4CRO
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![BU of 4cro by Molmil](/molmil-images/mine/4cro) | PROTEIN-DNA CONFORMATIONAL CHANGES IN THE CRYSTAL STRUCTURE OF A LAMBDA CRO-OPERATOR COMPLEX | Descriptor: | DNA (5'-D(*TP*AP*TP*CP*AP*CP*CP*GP*CP*GP*GP*GP*TP*GP*AP*TP*A)-3'), PROTEIN (LAMBDA CRO) | Authors: | Brennan, R.G, Roderick, S.L, Takeda, Y, Matthews, B.W. | Deposit date: | 1992-01-15 | Release date: | 1992-01-15 | Last modified: | 2022-11-23 | Method: | X-RAY DIFFRACTION (3.9 Å) | Cite: | Protein-DNA conformational changes in the crystal structure of a lambda Cro-operator complex. Proc.Natl.Acad.Sci.USA, 87, 1990
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3ECO
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![BU of 3eco by Molmil](/molmil-images/mine/3eco) | |
1DN8
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![BU of 1dn8 by Molmil](/molmil-images/mine/1dn8) | |
2PEX
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![BU of 2pex by Molmil](/molmil-images/mine/2pex) | |
2PFB
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![BU of 2pfb by Molmil](/molmil-images/mine/2pfb) | |
8SSH
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![BU of 8ssh by Molmil](/molmil-images/mine/8ssh) | MtrR from Neisseria gonorrhoeae bound to Ethinyl Estradiol | Descriptor: | Ethinyl estradiol, HTH-type transcriptional regulator MtrR, PHOSPHATE ION | Authors: | Hooks, G.M, Brennan, R.G. | Deposit date: | 2023-05-08 | Release date: | 2024-02-14 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Hormonal steroids induce multidrug resistance and stress response genes in Neisseria gonorrhoeae by binding to MtrR. Nat Commun, 15, 2024
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6WMP
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![BU of 6wmp by Molmil](/molmil-images/mine/6wmp) | F. tularensis RNAPs70-iglA DNA complex | Descriptor: | DNA NT-strand, DNA T-strand, DNA-directed RNA polymerase subunit alpha 1, ... | Authors: | Travis, B.A, Brennan, R.G, Schumacher, M.A. | Deposit date: | 2020-04-21 | Release date: | 2020-11-11 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | Structural Basis for Virulence Activation of Francisella tularensis. Mol.Cell, 81, 2021
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1R8E
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![BU of 1r8e by Molmil](/molmil-images/mine/1r8e) | Crystal Structure of BmrR Bound to DNA at 2.4A Resolution | Descriptor: | 5'-D(*GP*AP*CP*CP*CP*TP*CP*CP*CP*CP*TP*TP*AP*GP*GP*GP*GP*AP*GP*GP*GP*TP*C)-3', GLYCEROL, IMIDAZOLE, ... | Authors: | Newberry, K.J, Brennan, R.G. | Deposit date: | 2003-10-23 | Release date: | 2004-08-17 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | The structural mechanism for transcription activation by MerR family member multidrug transporter activation, N terminus. J.Biol.Chem., 279, 2004
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6WMR
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![BU of 6wmr by Molmil](/molmil-images/mine/6wmr) | F. tularensis RNAPs70-(MglA-SspA)-iglA DNA complex | Descriptor: | DNA NT-strand, DNA NT-strand downstream, DNA T-strand, ... | Authors: | Travis, B.A, Brennan, R.G, Schumacher, M.A. | Deposit date: | 2020-04-21 | Release date: | 2020-11-11 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.46 Å) | Cite: | Structural Basis for Virulence Activation of Francisella tularensis. Mol.Cell, 81, 2021
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6WMU
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![BU of 6wmu by Molmil](/molmil-images/mine/6wmu) | E. coli RNAPs70-SspA-gadA DNA complex | Descriptor: | DNA NT-strand, DNA NT-strand downstream, DNA T-strand, ... | Authors: | Travis, B.A, Brennan, R.G, Schumacher, M.A. | Deposit date: | 2020-04-21 | Release date: | 2020-11-11 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.18 Å) | Cite: | Structural Basis for Virulence Activation of Francisella tularensis. Mol.Cell, 81, 2021
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1RPW
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![BU of 1rpw by Molmil](/molmil-images/mine/1rpw) | Crystal Structure Of The Multidrug Binding Protein Qacr Bound To The Diamidine Hexamidine | Descriptor: | 4,4'[1,6-HEXANEDIYLBIS(OXY)]BISBENZENECARBOXIMIDAMIDE, SULFATE ION, Transcriptional regulator qacR | Authors: | Murray, D.S, Schumacher, M.A, Brennan, R.G. | Deposit date: | 2003-12-03 | Release date: | 2004-06-01 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal structures of QacR-diamidine complexes reveal additional multidrug-binding modes and a novel mechanism of drug charge neutralization. J.Biol.Chem., 279, 2004
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1RKW
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![BU of 1rkw by Molmil](/molmil-images/mine/1rkw) | CRYSTAL STRUCTURE OF THE MULTIDRUG BINDING TRANSCRIPTIONAL REPRESSOR QACR BOUND TO PENTAMADINE | Descriptor: | 1,5-BIS(4-AMIDINOPHENOXY)PENTANE, SULFATE ION, Transcriptional regulator qacR | Authors: | Murray, D.S, Schumacher, M.A, Brennan, R.G. | Deposit date: | 2003-11-23 | Release date: | 2004-06-01 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.62 Å) | Cite: | Crystal structures of QacR-diamidine complexes reveal additional multidrug-binding modes and a novel mechanism of drug charge neutralization. J.Biol.Chem., 279, 2004
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6WMT
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![BU of 6wmt by Molmil](/molmil-images/mine/6wmt) | F. tularensis RNAPs70-(MglA-SspA)-ppGpp-PigR-iglA DNA complex | Descriptor: | DNA NT-strand, DNA NT-strand downstream, DNA T-strand, ... | Authors: | Travis, B.A, Brennan, R.G, Schumacher, M.A. | Deposit date: | 2020-04-21 | Release date: | 2020-11-11 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4.43 Å) | Cite: | Structural Basis for Virulence Activation of Francisella tularensis. Mol.Cell, 81, 2021
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8FHW
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8FO1
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![BU of 8fo1 by Molmil](/molmil-images/mine/8fo1) | |
8FW0
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![BU of 8fw0 by Molmil](/molmil-images/mine/8fw0) | MtrR from Neisseria gonorrhoeae bound to beta-Estradiol | Descriptor: | ESTRADIOL, GLYCEROL, HTH-type transcriptional regulator MtrR, ... | Authors: | Hooks, G.H, Brennan, R.G. | Deposit date: | 2023-01-20 | Release date: | 2024-01-24 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.37 Å) | Cite: | Hormonal steroids induce multidrug resistance and stress response genes in Neisseria gonorrhoeae by binding to MtrR. Nat Commun, 15, 2024
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8FW8
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![BU of 8fw8 by Molmil](/molmil-images/mine/8fw8) | MtrR from Neisseria gonorrhoeae bound to Progesterone | Descriptor: | 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, HTH-type transcriptional regulator MtrR, PHOSPHATE ION, ... | Authors: | Hooks, G.H, Brennan, R.G. | Deposit date: | 2023-01-20 | Release date: | 2024-01-24 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Hormonal steroids induce multidrug resistance and stress response genes in Neisseria gonorrhoeae by binding to MtrR. Nat Commun, 15, 2024
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3ZQL
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![BU of 3zql by Molmil](/molmil-images/mine/3zql) | DNA-bound form of TetR-like repressor SimR | Descriptor: | 5'-D(*DTP*TP*CP*GP*TP*AP*CP*GP*CP*CP*GP*TP*AP*DCP *GP*AP*A)-3', 5'-D(*DTP*TP*CP*GP*TP*AP*CP*GP*GP*CP*GP*TP*AP*DCP *GP*AP*A)-3', PUTATIVE REPRESSOR SIMREG2 | Authors: | Le, T.B.K, Schumacher, M.A, Lawson, D.M, Brennan, R.G, Buttner, M.J. | Deposit date: | 2011-06-10 | Release date: | 2011-08-31 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.99 Å) | Cite: | The Crystal Structure of the Tetr Family Transcriptional Repressor Simr Bound to DNA and the Role of a Flexible N-Terminal Extension in Minor Groove Binding. Nucleic Acids Res., 39, 2011
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3VIB
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7JU3
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![BU of 7ju3 by Molmil](/molmil-images/mine/7ju3) | MtrR bound to the mtrCDE operator from Neisseria gonorrhoeae | Descriptor: | CALCIUM ION, DNA (5'-D(*AP*CP*AP*TP*AP*CP*AP*CP*GP*AP*TP*TP*GP*CP*AP*CP*GP*GP*AP*TP*A)-3'), DNA (5'-D(*TP*AP*TP*CP*CP*GP*TP*GP*CP*AP*AP*TP*CP*GP*TP*GP*TP*AP*TP*GP*T)-3'), ... | Authors: | Beggs, G.A, Shafer, W.M, Brennan, R.G. | Deposit date: | 2020-08-19 | Release date: | 2021-03-24 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structures of Neisseria gonorrhoeae MtrR-operator complexes reveal molecular mechanisms of DNA recognition and antibiotic resistance-conferring clinical mutations. Nucleic Acids Res., 49, 2021
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7JNP
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![BU of 7jnp by Molmil](/molmil-images/mine/7jnp) | MtrR bound to the rpoH operator from Neisseria gonorrhoeae | Descriptor: | CALCIUM ION, DNA (5'-D(*TP*AP*CP*AP*TP*AP*CP*GP*TP*GP*GP*TP*TP*GP*TP*AP*TP*GP*TP*AP*A)-3'), DNA (5'-D(*TP*TP*AP*CP*AP*TP*AP*CP*AP*AP*CP*CP*AP*CP*GP*TP*AP*TP*GP*TP*A)-3'), ... | Authors: | Beggs, G.A, Shafer, W.M, Brennan, R.G. | Deposit date: | 2020-08-05 | Release date: | 2021-03-24 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structures of Neisseria gonorrhoeae MtrR-operator complexes reveal molecular mechanisms of DNA recognition and antibiotic resistance-conferring clinical mutations. Nucleic Acids Res., 49, 2021
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8FW3
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![BU of 8fw3 by Molmil](/molmil-images/mine/8fw3) | MtrR from Neisseria gonorrhoeae bound to Testosterone | Descriptor: | HTH-type transcriptional regulator MtrR, PHOSPHATE ION, TESTOSTERONE | Authors: | Hooks, G.H, Brennan, R.G. | Deposit date: | 2023-01-20 | Release date: | 2024-01-24 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.22 Å) | Cite: | Hormonal steroids induce multidrug resistance and stress response genes in Neisseria gonorrhoeae by binding to MtrR. Nat Commun, 15, 2024
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7LQ4
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![BU of 7lq4 by Molmil](/molmil-images/mine/7lq4) | Rr (RsiG)2-(c-di-GMP)2-WhiG complex | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), RsiG, WhiG | Authors: | Schumacher, M.A, Brennan, R.G. | Deposit date: | 2021-02-12 | Release date: | 2021-07-14 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Evolution of a sigma-(c-di-GMP)-anti-sigma switch. Proc.Natl.Acad.Sci.USA, 118, 2021
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7LQ2
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![BU of 7lq2 by Molmil](/molmil-images/mine/7lq2) | Apo Rr RsiG- crystal form 1 | Descriptor: | ISOPROPYL ALCOHOL, MAGNESIUM ION, RR RsiG | Authors: | Schumacher, M.A, Brennan, R.G. | Deposit date: | 2021-02-12 | Release date: | 2021-07-14 | Last modified: | 2021-08-25 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Evolution of a sigma-(c-di-GMP)-anti-sigma switch. Proc.Natl.Acad.Sci.USA, 118, 2021
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7LQ3
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![BU of 7lq3 by Molmil](/molmil-images/mine/7lq3) | |