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PDB: 1279 件
4ZZ2
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HUMAN GAR TRANSFORMYLASE IN COMPLEX WITH GAR AND (S)-2-({5-[3-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-6-YL)-PROPYL]-THIOPHENE-3-CARBONYL}-AMINO)-PENTANEDIOIC ACID
分子名称: (S)-2-({5-[3-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-propyl]-thiophene-3-carbonyl}-amino)-pentanedioic acid, GLYCINAMIDE RIBONUCLEOTIDE, Trifunctional purine biosynthetic protein adenosine-3
著者Deis, S.M, Dann III, C.E.
登録日2015-05-22
公開日2015-12-16
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.451 Å)
主引用文献6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor alpha and the Proton-Coupled Folate Transporter in Human Tumors.
J.Med.Chem., 58, 2015
4ZYU
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Human GAR transformylase in complex with GAR and N-{4-[4-(2-Amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)-butyl]benzoyl}-L-glutamic acid (AGF50)
分子名称: GLYCINAMIDE RIBONUCLEOTIDE, N-{4-[4-(2-amino-4-oxo-1,4-dihydrothieno[2,3-d]pyrimidin-6-yl)butyl]benzoyl}-L-glutamic acid, Trifunctional purine biosynthetic protein adenosine-3
著者Deis, S.M, Dann III, C.E.
登録日2015-05-22
公開日2016-04-20
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structural and Enzymatic Analysis of Tumor-Targeted Antifolates That Inhibit Glycinamide Ribonucleotide Formyltransferase.
Biochemistry, 55, 2016
3B65
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Crystal structure of the androgen receptor ligand binding domain in complex with SARM S-24
分子名称: (2S)-N-(4-cyano-3-iodophenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide, Androgen receptor
著者Bohl, C.E, Miller, D.D, Dalton, J.T.
登録日2007-10-27
公開日2008-09-09
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Effect of B-ring substitution pattern on binding mode of propionamide selective androgen receptor modulators
Bioorg.Med.Chem.Lett., 18, 2008
3B67
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Crystal structure of the androgen receptor ligand binding domain in complex with SARM C-23
分子名称: (2S)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-3-(pentafluorophenoxy)propanamide, Androgen receptor
著者Bohl, C.E, Miller, D.D, Dalton, J.T.
登録日2007-10-27
公開日2008-09-09
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Effect of B-ring substitution pattern on binding mode of propionamide selective androgen receptor modulators
Bioorg.Med.Chem.Lett., 18, 2008
3B68
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Crystal structure of the androgen receptor ligand binding domain in complex with SARM S-4
分子名称: (2S)-3-[4-(acetylamino)phenoxy]-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide, Androgen receptor
著者Bohl, C.E, Miller, D.D, Dalton, J.T.
登録日2007-10-27
公開日2008-09-09
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Effect of B-ring substitution pattern on binding mode of propionamide selective androgen receptor modulators
Bioorg.Med.Chem.Lett., 18, 2008
9BRB
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Synaptic Vesicle V-ATPase with synaptophysin and SidK, State 1
分子名称: ATPase H+-transporting V1 subunit D, ATPase, H+ transporting, ...
著者Coupland, C.E, Rubinstein, J.L.
登録日2024-05-11
公開日2024-06-26
最終更新日2024-07-24
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献High-resolution electron cryomicroscopy of V-ATPase in native synaptic vesicles.
Science, 385, 2024
9BRD
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Synaptic Vesicle V-ATPase with synaptophysin and SidK, State 3
分子名称: (7R)-4,7-DIHYDROXY-N,N,N-TRIMETHYL-10-OXO-3,5,9-TRIOXA-4-PHOSPHAHEPTACOSAN-1-AMINIUM 4-OXIDE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Coupland, C.E, Rubinstein, J.L.
登録日2024-05-11
公開日2024-06-26
最終更新日2024-07-24
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献High-resolution electron cryomicroscopy of V-ATPase in native synaptic vesicles.
Science, 385, 2024
9B8O
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Synaptic Vesicle V-ATPase with synaptophysin and SidK, State 3, Vo
分子名称: (7R)-4,7-DIHYDROXY-N,N,N-TRIMETHYL-10-OXO-3,5,9-TRIOXA-4-PHOSPHAHEPTACOSAN-1-AMINIUM 4-OXIDE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Coupland, C.E, Rubinstein, J.L.
登録日2024-03-31
公開日2024-06-26
最終更新日2024-07-24
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献High-resolution electron cryomicroscopy of V-ATPase in native synaptic vesicles.
Science, 385, 2024
9BRC
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Synaptic Vesicle V-ATPase with synaptophysin and SidK, State 2
分子名称: ATPase H+-transporting V1 subunit D, ATPase, H+ transporting, ...
著者Coupland, C.E, Rubinstein, J.L.
登録日2024-05-11
公開日2024-06-26
最終更新日2024-07-24
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献High-resolution electron cryomicroscopy of V-ATPase in native synaptic vesicles.
Science, 385, 2024
9B8Q
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Synaptic Vesicle V-ATPase with synaptophysin and SidK, State 3, peripheral stalks
分子名称: V-type proton ATPase 116 kDa subunit a isoform 1, V-type proton ATPase subunit C 1, V-type proton ATPase subunit E 1, ...
著者Coupland, C.E, Rubinstein, J.L.
登録日2024-03-31
公開日2024-06-26
最終更新日2024-07-24
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献High-resolution electron cryomicroscopy of V-ATPase in native synaptic vesicles.
Science, 385, 2024
6Z7C
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Variant Surface Glycoprotein VSGsur mutant H122A
分子名称: Variant surface glycoprotein Sur, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Zeelen, J.P, Straaten van, M, Stebbins, C.E.
登録日2020-05-30
公開日2021-03-17
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.64 Å)
主引用文献Structure of trypanosome coat protein VSGsur and function in suramin resistance.
Nat Microbiol, 6, 2021
6Z7E
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Variant Surface Glycoprotein VSGsur mutant H122A soaked in 7.7 mM suramin
分子名称: Variant surface glycoprotein Sur, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Zeelen, J.P, Straaten van, M, Stebbins, C.E.
登録日2020-05-30
公開日2021-03-17
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.663 Å)
主引用文献Structure of trypanosome coat protein VSGsur and function in suramin resistance.
Nat Microbiol, 6, 2021
6Z7B
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Variant Surface Glycoprotein VSGsur bound to suramin
分子名称: 8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFON IC ACID, Variant surface glycoprotein Sur, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Zeelen, J.P, Straaten van, M, Stebbins, C.E, Jeffrey, P.
登録日2020-05-30
公開日2021-03-24
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Structure of trypanosome coat protein VSGsur and function in suramin resistance.
Nat Microbiol, 6, 2021
6Z8G
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Crystal structure of VSG13 soaked in 0.5 M used to phase VSG13 to solve the structure.
分子名称: BROMIDE ION, SULFATE ION, Variant surface glycoprotein MITat 1.13, ...
著者Stebbins, C.E, Hempelmann, A, Van Straaten, M, Zeelen, J.
登録日2020-06-02
公開日2021-03-17
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Structure of trypanosome coat protein VSGsur and function in suramin resistance.
Nat Microbiol, 6, 2021
6Z7D
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Variant Surface Glycoprotein VSGsur mutant H122A soaked in 0.77 mM Suramin.
分子名称: Variant surface glycoprotein Sur, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Zeelen, J.P, Straaten van, M, Stebbins, C.E.
登録日2020-05-30
公開日2021-03-17
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structure of trypanosome coat protein VSGsur and function in suramin resistance.
Nat Microbiol, 6, 2021
6Z79
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Variant Surface Glycoprotein VSGsur, I3C ("Magic Triangle") derivative used for phasing of the structure and subsequently as a model for molecular replacement of native, mutants, and drug soaks.
分子名称: 5-amino-2,4,6-triiodobenzene-1,3-dicarboxylic acid, Variant surface glycoprotein Sur, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Zeelen, J.P, Straaten van, M, Stebbins, C.E.
登録日2020-05-30
公開日2021-03-17
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Structure of trypanosome coat protein VSGsur and function in suramin resistance.
Nat Microbiol, 6, 2021
6Z8H
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Crystal structure of Variant Surface Glycoprotein VSG13
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, Variant surface glycoprotein MITat 1.13, ...
著者Stebbins, C.E, Hempelmann, A, Van Straaten, M, Zeelen, J.
登録日2020-06-02
公開日2021-03-17
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.38 Å)
主引用文献Structure of trypanosome coat protein VSGsur and function in suramin resistance.
Nat Microbiol, 6, 2021
6Z7A
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Variant Surface Glycoprotein VSGsur
分子名称: Variant surface glycoprotein Sur, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Zeelen, J.P, Straaten van, M, Stebbins, C.E, Hashemi, H.
登録日2020-05-30
公開日2021-05-26
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.21 Å)
主引用文献A Parasite Coat Protein Binds Suramin to Confer Drug Resistance
Nat Microbiol, 6, 2021
3CLN
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STRUCTURE OF CALMODULIN REFINED AT 2.2 ANGSTROMS RESOLUTION
分子名称: CALCIUM ION, CALMODULIN
著者Babu, Y.S, Bugg, C.E, Cook, W.J.
登録日1988-05-11
公開日1988-07-16
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of calmodulin refined at 2.2 A resolution.
J.Mol.Biol., 204, 1988
4CBC
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Open-form NavMS Sodium Channel Pore (with C-terminal Domain) after thallium soak
分子名称: HEGA-10, ION TRANSPORT PROTEIN, SODIUM ION
著者Bagneris, C, Naylor, C.E, Wallace, B.A.
登録日2013-10-12
公開日2014-05-28
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.664 Å)
主引用文献Prokaryotic Navms Channel as a Structural and Functional Model for Eukaryotic Sodium Channel Antagonism.
Proc.Natl.Acad.Sci.USA, 111, 2014
1ABW
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DEOXY RHB1.1 (RECOMBINANT HEMOGLOBIN)
分子名称: HEMOGLOBIN-BASED BLOOD SUBSTITUTE, LEUCINE, METHIONINE, ...
著者Kundrot, C.E, Kroeger, K.S.
登録日1997-01-29
公開日1998-06-17
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structures of a hemoglobin-based blood substitute: insights into the function of allosteric proteins.
Structure, 5, 1997
1ABY
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CYANOMET RHB1.1 (RECOMBINANT HEMOGLOBIN)
分子名称: CYANIDE ION, HEMOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE
著者Kundrot, C.E, Kroeger, K.S.
登録日1997-01-29
公開日1998-02-25
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structures of a hemoglobin-based blood substitute: insights into the function of allosteric proteins.
Structure, 5, 1997
1AF8
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ACTINORHODIN POLYKETIDE SYNTHASE ACYL CARRIER PROTEIN FROM STREPTOMYCES COELICOLOR A3(2), NMR, 24 STRUCTURES
分子名称: ACTINORHODIN POLYKETIDE SYNTHASE ACYL CARRIER PROTEIN
著者Crump, M.P, Crosby, J, Dempsey, C.E, Parkinson, J.A, Murray, M, Hopwood, D.A, Simpson, T.J.
登録日1997-03-23
公開日1997-09-26
最終更新日2024-04-10
実験手法SOLUTION NMR
主引用文献Solution structure of the actinorhodin polyketide synthase acyl carrier protein from Streptomyces coelicolor A3(2).
Biochemistry, 36, 1997
1B8Z
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HU FROM THERMOTOGA MARITIMA
分子名称: PROTEIN (HISTONELIKE PROTEIN HU)
著者Christodoulou, E, Rypniewski, W.R, Vorgias, C.E.
登録日1999-02-03
公開日2000-02-03
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Cloning, overproduction, purification and crystallization of the DNA binding protein HU from the hyperthermophilic eubacterium Thermotoga maritima.
Acta Crystallogr.,Sect.D, 54, 1998
1B79
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N-TERMINAL DOMAIN OF DNA REPLICATION PROTEIN DNAB
分子名称: DnaB Helicase
著者Fass, D, Bogden, C.E, Berger, J.M.
登録日1999-01-28
公開日1999-06-30
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of the N-terminal domain of the DnaB hexameric helicase.
Structure Fold.Des., 7, 1999

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