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PDB: 271 件
8AE2
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BU of 8ae2 by Molmil
Cryo-EM structure of full-length human immunoglobulin M - F(ab')2 conformation 5
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IgM C2-domain from mouse, ...
著者Chen, Q, Rosenthal, P, Tolar, P.
登録日2022-07-12
公開日2022-10-26
最終更新日2022-11-09
実験手法ELECTRON MICROSCOPY (8.5 Å)
主引用文献Cryomicroscopy reveals the structural basis for a flexible hinge motion in the immunoglobulin M pentamer.
Nat Commun, 13, 2022
8BPG
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BU of 8bpg by Molmil
FcMR binding at subunit Fcu3 of IgM pentamer
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fas apoptotic inhibitory molecule 3, ...
著者Chen, Q, Rosenthal, P, Tolar, P.
登録日2022-11-16
公開日2023-04-12
最終更新日2023-07-26
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural basis for Fc receptor recognition of immunoglobulin M.
Nat.Struct.Mol.Biol., 30, 2023
8BPF
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BU of 8bpf by Molmil
FcMR binding at subunit Fcu1 of IgM pentamer
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fas apoptotic inhibitory molecule 3, ...
著者Chen, Q, Rosenthal, P, Tolar, P.
登録日2022-11-16
公開日2023-04-12
最終更新日2023-07-26
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structural basis for Fc receptor recognition of immunoglobulin M.
Nat.Struct.Mol.Biol., 30, 2023
8BPE
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BU of 8bpe by Molmil
8:1 binding of FcMR on IgM pentameric core
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fas apoptotic inhibitory molecule 3, ...
著者Chen, Q, Rosenthal, P, Tolar, P.
登録日2022-11-16
公開日2023-04-12
最終更新日2023-07-26
実験手法ELECTRON MICROSCOPY (3.63 Å)
主引用文献Structural basis for Fc receptor recognition of immunoglobulin M.
Nat.Struct.Mol.Biol., 30, 2023
1R3U
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BU of 1r3u by Molmil
Crystal Structure of Hypoxanthine-Guanine Phosphoribosyltransferase from Thermoanaerobacter tengcongensis
分子名称: ACETATE ION, Hypoxanthine-guanine phosphoribosyltransferase, MAGNESIUM ION
著者Chen, Q, Liang, Y.H, Gu, X.C, Luo, M, Su, X.D.
登録日2003-10-03
公開日2004-10-19
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal Structure of Hypoxanthine-Guanine Phosphoribosyltransferase from Thermoanaerobacter tengcongensis
To be published
4D90
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BU of 4d90 by Molmil
Crystal Structure of Del-1 EGF domains
分子名称: 2-acetamido-2-deoxy-beta-D-galactopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Chen, Q, Schurpf, T, Springer, T, Wang, J.
登録日2012-01-11
公開日2012-05-30
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.601 Å)
主引用文献The RGD finger of Del-1 is a unique structural feature critical for integrin binding.
Faseb J., 26, 2012
6E5V
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BU of 6e5v by Molmil
human mGlu8 receptor amino terminal domain in complex with (S)-3,4-Dicarboxyphenylglycine (DCPG)
分子名称: 4-[(S)-amino(carboxy)methyl]benzene-1,2-dicarboxylic acid, CHLORIDE ION, Metabotropic glutamate receptor 8
著者Chen, Q, Ho, J.D, Ashok, S, Vargas, M.C, Wang, J, Atwell, S, Bures, M, Schkeryantz, J.M, Monn, J.A, Hao, J.
登録日2018-07-23
公開日2018-11-07
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Structural Basis for ( S)-3,4-Dicarboxyphenylglycine (DCPG) As a Potent and Subtype Selective Agonist of the mGlu8Receptor.
J. Med. Chem., 61, 2018
7QDO
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BU of 7qdo by Molmil
Cryo-EM structure of human monomeric IgM-Fc
分子名称: Isoform 2 of Immunoglobulin heavy constant mu
著者Chen, Q, Rosenthal, P, Tolar, P.
登録日2021-11-27
公開日2022-10-26
最終更新日2022-11-09
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Cryomicroscopy reveals the structural basis for a flexible hinge motion in the immunoglobulin M pentamer.
Nat Commun, 13, 2022
6J2B
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BU of 6j2b by Molmil
CTX-M-64 beta-lactamase S130T sulbactam complex
分子名称: Beta-lactamase, GLYCEROL, TRANS-ENAMINE INTERMEDIATE OF SULBACTAM
著者Cheng, Q, Chen, S.
登録日2018-12-31
公開日2019-10-30
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.44 Å)
主引用文献Structural Insight into the Mechanism of Inhibitor Resistance in CTX-M-199, a CTX-M-64 Variant Carrying the S130T Substitution.
Acs Infect Dis., 6, 2020
6J2O
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BU of 6j2o by Molmil
Crystal structure of CTX-M-64 clavulanic acid complex
分子名称: (2E)-3-[(4-hydroxy-2-oxobutyl)amino]prop-2-enal, Beta-lactamase
著者Cheng, Q, Chen, S.
登録日2019-01-02
公開日2019-10-30
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural Insight into the Mechanism of Inhibitor Resistance in CTX-M-199, a CTX-M-64 Variant Carrying the S130T Substitution.
Acs Infect Dis., 6, 2020
6J25
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BU of 6j25 by Molmil
CTX-M-64 beta-lactamase mutant-S130T
分子名称: Beta-lactamase
著者Cheng, Q, Chen, S.
登録日2018-12-30
公開日2019-10-30
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Structural Insight into the Mechanism of Inhibitor Resistance in CTX-M-199, a CTX-M-64 Variant Carrying the S130T Substitution.
Acs Infect Dis., 6, 2020
6ITY
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BU of 6ity by Molmil
CTX-M-64 sulbactam complex
分子名称: ACRYLIC ACID, Beta-lactamase, TRANS-ENAMINE INTERMEDIATE OF SULBACTAM
著者Cheng, Q, Chen, S.
登録日2018-11-26
公開日2019-10-30
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献Structural Insight into the Mechanism of Inhibitor Resistance in CTX-M-199, a CTX-M-64 Variant Carrying the S130T Substitution.
Acs Infect Dis., 6, 2020
7S03
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BU of 7s03 by Molmil
DNA-binding domain of human SETMAR in complex with Hsmar1 terminal inverted repeat (TIR) DNA
分子名称: Histone-lysine N-methyltransferase SETMAR, Hsmar1 terminal inverted repeats
著者Chen, Q, Georgiadis, M.M.
登録日2021-08-28
公開日2022-08-03
実験手法X-RAY DIFFRACTION (2.37 Å)
主引用文献Structural and genome-wide analyses suggest that transposon-derived protein SETMAR alters transcription and splicing.
J.Biol.Chem., 298, 2022
6J2K
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BU of 6j2k by Molmil
CTX-M-64 beta-lactamase S130T clavulanic acid complex
分子名称: (2E)-3-[(4-hydroxy-2-oxobutyl)amino]prop-2-enal, Beta-lactamase
著者Cheng, Q, Chen, S.
登録日2019-01-01
公開日2019-10-30
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.44 Å)
主引用文献Structural Insight into the Mechanism of Inhibitor Resistance in CTX-M-199, a CTX-M-64 Variant Carrying the S130T Substitution.
Acs Infect Dis., 6, 2020
4XHQ
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BU of 4xhq by Molmil
Re-refinement the crystal structure of Dscam1 isoform 1.34, N-terminal four Ig domains
分子名称: CHLORIDE ION, Dscam, GLYCEROL, ...
著者Chen, Q, Yu, Y.
登録日2015-01-06
公開日2016-10-12
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.948 Å)
主引用文献Structural basis of Dscam1 homodimerization: Insights into context constraint for protein recognition
Sci Adv, 2, 2016
4X9H
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BU of 4x9h by Molmil
Crystal structure of Dscam1 isoform 8.4, N-terminal four Ig domains
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Down syndrome cell adhesion molecule, isoform AP, ...
著者Chen, Q.
登録日2014-12-11
公開日2015-12-16
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Structural basis of Dscam1 homodimerization: Insights into context constraint for protein recognition
Sci Adv, 2, 2016
4Z90
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BU of 4z90 by Molmil
ELIC bound with the anesthetic isoflurane in the resting state
分子名称: (2R)-2-chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Gamma-aminobutyric-acid receptor subunit beta-1
著者Chen, Q, Kinde, M, Arjunan, P, Cohen, A, Xu, Y, Tang, P.
登録日2015-04-09
公開日2015-09-16
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Direct Pore Binding as a Mechanism for Isoflurane Inhibition of the Pentameric Ligand-gated Ion Channel ELIC.
Sci Rep, 5, 2015
4Z91
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BU of 4z91 by Molmil
ELIC cocrystallized with isofluorane in a desensitized state
分子名称: (2R)-2-chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane, 1.7.6 3-bromanylpropan-1-amine, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
著者Chen, Q, Kinde, M.N, Arjunan, P, Cohen, A, Xu, Y, Tang, P.
登録日2015-04-09
公開日2015-09-16
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.3915 Å)
主引用文献Direct Pore Binding as a Mechanism for Isoflurane Inhibition of the Pentameric Ligand-gated Ion Channel ELIC.
Sci Rep, 5, 2015
4QH9
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BU of 4qh9 by Molmil
Crystal structure of Mn2+ bound human APE1
分子名称: 1,2-ETHANEDIOL, DNA-(apurinic or apyrimidinic site) lyase, MANGANESE (II) ION
著者Chen, Q, He, H, Georgiadis, M.M.
登録日2014-05-27
公開日2014-11-12
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.175 Å)
主引用文献High-resolution crystal structures reveal plasticity in the metal binding site of apurinic/apyrimidinic endonuclease I.
Biochemistry, 53, 2014
5ZB7
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BU of 5zb7 by Molmil
CTX-M-64 apoenzyme
分子名称: Beta-lactamase
著者Cheng, Q, Chen, S.
登録日2018-02-10
公開日2019-02-13
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献Structural Insight into the Mechanism of Inhibitor Resistance in CTX-M-199, a CTX-M-64 Variant Carrying the S130T Substitution.
Acs Infect Dis., 6, 2020
4IRE
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BU of 4ire by Molmil
Crystal structure of GLIC with mutations at the loop C region
分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ACETATE ION, OXALATE ION, ...
著者Chen, Q, Pan, J, Liang, Y.H, Xu, Y, Tang, P.
登録日2013-01-14
公開日2013-04-24
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.19 Å)
主引用文献Signal transduction pathways in the pentameric ligand-gated ion channels.
Plos One, 8, 2013
6JV4
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BU of 6jv4 by Molmil
Crystal structure of metallo-beta-lactamase VMB-1
分子名称: CITRIC ACID, VMB-1, ZINC ION
著者Cheng, Q, Chen, S.
登録日2019-04-15
公開日2019-11-27
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Genetic and Biochemical Characterization of VMB-1, a Novel Metallo-beta-Lactamase Encoded by a Conjugative, Broad-Host Range IncC Plasmid from Vibrio spp.
Adv Biosyst, 4, 2020
6LFD
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BU of 6lfd by Molmil
Crystal structure of VMB-1 at pH5.5(Bis-Tris)
分子名称: GLYCEROL, VMB-1, ZINC ION
著者Cheng, Q, Chen, S.
登録日2019-12-02
公開日2020-02-26
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Crystal structure of VMB-1 at pH 5.5(Bis-Tris)
To Be Published
6LF4
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BU of 6lf4 by Molmil
Crystal structure of VMB-1 bound to hydrolyzed meropenem
分子名称: (2~{S},3~{R},4~{S})-2-[(2~{S},3~{R})-1,3-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]-4-[(3~{S},5~{S})-5-(dimethylcarbamoy l)pyrrolidin-3-yl]sulfanyl-3-methyl-3,4-dihydro-2~{H}-pyrrole-5-carboxylic acid, VMB-1 metallo-beta-lactamase, ZINC ION
著者Cheng, Q, Chen, S.
登録日2019-11-28
公開日2020-03-25
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Crystal structure of VMB-1 bound to hydrolyzed meropenem
To Be Published
7Y5J
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BU of 7y5j by Molmil
Crystal structure of sDscam Ig1 domain, isoform alpha1v7
分子名称: Down Syndrome Cell Adhesion Molecules
著者Chen, Q, Yu, Y, Cheng, J.
登録日2022-06-17
公開日2023-05-24
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural basis for the self-recognition of sDSCAM in Chelicerata.
Nat Commun, 14, 2023

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