6HWG
 
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8OYR
 | | DNA Major Groove Binding by lambda-[Ru(phen)2(phi)]2+ | | Descriptor: | DNA (5'-D(*CP*CP*GP*GP*TP*AP*CP*CP*GP*G)-3'), STRONTIUM ION, ruthenium polypyridyl complex (lambda enantiomer) | | Authors: | Prieto-Otoya, T.D, Cardin, C.J, McQuaid, K.T, Paterson, N.G. | | Deposit date: | 2023-05-05 | | Release date: | 2024-03-13 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.21 Å) | | Cite: | Probing a Major DNA Weakness: Resolving the Groove and Sequence Selectivity of the Diimine Complex Lambda-[Ru(phen) 2 phi] 2.
Angew.Chem.Int.Ed.Engl., 63, 2024
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5ET2
 | | Lambda-Ru(TAP)2(dppz)]2+ bound to d(TTGGCGCCAA) | | Descriptor: | BARIUM ION, DNA (5'-D(*(THM)P*TP*GP*GP*CP*GP*CP*CP*AP*A)-3'), Ru(tap)2(dppz) complex | | Authors: | Hall, J.P, Cardin, C.J. | | Deposit date: | 2015-11-17 | | Release date: | 2016-11-23 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.39 Å) | | Cite: | Inosine Can Increase DNA's Susceptibility to Photo-oxidation by a Ru(II) Complex due to Structural Change in the Minor Groove.
Chemistry, 23, 2017
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8P6B
 | | Ruthenium complex bound to an antiparallel G-quadruplex | | Descriptor: | DNA (5'-D(*GP*GP*GP*TP*TP*TP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*G)-3'), POTASSIUM ION, Ruthenium bis-(phenanthroline) 12,17-dihydro-naphthodipyridophenazine-12,17-dione | | Authors: | McQuaid, K.T, Cardin, C.J. | | Deposit date: | 2023-05-25 | | Release date: | 2024-06-12 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Ruthenium complex bound to an antiparallel G-quadruplex
To Be Published
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4YMC
 | | Lambda-[Ru(TAP)2(dppz)]2+ bound to d(CCGGATCCGG)2 | | Descriptor: | BARIUM ION, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*GP*AP*TP*CP*CP*GP*G)-3'), ... | | Authors: | Gurung, S.P, Hall, J.P, Cardin, C.J. | | Deposit date: | 2015-03-06 | | Release date: | 2016-03-23 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.88 Å) | | Cite: | Reversal of a single base pair step controls guanine photo-oxidation by an intercalating Ru(II) dipyridophenazine complex.
To Be Published
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4E8S
 | | Lambda-[Ru(TAP)2(dppz{Me2}2)]2+ bound to TCGGCGCCGA at high resolution | | Descriptor: | (11,12-dimethyldipyrido[3,2-a:2',3'-c]phenazine-kappa~2~N~4~,N~5~)[bis(pyrazino[2,3-f]quinoxaline-kappa~2~N~1~,N~10~)]ruthenium(2+), 5'-D(*TP*CP*GP*GP*CP*GP*CP*CP*GP*A)-3', BARIUM ION, ... | | Authors: | Hall, J.P, Cardin, C.J. | | Deposit date: | 2012-03-20 | | Release date: | 2013-03-20 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.24 Å) | | Cite: | The Structural Effect of Methyl Substitution on the Binding of Polypyridyl Ru dppz Complexes to DNA
Organometallics, 2015
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452D
 | | ACRIDINE BINDING TO DNA | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 9-AMINO-(N-(2-DIMETHYLAMINO)ETHYL)ACRIDINE-4-CARBOXAMIDE, DNA (5'-D(*CP*GP*TP*AP*CP*G)-3') | | Authors: | Thorpe, J.H, Todd, A.K, Cardin, C.J. | | Deposit date: | 1999-02-18 | | Release date: | 2003-03-04 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Major groove binding and 'DNA-induced' fit in the intercalation of a derivative of the mixed topoisomerase I/II poison N-(2-(dimethlyamino)ethyl)acridine-4-carboxamide (DACA) into DNA: X-ray structure complexed to d(CG(5Br-U)ACG)2 at 1.3-angstrom resolution
J.Med.Chem., 42, 1999
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6R6D
 | | [Ru(TAP)2(11,12-CN2-dppz)]2+ bound to d(TCGGCGCCGA)2 | | Descriptor: | BARIUM ION, DNA (5'-D(*TP*CP*GP*GP*CP*GP*CP*CP*GP*A)-3'), Ruthenium (bis-(tetraazaphenanthrene)) (11,12-dicyano-dipyridophenazine), ... | | Authors: | McQuaid, K.T, Hall, J.P, Cardin, C.J. | | Deposit date: | 2019-03-27 | | Release date: | 2020-05-06 | | Last modified: | 2024-05-15 | | Method: | X-RAY DIFFRACTION (1.838 Å) | | Cite: | X-ray Crystal Structures Show DNA Stacking Advantage of Terminal Nitrile Substitution in Ru-dppz Complexes.
Chemistry, 24, 2018
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6RNL
 | | L-[Ru(TAP)2(dppz)]2+ bound to the G-quadruplex forming sequence d(TAGGGTT) | | Descriptor: | DNA (5'-D(*TP*AP*GP*GP*GP*TP*T)-3'), POTASSIUM ION, Ru(tap)2(dppz) complex, ... | | Authors: | McQuaid, K.T, Hall, J.P, Cardin, C.J. | | Deposit date: | 2019-05-09 | | Release date: | 2019-08-28 | | Last modified: | 2024-05-15 | | Method: | X-RAY DIFFRACTION (1.88 Å) | | Cite: | Three thymine/adenine binding modes of the ruthenium complex Lambda-[Ru(TAP)2(dppz)]2+to the G-quadruplex forming sequence d(TAGGGTT) shown by X-ray crystallography.
Chem.Commun.(Camb.), 55, 2019
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5LFW
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5LFX
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5LFS
 | | Lambda-[Ru(bpy)2(dppz)]2+ bound to brominated DNA | | Descriptor: | BARIUM ION, CHLORIDE ION, DNA (5'-D(*(CBR)P*GP*GP*C)-3'), ... | | Authors: | Hall, J.P, Cardin, C.J. | | Deposit date: | 2016-07-04 | | Release date: | 2017-02-15 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Guanine Can Direct Binding Specificity of Ru-dipyridophenazine (dppz) Complexes to DNA through Steric Effects.
Chemistry, 23, 2017
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5LS8
 | | Light-activated ruthenium complex bound to a DNA quadruplex | | Descriptor: | DNA (5'-D(*TP*AP*GP*GP*GP*TP*TP*A)-3'), POTASSIUM ION, delta-[Ru(tap2-dppz-CN)]2+, ... | | Authors: | McQuaid, K.T, Abell, H, Hall, J.P, Cardin, C.J. | | Deposit date: | 2016-08-22 | | Release date: | 2018-01-17 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | Structural Studies Reveal Enantiospecific Recognition of a DNA G-Quadruplex by a Ruthenium Polypyridyl Complex.
Angew.Chem.Int.Ed.Engl., 58, 2019
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5JEU
 | | del-[Ru(phen)2(dppz)]2+ bound to d(TCGGCGCCGA) with Ba2+ | | Descriptor: | BARIUM ION, CHLORIDE ION, DNA (5'-D(*TP*CP*GP*GP*CP*GP*CP*CP*GP*A)-3'), ... | | Authors: | Hall, J.P, Cardin, C.J. | | Deposit date: | 2016-04-19 | | Release date: | 2016-09-14 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (0.97 Å) | | Cite: | Delta chirality ruthenium 'light-switch' complexes can bind in the minor groove of DNA with five different binding modes.
Nucleic Acids Res., 44, 2016
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5IP8
 | | Lambda-Ru(TAP)2dppz bound to d(CCGGCTCCGG) | | Descriptor: | BARIUM ION, DNA (5'-D(*CP*CP*GP*GP*AP*GP*CP*CP*GP*G)-3'), DNA (5'-D(*CP*CP*GP*GP*CP*TP*CP*CP*GP*G)-3'), ... | | Authors: | Souter, J.E, Hall, J.P, Cardin, C.J. | | Deposit date: | 2016-03-09 | | Release date: | 2017-03-29 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.76 Å) | | Cite: | Sequence specific binding of light activated Ru-polypyridyls
To Be Published
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5IU5
 | | Lambda-[Ru(TAP)2(dppz)]2+ bound to d(TCGGCICCGA)2 | | Descriptor: | BARIUM ION, DNA (5'-D(*TP*CP*GP*GP*CP*IP*CP*CP*GP*A)-3'), Ru(tap)2(dppz) complex | | Authors: | Hall, J.P, Cardin, C.J. | | Deposit date: | 2016-03-17 | | Release date: | 2017-06-21 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Unexpected enhancement of sensitised photo-oxidation by a Ru(II) complex on replacement of guanine with inosine in DNA
To Be Published
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4MJ9
 | | lambda-[Ru(TAP)2(dppz-10-Me)]2+ bound to a synthetic DNA oligomer | | Descriptor: | (10-methyldipyrido[3,2-a:2',3'-c]phenazine-kappa~2~N~4~,N~5~)[bis(pyrazino[2,3-f]quinoxaline-kappa~2~N~1~,N~10~)]ruthenium(2+), BARIUM ION, CHLORIDE ION, ... | | Authors: | Hall, J.P, Cardin, C.J. | | Deposit date: | 2013-09-03 | | Release date: | 2014-09-24 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (0.97 Å) | | Cite: | The Structural Effect of Methyl Substitution on the Binding of Polypyridyl Ru dppz Complexes to DNA
Organometallics, 2015
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8PJL
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8PIP
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4E7Y
 | | Lambda-[Ru(phen)2(dppz)]2+ Bound to CCGGATCCGG | | Descriptor: | 5'-D(*CP*CP*GP*GP*AP*TP*CP*CP*GP*G)-3', BARIUM ION, Lambda-Ru(phen)2(dppz) complex | | Authors: | Hall, J.P, Cardin, C.J. | | Deposit date: | 2012-03-19 | | Release date: | 2012-07-04 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Crystal Structure of lambda-[Ru(phen)2(dppz)]2+ with oligonucleotides containing TA/TA and AT/AT steps show two intercalation modes.
Nat Chem, 4, 2012
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3PBX
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2GWA
 | | Crystal Structure of a Complex Formed Between the DNA Holliday Junction and a Bis-Acridine Molecule. | | Descriptor: | 5'-D(*Tp*Cp*Gp*Gp*Tp*Ap*Cp*Cp*Gp*A)-3', 9,9'-(HEXANE-1,6-DIYLDIIMINO)BIS{N-[2-(DIMETHYLAMINO)ETHYL]ACRIDINE-4-CARBOXAMIDE}, SPERMINE | | Authors: | Brogden, A.L, Hopcroft, N.H, Cardin, C.J, Searcey, M. | | Deposit date: | 2006-05-04 | | Release date: | 2006-06-06 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Ligand bridging of the DNA Holliday junction: molecular recognition of a stacked-X four-way junction by a small molecule.
Angew.Chem.Int.Ed.Engl., 46, 2007
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2GJB
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6RSP
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2GB9
 | | d(CGTACG)2 crosslinked bis-acridine complex | | Descriptor: | 5'-D(*CP*GP*TP*AP*CP*G)-3', 9,9'-(HEXANE-1,6-DIYLDIIMINO)BIS{N-[2-(DIMETHYLAMINO)ETHYL]ACRIDINE-4-CARBOXAMIDE}, STRONTIUM ION | | Authors: | Hopcroft, N.H, Brogden, A.L, Searcey, M, Cardin, C.J. | | Deposit date: | 2006-03-10 | | Release date: | 2006-04-25 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | X-ray crystallographic study of DNA duplex cross-linking: simultaneous binding to two d(CGTACG)2 molecules by a bis(9-aminoacridine-4-carboxamide) derivative.
Nucleic Acids Res., 34, 2006
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