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PDB: 1278 件
6Z7C
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BU of 6z7c by Molmil
Variant Surface Glycoprotein VSGsur mutant H122A
分子名称: Variant surface glycoprotein Sur, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Zeelen, J.P, Straaten van, M, Stebbins, C.E.
登録日2020-05-30
公開日2021-03-17
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.64 Å)
主引用文献Structure of trypanosome coat protein VSGsur and function in suramin resistance.
Nat Microbiol, 6, 2021
6Z7E
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BU of 6z7e by Molmil
Variant Surface Glycoprotein VSGsur mutant H122A soaked in 7.7 mM suramin
分子名称: Variant surface glycoprotein Sur, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Zeelen, J.P, Straaten van, M, Stebbins, C.E.
登録日2020-05-30
公開日2021-03-17
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.663 Å)
主引用文献Structure of trypanosome coat protein VSGsur and function in suramin resistance.
Nat Microbiol, 6, 2021
6Z8G
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BU of 6z8g by Molmil
Crystal structure of VSG13 soaked in 0.5 M used to phase VSG13 to solve the structure.
分子名称: BROMIDE ION, SULFATE ION, Variant surface glycoprotein MITat 1.13, ...
著者Stebbins, C.E, Hempelmann, A, Van Straaten, M, Zeelen, J.
登録日2020-06-02
公開日2021-03-17
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Structure of trypanosome coat protein VSGsur and function in suramin resistance.
Nat Microbiol, 6, 2021
6Z7B
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BU of 6z7b by Molmil
Variant Surface Glycoprotein VSGsur bound to suramin
分子名称: 8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFON IC ACID, Variant surface glycoprotein Sur, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Zeelen, J.P, Straaten van, M, Stebbins, C.E, Jeffrey, P.
登録日2020-05-30
公開日2021-03-24
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Structure of trypanosome coat protein VSGsur and function in suramin resistance.
Nat Microbiol, 6, 2021
6Z7D
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BU of 6z7d by Molmil
Variant Surface Glycoprotein VSGsur mutant H122A soaked in 0.77 mM Suramin.
分子名称: Variant surface glycoprotein Sur, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Zeelen, J.P, Straaten van, M, Stebbins, C.E.
登録日2020-05-30
公開日2021-03-17
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structure of trypanosome coat protein VSGsur and function in suramin resistance.
Nat Microbiol, 6, 2021
6Z79
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BU of 6z79 by Molmil
Variant Surface Glycoprotein VSGsur, I3C ("Magic Triangle") derivative used for phasing of the structure and subsequently as a model for molecular replacement of native, mutants, and drug soaks.
分子名称: 5-amino-2,4,6-triiodobenzene-1,3-dicarboxylic acid, Variant surface glycoprotein Sur, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Zeelen, J.P, Straaten van, M, Stebbins, C.E.
登録日2020-05-30
公開日2021-03-17
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Structure of trypanosome coat protein VSGsur and function in suramin resistance.
Nat Microbiol, 6, 2021
6Z8H
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BU of 6z8h by Molmil
Crystal structure of Variant Surface Glycoprotein VSG13
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, Variant surface glycoprotein MITat 1.13, ...
著者Stebbins, C.E, Hempelmann, A, Van Straaten, M, Zeelen, J.
登録日2020-06-02
公開日2021-03-17
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.38 Å)
主引用文献Structure of trypanosome coat protein VSGsur and function in suramin resistance.
Nat Microbiol, 6, 2021
6Z7A
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BU of 6z7a by Molmil
Variant Surface Glycoprotein VSGsur
分子名称: Variant surface glycoprotein Sur, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Zeelen, J.P, Straaten van, M, Stebbins, C.E, Hashemi, H.
登録日2020-05-30
公開日2021-05-26
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.21 Å)
主引用文献A Parasite Coat Protein Binds Suramin to Confer Drug Resistance
Nat Microbiol, 6, 2021
4OXS
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BU of 4oxs by Molmil
Structure of NavMS in complex with channel blocking compound
分子名称: BROMIDE ION, HEGA-10, Ion transport protein, ...
著者Naylor, C.E, Bagneris, C, Wallace, B.A.
登録日2014-02-06
公開日2014-06-04
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism.
Proc.Natl.Acad.Sci.USA, 111, 2014
6ZT5
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BU of 6zt5 by Molmil
Complex between a homodimer of Mycobacterium smegmatis MfpA and a single copy of the N-terminal 47 kDa fragment of the Mycobacterium smegmatis DNA Gyrase B subunit
分子名称: DNA gyrase subunit B, Pentapeptide repeat protein MfpA, SULFATE ION
著者Feng, L, Mundy, J.E.A, Stevenson, C.E.M, Mitchenall, L.A, Lawson, D.M, Mi, K, Maxwell, A.
登録日2020-07-17
公開日2021-03-03
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The pentapeptide-repeat protein, MfpA, interacts with mycobacterial DNA gyrase as a DNA T-segment mimic.
Proc.Natl.Acad.Sci.USA, 118, 2021
6ZT3
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BU of 6zt3 by Molmil
N-terminal 47 kDa fragment of the Mycobacterium smegmatis DNA Gyrase B subunit complexed with ADPNP
分子名称: 1,2-ETHANEDIOL, DNA gyrase subunit B, MAGNESIUM ION, ...
著者Feng, L, Mundy, J.E.A, Stevenson, C.E.M, Mitchenall, L.A, Lawson, D.M, Mi, K, Maxwell, A.
登録日2020-07-17
公開日2021-03-03
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献The pentapeptide-repeat protein, MfpA, interacts with mycobacterial DNA gyrase as a DNA T-segment mimic.
Proc.Natl.Acad.Sci.USA, 118, 2021
6ZT4
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BU of 6zt4 by Molmil
Pentapeptide repeat protein MfpA from Mycobacterium smegmatis
分子名称: 1,2-ETHANEDIOL, Pentapeptide repeat protein MfpA
著者Feng, L, Mundy, J.E.A, Stevenson, C.E.M, Mitchenall, L.A, Lawson, D.M, Mi, K, Maxwell, A.
登録日2020-07-17
公開日2021-03-03
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献The pentapeptide-repeat protein, MfpA, interacts with mycobacterial DNA gyrase as a DNA T-segment mimic.
Proc.Natl.Acad.Sci.USA, 118, 2021
4PA4
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BU of 4pa4 by Molmil
Structure of NavMS in complex with channel blocking compound
分子名称: BROMIDE ION, DODECAETHYLENE GLYCOL, HEGA-10, ...
著者Naylor, C.E, Bagneris, C, Wallace, B.A.
登録日2014-04-07
公開日2014-06-04
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (3.02 Å)
主引用文献Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism.
Proc.Natl.Acad.Sci.USA, 111, 2014
4P6F
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BU of 4p6f by Molmil
Crystal structure of the peptolide 12C bound to bacterial ribosome
分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
著者Fagan, C.E, Dunham, C.M.
登録日2014-03-24
公開日2014-10-01
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Macrolide-Peptide Conjugates as Probes of the Path of Travel of the Nascent Peptides through the Ribosome.
Acs Chem.Biol., 9, 2014
4P9O
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BU of 4p9o by Molmil
Complex of Voltage-gated ion channel in a the presence of channel blocking compound
分子名称: BROMIDE ION, HEGA-10, Ion transport protein
著者Naylor, C.E, Bagneris, C, Wallace, B.A.
登録日2014-04-04
公開日2014-06-04
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.89 Å)
主引用文献Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism.
Proc.Natl.Acad.Sci.USA, 111, 2014
6Z1A
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BU of 6z1a by Molmil
Ternary complex of Staphylococcus aureus DNA gyrase with AMK12 and DNA
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
著者Kolaric, A, Germe, T, Hrast, M, Stevenson, C.E.M, Lawson, D.M, Burton, N, Voros, J, Maxwell, A, Minovski, N, Anderluh, M.
登録日2020-05-13
公開日2020-11-11
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Potent DNA gyrase inhibitors bind asymmetrically to their target using symmetrical bifurcated halogen bonds.
Nat Commun, 12, 2021
6ZLR
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BU of 6zlr by Molmil
Soaking competent crystal form of the SARS-CoV-2 Receptor Binding Domain (RBD):CR3022 complex.
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CR3022 FAB HEAVY CHAIN, CR3022 FAB LIGHT CHAIN, ...
著者de Nicola, G.F, Nichols, C.E.
登録日2020-07-01
公開日2020-12-23
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献A New Crystal Form of the SARS-CoV-2 Receptor Binding Domain: CR3022 Complex-An Ideal Target for In-Crystal Fragment Screening of the ACE2 Binding Site Surface.
Front Pharmacol, 11, 2020
4P9P
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BU of 4p9p by Molmil
Structure of NavMS in complex with channel blocking compound
分子名称: BROMIDE ION, DODECAETHYLENE GLYCOL, HEGA-10, ...
著者Naylor, C.E, Bagneris, C, Wallace, B.A.
登録日2014-04-04
公開日2014-06-04
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.91 Å)
主引用文献Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism.
Proc.Natl.Acad.Sci.USA, 111, 2014
4PA3
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BU of 4pa3 by Molmil
Structure of NavMS in complex with channel blocking compound
分子名称: BROMIDE ION, DODECAETHYLENE GLYCOL, HEGA-10, ...
著者Naylor, C.E, Bagneris, C, Wallace, B.A.
登録日2014-04-07
公開日2014-06-04
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.25 Å)
主引用文献Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism.
Proc.Natl.Acad.Sci.USA, 111, 2014
4P5H
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BU of 4p5h by Molmil
Structure of Clostridium perfringens Enterotoxin with a peptide derived from a modified version of ECL-2 of Claudin 2
分子名称: Claudin-2, Heat-labile enterotoxin B chain
著者Naylor, C.E, Yelland, T.S, Basak, A.K.
登録日2014-03-17
公開日2014-07-16
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.38 Å)
主引用文献Structure of a C. perfringens Enterotoxin Mutant in Complex with a Modified Claudin-2 Extracellular Loop 2.
J.Mol.Biol., 426, 2014
4PY0
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BU of 4py0 by Molmil
Crystal structure of P2Y12 receptor in complex with 2MeSATP
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-(methylsulfanyl)adenosine 5'-(tetrahydrogen triphosphate), P2Y purinoceptor 12, ...
著者Zhang, J, Zhang, K, Gao, Z.G, Paoletta, S, Zhang, D, Han, G.W, Li, T, Ma, L, Zhang, W, Muller, C.E, Yang, H, Jiang, H, Cherezov, V, Katritch, V, Jacobson, K.A, Stevens, R.C, Wu, B, Zhao, Q, GPCR Network (GPCR)
登録日2014-03-25
公開日2014-04-30
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Agonist-bound structure of the human P2Y12 receptor
Nature, 509, 2014
4PA9
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BU of 4pa9 by Molmil
Structure of NavMS in complex with channel blocking compound
分子名称: BROMIDE ION, DODECAETHYLENE GLYCOL, HEGA-10, ...
著者Naylor, C.E, Bagneris, C, Wallace, B.A.
登録日2014-04-07
公開日2014-06-04
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.43 Å)
主引用文献Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism.
Proc.Natl.Acad.Sci.USA, 111, 2014
7AQX
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Co-Crystal Structure of Variant Surface Glycoprotein VSG2 in complex with Nanobody VSG2(NB9)
分子名称: CITRIC ACID, Nanobody VSG2(NB9), SODIUM ION, ...
著者Stebbins, C.E, Hempelmann, A.
登録日2020-10-23
公開日2021-11-03
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.499 Å)
主引用文献Nanobody-mediated macromolecular crowding induces membrane fission and remodeling in the African trypanosome.
Cell Rep, 37, 2021
7AQY
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BU of 7aqy by Molmil
Co-Crystal Structure of Variant Surface Glycoprotein VSG2 in complex with Nanobody VSG2(NB11)
分子名称: Nanobody VSG2(NB11), Variant surface glycoprotein MITAT 1.2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Stebbins, C.E, Hempelmann, A, VanStraaten, M.
登録日2020-10-23
公開日2021-11-03
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Nanobody-mediated macromolecular crowding induces membrane fission and remodeling in the African trypanosome.
Cell Rep, 37, 2021
7AR0
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BU of 7ar0 by Molmil
Co-Crystal Structure of Variant Surface Glycoprotein VSG2 in complex with Nanobody VSG2(NB19)
分子名称: Nanobody VSG2(NB19), Variant surface glycoprotein MITAT 1.2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Stebbins, C.E, Hempelmann, A.
登録日2020-10-23
公開日2021-11-03
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.139 Å)
主引用文献Nanobody-mediated macromolecular crowding induces membrane fission and remodeling in the African trypanosome.
Cell Rep, 37, 2021

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件を2024-06-26に公開中

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