6Z7A

Variant Surface Glycoprotein VSGsur

Summary for 6Z7A

• Entry DOI: 10.2210/pdb6z7a/pdb
• Descriptor: Variant surface glycoprotein Sur, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• Functional Keywords: variant surface glycoprotein suramin trypanosomiasis drug resistance glycosylation, membrane protein
• Biological source: Trypanosoma brucei rhodesiense
• Total number of polymer chains: 1
• Total formula weight: 53541.05

Authors

Zeelen, J.P.,Straaten van, M.,Stebbins, C.E.,Hashemi, H. (deposition date: 2020-05-30, release date: 2021-05-26, Last modification date: 2024-01-24)

• Primary citation: Zeelen, J.P.,van Straaten, M.,Verdi, J.,Hempelmann, A.,Hashemi, H.,Perez, K.,Jeffrey, P.D.,Haelg, S.,Wiedemar, N.,Maeser, P.,Papavasiliou, F.N.,Stebbins, C.E.; A Parasite Coat Protein Binds Suramin to Confer Drug Resistance; Nat Microbiol, 6:392-400, 2021; DOI: 10.1038/s41564-020-00844-1

Experimental method

X-RAY DIFFRACTION (1.21 Å)