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PDB: 17 件
8SMS
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BU of 8sms by Molmil
Crosslinked Crystal Structure of Type II Fatty Acid Synthase, FabB, and cerulenin crosslinker-crypto Acyl Carrier Protein, AcpP
分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 1, Acyl carrier protein, N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-{2-[(2R)-2-hydroxy-4-oxododecanamido]ethyl}-beta-alaninamide
著者Jiang, Z, Chen, A, Chen, J, Sekhon, A, Louie, G.V, Noel, J.P, La Clair, J.J, Burkart, M.D.
登録日2023-04-26
公開日2023-09-27
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Masked cerulenin enables a dual-site selective protein crosslink.
Chem Sci, 14, 2023
5KBZ
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Structure of the PksA Product Template domain in complex with a phosphopantetheine mimetic
分子名称: (14R)-14-hydroxy-15,15-dimethyl-1-[5-({[(5-methyl-1,2-oxazol-3-yl)methyl]sulfanyl}methyl)-1,2-oxazol-3-yl]-4,9,13-trioxo-2-thia-5,8,12-triazahexadecan-16-yl dihydrogen phosphate, Noranthrone synthase
著者Tsai, S.C, Burkart, M.D, Townsend, C.A, Barajas, J.F, Shakya, G, Topper, C.L, Moreno, G, Jackson, D.R, Rivera, H, La Clair, J.J, Vagstad, A.
登録日2016-06-03
公開日2017-05-10
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.803 Å)
主引用文献Polyketide mimetics yield structural and mechanistic insights into product template domain function in nonreducing polyketide synthases.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
7L4L
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Crosslinked Crystal Structure of Type II Fatty Acid Synthase Ketosynthase, FabF, and C8-crypto Acyl Carrier Protein, AcpP
分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, Acyl carrier protein, SODIUM ION, ...
著者Mindrebo, J.T, Chen, A, Kim, W.E, Burkart, M.D, Noel, J.P.
登録日2020-12-19
公開日2021-09-22
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Structure and Mechanistic Analyses of the Gating Mechanism of Elongating Ketosynthases
Acs Catalysis, 11, 2021
7L4E
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Crosslinked Crystal Structure of Type II Fatty Acid Synthase Ketosynthase, FabF, and C16:1-crypto Acyl Carrier Protein, AcpP
分子名称: 1,2-ETHANEDIOL, 3-oxoacyl-[acyl-carrier-protein] synthase 2, Acyl carrier protein, ...
著者Mindrebo, J.T, Chen, A, Kim, W.E, Burkart, M.D, Noel, J.P.
登録日2020-12-18
公開日2021-10-06
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure and Mechanistic Analyses of the Gating Mechanism of Elongating Ketosynthases
Acs Catalysis, 11, 2021
6U0J
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Crosslinked Crystal Structure of Malonyl-CoA Acyl Carrier Protein Transacylase, FabD, and Acyl Carrier Protein, AcpP
分子名称: 1,2-ETHANEDIOL, Acyl carrier protein, Malonyl CoA-acyl carrier protein transacylase, ...
著者Mindrebo, J.T, Misson, L, Davis, T.D, Burkart, M.D, Noel, J.P.
登録日2019-08-14
公開日2020-07-22
最終更新日2020-10-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Interfacial plasticity facilitates high reaction rate of E. coli FAS malonyl-CoA:ACP transacylase, FabD.
Proc.Natl.Acad.Sci.USA, 117, 2020
5JDX
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PigG holo
分子名称: 4'-PHOSPHOPANTETHEINE, Putative peptidyl carrier protein
著者Jaremko, M.J, Lee, D.J, Burkart, M.D.
登録日2016-04-17
公開日2017-08-23
最終更新日2019-12-04
実験手法SOLUTION NMR
主引用文献PigG holo
To Be Published
6OLT
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Crosslinked Crystal Structure of Type II Fatty Acid Synthase Ketosynthase, FabF, and C12-crypto Acyl Carrier Protein, AcpP
分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, Acyl carrier protein, N-[2-(dodecanoylamino)ethyl]-N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide
著者Mindrebo, J.T, Kim, W.E, Bartholow, T.G, Chen, A, Davis, T.D, La Clair, J, Burkart, M.D, Noel, J.P.
登録日2019-04-17
公開日2020-04-22
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Gating mechanism of elongating beta-ketoacyl-ACP synthases.
Nat Commun, 11, 2020
6OKF
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Crosslinked Crystal Structure of Type II Fatty Acid Synthase Ketosynthase, FabB, and C16-crypto Acyl Carrier Protein, AcpP
分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 1, Acyl carrier protein, N-[2-(dodecanoylamino)ethyl]-N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide, ...
著者Mindrebo, J.T, Kim, W.E, Bartholow, T.G, Chen, A, Davis, T.D, La Clair, J, Burkart, M.D, Noel, J.P.
登録日2019-04-12
公開日2020-04-22
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Gating mechanism of elongating beta-ketoacyl-ACP synthases.
Nat Commun, 11, 2020
6OKC
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Crosslinked Crystal Structure of Type II Fatty Acid Synthase Ketosynthase, FabB, and C12-crypto Acyl Carrier Protein, AcpP
分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 1, Acyl carrier protein, N-[2-(dodecanoylamino)ethyl]-N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide
著者Mindrebo, J.T, Kim, W.E, Bartholow, T.G, Chen, A, Davis, T.D, La Clair, J, Burkart, M.D, Noel, J.P.
登録日2019-04-12
公開日2020-04-15
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Gating mechanism of elongating beta-ketoacyl-ACP synthases.
Nat Commun, 11, 2020
6OKG
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Crosslinked Crystal Structure of Type II Fatty Acid Synthase Ketosynthase, FabF, and C16-crypto Acyl Carrier Protein, AcpP
分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, Acyl carrier protein, N-[2-(hexadecanoylamino)ethyl]-N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide, ...
著者Mindrebo, J.T, Kim, W.E, Bartholow, T.G, Chen, A, Davis, T.D, La Clair, J, Burkart, M.D, Noel, J.P.
登録日2019-04-12
公開日2020-04-22
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Gating mechanism of elongating beta-ketoacyl-ACP synthases.
Nat Commun, 11, 2020
4QJK
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Crystal structure of M. tuberculosis phosphopantetheinyl transferase PptT
分子名称: COENZYME A, Phosphopantetheinyl transferase PptT, SULFATE ION
著者Noel, J.P, Burkart, M.D, Vickery, C.R.
登録日2014-06-04
公開日2014-07-16
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献Structure, biochemistry, and inhibition of essential 4'-phosphopantetheinyl transferases from two species of mycobacteria.
Acs Chem.Biol., 9, 2014
4QJL
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Crystal structure of M. ulcerans phosphopantetheinyl transferase MuPPT
分子名称: COENZYME A, MAGNESIUM ION, Phosphopantetheinyl transferase, ...
著者Noel, J.P, Burkart, M.D, Vickery, C.R.
登録日2014-06-04
公開日2014-07-16
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structure, biochemistry, and inhibition of essential 4'-phosphopantetheinyl transferases from two species of mycobacteria.
Acs Chem.Biol., 9, 2014
7SQI
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Crosslinked Crystal Structure of Type II Fatty Acid Synthase Ketosynthase, FabB, and C14-crypto Acyl Carrier Protein, AcpP
分子名称: Acyl carrier protein, Beta-ketoacyl-ACP synthase I, N-{2-[(2Z)-3-chlorotetradec-2-enamido]ethyl}-N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide, ...
著者Chen, A, Mindrebo, J.T, Davis, T.D, Noel, J.P, Burkart, M.D.
登録日2021-11-05
公開日2022-08-03
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Mechanism-based cross-linking probes capture the Escherichia coli ketosynthase FabB in conformationally distinct catalytic states.
Acta Crystallogr D Struct Biol, 78, 2022
7SZ9
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Crosslinked Crystal Structure of Type II Fatty Acid Synthase Ketosynthase, FabB, and C16:1-crypto Acyl Carrier Protein, AcpP
分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 1, Acyl carrier protein, N~3~-{(2R)-4-[(dihydroxyphosphanyl)oxy]-2-hydroxy-3,3-dimethylbutanoyl}-N-(2-{[(9Z)-hexadec-9-enoyl]amino}ethyl)-beta-alaninamide, ...
著者Mindrebo, J.T, Chen, A, Noel, J.P, Burkart, M.D.
登録日2021-11-26
公開日2022-11-23
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Mechanism-based cross-linking probes capture the Escherichia coli ketosynthase FabB in conformationally distinct catalytic states.
Acta Crystallogr D Struct Biol, 78, 2022
8DLE
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BU of 8dle by Molmil
Crosslinked Crystal Structure of the 8-amino-7-oxonanoate synthase, BioF, and Benzene Sulfonyl Fluoride-crypto Acyl Carrier Protein, BSF-ACP
分子名称: 1,2-ETHANEDIOL, 8-amino-7-oxononanoate synthase, Acyl carrier protein, ...
著者Chen, A, Davis, T.D, Louie, G.V, Bowman, M.E, Noel, J.P, Burkart, M.D.
登録日2022-07-07
公開日2023-07-12
最終更新日2024-07-24
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Visualizing the Interface of Biotin and Fatty Acid Biosynthesis through SuFEx Probes.
J.Am.Chem.Soc., 146, 2024
2N5H
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BU of 2n5h by Molmil
PltL-holo
分子名称: 4'-PHOSPHOPANTETHEINE, Peptidyl carrier protein PltL
著者Jaremko, M.J, Lee, D.J, Burkart, M.D.
登録日2015-07-17
公開日2015-09-16
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Structure and Substrate Sequestration in the Pyoluteorin Type II Peptidyl Carrier Protein PltL.
J.Am.Chem.Soc., 137, 2015
2N5I
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PltL-pyrrolyl
分子名称: (3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-{[3-oxo-3-({2-[(1H-pyrrol-2-ylcarbonyl)amino]ethyl}amino)propyl]amino}butyl dihydrogen phosphate, Peptidyl carrier protein PltL
著者Jaremko, M.J, Lee, D.J, Burkart, M.D.
登録日2015-07-17
公開日2015-09-16
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Structure and Substrate Sequestration in the Pyoluteorin Type II Peptidyl Carrier Protein PltL.
J.Am.Chem.Soc., 137, 2015

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