 | 2011-03-30 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | A strategy for antagonizing quorum sensing. Mol.Cell, 42, 2011
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3QP5
| Crystal structure of CviR bound to antagonist chlorolactone (CL) | 分子名称: | 4-(4-chlorophenoxy)-N-[(3S)-2-oxotetrahydrofuran-3-yl]butanamide, CviR transcriptional regulator | 著者 | Chen, G, Swem, L, Swem, D, Stauff, D, O'Loughlin, C, Jeffrey, P, Bassler, B, Hughson, F. | 登録日 | 2011-02-11 | 公開日 | 2011-03-30 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3.249 Å) | 主引用文献 | A strategy for antagonizing quorum sensing. Mol.Cell, 42, 2011
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3QP6
| Crystal structure of CviR (Chromobacterium violaceum 12472) bound to C6-HSL | 分子名称: | CviR transcriptional regulator, N-[(3S)-2-oxotetrahydrofuran-3-yl]hexanamide | 著者 | Chen, G, Swem, L, Swem, D, Stauff, D, O'Loughlin, C, Jeffrey, P, Bassler, B, Hughson, F. | 登録日 | 2011-02-11 | 公開日 | 2011-03-30 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A strategy for antagonizing quorum sensing. Mol.Cell, 42, 2011
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3QP1
| Crystal structure of CviR ligand-binding domain bound to the native ligand C6-HSL | 分子名称: | CviR transcriptional regulator, N-[(3S)-2-oxotetrahydrofuran-3-yl]hexanamide | 著者 | Chen, G, Swem, L, Swem, D, Stauff, D, O'Loughlin, C, Jeffrey, P, Bassler, B, Hughson, F. | 登録日 | 2011-02-11 | 公開日 | 2011-03-30 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | A strategy for antagonizing quorum sensing. Mol.Cell, 42, 2011
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2O81
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6KAG
| Crystal structure of the SMARCB1/SMARCC2 subcomplex | 分子名称: | SWI/SNF complex subunit SMARCC2, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 | 著者 | Chen, G, Zhou, H, Giancotti, F.G, Long, J. | 登録日 | 2019-06-22 | 公開日 | 2020-09-23 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.601 Å) | 主引用文献 | A heterotrimeric SMARCB1-SMARCC2 subcomplex is required for the assembly and tumor suppression function of the BAF chromatin-remodeling complex. Cell Discov, 6, 2020
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7YKD
| Cryo-EM structure of the human chemerin receptor 1 complex with the C-terminal nonapeptide of chemerin | 分子名称: | CHOLESTEROL, Chemerin-like receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Chen, G, Liao, Q, Ye, R.D, Wang, J. | 登録日 | 2022-07-22 | 公開日 | 2023-04-19 | 実験手法 | ELECTRON MICROSCOPY (2.81 Å) | 主引用文献 | Cryo-EM structure of the human chemerin receptor 1-Gi protein complex bound to the C-terminal nonapeptide of chemerin. Proc.Natl.Acad.Sci.USA, 120, 2023
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1MK3
| SOLUTION STRUCTURE OF HUMAN BCL-W PROTEIN | 分子名称: | Apoptosis regulator Bcl-W | 著者 | Denisov, A.Y, Madiraju, M.S, Chen, G, Khadir, A, Beauparlant, P, Attardo, G, Shore, G.C, Gehring, K. | 登録日 | 2002-08-28 | 公開日 | 2003-06-03 | 最終更新日 | 2021-10-27 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of human BCL-w: modulation of ligand binding by the C-terminal helix J.BIOL.CHEM., 278, 2003
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1F08
| CRYSTAL STRUCTURE OF THE DNA-BINDING DOMAIN OF THE REPLICATION INITIATION PROTEIN E1 FROM PAPILLOMAVIRUS | 分子名称: | BROMIDE ION, REPLICATION PROTEIN E1 | 著者 | Enemark, E.J, Chen, G, Vaughn, D.E, Stenlund, A, Joshua-Tor, L. | 登録日 | 2000-05-15 | 公開日 | 2001-05-16 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structure of the DNA binding domain of the replication initiation protein E1 from papillomavirus. Mol.Cell, 6, 2000
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